Search Results - (Author, Cooperation:E. J. Homan)

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  1. 1
    H. Gad ; T. Koolmeister ; A. S. Jemth ; S. Eshtad ; S. A. Jacques ; C. E. Strom ; L. M. Svensson ; N. Schultz ; T. Lundback ; B. O. Einarsdottir ; A. Saleh ; C. Gokturk ; P. Baranczewski ; R. Svensson ; R. P. Berntsson ; R. Gustafsson ; K. Stromberg ; K. Sanjiv ; M. C. Jacques-Cordonnier ; M. Desroses ; A. L. Gustavsson ; R. Olofsson ; F. Johansson ; E. J. Homan ; O. Loseva ; L. Brautigam ; L. Johansson ; A. Hoglund ; A. Hagenkort ; T. Pham ; M. Altun ; F. Z. Gaugaz ; S. Vikingsson ; B. Evers ; M. Henriksson ; K. S. Vallin ; O. A. Wallner ; L. G. Hammarstrom ; E. Wiita ; I. Almlof ; C. Kalderen ; H. Axelsson ; T. Djureinovic ; J. C. Puigvert ; M. Haggblad ; F. Jeppsson ; U. Martens ; C. Lundin ; B. Lundgren ; I. Granelli ; A. J. Jensen ; P. Artursson ; J. A. Nilsson ; P. Stenmark ; M. Scobie ; U. W. Berglund ; T. Helleday
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-04-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Catalytic Domain ; Cell Death/drug effects ; Cell Survival/drug effects ; Crystallization ; DNA Damage ; DNA Repair Enzymes/*antagonists & inhibitors/chemistry/metabolism ; Deoxyguanine Nucleotides/metabolism ; Enzyme Inhibitors/chemistry/pharmacokinetics/pharmacology/therapeutic use ; Female ; Humans ; Male ; Mice ; Models, Molecular ; Molecular Conformation ; Molecular Targeted Therapy ; Neoplasms/*drug therapy/*metabolism/pathology ; Nucleotides/*metabolism ; Oxidation-Reduction/drug effects ; Phosphoric Monoester Hydrolases/*antagonists & inhibitors/chemistry/metabolism ; Pyrimidines/chemistry/pharmacokinetics/pharmacology/therapeutic use ; Pyrophosphatases/antagonists & inhibitors ; Reproducibility of Results ; Xenograft Model Antitumor Assays
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-06-22
    Publisher:
    The American Society for Microbiology (ASM)
    Print ISSN:
    0019-9567
    Electronic ISSN:
    1098-5522
    Topics:
    Medicine
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
  4. 4
    Drijfhout, W. J. ; Homan, E. J. ; Brons, H. F. ; Oakley, N. R. ; Skingle, M. ; Grol, C. J. ; Westerink, B.H.C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1996
    Staff View
    ISSN:
    1600-079X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: The circadian rhythm of melatonin production was studied using on-line, in vivo microdialysis in the rat pineal gland. With this technique it was possible to record a pronounced melatonin rhythm with very high time resolution. Three phase-markers of the rhythm were calculated from the data, indicating increase (IT50), decrease (DT50) and amplitude of the rhythm. Comparing these phase markers led to several conclusions. Entrainment of the rhythm under constant darkness was performed with melatonin administration at different circadian stages [circadian time (CT) 8 and CT12] and for different periods of time (2 weeks and 4 weeks). Also, entrainment was established by applying 15 min light pulses at CTO. Entrainment of IT50 with melatonin partially uncoupled it from DT50. Four weeks entrainment in constant darkness (DD) caused a phase-delay in DT50 of 2.2 hr. Entrainment of IT50 with light at CTO for 2 weeks in DD caused a phase-advance in DT50 of 1.3 hr. The entrainment with melatonin was restricted to a narrow window for melatonin to be applied, since injections at CT8 did not result in entrainment. Exogenous melatonin reduced the amplitude of the rhythm of endogenous melatonin. This effect was not circadian time dependent, since administration at CT8 for 2 weeks and at CT12 for 4 weeks resulted in a highly significant decrease. Light did not seem to have an effect on the amplitude. The data presented here provide us with new information about the nature of entrainment by melatonin. Since the present development of melatonergic agents for clinical use focuses on the entrainment capacity, effects of these compounds on amplitude of circadian rhythms needs to be addressed. In vivo microdialysis seems to be a good technique for that.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses