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1Latest Papers from Table of Contents or Articles in PressM. Parker ; K. M. Mohankumar ; C. Punchihewa ; R. Weinlich ; J. D. Dalton ; Y. Li ; R. Lee ; R. G. Tatevossian ; T. N. Phoenix ; R. Thiruvenkatam ; E. White ; B. Tang ; W. Orisme ; K. Gupta ; M. Rusch ; X. Chen ; P. Nagahawhatte ; E. Hedlund ; D. Finkelstein ; G. Wu ; S. Shurtleff ; J. Easton ; K. Boggs ; D. Yergeau ; B. Vadodaria ; H. L. Mulder ; J. Becksfort ; P. Gupta ; R. Huether ; J. Ma ; G. Song ; A. Gajjar ; T. Merchant ; F. Boop ; A. A. Smith ; L. Ding ; C. Lu ; K. Ochoa ; D. Zhao ; R. S. Fulton ; L. L. Fulton ; E. R. Mardis ; R. K. Wilson ; J. R. Downing ; D. R. Green ; J. Zhang ; D. W. Ellison ; R. J. Gilbertson
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/genetics/metabolism ; Animals ; Base Sequence ; Brain Neoplasms/genetics/metabolism/pathology ; Cell Line ; Cell Nucleus/metabolism ; *Cell Transformation, Neoplastic/genetics ; Chromosomes, Human, Pair 11/genetics ; Ependymoma/*genetics/*metabolism/pathology ; Female ; Humans ; Mice ; Models, Genetic ; Molecular Sequence Data ; NF-kappa B/genetics/*metabolism ; Neural Stem Cells/metabolism/pathology ; Oncogene Proteins, Fusion/genetics/metabolism ; Phosphoproteins/genetics/metabolism ; Proteins/genetics/*metabolism ; *Signal Transduction ; Transcription Factor RelA/genetics/*metabolism ; Translocation, Genetic/geneticsPublished by: -
2Articles: DFG German National LicensesGriffin, W. S. T. ; Yeralan, O. ; Sheng, J. G. ; Boop, F. A. ; Mrak, R. E. ; Rovnaghi, C. R. ; Burnett, B. A. ; Feoktistova, A. ; Van Eldik, L. J.
Oxford, UK : Blackwell Science Ltd
Published 1995Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Neuritic sprouting and disturbances of calcium homeostasis are well described in epilepsy. S100β is an astrocyte-derived cytokine that promotes neurite growth and induces increases in levels of intracellular calcium in neurons. In sections of neocortex of surgically resected temporal lobe tissue from patients with intractable epilepsy, we found that the number of S100β-immunoreactive astrocytes was approximately threefold higher than that found in control patients (p 〈 0.001). These astrocytes were activated, i.e., enlarged, and had prominent processes. Temporal lobe tissue levels of S100β were shown by ELISA to be fivefold higher in 21 epileptics than in 12 controls (p 〈 0.001). The expression of the astrocyte intermediate filament protein, glial fibrillary acidic protein, was not significantly elevated in epileptics, suggesting a selective up-regulation of S100β expression. Our findings, together with established functions of S100β, suggest that this neurotrophic cytokine may be involved in the pathophysiology of epilepsy.Type of Medium: Electronic ResourceURL: