Search Results - (Author, Cooperation:D. Naidoo)

2013-09-03

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amidinotransferases/deficiency/*genetics/metabolism ; Cell Line ; Cholesterol/deficiency/metabolism/pharmacology ; Gene Expression Regulation/*drug effects ; Gene Knockdown Techniques ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects/pharmacology ; Lymphocytes/cytology/drug effects/metabolism ; Muscular Diseases/*chemically induced/genetics/metabolism ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Simvastatin/*adverse effects/pharmacology ; Sterol Regulatory Element Binding Proteins/metabolism ; Transcription, Genetic/drug effects

1527-3466

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1527-3466

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1471-0528

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Objective To evaluate prospectively mitral stenosis in pregnancy with emphasis on women with persistent symptoms.Setting King Edward VIII Hospital, a tertiary referral obstetric unit.Participants One hundred and twenty-eight consecutive women with mitral stenosis.Demographics The mean age was 27 years and 38 women (30%) were primigravidae. Seventy-eight (61%) women had their first cardiac evaluation in the third trimester. Fifty-four women (42%) of these women had mitral stenosis diagnosed for the first time in the index pregnancy. Twenty-nine (23%) had a previous mitral valvulotomy. Nineteen women (15%) developed hypertension during pregnancy, 10 of whom had pre-eclampsia. Sixty-three women (49%) had a mitral valve area of ≤ 1.2 cm2 with 11 having critical mitral stenosis (mitral valve area ≤ 0.8 cm2). Atrial fibrillation was present in 12 women. Most women (87%) required medical therapy to control the heart rate.Outcome in persistent symptomatic women Intervention was considered in 37 women (29%) who remained symptomatic, 11 (9%) of whom had a calcified mitral valve. The remaining 26 women were scheduled for balloon mitral valvulotomy during pregnancy, 20 of whom had balloon mitral valvulotomy with good effect (16 antepartum; 4 postpartum). In seven women, scheduled balloon mitral valvulotomy was not performed because of advanced preterm labour (n= 5), fetal distress (n= 1) and preterm labour with fetal distress (n= 1). These seven, together with the 11 with calcific mitral stenosis, were managed conservatively with good outcome.Maternal complications Fifty-one percent had maternal complications, the majority occurring at their initial admission to hospital. Pulmonary oedema was the most frequent. Multiple logistic regression analysis showed that the severity of stenosis assessed by measurement of the mitral valve area by echo-Doppler was the most powerful predictor of maternal pulmonary oedema. The other factors were late antenatal presentation, presence of symptoms prior to the index pregnancy and diagnosis of cardiac disease for the first time in the index pregnancy.Conclusion Despite serious disease, women with persistent symptoms treated either by balloon mitral valvulotomy where feasible, or conservatively with close noninvasive monitoring, had a satisfactory fetal and maternal outcome.

Electronic Resource

1471-0528

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Objective To describe the cardiac abnormalities by two-dimensional and Doppler echo-cardiography (echo-Doppler) in hypertensive crises in pregnancy (HCP) complicated by pulmonary oedema and identify pathogenic factors.Design A prospective observational study.Setting King Edward VIII Hospital, Durban, South Africa.Participants Sixteen patients with HCP complicated by pulmonary oedema over a six-month period. Two control groups, 55 patients with HCP alone and 16 with normotensive pregnancies, were also studied.Results Echocardiography diagnosed impaired left ventricular systolic function in 4 of 16 (25 %) patients with HCP and pulmonary oedema. In the remaining 12 patients with preserved systolic function, left ventricular diastolic filling abnormalities were demonstrated in a significant proportion compared to control hypertensive and normotensive groups. Fifteen of 16 (94%) study patients presented with pulmonary oedema antepartum; in seven of these patients, the use of dexamethasone to enhance fetal lung maturity appeared to be a contributing factor in precipitating pulmonary oedema.Conclusion This study demonstrates the value of echo-Doppler to diagnose structural and functional cardiac abnormalities in HCP complicated by pulmonary oedema. The potential role of left ventricular diastolic filling abnormalities in the pathogenesis of pulmonary oedema complicating HCP is discussed.

Electronic Resource

0891-5849

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Electronic Resource

0006-3002

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

0006-3002

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

0042-207X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Physics

Electronic Resource

1420-9071

Springer Online Journal Archives 1860-2000

Biology

Medicine

Zusammenfassung In Thiamin-Mangelküken wurde eine erhöhte Thiamin-Diphosphatase-Aktivität festgestellt. In Figur 1 sind die Mengen an freigesetztem anorganischem Phosphat in μMol/g Gewebe/h angegeben. Die Normalwerte betragen durchschnittlich 43,0 Einheiten, während das pathologische Gewebe bis zu 60 Einheiten enthält. Die Unterschiede sind signifikant,P〈0,05. Der Effekt kann durch Zusatz von Thiamin zum Futter aufgehoben werden.

Electronic Resource

1573-0581

Crustal magnetization ; Juan de Fuca Ridge ; oceanic crust ; propagating rift ; submarine mass-wasting ; transform zone

Springer Online Journal Archives 1860-2000

Geosciences

Physics

Abstract During July and August 1991, the French-American Blanconaute dive program used the French submersibleNautile to investigate the West Blanco Depression (WBD), a deep, elongate trough located at the intersection of the Blanco Transform Fault Zone with the southern Juan de Fuca Ridge (JdFR). Twenty dives were carried out along the north wall of the WBD, which exposes the upper oceanic crust over a 65 km distance, from the JdFR axis (to the west) to the oblique trace of an ancient propagator (to the east, crustal age around 2 Ma). Thirteen of these dives were precisely located within a 13 × 7 km zone of the north wall, covered by a high-resolution sonar mapping operation during the Blancotrough cruise in 1987. This series of geological traverses, plus 4 dives across the south wall of the WBD (one dive) and the adjacent Parks Plateau (3 dives), collected 242 rock samples. We report here the main results of the dive program and preliminary laboratory studies: 1. Transform-related tectonic activity has recently abandoned the southern margin of Parks Plateau, and is presently located inside the WBD area, mainly along its northern wall. The tectonic features observed are compatible with a right-lateral strike-slip system, with a NE-SW extensional component. 2. Three main lithological units are exposed along the north wall of the WBD. From top to bottom, they are: (1) a Volcanic Unit, forming a steep upper cliff, made of massive and pillow flows and basaltic dikes, with an estimated average thickness of 800 m; (2) a less steep Transition Zone, about 150 to 400 m thick, largely masked by rubble but exposing both diabase outcrops and pillow flows; and (3) a massive Diabase Unit, exposed over 700–800 m, with a dike complex structure visible from place to place, and cut by a net of hydrothermal veins. Deep crustal rocks such as gabbros were not observed. 3. Spectacular mass-wasting features are visible all along the north wall of the WBD. About 60% of the face of the wall is masked by talus cones, rubble, rock avalanche deposits and slide blocks. Three main landslides, of approximately one km3 in volume each, were tentatively identified. One of them was mapped in detail and consists of an approximately 300 m thick (0.85 km3), coherent slide block detached from a zone where intense hydrothermal alteration and faulting have obviously weakened the bedrock, that is in places entirely altered to blue clays. 4. The basaltic lavas of the WBD north wall show a remarkable evolution with time, from east to west. Around the tip of the ancient propagator, they are restricted to primitive, olivine-rich picritic basalts. Proceeding westward, they exhibit a wide range of differentiation, including highly fractionated, FeTi-rich ferrobasalts at about 35–45 km from the JdFR axis. When approaching the JdFR axis, the FeTi enrichment decreases gradually, and the ferrobasalts evolve towards slightly differentiated MORB-type basalts, typical of the southern JdFR. This magmatic evolution marks the transition from the end of a propagating rift regime to a steady-state accretion regime. 5. The WBD north wall also permits the study of weathering and hydrothermal alteration processes and their evolution in space and time. Vertically, the alteration products evolve from oceanic weathering and zeolite facies (Volcanic Unit) to the greenschist facies (Transition Zone and Diabase Unit). Horizontally, the evolution with time is mainly a general hydration of the crust that is, however, very irregularly distributed. 6. Several vertical magnetic traverses along the north wall of the WBD, using a bottom magnetometer attached to the basket of the submersible, have shown a sharp 5000 to 7000 nT positive anomaly at about 3500 m depth. This anomaly corresponds exactly to the first appearance of extrusive pillow-lava outcrops, and confirms the dramatic decrease in magnetic anomaly amplitude below that depth, detected during the Blancotrough cruise in 1987. The vertical magnetic profiles thus appear to have imaged the base of the magnetic source layer.

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