Search Results - (Author, Cooperation:D. Neal)
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1Latest Papers from Table of Contents or Articles in PressJ. M. Tubio ; Y. Li ; Y. S. Ju ; I. Martincorena ; S. L. Cooke ; M. Tojo ; G. Gundem ; C. P. Pipinikas ; J. Zamora ; K. Raine ; A. Menzies ; P. Roman-Garcia ; A. Fullam ; M. Gerstung ; A. Shlien ; P. S. Tarpey ; E. Papaemmanuil ; S. Knappskog ; P. Van Loo ; M. Ramakrishna ; H. R. Davies ; J. Marshall ; D. C. Wedge ; J. W. Teague ; A. P. Butler ; S. Nik-Zainal ; L. Alexandrov ; S. Behjati ; L. R. Yates ; N. Bolli ; L. Mudie ; C. Hardy ; S. Martin ; S. McLaren ; S. O'Meara ; E. Anderson ; M. Maddison ; S. Gamble ; C. Foster ; A. Y. Warren ; H. Whitaker ; D. Brewer ; R. Eeles ; C. Cooper ; D. Neal ; A. G. Lynch ; T. Visakorpi ; W. B. Isaacs ; L. van't Veer ; C. Caldas ; C. Desmedt ; C. Sotiriou ; S. Aparicio ; J. A. Foekens ; J. E. Eyfjord ; S. R. Lakhani ; G. Thomas ; O. Myklebost ; P. N. Span ; A. L. Borresen-Dale ; A. L. Richardson ; M. Van de Vijver ; A. Vincent-Salomon ; G. G. Van den Eynden ; A. M. Flanagan ; P. A. Futreal ; S. M. Janes ; G. S. Bova ; M. R. Stratton ; U. McDermott ; P. J. Campbell
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-08-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Carcinogenesis/genetics ; Chromatin/chemistry ; *DNA Transposable Elements ; Exons ; Genome, Human ; Humans ; *Long Interspersed Nucleotide Elements ; Mutagenesis, Insertional ; Neoplasms/*genetics ; *Transduction, Genetic ; Translocation, GeneticPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-01-18Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-08-10Publisher: MDPI PublishingPrint ISSN: 1661-7827Electronic ISSN: 1660-4601Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressHana Kahleova; Rebecca Fleeman; Adela Hlozkova; Richard Holubkov; Neal D. Barnard
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-11-08Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2044-4052Topics: MedicinePublished by: -
5Articles: DFG German National LicensesPaine, David C. ; Evans, Neal D. ; Stoffel, Ned G.
[S.l.] : American Institute of Physics (AIP)
Published 1991Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: In this paper we present the results of an experimental determination of the rate of solid phase epitaxical regrowth of amorphous Si1−xGex on 〈001〉 Si as a function of temperature and Ge concentration. Layers of chemical vapor deposited Si1−xGex roughly 200-nm thick containing 5.4, 11.6, and 17.0 at. % Ge were amorphized with a two-step process of 100 keV, followed by 200 keV, 29Si ion implantation. This procedure left the near surface region of the substrate, including the entire Si1−xGex film, amorphous to a depth of 380 nm. The epitaxical recrystallization of the alloy portion (5.4, 11.6, or 17 at. % Ge) of the amorphous layer results in the development of large lattice mismatch stresses (0.5–2 GPa). The rate of epitaxical regrowth of the amorphous material was studied with isothermal heating and in situ transmission electron microscopy observations. Isothermal annealing at temperatures between 476 and 602 °C show that, compared to pure unstrained Si, the rate of regrowth is decreased in strained alloys of Si1−xGex. Furthermore, we report that the activation energy for strained-layer regrowth of Si1−xGex is not a strong function of composition and, for all three compositions, was in the range 3.2±0.2 eV. This is significantly larger than the activation energy for the homoepitaxical regrowth of unstrained pure Si. Stress related origins of these observations are discussed.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesDoty, Donald B. ; Cafferty, Ann ; Kon, Neal D. ; Huysmans, Hans A. ; Krause, Albert H. ; Westaby, Stephen
Oxford, UK : Blackwell Publishing Ltd
Published 1998Staff ViewISSN: 1540-8191Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract Background: The Medtronic Freestyle aortic root bioprosthesis is a complete porcine aortic root to allow implantation (1) as a subcoronary valve replacement by removing graft sinus aorta, (2) as a cylinder with the sinotubular junction intact within the aorta (root inclusion), or (3) as a complete aortic root replacement. The choice among the three implant techniques depends on surgeon preference or upon the pathology encountered. The advantages and differences among the three implant techniques are examined. Methods: The Medtronic Freestyle bioprosthesis was implanted in 1163 patients in a Food and Drug administration (FDA) clinical trial between August 1992 and October 1997. There were 21 centers in the international trial using a single data repository. Clinical data was collected prior to and at operation, at 3 to 6 months and annually. The data were compiled and statistical analysis performed at the data center. Results: Patients having subcoronary valve implants were older (80% 〉 65 years) and aortic occlusion time was about 20 minutes less than the other methods. Patients having aortic root replacement presented with more aortic valve insufficiency (20%). Pathology of the aortic root and ascending aorta requiring repair was 26%, and larger (27 mm) valves were used in 40% of patients. Risk of operation was lowest (5.0%) with subcoronary valve implants and highest (11.7%) with root replacement technique. Thromboembolism was higher, early and late, with root inclusion (3.0,3.9%/patient per year) and root replacement (3.2, 3.0%/patient per year) than for subcoronary implants (1.8, 1.6%/patient per year). There were more patients taking warfarin at the 4-year point with root inclusion (20%) or root replacement techniques (24%) than among patients having subcoronary implants (14%). Explants of the valve occurred in 2% of patients, none of whom had aortic root replacement. Conclusions: The Medtronic Freestyle bioprosthesis is an effective and versatile device for replacement of the aortic valve. It offers implant techniques that can treat the aortic root pathology encountered at surgery and allows the operation to proceed according to surgeon preference.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: A meter using electronic capacitance to estimate weight of standing vegetation was first tested in 1949. It proved to be faster and more accurate than most indirect methods of measurement. Since then, other similar instruments have been built and several problems have become apparent. Short or dry vegetation, non-homogeneous distribution of vegetation, non-homogeneous phenology, and electronic circuit instability were the major problems. The chief steps in the development of capacitance instruments for estimating vegetation weight are discussed. The significance of each of the major problems has been greatly reduced by improvements in instrumentation. The technique of using electronic capacitance has now proved itself useful under a wide variety of range conditions.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesChakarian, Varoujan ; Shuh, David K. ; Yarmoff, Jory A. ; Tao, Hui-Shu ; Diebold, Ulrike ; Maschhoff, Brian L. ; Madey, Theodore E. ; Shinn, Neal D.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Soft-x-ray photoelectron spectroscopy (SXPS) is utilized to study the coadsorption of K and PF3 on Ru(0001) at 90 and 300 K. In the absence of K, PF3 adsorbs molecularly at both temperatures. In the presence of a fractional monolayer of K, initially PF3 completely dissociates resulting in the formation of adsorbed KF and P species. As the surface is further exposed to PF3, some of the PF3 molecules adsorb via partial dissociation, resulting in the formation of PF and PF2. This process continues until all the K has reacted. At 300 K, a fraction of the incoming PF3 molecules react with the adsorbed KF and form a species which is tentatively identified as KPF6. The data show that surface chemistry is different at the two temperatures, as some of the chemical reaction channels occurring at 300 K are blocked at 90 K. The reduced surface mobility of the incident PF3 molecules at 90 K adversely affects the probability of PF3 and KF interactions, which, in turn, causes the concentration of adsorbed PF3 relative to P to be larger at lower temperatures.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesShinn, Neal D. ; Madey, Theodore E.
College Park, Md. : American Institute of Physics (AIP)
Published 1985Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: High resolution electron energy loss spectroscopy (EELS), electron stimulated desorption ion angular distributions (ESDIAD), low energy electron diffraction (LEED), and Auger electron spectroscopy (AES) have been combined to study CO chemisorption on the Cr(110) surface. At 120 K, two molecular binding modes are sequentially populated. The first, α1CO, is a novel binding mode for a clean metal surface in which the molecules are bound with the C–O axis nearly parallel to the Cr(110) surface. These α1CO molecules exhibit a νCO of 1150–1330 cm−1, no detectable ion emission in ESDIAD, and form a c(4×2) α1CO overlayer at saturation (θCO(approximate)0.25). A model is proposed in which the α1CO are π bonded to the Cr(110) surface at twofold symmetric surface hollow sites. Annealing experiments demonstrate that the α1 binding mode is the precursor to dissociation on Cr(110). At higher CO coverages, 0.25〈θCO〈0.35, the α1CO overlayer is disordered by the addition of the second binding mode, α2CO. Three new vibrations, at 495, 1865, and 1975 cm−1, are observed by EELS while O+ ion emission along the [110] direction is seen in ESDIAD. These α2CO results are indicative of terminally bound molecules adsorbed at atop and bridge sites and aligned approximately perpendicular to the surface. Annealing studies of CO and O/CO adlayers provide evidence for a surface reaction in addition to direct dissociation above 170 K. In contrast, adsorption at 300 K leads to direct dissociative chemisorption with no detectable intermediate molecular adsorbate. The implications of these results to catalytic reactions of CO are considered and comparisons to CO adsorption on clean and "promoted'' transition metals are made.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Musculoskeletal dysfunction is a common feature of haemophilia and along with other manifestations of this condition, there is a general perception that health-related quality of life (QoL) will be affected. Previous research using standardized questionnaires has demonstrated that QoL is lower in haemophilia groups compared with normal populations. However, disability studies and interviews with disabled people suggest that many disabled people experience positive life changes as a result of their illness and an affirmative model of disability has been proposed. A qualitative study involving focus groups and interviews was undertaken to explore these issues in a group of 19 severely affected adults with haemophilia. The focus groups and interviews were tape recorded and fully transcribed and the results subjected to thematic analysis. This paper focuses specifically on key issues that impacted on perceptions of QoL. The findings suggest that the participants’ perceptions of their QoL were very positive. Possible reasons for this are proposed including the benefits of factor replacement, participants' recollections of their lifestyle before factor replacement, that having haemophilia was integral to the ‘self’ and finding a niche where they could be successful. A more positive affirmation of haemophilia may need to be considered when developing QoL measures.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: An electronic capacitance meter was used to estimate herbage yield from sown ranges in western USA. On an area in Arizona where the grass stand had heen sown broadcast, an r2 of 0.47 was obtained between the meter value and oven-dry weigbt estimate. Excluding tbose plots with very large amounts of standing dead organic matter (OM), or very succulent plants which had not been sown, improved yield estimates.Tests on pastures in Colorado in whicb seed had been drilled and tbe meter tested to evaluate performance in relation to drill rows showed that a common regression could be used for estimating yield. Metbods of placing the meter in relation to row directions are described which avoid a biased estimate of total pasture yield. Cutting the herbage in a 3-dimensional manner improved the r2 values over those obtained by the usual 2-dimensional cutting procedure. Separation of dead OM from living plant material did not significantly change the r2 values and showed that dead OM bad very little influence on the meter reading. This dead OM can contribute significantly to variation of the estimate about the regression line, however, and if differences in dead OM are substantial, sample sizes may need to be increased or sampling stratified to obtain an accurate yield estimate.Pertinent literature on the evolution of electronic capacitance instruments for estimating herbage yields has been presented in Part 1 of this series (3). Tbe present evaluation is restricted to the herbage yield estimates from mechanically sown pastures. The Neal Electronics Model 18–612 meter was used to make the yield estimates.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesDurant, Neal D. ; Myers, Vernon B. ; Eccles, Lawrence A.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1745-6592Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringGeosciencesNotes: The U.S. Environmental Protection Agency (EPA) recently proposed to amend federal regulations to require vadose zone monitoring at certain hazardous waste facilities. To support this proposal, EPA evaluated previous policy on vadose zone monitoring and examined advances in vadose zone monitoring technology. Changes in EPA vadose zone monitoring policy were driven by demonstrated advances in the available monitoring technology and improvements in understanding of vadose zone processes/When used under the appropriate conditions, currently available direct and indirect monitoring methods can effectively detect contamination that may leak from hazardous waste facilities into the vadose zone. Direct techniques examined include soil-core monitoring and soil-pore liquid monitoring. Indirect techniques examined include soil-gas monitoring, neutron moderation, complex resistivity, ground-penetrating radar, and electrical resistivity. Properly designed vadose zone monitoring networks can act as a complement to saturated zone monitoring networks at numerous hazardous waste facilities. At certain facilities, particularly those in arid climates where the saturated zone is relatively deep, effective vadose zone monitoring may allow a reduction in the scope of saturated zone monitoring programs.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Calcinosis, the process whereby calcium salts are deposited in soft tissues, may be idiopathic, metastatic or dystrophic. Metastatic calcinosis develops in a variety of systemic diseases characterized by cither hypercalcemia, hyperphosphatemia, or both. Dystrophic calcinosis refers to calcification of previously damaged or necrotic tissue. It may be found accompanying inflammatory or degenerative conditions and is frequently associated with connective tissue diseases. When pathologic calcification is widespread, an attempt must be made to determine the underlying cause. A case is presented in which there was multifocal calcium deposition in soft tissues, including an intra-oral site. The patient also exhibited severe arthritis, sicca syndrome, focal alopecia and vitiligo. In view of this clinical spectrum, one of the “collagen diseases” (dermatomyositis, lupus erythematosus, rheumatoid arthritis, and scleroderina) was suspected as a predisposing factor for disseminated calcinosis. When diagnostic workup failed to reveal a specific connective tissue disease, it was concluded that “undifferentiated connective tissue disease” was responsible for dystrophic calcinosis.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesPoetter, Karl ; Jiang, He ; Hassanzadeh, Shahin ; Master, Stephen R. ; Chang, Anthony ; Dalakas, Marinos C. ; Rayment, Ivan ; Sellers, James R. ; Fananapazir, Lameh ; Epstein, Neal D.
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] The muscle myosins are hexomeric proteins consisting of two heavy chains and two pairs of light chains, the latter called essential (ELC) and regulatory (RLC). The light chains stabilize the long alpha helical neck of the myosin head. Their function in striated muscle, however, is only partially ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesGust, Maria C. ; Evans, Neal D. ; Momoda, Leslie A. ; Mecartney, Martha L.
Westerville, Ohio : American Ceramics Society
Published 1997Staff ViewISSN: 1551-2916Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Barium titanate (BaTiO3) thin films that were derived from methoxypropoxide precursors were deposited onto (100) Si, Pt/Ti/SiO2/(100) Si, and molecular-beam-epitaxy-grown (MBE-grown) (100) BaTiO3 on (100) Si substrates by spin coating. The crystallization behavior of the amorphous-gel films was characterized using in-situ transmission electron microscopy heating experiments, glancing-angle X-ray diffraction, and differential thermal analysis/thermogravimetric analysis. Amorphous-gel films crystallized at a temperature of ∼600°C to an intermediate nanoscale (5–10 nm) barium titanium carbonate phase, presumably BaTiO2CO3, that subsequently transformed to nanocrystalline (20–60 nm) BaTiO3. Random nucleation in the bulk of the gel film was observed on all substrates. In addition, oriented growth of BaTiO3 was concurrently observed on MBE-grown BaTiO3 on (100) Si. High-temperature decomposition of the intermediate carbonate phase contributed to nanometer-scale residual porosity in the films. High concentrations of water of hydrolysis inhibited the formation of the intermediate carbonate phase; however, these sols precipitated and were not suitable for spin coating.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesGust, Maria C. ; Momoda, Leslie A. ; Evans, Neal D. ; Mecartney, Martha L.
Westerville, Ohio : American Ceramics Society
Published 2001Staff ViewISSN: 1551-2916Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Microstructural development of thin-film barium strontium titanate (BaxSr1–xTiO3) as a function of strontium concentration and thermal treatment were studied, using transmission electron microscopy (TEM) and X-ray diffractometry (XRD). Thin films, ∼250 nm thick, were spin-coated onto Pt/Ti/SiO2/Si substrates, using methoxypropoxide alkoxide precursors, and crystallized by heat-treating at 700°C. All films had the cubic perovskite structure, and their lattice parameters varied linearly with strontium content. Films with higher strontium concentrations had a larger average grain size. In situ TEM heating experiments, combined with differential thermal analysis/thermogravimetric analysis results, suggest that the gel films crystallize as an intermediate carbonate phase, BaxSr1–xTiO2CO3 (with a solid solution range from x= 1 to x= 0). Before decomposition at 600°C, this carbonate phase inhibits the formation of the desired perovskite phase.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesImamura, Philip H. ; Evans, Neal D. ; Sakuma, Taketo ; Mecartney, Martha L.
Westerville, Ohio : American Ceramics Society
Published 2000Staff ViewISSN: 1551-2916Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Amorphous grain boundary phases in 3-mol%-yttria-stabilized zirconia ceramics (3Y-TZP) were studied to determine the influence of intergranular amorphous silicate phases on tensile superplasticity at temperatures of 1300–1500°C. Controlled additions (1 wt%) of compositionally distinct barium silicate and borosilicate phases were used. The initial grain sizes of the pure, barium silicate added, and borosilicate-added samples were 0.45, 0.55, and 0.55 μm, respectively. Systems with added barium silicate and borosilicate glass both exhibited a 60% reduction in flow stress as compared with pure 3Y-TZP, with the lower-viscosity barium silicate system exhibiting a slightly greater reduction in flow stress. The higher-viscosity borosilicate glass/3Y-TZP materials exhibited the greatest elongation to failure, while the barium silicate/3Y-TZP materials had the least elongation. Yttrium was found to segregate to grain boundaries in the pure and borosilicate-containing samples, and both yttrium and barium were found to segregate to grain boundaries in the barium silicate containing samples. No silicon was observed along two-grain boundaries in any of the samples, even those containing pockets of glass. The difference in deformation behavior may be due to a combination of viscosity of the glass addition, grain boundary segregation, and grain boundary bond character.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesFANANAPAZIR, LAMEH ; EPSTEIN, STEPHEN E. ; EPSTEIN, NEAL D.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1540-8167Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Sir In the News article “Agony for researchers as mix-up forces retraction of ecstasy study” (Nature 425, 109; 2003) the 'agony' of the embarrassed researchers was dwarfed by that of their primate subjects. From an ...Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesQayum, A. ; Gullick, W.J. ; Mellon, K. ; Krausz, T. ; Neal, D. ; Sikora, K. ; Waxman, J.
Amsterdam : ElsevierStaff ViewISSN: 0960-0760Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: