Search Results - (Author, Cooperation:E. Lim)

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  1. 1
    Yves Mugabo, Mina Sadeghi, Nancy N. Fang, Thibault Mayor, Gareth E. Lim
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Published 2018
    Staff View
    Publication Date:
    2018-05-05
    Publisher:
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Print ISSN:
    0021-9258
    Electronic ISSN:
    1083-351X
    Topics:
    Biology
    Chemistry and Pharmacology
    Published by:
    http://www.asbmb.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-05-25
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Oncology
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    B. M. Neale ; Y. Kou ; L. Liu ; A. Ma'ayan ; K. E. Samocha ; A. Sabo ; C. F. Lin ; C. Stevens ; L. S. Wang ; V. Makarov ; P. Polak ; S. Yoon ; J. Maguire ; E. L. Crawford ; N. G. Campbell ; E. T. Geller ; O. Valladares ; C. Schafer ; H. Liu ; T. Zhao ; G. Cai ; J. Lihm ; R. Dannenfelser ; O. Jabado ; Z. Peralta ; U. Nagaswamy ; D. Muzny ; J. G. Reid ; I. Newsham ; Y. Wu ; L. Lewis ; Y. Han ; B. F. Voight ; E. Lim ; E. Rossin ; A. Kirby ; J. Flannick ; M. Fromer ; K. Shakir ; T. Fennell ; K. Garimella ; E. Banks ; R. Poplin ; S. Gabriel ; M. DePristo ; J. R. Wimbish ; B. E. Boone ; S. E. Levy ; C. Betancur ; S. Sunyaev ; E. Boerwinkle ; J. D. Buxbaum ; E. H. Cook, Jr. ; B. Devlin ; R. A. Gibbs ; K. Roeder ; G. D. Schellenberg ; J. S. Sutcliffe ; M. J. Daly
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-04-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Autistic Disorder/*genetics ; Case-Control Studies ; DNA-Binding Proteins/*genetics ; Exome/genetics ; Exons/*genetics ; Family Health ; Genetic Predisposition to Disease/*genetics ; Humans ; Models, Genetic ; Multifactorial Inheritance/genetics ; Mutation/*genetics ; Phenotype ; Poisson Distribution ; Protein Interaction Maps ; Transcription Factors/*genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2014-03-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antigens, CD24/metabolism ; Antigens, CD44/metabolism ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Cell Proliferation ; DNA-Binding Proteins/deficiency/genetics/*metabolism ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Gene Silencing ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism ; Mice ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Prognosis ; RNA Polymerase II/metabolism ; Transcription Factors/deficiency/genetics/*metabolism ; Transcription, Genetic ; Triple Negative Breast Neoplasms/blood supply/genetics/*metabolism/*pathology ; Unfolded Protein Response
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Cheng, K. K.-F., Lim, E. Y.-T., Kanesvaran, R.
    BMJ Publishing
    Published 2018
    Staff View
    Publication Date:
    2018-01-26
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Oncology, Chemotherapy, Radiotherapy
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2018-02-09
    Publisher:
    BMJ Publishing
    Electronic ISSN:
    2044-6055
    Topics:
    Medicine
    Keywords:
    Open access, Oncology
    Published by:
    http://group.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    Publication Date:
    2018-11-10
    Publisher:
    Institute of Physics (IOP)
    Print ISSN:
    1757-8981
    Electronic ISSN:
    1757-899X
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    Siebrand, W. ; Zgierski, M. Z. ; Amirav, A. ; Fuchs, B. ; Penner, A. ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1991
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The cold-beam excitation spectrum of the S0→T(nπ*) origin band of acetophenone shows two maxima separated by about 1.2 cm−1, interpreted as due to methyl tunneling. Consecutive deuteration of the methyl group leads to three maxima in acetophenone-d1 , two maxima in acetophenone-d2 and a single broad maximum in acetophenone-d3, with maximum separations of about 7 cm−1 in -d1 and about 3.5 cm−1 in -d2. These separations are due to the occurrence of two rotamers for isotopomers without threefold permutation symmetry. The spectra are analyzed in terms of hindered rotor potentials. It is shown that S0 and T(nπ*) share the same torsional equilibrium configuration, relative to which the S1(nπ*) equilibrium configuration is rotated by 60°. However, both nπ* states have very shallow torsional potentials with barrier heights of 70 and 90 cm−1 for T and S, respectively, compared with a barrier of about 800 cm−1 in the ground state. Hence, relative to S0 the two potentials are quite similar despite the shift. The potential terms entering upon partial deuteration are quite similar for S0 and T(nπ*) and hence depend only weakly on the barrier height. They are ascribed to kinetic coupling of the asymmetric rotor of the CH2D or CHD2 group with other modes in the molecule.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.460864

    Articles: DFG German National Licenses
  9. 9
    Modiano, Steven H. ; Locke, R. J. ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1988
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    It is shown that biphotonic excitation of diarylmethanes leads to the formation of ion pairs with extremely long time scale of charge recombination.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.455628

    Articles: DFG German National Licenses
  10. 10
    Cai, Jianjian ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1992
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    Time-resolved emission studies demonstrate the formation of intermolecular triplet excimers in fluid solutions of dibenzopyrrole, dibenzofuran, and dibenzothiophene at ambient temperature.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.462927

    Articles: DFG German National Licenses
  11. 11
    Cai, Jianjian ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1991
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    We report here highly novel emission characteristics of naphthalylnaphthalene which are manifestations of the violation of the energy-gap law in radiationless transitions.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.460905

    Articles: DFG German National Licenses
  12. 12
    Lim, E. J. ; Matsumoto, S. ; Fejer, M. M.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Inhomogeneities in waveguide dimensions are a serious problem for guided-wave frequency conversion devices. We discuss waveguide designs that make the phase matching "noncritical'' with respect to small changes in dimensions. Application of noncritical phase matching results in larger fabrication tolerances, facilitating the practical realization of nonlinear devices with long interaction lengths. We experimentally demonstrate the existence of a noncritical thickness in a lithium niobate waveguide, and analyze the dimensional tolerances for second-harmonic generation in a polymer waveguide.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.104166

    Articles: DFG German National Licenses
  13. 13
    Wang, Pei-Nan ; Liu, Haisheng ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1996
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    Level anticrossings and quantum beats have been observed for the fluorescence from single rotational levels of the vibrationless S1 pyrimidine in a supersonic free jet. The density of triplet levels (ρ) and the coupling matrix elements (v) deduced from the data obtained for R(0) transition confirm that the singlet–triplet coupling belongs to the weak coupling limit (vρ(very-much-less-than)1) of interstate interaction, in which electronic relaxation from the prepared singlet state to the triplet manifold does not occur in the absence of collisions. © 1996 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.472414

    Articles: DFG German National Licenses
  14. 14
    Lim, E. J. ; Hertz, H. M. ; Bortz, M. L. ; Fejer, M. M.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1991
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    We report quasi-phase-matched difference-frequency generation of 2.1 μm radiation at room temperature using the d33 nonlinear coefficient in a periodically poled lithium niobate channel waveguide. A tunable Ti:Al2O3 laser (λ≈0.8 μm) and a Nd:YAG laser (λ=1.32 μm) were the pump and signal sources, respectively. With 160 mW of 0.81 μm and 1 mW of 1.32 μm radiation coupled into the waveguide, 1.8 μW of 2.1 μm radiation was generated, tunable over a 6 nm bandwidth. We also show that the annealed proton exchange process can change the shape of ferroelectric domains in lithium niobate.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.106071

    Articles: DFG German National Licenses
  15. 15
    Saigusa, Hiroyuki ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The nature of electronic excitation and subsequent excited-state dynamics in small naphthalene clusters has been elucidated using isotope labeling techniques. The S1←S0 spectra of tetramer isotopomers are characterized by structurally inequivalent site splitting which is induced by an exciton interaction in the S2 state through vibronic coupling. It is suggested that the tetramer involves a pair of nearly overlapped chromophores, which is responsible for the excitonic interaction, and other two chromophores acting as solvents. An excitonic state originating in this pair is proposed to correlate with the lowest excimer state of the cluster as the interplanar separation and dihedral angle are reduced. In contrast, the spectra of trimer isotopomers are analyzed by invoking a symmetric geometry in which three chromophores are less overlapped and thus give rise to weak excitonic effects. The isomerization dynamics of these clusters is discussed in terms of a vibrationally activated process which makes the cluster framework wobble, allowing for stronger exciton interaction. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.470068

    Articles: DFG German National Licenses
  16. 16
    Liu, H. ; Lim, E. C. ; Judge, R. H. ; Moule, D. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The 000 origin band of the S1←S0, electronic transition that results from n→π* electron promotion has been observed under molecular beam conditions with a pulse amplified ring laser. At low temperatures, ∼0.7 K, the spectrum consisted of 11 lines that originated from Ka‘=0 and J‘=0 or 1 rotational levels. A rotational analysis revealed that the transition between the a1–a1 torsional levels gives rise to a c-type band, whereas the e–e levels are connected by a hybrid transition that has components along the a, b, and c principal axes. The fluorescence emission from the e levels was greatly reduced at temperatures above 3 K. The interpretation of this photophysical effect requires an intermolecular collision within the molecular beam that quenches the fluorescence from the S1 state. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.469479

    Articles: DFG German National Licenses
  17. 17
    Terazima, M. ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1987
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The time dependence of fluorescence polarization has been measured for several vibronic levels of S1 pyrimidine, 000 pyrazine, and 000 5-methylpyrimidine in the collision-free environment of a supersonic jet. In each case, the polarization decreases from the regular-rotor-limit value to a smaller constant value. The decay of the polarization occurs with a rate smaller than that of the fast-component fluorescence but larger than that of the slow-component emission. The decay rate of the fluorescence polarization increases with increasing density of triplet rovibronic levels coupled to the initially prepared S1 state. The results are interpreted as providing evidence for vibration–rotation interactions in the triplet manifold, leading to an extensive, but incomplete, K mixing. The time scale of the rotational dynamics is proposed to be in the tens of nanoseconds, based on the decay of the fluorescence polarization.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.452721

    Articles: DFG German National Licenses
  18. 18
    Liu, H. ; Lim, E. C. ; Muñoz-Caro, C. ; Niño, A. ; Judge, R. H. ; Moule, D. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1996
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The laser induced T1(nπ*)←S0 phosphorescence excitation spectrum of jet-cooled acetaldehyde has been observed for the first time with a rotating slit nozzle excitation system. The vibronic origins were fitted to a set of levels that were obtained from a Hamiltonian that employed flexible torsion-wagging large amplitude coordinates. The potential surface extracted from the fitting procedure yielded barriers to torsion and inversion of 609.68 and 869.02 cm−1, respectively. Minima in the potential hypersurface at θ=61.7° and α=42.2° defined the equilibrium positions for the torsion and wagging coordinates. A comparison to the corresponding S1-state parameters showed that the torsion barrier (in cm−1) does not greatly change, S1/T1=710.8/609.7, whereas the barrier height for the wagging-inversion barrier increases dramatically, 574.4/869.0. © 1996 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.472120

    Articles: DFG German National Licenses
  19. 19
    LIM, E. K. ; PEREIRA, R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1365-2044
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A patient developed paralysis over the left upper limb 2 days after an otherwise uneventful supraclavicular brachial plexus block. Symptoms continued for 8 weeks after the block. The various possible causes for this complication are discussed. Although brachial plexus injury following the block is rare, some recommendations are made to reduce the incidence of this complication.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2044.1984.tb06478.x

    Articles: DFG German National Licenses
  20. 20
    Zgierski, Marek Z. ; Chakraborty, Tapas ; Lim, E. C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1993
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The fluorescence excitation spectra of jet-cooled 9,10-dihydroanthracene and dibenzosuberane, in the region of their lowest-energy absorption band, exhibit two close-lying electronic origins that can be identified as the two exciton components of the lowest-energy benzene transition. The measured band positions and intensities of the two exciton components are in good agreement with the results of CNDO/S+CIS calculations based on the optimized QCFF/PI+CIS ground-state geometry.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.464413

    Articles: DFG German National Licenses