Search Results - (Author, Cooperation:E. C. Lai)
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1Latest Papers from Table of Contents or Articles in PressJ. B. Brown ; N. Boley ; R. Eisman ; G. E. May ; M. H. Stoiber ; M. O. Duff ; B. W. Booth ; J. Wen ; S. Park ; A. M. Suzuki ; K. H. Wan ; C. Yu ; D. Zhang ; J. W. Carlson ; L. Cherbas ; B. D. Eads ; D. Miller ; K. Mockaitis ; J. Roberts ; C. A. Davis ; E. Frise ; A. S. Hammonds ; S. Olson ; S. Shenker ; D. Sturgill ; A. A. Samsonova ; R. Weiszmann ; G. Robinson ; J. Hernandez ; J. Andrews ; P. J. Bickel ; P. Carninci ; P. Cherbas ; T. R. Gingeras ; R. A. Hoskins ; T. C. Kaufman ; E. C. Lai ; B. Oliver ; N. Perrimon ; B. R. Graveley ; S. E. Celniker
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alternative Splicing/genetics ; Animals ; Drosophila melanogaster/anatomy & histology/cytology/*genetics ; Female ; *Gene Expression Profiling ; Male ; Molecular Sequence Annotation ; Nerve Tissue/metabolism ; Organ Specificity ; Poly A/genetics ; Polyadenylation ; Promoter Regions, Genetic/genetics ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics/metabolism ; Sex Characteristics ; Stress, Physiological/genetics ; Transcriptome/*geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressC. Andreu-Agullo ; T. Maurin ; C. B. Thompson ; E. C. Lai
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-12-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Brain/*cytology ; Cell Proliferation ; Cells, Cultured ; Chromatin Immunoprecipitation ; Conserved Sequence/genetics ; DEAD-box RNA Helicases/deficiency ; Electrophoretic Mobility Shift Assay ; Enhancer Elements, Genetic/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Mice ; Mice, Knockout ; Neural Stem Cells/*cytology/*metabolism ; Neurogenesis/genetics ; Nuclear Proteins/chemistry/deficiency/genetics/*metabolism ; Olfactory Bulb/cytology ; Ribonuclease III/deficiency ; SOXB1 Transcription Factors/*genetics ; Transcription Factors/chemistry/deficiency/genetics/*metabolism ; *Transcriptional Activation ; Zinc FingersPublished by: -
3Latest Papers from Table of Contents or Articles in PressDuan, H., de Navas, L. F., Hu, F., Sun, K., Mavromatakis, Y. E., Viets, K., Zhou, C., Kavaler, J., Johnston, R. J., Tomlinson, A., Lai, E. C.
The Company of Biologists
Published 2018Staff ViewPublication Date: 2018-04-14Publisher: The Company of BiologistsPrint ISSN: 0950-1991Electronic ISSN: 1477-9129Topics: BiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressMohammed, J., Flynt, A. S., Panzarino, A. M., Mondal, M. M. H., De; Cruz, M., Siepel, A., Lai, E. C.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-01-03Publisher: Cold Spring Harbor Laboratory PressElectronic ISSN: 1549-5469Topics: BiologyMedicinePublished by: -
5Articles: DFG German National LicensesTo, E. W. H. ; Tsang, W. M. ; Pang, P. C. W. ; Cheng, J. H. H. ; Lai, E. C. H.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesCatterall, J. F. ; Stein, J. P. ; Lai, E. C. ; Woo, S. L. C. ; Dugaiczyk, A. ; Mace, M. L. ; Means, A. R. ; O'Malley, B. W.
[s.l.] : Nature Publishing Group
Published 1979Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] A 15-kilobase pair EcoRI chick DNA fragment, containing both the termination codon UGA and the 5′-portion of the structural ovomucoid gene, has been cloned in λ phage Charon 4A by in vitro packaging. Restriction mapping and electron microscopic analyses of this cloned DNA have revealed ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesNG, I. O. L. ; NG, M. ; LAI, E. C. S. ; WU, P. C.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Two cases of endoplasmic storage disease of liver are described. The liver tissue in each case showed numerous intracytoplasmic hyaline inclusions of varying sizes with formation of ground-glass hepatocytes. These inclusions were pale eosinophilic in hematoxylin & eosin stained sections, and were periodic acid-Schiff and HBsAg negative. Immunoperoxidase studies revealed strong positivity for fibrinogen and complement components C3 and C4 in case 1 and exclusive positivity for fibrinogen in case 2. On electron microscopy, the inclusions appeared as granular or fibrillar material within dilated cisternae of rough endoplasmic reticulum.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesLitvan, I. ; Booth, V. ; Wenning, G. K. ; Bartko, J. J. ; Goetz, C. G. ; McKee, A. ; Jankovic, J. ; Jellinger, K. ; Lai, E. C. ; Brandel, J. P. ; Verny, M. ; Chaudhuri, K. Ray ; Pearce, R. K. B. ; Agid, Y.
Springer
Published 1998Staff ViewISSN: 1435-1463Keywords: Keywords: Multiple system atrophy ; clinical diagnosis ; validity studies.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary. We estimated the accuracy of a modified commonly used set of clinical diagnostic criteria for the diagnosis of multiple system atrophy (MSA) by retrospectively applying the criteria to the features recorded by six neurologists who had evaluated 105 autopsy-confirmed cases (16 MSA and 89 non-MSA disorders). Cases were abstracted from the records of the patients' first visit to an academic center, and were presented as clinical vignettes to six neurologists, each of whom recorded the main clinical features of the presented clinical vignette on a standardized form. Sensitivity and positive predictive values were chosen as validity outcome measures and were calculated by comparing the applied diagnostic criteria to the neuropathologic information. Of note, most MSA patients in this study (mainly those with Shy-Drager type) had not received levodopa therapy since the primary neurologists often had not perceived a need to administer this treatment. The validity of the retrospectively applied criteria for the diagnosis of possible MSA (sensitivity: median, 53%, range, 50–69%; positive predictive value: 30%, 28–39%) and probable MSA (sensitivity: 44%, 31–60%; positive predictive value: 68%, 54–80%) at the first visit was suboptimal. The best, still not perfect, accuracy for this set of diagnostic criteria was obtained when six out of eight features (sporadic adult onset, dysautonomia, parkinsonism, pyramidal signs, cerebellar signs, no levodopa response, no cognitive dysfunction, or no downward gaze supranuclear palsy) were present (median sensitivity, 59%; range, 50–75%; positive predictive value: 67%, 53–83%). This is the first study to validate criteria for the clinical diagnosis of MSA. Our data suggest that it is difficult to achieve an early and accurate clinical diagnosis of this disorder. The probability of correctly diagnosing MSA increases when at least six features of this modified set of criteria are present or when requiring the set for probable MSA.Type of Medium: Electronic ResourceURL: