Search Results - (Author, Cooperation:E. Fredlund)
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1Latest Papers from Table of Contents or Articles in PressP. M. Westcott ; K. D. Halliwill ; M. D. To ; M. Rashid ; A. G. Rust ; T. M. Keane ; R. Delrosario ; K. Y. Jen ; K. E. Gurley ; C. J. Kemp ; E. Fredlund ; D. A. Quigley ; D. J. Adams ; A. Balmain
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenocarcinoma/chemically induced/genetics ; Animals ; Carcinogens/toxicity ; Carcinoma, Non-Small-Cell Lung/chemically induced/genetics ; Cell Transformation, Neoplastic/*chemically induced/*genetics ; DNA Copy Number Variations/genetics ; Disease Progression ; Female ; Genes, ras/*genetics ; Genomic Instability/genetics ; Germ-Line Mutation/genetics ; Humans ; Lung Neoplasms/*chemically induced/*genetics ; Male ; Methylnitrosourea/toxicity ; Mice ; Models, Genetic ; Mutation/*genetics ; Oncogene Protein p21(ras)/*genetics ; Point Mutation/genetics ; Proto-Oncogene Proteins p21(ras)/*genetics ; Urethane/toxicityPublished by: -
2Articles: DFG German National LicensesNagasue, Naofumi ; Fredlund, E. ; Kallum, Bengt ; Olin, Tord ; Bengmark, Stig
Springer
Published 1974Staff ViewISSN: 1436-2813Keywords: liver ischemia ; hepatic dearterialization ; hemorrhagic shock ; lysosomal enzymes ; acid hydrolases ; β-glucosidase ; β-galactosidase ; S-GOT ; pig ; glucocorticoidsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effect of glucocorticoids on the release of lysosomal enzymes was studied in liver ischemia created by dearterialization and in hemorrhagic shock in pigs. In shock the treatment with glucocoticoids suppressed the release of β-glucosidase and β-galactosidase into the circulation. The release of S-GOT was also suppressed in the treated group. However, a contrary effect was observed in liver ischemia indicating that glucocorticoids might even be harmful to the dearterialized hypoxic liver. Provided the plasma increase of acid hydrolases can be interpreted as quantitative signs of cell damage, the findings indicate that glucocorticoids may be of benefit in shock but not after hepatic dearterialization.Type of Medium: Electronic ResourceURL: