Search Results - (Author, Cooperation:D. Meyers)

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  1. 1
    Staff View
    Publication Date:
    2018-04-10
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    0031-9007
    Electronic ISSN:
    1079-7114
    Topics:
    Physics
    Keywords:
    Condensed Matter: Electronic Properties, etc.
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-07-11
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Electronic structure and strongly correlated systems
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-07-19
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    0031-9007
    Electronic ISSN:
    1079-7114
    Topics:
    Physics
    Keywords:
    Condensed Matter: Structure, etc.
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2018-01-19
    Publisher:
    American Physical Society (APS)
    Electronic ISSN:
    2160-3308
    Topics:
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2015-03-15
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Conservation of Natural Resources/economics ; *Ecosystem ; *Environment ; Guidelines as Topic ; Policy
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2018-11-03
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Magnetism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  7. 7
  8. 8
    Meyers, D. C. ; Kwong, D. L.

    [S.l.] : American Institute of Physics (AIP)
    Published 1985
    Staff View
    ISSN:
    1089-7550
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    In this paper an analytic analysis of the breakdown voltage of an ion-implanted junction is presented. A joined half-Gaussian distribution of the implanted ions is used, since it gives better description of the impurity profiles. The results are based on a closed-form solution of Poisson's equation in the depletion region. Fulop's average ionization coefficient is used to determine the values for the avalanche breakdown voltage as a function of implantation energy, implant dose, and substrate dopant concentration. The maximum electric field at junction breakdown is also calculated and the results are presented. Finally, the applicability and restrictions of the analysis are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    BLEECKER, E. R. ; MEYERS, D. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    PANHUYSEN, C. I. M. ; BLEECKER, E. R. ; KOÉTER, G. H. ; MEYERS, D. A. ; POSTMA, D. S.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    MEYERS, D. A. ; XU, J. ; POSTMA, D. S. ; LEVITT, R. C. ; BLEECKER, E. R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Howard, T. D. ; Wiesch, D. G. ; Koppelman, G. H. ; Postma, D. S. ; Meyers, D. A. ; Bleecker, E. R.

    Oxford BSL : Blackwell Science Ltd
    Published 1999
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Allergy and asthma are closely related complex diseases caused by a combination of both genetic and environmental influences. Two common genetic approaches, candidate gene studies and genome-wide screens, have been used to localize and evaluate potential genetic factors that confer susceptibility or modify the phenotype of these diseases. Four genome screens suggest multiple chromosomal locations likely to contain asthma and allergy genes and many potential candidate genes exist in these regions. These screens were performed in six different populations and identified many common susceptibility regions as well as novel regions for each population. Ideally, these genes may point towards key biological pathways that will eventually serve as targets for therapeutic agents.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    BLEECKER, E. R. ; AMELUNG, P. J. ; LEVITT, R. C. ; POSTMA, D. S. ; MEYERS, D. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Previous studies have reported a familial predisposition for the development of atopy, bronchial hyperresponsiveness and clinical asthma, and therefore have suggested the presence of a heritable component to these disorders. The specific contributions of genetic and environmental factors in the pathogenesis of allergic disease and asthma have not been determined although Cookson et al. [1] have postulated linkage between atopy and chromosome 11q. We have studied 20 families (two and three generations) ascertained through a proband identified as having asthma (90% were also allergic) during the period of time between 1962 and 1970. Of those who were originally skin test positive, 82% remained positive. All probands whose pulmonary function allowed retesting (FEV1 〉 1.21) remained hyperresponsive to histamine. The children of these probands are now in the same age range as their parents when they were originally evaluated; 66% are atopic using criteria described by Cookson et al. (one or more positive skin tests ≥2 mm, an elevated total serum IgE or a positive specific IgE) and 22% demonstrate bronchial hyperresponsiveness (PC20 FEV1) to histamine. Using the highly polymorphic marker INT2 (which maps 2 cM from pλMS.51 on chromosome 11q) and atopy, we obtained a lod score of – 2.00 at a recombination fraction of 0.12. In addition, because many studies have suggested an association between atopy and certain HLA antigens, we investigated the possibility of linkage between atopy and bronchial hyperresponsiveness and D6S105, a polymorphic marker on chromosome 6p, located 7 cM from HLA-DR. For this marker and atopy, we observed a lod score of – 2.00 with a recombination fraction of 0.07. Similar results were observed with both of these markers and bronchial hyperresponsiveness. By restudying these probands as well as their family members, we were unable to find evidence for linkage between atopy or bronchial hyperresponsiveness and these regions of chromosomes 11 and 6 in this population.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling.Objective To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma.Methods In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV1 decline.Results The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV1 (P〈0.05).Conclusion These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Koppelman, G. H. ; Jansen, D. F. ; Schouten, J. P. ; Van Der Heide, S. ; Bleecker, E. R. ; Meyers, D. A. ; Postma, D. S.

    Oxford, UK : Blackwell Science Ltd
    Published 2003
    Staff View
    ISSN:
    1365-2222
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background Multiple population studies have shown the presence of a sibling effect on atopic disease. However, it is unclear if the sibling effect is also of importance in subjects who are genetically at high risk for the development of atopy.Objective To study the presence of a sibling effect on markers of atopy (serum total IgE, specific IgE, skin tests) and asthma (bronchial hyper-responsiveness to histamine) in families ascertained through a parent with asthma.Methods First-degree offspring in 200 asthma families were studied (n = 541). Mixed effects regression models were used to account for the dependence of the observations within a family, and to adjust for possible confounding variables.Results Multiple regression analysis showed that having older siblings was inversely related to atopy, defined as ≥ 2, ≥ 3, ≥ 4, or ≥ 5 skin tests (P = 0.07–0.009). In addition, family size (number of siblings) had a significant protective effect on the presence of specific IgE to common aeroallergens (P = 0.03). Exposure to cigarette smoke in the first 3 years of life significantly increased the risk of having specific IgE to common aeroallergens (P = 0.04). No sibling effect was detected for serum total IgE or bronchial hyper-responsiveness to histamine.Conclusions This study shows a protective sibling effect on the presence and severity of atopy but not on bronchial hyper-responsiveness in children who are genetically at risk. The identification of the sibling effect in high-risk families stresses the need to understand the basis of this effect, in order to design future prevention programmes.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Narayanan, A. S. ; Meyers, D. F. ; Page, R. C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1988
    Staff View
    ISSN:
    1600-0765
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We have studied how collagen production is regulated in fibroblasts obtained from normal and phenytoin-induced hyperplastic human gingiva. Collagen production was determined as collagenase digestible radioactivity and degradation was examined by adding labelled procollagen to the cultures and by pulselabelling in the presence of lysosomal inhibitors. Collagen mRNA levels were measured using a [35S]-UTP labelled proα[1] probe. The normal and phenytoininduced fibroblasts did not degrade collagen extracellularly and lysosomal inhibitors did not enhance collagen production in either culture. Collagen production by the cultures correlated with mRNA levels, and in 2 of 3 phenytoin-induced fibroblasts, which produced more collagen than other cells. collagen mRNA levels were higher. We conclude that collagen production in gingival fibroblasts is primarily regulated by the mRNA levels and that overproduction of collagen by cells from phenytoin-induced hyperplastic gingiva results from an increased steady state level of collagen mRNA and not decreased collagen degradation.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
  19. 19
    Panhuysen, C. I. M. ; Meyers, D. A. ; Postma, D. S. ; Bleecker, E. R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Fairbairn, D. ; Meyers, D. ; O'Neill, K.
    Springer
    Published 1994
    Staff View
    ISSN:
    1432-0800
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses