Search Results - (Author, Cooperation:E. Esplugues)

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  1. 1
    Z. Shulman ; A. D. Gitlin ; J. S. Weinstein ; B. Lainez ; E. Esplugues ; R. A. Flavell ; J. E. Craft ; M. C. Nussenzweig
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-08-30
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; B-Lymphocytes/*immunology ; Calcium Signaling/*immunology ; Germinal Center/*immunology ; Green Fluorescent Proteins/metabolism ; Histocompatibility Antigens Class II/*immunology ; Interleukin-4/immunology ; Interleukins/immunology ; Mice ; Mice, Knockout ; Molecular Imaging ; T-Lymphocytes, Helper-Inducer/*immunology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2011-07-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Antibodies/immunology/pharmacology ; Antigens, CD3/immunology ; CD4-Positive T-Lymphocytes/immunology/transplantation ; Cell Movement/drug effects ; Chemokine CCL20/immunology ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Gene Expression Profiling ; Gene Expression Regulation/immunology ; Influenza A virus/immunology ; Interleukin-17/immunology ; Intestine, Small/cytology/*immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Orthomyxoviridae Infections/immunology ; Receptors, CCR6/immunology ; Sepsis/immunology ; Staphylococcal Infections/immunology ; Th17 Cells/*immunology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2015-04-30
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Cell Transdifferentiation ; Female ; Gene Expression Profiling ; Gene Expression Regulation ; Helminthiasis/immunology ; Male ; Mice ; Nippostrongylus/immunology ; Staphylococcal Infections/immunology ; Staphylococcus aureus/immunology ; T-Lymphocytes, Regulatory/*cytology/*immunology ; Th17 Cells/*cytology/*immunology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    ISSN:
    1619-7089
    Keywords:
    Myocardial perfusion single-photon emission tomography ; Coronary angiography ; Technetium99m tetrofosmin ; Same-day 2-hour rest/stress protocol ; Coronary artery disease
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Technetium-99m tetrofosmin (Myoview) has unique properties for myocardial perfusion imaging very early after injection of the tracer. We used a very short same-day rest/stress protocol, to be performed within 2 h and evaluated its diagnostic accuracy. The study included 144 patients from seven Spanish and four Portuguese centres with a diagnosis of uncomplicated coronary artery disease (CAD); 78 patients (54%) had no history of prior myocardial infarction. Patients were injected with ≤300 MBq99mTc-tetrofosmin at rest and ≤900 MBq approximately 1 h later at peak exercise. Single-photon emission tomographic (SPET) acquisitions were initiated within 5–30 min post injection. The results were compared with those of coronary angiography (CA). The data of 142 patients were completely evaluable (two with non-evaluable images were excluded). The quality of rest images was excellent or good in 86%, regionally problematic in 7%, poor but well interpretable in 5% and non-evaluable in 2%. The overall sensitivity for the detection of CAD was 93%, the specificity 38% and the accuracy 85%. The localization of defects by SPET in relation to the perfusion territories of stenosed vessels (≽50%) was achieved with a sensitivity of 64% for the left anterior descending artery, 49% for the left circumflex artery and 86% for the right coronary artery, and an accuracy of 71%, 72% and 73% respectively. Concordance of SPET and CA was 62% for single-vessel disease and 68% for multivessel disease. In conclusion, this Spanish-Portuguese multicentre clinical trial confirmed, in a considerable number of patients who underwent coronary angiography, the feasibility of99mTc tetrofosmin (Myoview) rest/stress myocardial SPET using a very short protocol (2 h).
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses