Search Results - (Author, Cooperation:D. M. Valenzuela)

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  1. 1
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    Publication Date:
    2015-01-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Acute Disease/therapy ; Animals ; Anti-HIV Agents/administration & dosage/pharmacology/therapeutic use ; CD4-Positive T-Lymphocytes/cytology/immunology/virology ; Chronic Disease/drug therapy ; Epitopes, T-Lymphocyte/genetics/immunology ; Female ; Genes, Dominant/*genetics ; Genes, Viral/*genetics ; HIV Infections/blood/drug therapy/immunology/virology ; HIV-1/drug effects/*genetics/growth & development/*immunology ; Humans ; Male ; Mice ; Mutation/*genetics ; RNA, Viral/blood ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Load/drug effects ; Virus Latency/genetics/*immunology ; Virus Replication/immunology ; gag Gene Products, Human Immunodeficiency Virus/genetics/immunology
    Published by:
    http://www.nature.com/

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  2. 2
    Staff View
    Publication Date:
    2012-10-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Cell Transformation, Neoplastic ; Colitis/complications/metabolism/pathology ; Colon/metabolism/pathology ; Colonic Neoplasms/complications/metabolism/pathology ; Disease Models, Animal ; Down-Regulation ; Epithelial Cells/metabolism/pathology ; Genes, APC ; Inflammasomes/*metabolism ; Interleukin-18/metabolism ; Interleukins/deficiency/genetics/metabolism ; Intestines/*metabolism/*pathology ; Mice ; Mice, Knockout ; Receptors, Interleukin/deficiency/genetics/*metabolism ; Time Factors ; Weight Loss
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Schaeren-Wiemers, N. ; Schaefer, C. ; Valenzuela, D. M. ; Yancopoulos, G. D. ; Schwab, M. E.

    Oxford, UK : Blackwell Science Ltd
    Published 1995
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: We have isolated several new genes that are specifically expressed by oligodendrocytes in the CNS. This was achieved by differential screening of a rat spinal cord cDNA library with probes derived from normal and from oligodendrocyte-free spinal cord mRNAs. Four of these genes are exclusively expressed by oligodendrocytes: Three of these are not related to known genes, whereas one encodes the myelin oligodendrocyte glycoprotein (MOG). Four other genes are expressed by oligodendrocytes as well as by Schwann cells. One gene codes for apolipoprotein D, which is thought to be involved in lipid metabolism. A second cDNA sequence codes for the recently identified galactosylceramide-synthesizing enzyme UDP-galactose:ceramide galactosyl-transferase. The third gene encodes a small protein with four putative transmembrane domains that is related to a T-lymphocyte-specific membrane protein, MAL. The fourth gene encodes the rat homologue of the stearyl-CoA-desaturase 2 (SCD2) gene, which is specifically expressed in the nervous system and involved in the synthesis and regulation of long-chain unsaturated fatty acids essential for myelination. Finally, we found that a member of the β-tubulin family is highly expressed in oligodendrocytes as well as neurons. The identification of several new proteins that may play a role in myelin synthesis and sheath formation will lead to new insight into this complex mechanism.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1471-4159.1995.65010010.x

    Articles: DFG German National Licenses