Search Results - (Author, Cooperation:F. Ferre)
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1C. J. Ceol ; Y. Houvras ; J. Jane-Valbuena ; S. Bilodeau ; D. A. Orlando ; V. Battisti ; L. Fritsch ; W. M. Lin ; T. J. Hollmann ; F. Ferre ; C. Bourque ; C. J. Burke ; L. Turner ; A. Uong ; L. A. Johnson ; R. Beroukhim ; C. H. Mermel ; M. Loda ; S. Ait-Si-Ali ; L. A. Garraway ; R. A. Young ; L. I. Zon
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Age of Onset ; Amino Acid Substitution ; Animals ; Animals, Genetically Modified ; Cell Transformation, Neoplastic/genetics ; Chromatin Immunoprecipitation ; Chromosomes, Human, Pair 1/genetics ; DNA Copy Number Variations/*genetics ; Disease Models, Animal ; Gene Amplification/*genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Homeobox/genetics ; Histone-Lysine N-Methyltransferase/*genetics/metabolism ; Humans ; Melanocytes/cytology/enzymology/metabolism/pathology ; Melanoma/enzymology/*genetics/*pathology ; Nevus/enzymology ; Oncogenes/genetics ; Protein Methyltransferases/*genetics/*metabolism ; Proto-Oncogene Proteins B-raf/chemistry/genetics/metabolism ; Zebrafish/geneticsPublished by: -
2Rubio, G. ; Leon, G. ; Ferre, F. ; Pascual, J. ; Santo-Domingo, J.
Oxford, UK : Carfax Publishing Limited
Published 1998Staff ViewISSN: 1360-0443Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Abstract Aims. To evaluate Cloninger's classification in a sample of alcoholic Spanish men. Design. A crosssectional study was carried out on subjects diagnosed as alcoholics. Setting. Out-patient units specializing in the treatment of alcoholics and the psychiatry unit of a general hospital. Participants. One hundred and ninety-eight males diagnosed as alcoholics. The mean age was 44.4 11.6 years and 98% were from urban areas. Measurements. Participants were interviewed using the Structured Clinical Interview for DSMIII-R(SCID). They were classified using type 1 and type 2 criteria of Cloninger's classification. Findings. Only one-third of our sample could be classified by Cloninger's type 1 and type 2 criteria. Patients classified as belonging to type 2 had an earlier onset of regular drinking compared to type 1 patients. Type 2 subjects presented a higher percentage of alcohol-related problems as well as problems related to drugs other than alcohol and they also presented a higher percentage of antisocial personality disorder. No differences in alcoholism family history were found between the groups. Criteria showing the poorest discriminative ability between both groups were "failure to keep abstinent" and "benders lasting at least two days". Conclusions. Our results do not support Cloninger's etiological hypotheses for alcoholism. Cultural differences may be responsible for the different drinking patterns observed.Type of Medium: Electronic ResourceURL: -
3Leroy, M. J. ; Tanguy, G. ; Vial, M. ; Rostène, W. ; Malassiné, A. ; Ferré, F.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1440-1681Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 1. In the present study we examined the in vitro effect of vasoactive intestinal peptide (VIP) on spontaneous contractions in both inner and outer layers of non-pregnant human myometrium. A dose-dependent relaxation was observed, but with a marked difference in sensitivity to VIP between the two layers, with an IC50 value of 1 X 10−8 and 1 X 10−5 mol/L in the outer and inner layers, respectively.2. We also established that VIP did not directly stimulate the adenylate cyclase activity. The only slight stimulations were observed in non-initial rate conditions. The maximal response of this indirect effect was obtained for VIP concentrations between 1 X 10−9 and 1 X 10−8 mol/L and this occurred to the same extent (an approximately 1.4-fold increase) in both layers. However this response is specific, since structurally related peptides such as glucagon, gastric inhibitory polypeptide (GIP), secretin, or human growth hormone-releasing factor (hGRF) had no effect in our preparations.3. Autoradiographic studies revealed that specific VIP binding sites were located on the vascularization of the intermediate vascular layer and on arterioles and venules distributed in the inner and outer myometrial layers. They were also present in the endometrium, but not on smooth muscle cells of either layer.4. Such observations could provide evidence for another signal transduction pathway to mediate the biological effect of VIP. An additional intermediate step on the vascularization distributed in all of the muscle cannot be excluded.Type of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
6Piechaczyk, M. ; Blanchard, J.-M. ; Bonnieu, A. ; Fort, P. ; Mechti, N. ; Rech, J. ; Cuny, M. ; Marty, L. ; Lebleu, B. ; Ferre, F. ; Jeanteur, P.
Amsterdam : ElsevierStaff ViewISSN: 0378-1119Keywords: Recombinant DNA ; antisense RNA ; elongation block ; exon ; intron ; mRNA instability ; oncogenes ; retrovirus ; transcriptionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Valverde-Garcia, A. ; Gonzalez-Pradas, E. ; Aguilera-Del Real, A. ; Urena-Amate, M.D. ; Camacho-Ferre, F.
Amsterdam : ElsevierStaff ViewISSN: 0003-2670Keywords: Chlorothalonil ; Fungicides ; Gas chromatography ; Gas chromatography-mass spectrometry ; Pesticides ; VegetablesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Ferre, F. ; Breuiller, M. ; Cedard, L. ; Duchesne, M.-J. ; Saintot, M. ; Descomps, B. ; De Paulet, A.
Amsterdam : ElsevierStaff ViewISSN: 0039-128XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
14Leroy, M.-J. ; Lugnier, C. ; Merezak, J. ; Tanguy, G. ; Olivier, S. ; Le Bec, A. ; Ferre, F.
Amsterdam : ElsevierStaff ViewISSN: 0898-6568Keywords: Pregnancy ; contractile activity ; cyclic nucleotide phosphodiesterases ; human myometrium ; isoenzyme selective inhibitorsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
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ISSN: 0304-4165Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 1572-8358Keywords: human partition ; myometrial contractions ; mathematical modelSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract We have developed a simple mathematical model with three physiologically significant states to describe the changes in intrauterine pressure associated with a contraction during human parturition. The myometrium is modelled as a set of smooth muscle cells, each of which is in one of three states (quiescent, contracted, refractory) at a given time. These states are occupied according to a cycle governed by three temporal parameters. The solutions of the equations describing the model show an oscillatory behavior for particular values of these parameters, which is very similar to the time dependant development of intrauterine pressure during labor. Due to its non-linear terms, our model could lead to chaotic oscillations (in the mathematical sense), whose clinical counterpart may occur in cases of dystocia. Despite its simplicity, this model appears to be a useful guide to further investigations of the oscillatory behavior of the myometrium, or other smooth muscles, in normal and pathological situations.Type of Medium: Electronic ResourceURL: -
17Effects of prostaglandins on cyclic nucleotide phosphodiesterase activity in the human term placentaStaff View
ISSN: 0090-6980Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 0090-6980Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 0167-0115Keywords: Blood flow ; Fetal vascularization ; Peptide hormone ; Placental physiology ; Receptor ; cAMPSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 0040-5639Topics: Theology and Religious StudiesNotes: BOOK REVIEWSURL: