Search Results - (Author, Cooperation:F. K. Swirski)
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1Latest Papers from Table of Contents or Articles in PressG. F. Weber ; B. G. Chousterman ; S. He ; A. M. Fenn ; M. Nairz ; A. Anzai ; T. Brenner ; F. Uhle ; Y. Iwamoto ; C. S. Robbins ; L. Noiret ; S. L. Maier ; T. Zonnchen ; N. N. Rahbari ; S. Scholch ; A. Klotzsche-von Ameln ; T. Chavakis ; J. Weitz ; S. Hofer ; M. A. Weigand ; M. Nahrendorf ; R. Weissleder ; F. K. Swirski
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-03-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; B-Lymphocyte Subsets/immunology ; Cytokines/immunology/metabolism ; Disease Models, Animal ; Humans ; Inflammation ; Interleukin-3/blood/*immunology/metabolism ; Lipopolysaccharides/immunology ; Lymphoid Tissue/immunology ; Mice ; Mice, Inbred BALB C ; Monocytes/immunology ; Myelopoiesis ; Neutrophils/immunology ; Peritonitis/immunology/pathology ; Prognosis ; Sepsis/*immunology/mortality/pathology/therapyPublished by: -
2Latest Papers from Table of Contents or Articles in PressF. K. Swirski ; M. Nahrendorf
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-01-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptive Immunity ; Animals ; Atherosclerosis/complications/*immunology/*physiopathology ; Disease Progression ; Heart Failure/etiology/immunology/*physiopathology ; Humans ; Leukocytes/immunology/*physiology ; Macrophages/immunology/physiology ; Myocardial Infarction/etiology/immunology/*physiopathologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressM. Nahrendorf ; F. K. Swirski
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-07-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Atherosclerosis/*immunology ; Extracellular Traps/*immunology ; Humans ; Interleukin-1beta/*biosynthesis ; Macrophages/*immunology ; Neutrophils/*immunologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressP. J. Rauch ; A. Chudnovskiy ; C. S. Robbins ; G. F. Weber ; M. Etzrodt ; I. Hilgendorf ; E. Tiglao ; J. L. Figueiredo ; Y. Iwamoto ; I. Theurl ; R. Gorbatov ; M. T. Waring ; A. T. Chicoine ; M. Mouded ; M. J. Pittet ; M. Nahrendorf ; R. Weissleder ; F. K. Swirski
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-01-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; B-Lymphocyte Subsets/*immunology/metabolism ; Cell Lineage ; Cell Separation ; Escherichia coli Infections/*immunology ; Female ; Flow Cytometry ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology/*metabolism ; *Immunity, Innate ; Immunoglobulin M/metabolism ; Immunophenotyping ; Integrin alpha4beta1/immunology/metabolism ; Lipopolysaccharides ; Lymphocyte Activation ; Lymphocyte Function-Associated Antigen-1/immunology/metabolism ; Mice ; Mice, Inbred C57BL ; Parabiosis ; Peritonitis/*immunology ; Sepsis/*immunology ; Shock, Septic/immunology ; Spleen/immunology ; Toll-Like Receptor 4/immunologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressP. Dutta ; G. Courties ; Y. Wei ; F. Leuschner ; R. Gorbatov ; C. S. Robbins ; Y. Iwamoto ; B. Thompson ; A. L. Carlson ; T. Heidt ; M. D. Majmudar ; F. Lasitschka ; M. Etzrodt ; P. Waterman ; M. T. Waring ; A. T. Chicoine ; A. M. van der Laan ; H. W. Niessen ; J. J. Piek ; B. B. Rubin ; J. Butany ; J. R. Stone ; H. A. Katus ; S. A. Murphy ; D. A. Morrow ; M. S. Sabatine ; C. Vinegoni ; M. A. Moskowitz ; M. J. Pittet ; P. Libby ; C. P. Lin ; F. K. Swirski ; R. Weissleder ; M. Nahrendorf
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Apolipoproteins E/genetics ; Atherosclerosis/*etiology/*pathology ; Hematopoietic Stem Cells/cytology ; Inflammation/complications ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology ; Myocardial Infarction/*complications/*pathology ; Spleen/cytology ; Stem Cells/cytologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressHulsmans, M., Sager, H. B., Roh, J. D., Valero-Munoz, M., Houstis, N. E., Iwamoto, Y., Sun, Y., Wilson, R. M., Wojtkiewicz, G., Tricot, B., Osborne, M. T., Hung, J., Vinegoni, C., Naxerova, K., Sosnovik, D. E., Zile, M. R., Bradshaw, A. D., Liao, R., Tawakol, A., Weissleder, R., Rosenzweig, A., Swirski, F. K., Sam, F., Nahrendorf, M.
Rockefeller University Press
Published 2018Staff ViewPublication Date: 2018-02-10Publisher: Rockefeller University PressPrint ISSN: 0022-1007Electronic ISSN: 1540-9538Topics: MedicineKeywords: Cardiovascular Biology, Innate Immunity and Inflammation, HematopoiesisPublished by: -
7Articles: DFG German National LicensesSwirski, F. K. ; Gajewska, B. U. ; Alvarez, D. ; Ritz, S. A. ; Cundall, M. J. ; Cates, E. C. ; Coyle, A. J. ; Gutierrez-Ramos, J.-C. ; Inman, M. D. ; Jordana, M. ; Stämpfli, M. R.
Oxford, UK : Blackwell Science, Ltd
Published 2002Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Exposure to aerosolized harmless antigen such as ovalbumin (OVA) has previously been shown to induce inhalation tolerance, a state characterized by inhibition of IgE synthesis and airway inflammation, upon secondary immunogenic antigen encounter. Immune events associated with this phenomenon are still poorly understood.Objective The aim of this study was to investigate cellular and molecular mechanisms underlying this state of ‘unresponsiveness’.Methods; After initial repeated OVA exposure, mice were subjected to a protocol of antigen-induced airway inflammation, encompassing two intraperitoneal injections of OVA adsorbed to aluminium hydroxide followed by airway challenge. We assessed immune events in the draining lymph nodes after sensitization, and in the lungs after challenge.Results In animals initially exposed to OVA, we observed, at the time of sensitization, considerable expansion of T cells, many of which expressed the activation markers CD69 and CD25, as well as increased numbers of antigen-presenting cells, particularly B cells. While these animals produced low levels of IgE, the observed elevated levels of IgG1 signified isotype switching. Splenocytes and lymph node cells from OVA-exposed mice produced low levels of IL-4, IL-5, IL-13 and IFN-γ, indicating aborted effector function of both T helper (Th)2- and Th1-associated cytokines. Real time quantitative polymerase chain reaction (PCR) (TaqMan) analysis of costimulatory molecules in the lungs after in vivo challenge showed that B7.1, B7.2, CD28 and CTLA-4 mRNA expression was low in animals initially exposed to OVA. Ultimately, these events were associated with abrogated airway inflammation and attenuated airway hyper-responsiveness. The decreased inflammation was antigen-specific and independent of IL-10 or IFN-γ.Conclusion Initial exposure to OVA establishes a programme that prevents the generation of intact, fully functional inflammatory responses upon secondary antigen encounter. The absence of inflammation, however, is not associated with categorical immune unresponsiveness.Type of Medium: Electronic ResourceURL: