Search Results - (Author, Cooperation:D. Smyth)

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  1. 1
    Staff View
    Publication Date:
    2013-10-19
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Class I Phosphatidylinositol 3-Kinases ; *Genetic Predisposition to Disease ; Humans ; Immunologic Deficiency Syndromes/*genetics/immunology/*pathology ; Lymphocytes/immunology ; Mutation ; Pedigree ; Phosphatidylinositol 3-Kinases/*genetics ; Phosphatidylinositol Phosphates/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Respiratory Tract Infections/*genetics/immunology/*pathology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2016-03-19
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bacterial Infections/genetics/immunology ; Dinoprostone/*immunology ; Gene Expression ; Humans ; Immunity, Innate ; Inflammation/drug therapy/*immunology/microbiology ; Interleukins/*immunology ; Intestines/*immunology/microbiology ; Lymphocytes/*immunology ; Mice ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & ; inhibitors/genetics/*immunology ; Signal Transduction
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Type of Medium:
    article
    Publication Date:
    1982
    Keywords:
    Geschichte (Histor) ; Hochschulpolitik ; Hochschule ; Kanada
    In:
    Interchange : a quarterly review of education, Bd. 13 (1982) H. 3, S. 29-52, 0020-5230
    0826-4805
    Language:
    English
    Note:
    Literaturangaben 49
    FIS Bildung Literaturdatenbank
  4. 4
  5. 5
    Smyth, D. G. ; Maruthainar, K. ; Darby, N. J. ; Fricker, L. D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine. Synthetic peptides terminating in -His-Lys or -Tyr-Lys were used as model substrates for the enzyme and amino acid analysis was employed to detect release of the terminal amino acids. With N-acetyl-β-Ala-Asn-Ala-His-Lys and N-acetyl-β-Ala-Asn-Ala-Tyr-Lys, which correspond to intermediates in the processing of porcine and human β-endorphin, lysine was removed rapidly and quantitatively but no release of histidine or tyrosine could be detected. To allow more sensitive analysis, radiolabelled substrates were employed and the amounts of the products formed on incubation with CpAse H were determined after separation by ion-exchange chromatography. With 125I-D-Tyr-Ala-His-Lys-Lys as substrate at pH 5.7, very small amounts of D-Tyr-Ala were released; the main product was D-Tyr-Ala-His. At pH 5.0 the release of histidine from 125I-D-Tyr-AlaHis took place 6,000 times more slowly than the release of lysine from l25I-D-Tyr-Ala-Lys. When the tripeptides were incubated at pH 5 with porcine pituitary secretory granules, the lysine was released rapidly but no release of histidine could be detected. The results demonstrate that CpAse H catalyses the release of C-terminal histidine with great difficulty. Evidence is also presented that CpAse H catalyses a similar slow reaction in converting α-neo-endorphin to β-neo-endorphin, which involves removal of lysine from a Pro-Lys sequence. These very slow reactions provide an explanation for the incomplete processing that is observed with neuropeptides terminating in histidine, tyrosine, or phenylalanine or in prolyllysine.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Smyth, D. J.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1967
    Staff View
    ISSN:
    1467-999X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Economics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Ash, J. C. K. ; Smyth, D. J. ; Heravi, S. M.

    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Published 1997
    Staff View
    ISSN:
    1468-0106
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Economics
    Notes:
    A variety of accuracy measures, error diagnostics and rationality tests are applied to the OECD's macroeconomic forecasts for Japan of aggregate demand and output, inflation and the balance of payments. It is found that the OECD forecasts are superior to naive no-change predictions and forecasts generated by simple autoregressive time-series models. Most forecasting error is nonsystematic. As predictors of direction the OECD's six-month ahead forecasts should be considered valuable; this cannot be said for forecasts which look ahead a year and 18 months. Many forecasts fail bias, efficiency and consistency tests so that the rational expectations hypothesis is not generally supported.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    GLAVIN, G. B. ; SMYTH, D. D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    ERNSBERGER, P. ; LI, P. ; SMYTH, D. D.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Baker, Gary E. ; Thompson, I. D. ; Krug, K. ; Smyth, D. ; Tolhurst, D. J.

    Oxford, UK : Blackwell Science Ltd
    Published 1998
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We have examined the spatial-frequency selectivity of neurons in areas 17 and 18 of the adult pigmented ferret, by measuring how the amplitude of response depends on the spatial-frequency of moving sinusoidal gratings of optimal orientation and fixed contrast. Neurons in area 17 of the ferret respond optimally to low spatial frequencies [average 0.25 cycles per degree (c/deg)], much lower than the optima for cat area 17. The tuning curves are of the same form as those found in cat and monkey: unimodal with bandwidths in the range 0.8–3.5 octaves. Neurons in area 18 of the ferret respond optimally to even lower spatial frequencies (average 0.087 c/deg) than area 17 neurons, and the distributions of optimal spatial frequency for areas 17 and 18 hardly overlap. In both cortical areas, the bandwidth of the tuning curves is inversely correlated with optimal spatial frequency. This marked difference in tuning between the two cortical areas is probably attributable to differential geniculo-cortical projections. Small injections of fluorescent latex microspheres or horseradish peroxidase (HRP) were made into area 17 or area 18 in order to investigate the populations of geniculate neurons projecting to the two cortical areas. After injections into area 17, labelled neurons are found predominantly in the geniculate A layers, with a few neurons labelled in the C layers. Conversely, after an area 18 injection, similar numbers of labelled neurons are found in the C layers as in the A layers. Soma-size analysis of the neurons in the A-layers suggests the existence of two populations of relay neurons, which project differentially to areas 17 and 18. The different geniculate inputs and the different spatial-frequency tuning in areas 17 and 18 may imply that the two cortical areas process visual information more in parallel than in series.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    AUSTEN, B. M. ; SMYTH, D. G. ; SNELL, C. R.

    [s.l.] : Nature Publishing Group
    Published 1977
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The use of iodine-labelled peptide, with the radiolabel on the NH2-terminal tyrosine, ensured that the substrates could be studied at near physiological concentration and products containing the NH.2-terminal region of C fragment were readily identified. Membranes from rat brain were prepared by ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Bradbury, A. F. ; Finnie, M. D. A. ; Smyth, D. G.

    [s.l.] : Nature Publishing Group
    Published 1982
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] An assay system for detecting and estimating amidating activity in pituitary was obtained by examining the ability of enzyme preparations to convert the synthetic tripeptide D-tyrosylvalylglycine to the corresponding dipeptide amide D-tyrosylvaline amide. The sequence Val-Gly was selected because ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Zakarian, S. ; Smyth, D. G.

    [s.l.] : Nature Publishing Group
    Published 1982
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Dissected regions of rat pituitary (10 male Sprague-Dawley rats, 250 g) and of rat brain (30 rats), and also whole brain (5 rats), were extracted in acetone/HCl/water (40:1:5, v/v) and the soluble products fractionated by gel filtration on a Sephadex G75 column (70x1.5 cm) in 50% acetic acid. The ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    VAN REE, J. M. ; DE WIED, D. ; BRADBURY, A. F. ; HULME, E. C. ; SMYTH, D. G. ; SNELL, C. R.

    [s.l.] : Nature Publishing Group
    Published 1976
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] C-Fragment was isolated from pig pituitary glands as described previously2. Cannulae were implanted in the lateral ventricles of male Wistar rats weighing 150?170 g10. After a recovery period of at least 1 week, response latencies of the animals were measured on a hot plate (54.2 ± 0.2 C) ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    GISPEN, W. H. ; WIEGANT, V. M. ; BRADBURY, A. F. ; HULME, E. C. ; SMYTH, D. G. ; SNELL, C. R. ; de WIED, D.

    [s.l.] : Nature Publishing Group
    Published 1976
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The methodology has been described in detail elsewhere14,15. Briefly, female rats of an inbred Wistar strain (TNO, Zeist, The Netherlands) had plastic canulae implanted in the 3rd cerebral ventricle, 1 week before the observation session. The behavioural procedure consisted of a 15th-s sampling ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    BRADBURY, A. F. ; SMYTH, D. G. ; SNELL, C. R.

    [s.l.] : Nature Publishing Group
    Published 1976
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Spatial models of morphine (I), oripavine (II), a potent derivative of morphine, and methionine enkephalin were constructed. The conformation of morphine is essentially defined by the rigidity of its molecular structure and similar considerations apply to the assignment of conformation in ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    BRADBURY, A. F. ; SMYTH, D. G. ; SNELL, C. R. ; BIRDSALL, N. J. M. ; HULME, E. C.

    [s.l.] : Nature Publishing Group
    Published 1976
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Recent reports have shown that in pituitary there is an endogenous peptide with opiate activity3,4 and similar peptides have been found in brain5?7. One of the brain peptides, termed methionine enkephalin, was isolated and described as a pentapeptide with the sequence Tyr?Gly?Gly?Phe?Met8, which is ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    SMYTH, D. G. ; MASSEY, D. E. ; ZAKARIAN, S. ; FINNIE, M. D. A.

    [s.l.] : Nature Publishing Group
    Published 1979
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Fig. 1 Chromatography of basic peptides extracted from porcine pituitary. The peptides were eluted from a column (70 x 0.9 cm) of SP-Sephadex C25 in 0.02 M sodium phosphate at p H 7.0 with a linear gradient from 0 to 0.5 M sodium chloride. The mixer volume was 200 ml and the fraction size 3.2 ml. ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    NEWEY, H. ; SMYTH, D. H.

    [s.l.] : Nature Publishing Group
    Published 1964
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Everted sacs (approximately 17 era long) of intestine were made from the middle fifth of the combined jejunum and ileum of the rat. The sacs were filled with 1 ml. bicarbonate saline and were suspended in 50 ml. bicarbonate saline to which various sugars and amino-acids were added. At the end of a ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    JACKSON, M. J. ; SMYTH, D. H.

    [s.l.] : Nature Publishing Group
    Published 1968
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The transport of propionate across rat small intestine in vitro has the characteristics of active transport3'4 and we decided to investigate whether this was sodium-dependent. Experiments were carried out with sacs of everted intestine of rat prepared from the middle fifth of the combined jejunum ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses