Search Results - (Author, Cooperation:D. M. Wilson)

2014-10-04

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Enzyme Inhibitors/*pharmacology ; Humans ; Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors ; Macrophages/*drug effects/*immunology

2012-07-31

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; Animals ; Biocatalysis/drug effects ; Catalytic Domain ; Cells, Cultured ; Enzyme Inhibitors/metabolism/*pharmacology ; Evolution, Molecular ; Histones/chemistry/metabolism ; Humans ; Inhibitory Concentration 50 ; Jumonji Domain-Containing Histone Demethylases/*antagonists & ; inhibitors/chemistry/classification/metabolism ; Lysine/metabolism ; Macrophages/*drug effects/enzymology/*immunology/metabolism ; Methylation/drug effects ; Mice ; Models, Molecular ; Substrate Specificity ; Tumor Necrosis Factor-alpha/biosynthesis

2015-12-10

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; BRCA1 Protein/metabolism ; BRCA2 Protein/metabolism ; CRISPR-Cas Systems/genetics ; Carrier Proteins/metabolism ; Cell Line ; Cullin Proteins/metabolism ; DNA/metabolism ; DNA Damage ; DNA Repair ; *G1 Phase ; G2 Phase ; Gene Targeting ; *Homologous Recombination ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Molecular Sequence Data ; Multiprotein Complexes/chemistry/metabolism ; Nuclear Proteins/chemistry/metabolism ; Protein Binding ; Rad51 Recombinase/metabolism ; S Phase ; Thiolester Hydrolases/metabolism ; Tumor Suppressor Proteins/chemistry/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination

2012-12-22

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

*Alternative Splicing ; Animals ; Biological Evolution ; Chickens/genetics ; *Evolution, Molecular ; Exons ; Introns ; Lizards/genetics ; Mice/genetics ; Mice, Inbred C57BL/genetics ; Opossums/genetics ; Phenotype ; Platypus/genetics ; Primates/genetics ; RNA Splice Sites ; Regulatory Sequences, Ribonucleic Acid ; Species Specificity ; *Transcriptome ; Vertebrates/*genetics ; Xenopus/genetics

2018-04-05

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

0090-9556

1521-009X

Chemistry and Pharmacology

Medicine

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The determination of true steric configuration is important in the study of both linear and cyclic fossil isoprenoids. For example, the structural information gathered on these compounds could be used in an analogous manner to the chemo-taxonomic conclusions of recent flora. The biosynthesis of ...

Electronic Resource

0007-0955

Law

1750-3841

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Process Engineering, Biotechnology, Nutrition Technology

A study was undertaken to isolate and identify the major pigment molecule of pecan. During the isolation process, the dependence of pH on the visual expression of one or more of the major groups of pigments was noted. Based on these observations, a study was undertaken to test the feasibility of enhancing the color of dark pecans, which are otherwise of high quality, thus increasing their market value. Results indicate acidification of pecan kernels with dilute acid solutions significantly lightens kernel color. Phosphoric acid proved the most effective color lightener without detectable effect on flavor. Treatment of pecans with dilute solutions of citric acid enhanced the color rating but affected taste. Treatment with dilute solutions of HCl resulted in some lightening of the kernels but response was variable. The degree of alternation of pecan kernel color by ammonia and SO2 gases was in part dependent upon the degree of hydration of the kernels. SO2 decreased the degree of darkness of both kernels of normal coloration and kernels that had been damaged previously by ammonia vapors.

Electronic Resource

1573-0832

Pennisetum glaucum

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract The response to delayed harvest of fungal and mycotoxin contamination of grain of the pearl millet hybrid HGM 100 was examined in 1992 and 1993. Samples of grain were assayed from seven plantings at locations near Tifton, Georgia, USA. Grain was harvested at 30, 40, and 50 days after anthesis and evaluated for infection byFusarium species andAspergillus flavus, and mycotoxin contamination. Mean isolation frequencies ofF. semitectum (35.6%) andF. chlamydosporum (17.2%) increased linearly with delayed harvest.Fusarium moniliforme andF. equisiti were infrequently isolated (〈0.5%) and did not increase in the grain when harvest was delayed. Low mean concentrations of zearalenone (0.17 ppm), nivalenol (0.42 ppm), and deoxynivalenol (0.01 ppm) were detected but were not affected by delayed harvest. Isolation frequencies ofF. chlamydosporum andF. equiseti were correlated (P=0.07) with levels of nivalenol.Aspergillus flavus was not isolated from the grain, and aflatoxin concentrations averaged 1.9 ppb.

Electronic Resource

0037-6795

History

Slavonic Studies

SHORTER NOTICES

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] During the investigation of 18C NMR shifts and the structural correspondence of pentacyclic triterpenes we undertook a 13C NMR study on one of the most abundant components of the hexane soluble fraction of oil shale bitumen of the Green River Formation. Gelpi et al. isolated and collected this ...

Electronic Resource

1420-9071

Springer Online Journal Archives 1860-2000

Biology

Medicine

Electronic Resource

1432-1920

Septo-optic dysplasia ; growth hormone deficiency ; septum pellucidum ; hypopituitarism ; hypothalamic-dysfunction states

Springer Online Journal Archives 1860-2000

Medicine

Summary The clinical and radiological findings in four children with septo-optic dysplasia are reported. All four had growth retardation associated with growth hormone deficiency, as well as varying degrees of ophthalmologic dysfunction. The CT scan findings spanned a spectrum from normal to the expected abnormalities involving the ventricular system and orbits. Only two of the four had an absent septum pellucidum. A third patient had normal CT scans except for optic nerve hypoplasia, while the fourth had entirely normal CT scans of both the brain and orbits. Because the anatomic defects of septo-optic dysplasia may be subtle, an apparently normal CT scan does not invalidate the clinical diagnosis of septo-optic dysplasia.

Electronic Resource

1432-0800

Springer Online Journal Archives 1860-2000

Energy, Environment Protection, Nuclear Power Engineering

Medicine

Summary Residues of chlordane were determined in alfalfa up to one year after application of Velsicol HCS-3260 to soil at 5 and 10 lbs active ingredient per acre. The major residues were cis-, trans-,photo-cis-, and oxychlordane. The latter two accounted for a maximum of 16% and 17%, respectively, during the first four months after treatment. The identity of oxychlordane was confirmed by four different GLC columns, chemical derivatization, p-value determination, and column chromatography.

Electronic Resource

1432-0789

Biocontrol ; Aspergillus flavus ; Aspergillus parasiticus ; Paecilomyces lilacinus ; Sclerotia

Springer Online Journal Archives 1860-2000

Biology

Geosciences

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Abstract This study was undertaken to investigate the feasibility of using Paecilomyces lilacinus NRRL 13 866, chitin, and cellulose amendments, in order to reduce survival and prevent germination of sclerotia from Aspergillus flavus NRRL 6556, NRRL 13 048, and A. parasiticus NRRL 13 005, NRRL 13 539 buried in sandy soil in Georgia and Illinois (April–October, 1990). The number of sclerotia that germinated sporogenically in moist chambers following burial in Illinois was twice that of sclerotia buried in Georgia and varied among the four sclerotium-producing Aspergillus spp. strains. Sclerotium viability, as measured by Aspergillus spp. colony formation on potato dextrose agar, was high (〉84%) for all strains and treatments (e.g. amendment, location). Even so, A. parasiticus NRRL 13 539 sclerotia were apparently more susceptible to P. lilacinus colonization than sclerotia from other strains. Treatment with Paecilomyces sp. caused a small but significant reduction in germination among sclerotia buried in Georgia.

Electronic Resource

1618-2650

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Electronic Resource

1439-6327

Training ; Swimming ; Muscle histochemistry ; Enzyme activities ; Maximal oxygen uptake

Springer Online Journal Archives 1860-2000

Medicine

Summary To test the hypothesis that a smaller quantity of high intensity (HI) as opposed to a larger quantity of moderate intensity (MI) swim training would result in adaptations more specific to the short performance times of swimming competitions, two groups of elite university swimmers were tested before and after 6.5 weeks of specific HI or MI intermittent swim training. In training, swimming times were faster and blood lactate concentrations were higher (10.2 vs. 7.5 mM) during HI compared to MI training. No significant differences were observed between the two groups for any of the variables measured, before or after training. However, significant increases with training were observed for the activities of hexokinase, phosphorylase, phosphofructokinase, succinate dehydrogenase, and 3-hydroxyacyl CoA dehydrogenase in the deltoid, but not the gastrocnemius muscles. Training resulted in significant increases in $$\dot V$$ O2 max during treatmill running, but not during tethered swimming. It is concluded that a larger quantity of MI swim training results in physiological adaptations that are similar to those obtained with a smaller quantity of HI training, at least over a relatively short training period.

Electronic Resource

1573-1979

analog VLSI ; focal plane processing ; photo detectors

Springer Online Journal Archives 1860-2000

Electrical Engineering, Measurement and Control Technology

Abstract A simple technique for detecting adjustable contrast in a visual scene is presented. The circuit elements can be used to detect contrast in any array of sensors or processing elements where spatial relationships among neighboring elements define contrast or the presence of an edge. This technique eliminates the need for a differential pair, thereby allowing more than two inputs to be compared for contrast in a single processing step. The circuit elements first smooth erroneous edges in the array through the use of a resistive network, then, the mean (scaled by an adjustable amount) of a pixel and its neighbors is compared to the harmonic mean of the same pixels to detect the presence of contrast within the pixel neighborhood. Comparison between the mean and harmonic mean allows the detection of contrast to be scale-invariant as long as the transistors remain in subthreshold operation. This circuit offers the massively parallel processing inherent to focal plane processing within an 18% fill factor in a 2 μm process, 6.8 μW typical power dissipation per element, and 0.67 ms response time at low power subthreshold operation. Results for a proof of concept, 8×8 array of pixels with light inputs, as well as a purely electronic input, 4×4 array are presented.

Electronic Resource

1573-0832

Competition effects ; Corn ; Inoculation ; Mycotoxin ; Zea mays L.

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract A two-year factorial experiment was utilized to test plants field-inoculated singly and in combination withAspergillus flavus andFusarium moniliforme. Pinbar inoculations were made through the husks with conidial suspensions, and 10-ear maize samples were harvested at 60 days post-silking for aflatoxin determinations. When ears were inoculated with both fungi simultaneously,F. moniliforme reduced aflatoxin formation byA. flavus isolate NRRL 3357 by approximately two-thirds.F. moniliforme had no significant effect on naturally occurring aflatoxin contamination byA. flavus. This may be due to the timing of infection by both fungi in the field. In nature,A. flavus andF. moniliforme respond differently to the environment, offering one explanation of whyF. moniliforme did not measurably affect the other fungus.

Electronic Resource

1573-0832

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract Aspergillus flavus Link ex Fries and A. parasiticus Speare can invade peanut kernels and under certain environmental conditions produce unacceptable levels of the mycotoxin aflatoxin. A concerted effort is underway to reduce aflatoxin contamination in peanut and peanut products. A potentially effective method of control in peanut is the discovery and use of genes for resistance to either fungal invasion or aflatoxin formation. The objective of the present experimental study was to develop an effective and efficient procedure for screening individual plants or pods of single plants for resistance to invasion by the aflatoxigenic fungi and subsequent aflatoxin production. Methods of obtaining adequate drought-stress and fungal infection were developed through this series of experiments. By completely isolating the pods from the root zone and imposing drought-stress only on pegs and pods, high levels of fungal infection were observed. High amounts of preharvest aflatoxin accumulation were also produced by completely isolating the pods from the root zone. Mid-bloom inoculation with A. parasiticus-contaminated cracked corn and drought-stress periods of 40 to 60 days were the most effective procedures. This technique was used to assess peanut genotypes previously identified as being partially resistant to A. parasiticus infection or aflatoxin contamination, and segregating populations from four crosses. Variability in aflatoxin contamination was found among the 11 genotypes evaluated, however, none were significantly lower than the standard cultivars. Broad-sense heritability of four crosses was estimated through evaluation of seed from individual plants in the F2 generation. The heritability estimates of crosses GFA-2 × NC-V11 and Tifton-8 × NC-V11 were 0.46 and 0.29, respectively, but mean aflatoxin contamination levels were high (73,295 and 27,305 ppb). This greenhouse screening method could be an effective tool when genes for superior aflatoxin resistance are identified.

Electronic Resource