Search Results - (Author, Cooperation:E. C. Holmes)
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1Latest Papers from Table of Contents or Articles in PressE. Simon-Loriere ; O. Faye ; L. Koivogui ; N. Magassouba ; S. Keita ; J. M. Thiberge ; L. Diancourt ; C. Bouchier ; M. Vandenbogaert ; V. Caro ; G. Fall ; J. P. Buchmann ; C. B. Matranga ; P. C. Sabeti ; J. C. Manuguerra ; E. C. Holmes ; A. A. Sall
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. T. Lam ; B. Zhou ; J. Wang ; Y. Chai ; Y. Shen ; X. Chen ; C. Ma ; W. Hong ; Y. Chen ; Y. Zhang ; L. Duan ; P. Chen ; J. Jiang ; L. Li ; L. L. Poon ; R. J. Webby ; D. K. Smith ; G. M. Leung ; J. S. Peiris ; E. C. Holmes ; Y. Guan ; H. Zhu
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-03-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Chickens/*virology ; China/epidemiology ; Ecosystem ; *Evolution, Molecular ; Genotype ; Humans ; Influenza A Virus, H7N9 Subtype/classification/*genetics/*isolation & ; purification ; Influenza in Birds/*epidemiology/transmission/*virology ; Influenza, Human/epidemiology/transmission/virology ; Molecular Sequence Data ; Reassortant Viruses/genetics/isolation & purification ; Zoonoses/transmission/virologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressL. C. Katzelnick ; J. M. Fonville ; G. D. Gromowski ; J. Bustos Arriaga ; A. Green ; S. L. James ; L. Lau ; M. Montoya ; C. Wang ; L. A. VanBlargan ; C. A. Russell ; H. M. Thu ; T. C. Pierson ; P. Buchy ; J. G. Aaskov ; J. L. Munoz-Jordan ; N. Vasilakis ; R. V. Gibbons ; R. B. Tesh ; A. D. Osterhaus ; R. A. Fouchier ; A. Durbin ; C. P. Simmons ; E. C. Holmes ; E. Harris ; S. S. Whitehead ; D. J. Smith
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigens, Viral/*immunology ; Cercopithecus aethiops ; Dengue Vaccines/immunology ; Dengue Virus/*classification/genetics/*immunology ; Evolution, Molecular ; Humans ; Immune Sera/immunology ; Phylogeny ; Serogroup ; Serotyping ; Vaccination ; Viral Envelope Proteins/geneticsPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. S. Sabir ; T. T. Lam ; M. M. Ahmed ; L. Li ; Y. Shen ; S. E. Abo-Aba ; M. I. Qureshi ; M. Abu-Zeid ; Y. Zhang ; M. A. Khiyami ; N. S. Alharbi ; N. H. Hajrah ; M. J. Sabir ; M. H. Mutwakil ; S. A. Kabli ; F. A. Alsulaimany ; A. Y. Obaid ; B. Zhou ; D. K. Smith ; E. C. Holmes ; H. Zhu ; Y. Guan
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-12-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Camels/*virology ; Coinfection/epidemiology/veterinary/*virology ; Coronavirus Infections/epidemiology/veterinary/*virology ; Disease Reservoirs/veterinary/*virology ; Epidemiological Monitoring ; Humans ; Middle East Respiratory Syndrome Coronavirus/classification/*genetics/*physiology ; Molecular Sequence Data ; Phylogeny ; *Recombination, Genetic ; Saudi Arabia/epidemiologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2011-10-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Genome, Bacterial/*genetics ; Humans ; Plague/*microbiology ; Yersinia pestis/*genetics/*isolation & purificationPublished by: -
6Latest Papers from Table of Contents or Articles in PressVoorhees, I. E. H., Dalziel, B. D., Glaser, A., Dubovi, E. J., Murcia, P. R., Newbury, S., Toohey-Kurth, K., Su, S., Kriti, D., Van Bakel, H., Goodman, L. B., Leutenegger, C., Holmes, E. C., Parrish, C. R.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-08-01Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
7Latest Papers from Table of Contents or Articles in PressQi, W., Jia, W., Liu, D., Li, J., Bi, Y., Xie, S., Li, B., Hu, T., Du, Y., Xing, L., Zhang, J., Zhang, F., Wei, X., Eden, J.-S., Li, H., Tian, H., Li, W., Su, G., Lao, G., Xu, C., Xu, B., Liu, W., Zhang, G., Ren, T., Holmes, E. C., Cui, J., Shi, W., Gao, G. F., Liao, M.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-01-03Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
8Latest Papers from Table of Contents or Articles in PressMahar, J. E., Hall, R. N., Peacock, D., Kovaliski, J., Piper, M., Mourant, R., Huang, N., Campbell, S., Gu, X., Read, A., Urakova, N., Cox, T., Holmes, E. C., Strive, T.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-01-03Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
9Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-07Publisher: Genetics Society of America (GSA)Print ISSN: 0016-6731Topics: BiologyPublished by: -
10Articles: DFG German National LicensesEllis, S. A. ; Martin, A. J. ; Holmes, E. C. ; Morrison, W. I.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1744-313XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Nineteen horse MHC class I specificities have been serologically identified previously at a single locus (ELA-A), and two other specificities appear to be coded at other loci. Biochemical studies indicate that there are at least two expressed loci. In order to establish the number of transcribed horse MHC class I genes, we made a cDNA library from a heterozygous animal (ELA-A3/A7), and screened for positive clones using a bovine class I probe. More than 200 class I clones were isolated in this way, and so far seven unique full length sequences have been identified. All of the sequences are predicted to code for surface expressed, functional molecules. The number of different sequences identified demonstrate that at least four genes are transcribed, although variations in transmembrane length (which is generally conserved in class I loci) suggest that five genes could be represented. Evolutionary analysis of these sequences (and two additional sequences known to represent different horse class I loci) reveals no firm relationships, such that the division between the different loci cannot be discerned. These results suggest an unusual evolutionary history for the horse MHC, the precise nature of which may be revealed only following further cross-species comparisons.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesLeslie, A J ; Pfafferott, K J ; Chetty, P ; Draenert, R ; Addo, M M ; Feeney, M ; Tang, Y ; Holmes, E C ; Allen, T ; Prado, J G ; Altfeld, M ; Brander, C ; Dixon, C ; Ramduth, D ; Jeena, P ; Thomas, S A ; John, A St ; Roach, T A ; Kupfer, B ; Luzzi, G ; Edwards, A ; Taylor, G ; Lyall, H ; Tudor-Williams, G ; Novelli, V
[s.l.] : Nature Publishing Group
Published 2004Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Within-patient HIV evolution reflects the strong selection pressure driving viral escape from cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape mutations translates into HIV evolution at the population level has not been evaluated. We studied over 300 ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesMcClure, M. O. ; Bieniasz, P. D. ; Weber, J. N. ; Tedder, R. S. ; O'Shea, S. ; Banatvala, J. E. ; Tudor-Williams, G. ; Simmonds ; Holmes, E. C.
[s.l.] : Nature Publishing Group
Published 1995Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] SIR - Infants born to HIV-infected mothers acquire maternal antibody trans-placentally, rendering the interpretation of serological assays difficult. Secure diagnosis of perinatal infection should include investigation both of a maternal sample and of two or more infant ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1432Keywords: Maximum likelihood method ; Rates of substitution ; Fossil record ; Primates ; Artiodactyls ; RodentsSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary In an attempt to resolve some points of branching order in the phylogeny of the eutherian mammals, a phylogenetic analysis of 26 nuclear and 6 mitochondrial genes was undertaken using a maximum likelihood method on a constant rate stochastic model of molecular evolution. Seventeen of the nuclear genes gave a primates/artiodactyls grouping highest support whereas three of the mitochondrial genes found a rodents/artiodactyls grouping to be best supported. The primates/rodents grouping was never the best supported. On the assumption that rodents are indeed an outgroup to primates and artiodactyls and that the latter taxa diverged 70 million years ago, an estimation was made, for each gene, of the time of divergence of the rodent lineage. In most cases such estimates were beyond the limits set by present interpretations of the paleontological record as were many estimates of the divergence time of mouse and rat. These results suggest that, although there is locus variation, the divergent position of the rodent lineage may be an artifact of an elevated rate of nucleotide substitution in this order.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMorton, D. L. ; Eilber, F. R. ; Holmes, E. C. ; Sparks, F. C. ; Ramming, K. P.
Springer
Published 1976Staff ViewISSN: 1432-0851Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary BCG systemic adjuvant immunotherapy may be effective for improving both the recurrence and survival rates in patients with regional metastases from malignant melanoma. Clinical trials show that many of the principles derived from the study of animal tumor systems are applicable to human cancer in that immunotherapy is most effective for a small residual number of tumor cells. BCG treatment fulfills many of the ideal criteria for adjuvant treatment following surgery when disease burden is lowest. It is relatively nontoxic; it is effective for disseminated melanoma; it has systemic activity in the adjuvant treatment of subclinical metastases. However, until clinical trials are complete, BCG adjuvant therapy must be considered investigational.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-0851Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Twenty levamisole-treated and 14 placebo-treated lung cancer patients were studied sequentially in assays of lymphocyte proliferation. Prior to treatment, the patients as a group had significantly depressed proliferative responses to mitogens and allogeneic cells (MLC), and this immunosuppression was especially noticeable in patients with clinically detectable tumor burdens. Following treatment, responses in both levamisole and placebo groups tended to increase slightly, although the increases were more consistent and persistent in the levamisole group. Increases within the levamisole group were similar for patients with and without detectable tumor burdens. Proportions of E and EAC rosette-forming cells were stable throughout treatment for all groups. No consistent response pattern was observed in patients crossed-over from placebo to levamisole treatments. Although these results do not contradict the concept that levamisole can reverse malignancy-induced immunosuppression, levamisole treatment clearly did not result in normalization of lymphocyte-proliferative capacity in these lung cancer patients. The usefulness of a placebo-treated group was apparent, as some increased responsiveness was commonly found with placebo treatment.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesEllis, S. A. ; Holmes, E. C. ; Staines, K. A. ; Smith, K. B. ; Stear, M. J. ; McKeever, D. J. ; MacHugh, N. D. ; Morrison, W. I.
Springer
Published 1999Staff ViewISSN: 1432-1211Keywords: Key words Cattle ; MHC class I ; Haplotypes ; EvolutionSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Analysis of cattle major histocompatibility complex (MHC) (BoLA) class I gene expression using serological and biochemical methods has demonstrated a high level of polymorphism. However, analysis of class I cDNA sequences has failed to produce conclusive evidence concerning the number and nature of expressed genes. Such information is essential for detailed studies of cattle immune responses, and to increase our understanding of the mechanisms of MHC evolution. In this study a selective breeding programme has been used to generate a number of MHC homozygous cattle expressing common serologically defined class I specificities. Detailed analysis of five class I haplotypes was carried out, with transcribed class I genes identified and characterized by cDNA cloning, sequence analysis, and transfection/expression studies. Surface expression of the gene products (on lymphocytes) was confirmed using monoclonal antibodies of defined BoLA specificity. Phylogenetic analysis of available transcribed cattle MHC class I sequences revealed complex evolutionary relationships including possible evidence for recombination. The study of individual haplotypes suggests that certain groupings of related sequences may correlate with loci, but overall it was not possible to define the origin of individual alleles using this approach. The most striking finding of this study is that none of the cattle class I genes is consistently expressed, and that in contrast to human, haplotypes differ from one another in both the number and composition of expressed classical class I genes.Type of Medium: Electronic ResourceURL: