Search Results - (Author, Cooperation:D. Smyth)
-
1Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damageI. Angulo ; O. Vadas ; F. Garcon ; E. Banham-Hall ; V. Plagnol ; T. R. Leahy ; H. Baxendale ; T. Coulter ; J. Curtis ; C. Wu ; K. Blake-Palmer ; O. Perisic ; D. Smyth ; M. Maes ; C. Fiddler ; J. Juss ; D. Cilliers ; G. Markelj ; A. Chandra ; G. Farmer ; A. Kielkowska ; J. Clark ; S. Kracker ; M. Debre ; C. Picard ; I. Pellier ; N. Jabado ; J. A. Morris ; G. Barcenas-Morales ; A. Fischer ; L. Stephens ; P. Hawkins ; J. C. Barrett ; M. Abinun ; M. Clatworthy ; A. Durandy ; R. Doffinger ; E. R. Chilvers ; A. J. Cant ; D. Kumararatne ; K. Okkenhaug ; R. L. Williams ; A. Condliffe ; S. Nejentsev
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-10-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Class I Phosphatidylinositol 3-Kinases ; *Genetic Predisposition to Disease ; Humans ; Immunologic Deficiency Syndromes/*genetics/immunology/*pathology ; Lymphocytes/immunology ; Mutation ; Pedigree ; Phosphatidylinositol 3-Kinases/*genetics ; Phosphatidylinositol Phosphates/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Respiratory Tract Infections/*genetics/immunology/*pathologyPublished by: -
2R. Duffin ; R. A. O'Connor ; S. Crittenden ; T. Forster ; C. Yu ; X. Zheng ; D. Smyth ; C. T. Robb ; F. Rossi ; C. Skouras ; S. Tang ; J. Richards ; A. Pellicoro ; R. B. Weller ; R. M. Breyer ; D. J. Mole ; J. P. Iredale ; S. M. Anderton ; S. Narumiya ; R. M. Maizels ; P. Ghazal ; S. E. Howie ; A. G. Rossi ; C. Yao
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-03-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacterial Infections/genetics/immunology ; Dinoprostone/*immunology ; Gene Expression ; Humans ; Immunity, Innate ; Inflammation/drug therapy/*immunology/microbiology ; Interleukins/*immunology ; Intestines/*immunology/microbiology ; Lymphocytes/*immunology ; Mice ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & ; inhibitors/genetics/*immunology ; Signal TransductionPublished by: -
3Staff View
Type of Medium: articlePublication Date: 1982Keywords: Geschichte (Histor) ; Hochschulpolitik ; Hochschule ; KanadaIn: Interchange : a quarterly review of education, Bd. 13 (1982) H. 3, S. 29-52, 0020-52300826-4805Language: EnglishNote: Literaturangaben 49 -
4Richards-Belle, A., Mouncey, P. R., Wade, D., Brewin, C. R., Emerson, L. M., Grieve, R., Harrison, D. A., Harvey, S., Howell, D., Mythen, M., Sadique, Z., Smyth, D., Weinman, J., Welch, J., Rowan, K. M., On behalf of the POPPI Trial Investigators
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-02-09Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Intensive care, Open accessPublished by: -
5Smyth, D. G. ; Maruthainar, K. ; Darby, N. J. ; Fricker, L. D.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine. Synthetic peptides terminating in -His-Lys or -Tyr-Lys were used as model substrates for the enzyme and amino acid analysis was employed to detect release of the terminal amino acids. With N-acetyl-β-Ala-Asn-Ala-His-Lys and N-acetyl-β-Ala-Asn-Ala-Tyr-Lys, which correspond to intermediates in the processing of porcine and human β-endorphin, lysine was removed rapidly and quantitatively but no release of histidine or tyrosine could be detected. To allow more sensitive analysis, radiolabelled substrates were employed and the amounts of the products formed on incubation with CpAse H were determined after separation by ion-exchange chromatography. With 125I-D-Tyr-Ala-His-Lys-Lys as substrate at pH 5.7, very small amounts of D-Tyr-Ala were released; the main product was D-Tyr-Ala-His. At pH 5.0 the release of histidine from 125I-D-Tyr-AlaHis took place 6,000 times more slowly than the release of lysine from l25I-D-Tyr-Ala-Lys. When the tripeptides were incubated at pH 5 with porcine pituitary secretory granules, the lysine was released rapidly but no release of histidine could be detected. The results demonstrate that CpAse H catalyses the release of C-terminal histidine with great difficulty. Evidence is also presented that CpAse H catalyses a similar slow reaction in converting α-neo-endorphin to β-neo-endorphin, which involves removal of lysine from a Pro-Lys sequence. These very slow reactions provide an explanation for the incomplete processing that is observed with neuropeptides terminating in histidine, tyrosine, or phenylalanine or in prolyllysine.Type of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1467-999XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsType of Medium: Electronic ResourceURL: -
7Ash, J. C. K. ; Smyth, D. J. ; Heravi, S. M.
Oxford, UK and Boston, USA : Blackwell Publishers Ltd
Published 1997Staff ViewISSN: 1468-0106Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: A variety of accuracy measures, error diagnostics and rationality tests are applied to the OECD's macroeconomic forecasts for Japan of aggregate demand and output, inflation and the balance of payments. It is found that the OECD forecasts are superior to naive no-change predictions and forecasts generated by simple autoregressive time-series models. Most forecasting error is nonsystematic. As predictors of direction the OECD's six-month ahead forecasts should be considered valuable; this cannot be said for forecasts which look ahead a year and 18 months. Many forecasts fail bias, efficiency and consistency tests so that the rational expectations hypothesis is not generally supported.Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
10Baker, Gary E. ; Thompson, I. D. ; Krug, K. ; Smyth, D. ; Tolhurst, D. J.
Oxford, UK : Blackwell Science Ltd
Published 1998Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We have examined the spatial-frequency selectivity of neurons in areas 17 and 18 of the adult pigmented ferret, by measuring how the amplitude of response depends on the spatial-frequency of moving sinusoidal gratings of optimal orientation and fixed contrast. Neurons in area 17 of the ferret respond optimally to low spatial frequencies [average 0.25 cycles per degree (c/deg)], much lower than the optima for cat area 17. The tuning curves are of the same form as those found in cat and monkey: unimodal with bandwidths in the range 0.8–3.5 octaves. Neurons in area 18 of the ferret respond optimally to even lower spatial frequencies (average 0.087 c/deg) than area 17 neurons, and the distributions of optimal spatial frequency for areas 17 and 18 hardly overlap. In both cortical areas, the bandwidth of the tuning curves is inversely correlated with optimal spatial frequency. This marked difference in tuning between the two cortical areas is probably attributable to differential geniculo-cortical projections. Small injections of fluorescent latex microspheres or horseradish peroxidase (HRP) were made into area 17 or area 18 in order to investigate the populations of geniculate neurons projecting to the two cortical areas. After injections into area 17, labelled neurons are found predominantly in the geniculate A layers, with a few neurons labelled in the C layers. Conversely, after an area 18 injection, similar numbers of labelled neurons are found in the C layers as in the A layers. Soma-size analysis of the neurons in the A-layers suggests the existence of two populations of relay neurons, which project differentially to areas 17 and 18. The different geniculate inputs and the different spatial-frequency tuning in areas 17 and 18 may imply that the two cortical areas process visual information more in parallel than in series.Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The use of iodine-labelled peptide, with the radiolabel on the NH2-terminal tyrosine, ensured that the substrates could be studied at near physiological concentration and products containing the NH.2-terminal region of C fragment were readily identified. Membranes from rat brain were prepared by ...Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] An assay system for detecting and estimating amidating activity in pituitary was obtained by examining the ability of enzyme preparations to convert the synthetic tripeptide D-tyrosylvalylglycine to the corresponding dipeptide amide D-tyrosylvaline amide. The sequence Val-Gly was selected because ...Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Dissected regions of rat pituitary (10 male Sprague-Dawley rats, 250 g) and of rat brain (30 rats), and also whole brain (5 rats), were extracted in acetone/HCl/water (40:1:5, v/v) and the soluble products fractionated by gel filtration on a Sephadex G75 column (70x1.5 cm) in 50% acetic acid. The ...Type of Medium: Electronic ResourceURL: -
14VAN REE, J. M. ; DE WIED, D. ; BRADBURY, A. F. ; HULME, E. C. ; SMYTH, D. G. ; SNELL, C. R.
[s.l.] : Nature Publishing Group
Published 1976Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] C-Fragment was isolated from pig pituitary glands as described previously2. Cannulae were implanted in the lateral ventricles of male Wistar rats weighing 150?170 g10. After a recovery period of at least 1 week, response latencies of the animals were measured on a hot plate (54.2 ± 0.2 C) ...Type of Medium: Electronic ResourceURL: -
15GISPEN, W. H. ; WIEGANT, V. M. ; BRADBURY, A. F. ; HULME, E. C. ; SMYTH, D. G. ; SNELL, C. R. ; de WIED, D.
[s.l.] : Nature Publishing Group
Published 1976Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The methodology has been described in detail elsewhere14,15. Briefly, female rats of an inbred Wistar strain (TNO, Zeist, The Netherlands) had plastic canulae implanted in the 3rd cerebral ventricle, 1 week before the observation session. The behavioural procedure consisted of a 15th-s sampling ...Type of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Spatial models of morphine (I), oripavine (II), a potent derivative of morphine, and methionine enkephalin were constructed. The conformation of morphine is essentially defined by the rigidity of its molecular structure and similar considerations apply to the assignment of conformation in ...Type of Medium: Electronic ResourceURL: -
17BRADBURY, A. F. ; SMYTH, D. G. ; SNELL, C. R. ; BIRDSALL, N. J. M. ; HULME, E. C.
[s.l.] : Nature Publishing Group
Published 1976Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Recent reports have shown that in pituitary there is an endogenous peptide with opiate activity3,4 and similar peptides have been found in brain5?7. One of the brain peptides, termed methionine enkephalin, was isolated and described as a pentapeptide with the sequence Tyr?Gly?Gly?Phe?Met8, which is ...Type of Medium: Electronic ResourceURL: -
18SMYTH, D. G. ; MASSEY, D. E. ; ZAKARIAN, S. ; FINNIE, M. D. A.
[s.l.] : Nature Publishing Group
Published 1979Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. 1 Chromatography of basic peptides extracted from porcine pituitary. The peptides were eluted from a column (70 x 0.9 cm) of SP-Sephadex C25 in 0.02 M sodium phosphate at p H 7.0 with a linear gradient from 0 to 0.5 M sodium chloride. The mixer volume was 200 ml and the fraction size 3.2 ml. ...Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Everted sacs (approximately 17 era long) of intestine were made from the middle fifth of the combined jejunum and ileum of the rat. The sacs were filled with 1 ml. bicarbonate saline and were suspended in 50 ml. bicarbonate saline to which various sugars and amino-acids were added. At the end of a ...Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The transport of propionate across rat small intestine in vitro has the characteristics of active transport3'4 and we decided to investigate whether this was sodium-dependent. Experiments were carried out with sacs of everted intestine of rat prepared from the middle fifth of the combined jejunum ...Type of Medium: Electronic ResourceURL: