ILSE | Search Results - (Author, Cooperation:D. M. Sabatini)

1

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

D. W. Lamming ; L. Ye ; P. Katajisto ; M. D. Goncalves ; M. Saitoh ; D. M. Stevens ; J. G. Davis ; A. B. Salmon ; A. Richardson ; R. S. Ahima ; D. A. Guertin ; D. M. Sabatini ; J. A. Baur
American Association for the Advancement of Science (AAAS)
Published 2012

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Publication Date:	2012-03-31
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Adipose Tissue, White/metabolism ; Animals ; Carrier Proteins/genetics/metabolism ; Female ; Gluconeogenesis ; Glucose/metabolism ; Glucose Clamp Technique ; Homeostasis ; Insulin/administration & dosage/blood ; Insulin Resistance ; Liver/metabolism ; Longevity ; Male ; Mice ; Mice, Inbred C57BL ; Multiprotein Complexes ; Muscle, Skeletal/metabolism ; Phosphorylation ; Proteins/antagonists & inhibitors/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Sirolimus/*pharmacology ; TOR Serine-Threonine Kinases/genetics/metabolism
Published by:	http://www.aaas.org/

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2

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

K. Birsoy ; R. Possemato ; F. K. Lorbeer ; E. C. Bayraktar ; P. Thiru ; B. Yucel ; T. Wang ; W. W. Chen ; C. B. Clish ; D. M. Sabatini
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-03-29
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Adenosine Triphosphate/metabolism ; Animals ; Biguanides/pharmacology ; Cell Culture Techniques/instrumentation/methods ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Culture Media/chemistry/metabolism/pharmacology ; DNA, Mitochondrial/genetics ; Electron Transport Complex I/deficiency/genetics/metabolism ; Glucose/deficiency/metabolism/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Male ; Mice ; Mitochondria/genetics/metabolism ; Molecular Typing ; Mutation ; Neoplasm Transplantation ; Neoplasms/drug therapy/*metabolism/pathology ; Oxidative Phosphorylation/drug effects ; Phenformin/pharmacology ; RNA Interference ; Saccharomyces cerevisiae Proteins/genetics/metabolism ; Xenograft Model Antitumor Assays
Published by:	http://www.nature.com/

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3

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling

P. P. Hsu ; S. A. Kang ; J. Rameseder ; Y. Zhang ; K. A. Ottina ; D. Lim ; T. R. Peterson ; Y. Choi ; N. S. Gray ; M. B. Yaffe ; J. A. Marto ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-06-11
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Animals ; Cell Line ; GRB10 Adaptor Protein/metabolism ; Humans ; Insulin/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Mass Spectrometry ; Mice ; Multiprotein Complexes ; Naphthyridines/pharmacology ; Phosphoproteins/metabolism ; Phosphorylation ; Proteins/metabolism ; Proteome/metabolism ; Signal Transduction ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/*metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

4

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

S. Beyaz ; M. D. Mana ; J. Roper ; D. Kedrin ; A. Saadatpour ; S. J. Hong ; K. E. Bauer-Rowe ; M. E. Xifaras ; A. Akkad ; E. Arias ; L. Pinello ; Y. Katz ; S. Shinagare ; M. Abu-Remaileh ; M. M. Mihaylova ; D. W. Lamming ; R. Dogum ; G. Guo ; G. W. Bell ; M. Selig ; G. P. Nielsen ; N. Gupta ; C. R. Ferrone ; V. Deshpande ; G. C. Yuan ; S. H. Orkin ; D. M. Sabatini ; O. H. Yilmaz
Nature Publishing Group (NPG)
Published 2016

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Publication Date:	2016-03-05
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Cell Count ; Cell Self Renewal/drug effects ; Cell Transformation, Neoplastic/drug effects ; Colonic Neoplasms/pathology ; Diet, High-Fat/adverse effects ; Female ; Genes, APC ; Humans ; Intestines/pathology ; Male ; Mice ; Obesity/chemically induced/pathology ; Organoids/drug effects/metabolism/pathology ; PPAR delta/metabolism ; Signal Transduction/drug effects ; Stem Cell Niche/drug effects ; Stem Cells/drug effects/metabolism/pathology ; beta Catenin/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

5

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

R. Zoncu ; L. Bar-Peled ; A. Efeyan ; S. Wang ; Y. Sancak ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-11-05
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Amino Acids/metabolism ; Animals ; Cell Line ; Drosophila ; GTP Phosphohydrolases/metabolism ; Humans ; Lysosomes/metabolism ; Multiprotein Complexes ; Proteins/metabolism ; RNA Interference ; Signal Transduction ; TOR Serine-Threonine Kinases ; Vacuolar Proton-Translocating ATPases/metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

6

Cell biology. The TASCC of secretion

R. Zoncu ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-05-21
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Autophagy ; Cell Aging ; Cytoplasmic Vesicles/metabolism/ultrastructure ; Endoplasmic Reticulum/metabolism/ultrastructure ; Genes, ras ; Golgi Apparatus/metabolism/ultrastructure ; Humans ; Interleukins/secretion ; Intracellular Signaling Peptides and Proteins/metabolism ; Multiprotein Complexes ; Phagosomes/metabolism/ultrastructure ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; Proteins/metabolism/secretion ; Secretory Pathway ; TOR Serine-Threonine Kinases ; ras Proteins/metabolism ; trans-Golgi Network/metabolism/ultrastructure
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

7

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

S. R. Floyd ; M. E. Pacold ; Q. Huang ; S. M. Clarke ; F. C. Lam ; I. G. Cannell ; B. D. Bryson ; J. Rameseder ; M. J. Lee ; E. J. Blake ; A. Fydrych ; R. Ho ; B. A. Greenberger ; G. C. Chen ; A. Maffa ; A. M. Del Rosario ; D. E. Root ; A. E. Carpenter ; W. C. Hahn ; D. M. Sabatini ; C. C. Chen ; F. M. White ; J. E. Bradner ; M. B. Yaffe
Nature Publishing Group (NPG)
Published 2013

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Publication Date:	2013-06-04
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Acetylation ; Adenosine Triphosphatases/metabolism ; Cell Cycle Checkpoints/radiation effects ; Cell Line, Tumor ; Cell Survival/radiation effects ; Chromatin/chemistry/metabolism/radiation effects ; Chromatin Assembly and Disassembly/radiation effects ; DNA Damage ; DNA Repair/radiation effects ; DNA-Binding Proteins/metabolism ; Histones/chemistry/metabolism ; Humans ; Lysine/chemistry/metabolism ; Multiprotein Complexes/metabolism ; Nuclear Proteins/chemistry/deficiency/genetics/metabolism ; Phosphorylation/radiation effects ; Positive Transcriptional Elongation Factor B/metabolism ; Protein Isoforms/metabolism ; Radiation, Ionizing ; Signal Transduction/radiation effects ; Transcription Factors/chemistry/deficiency/genetics/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

8

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

A. Efeyan ; R. Zoncu ; S. Chang ; I. Gumper ; H. Snitkin ; R. L. Wolfson ; O. Kirak ; D. D. Sabatini ; D. M. Sabatini
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-12-25
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Amino Acids/metabolism ; Animals ; Animals, Newborn/metabolism/physiology ; Autophagy/genetics ; Blood Glucose/metabolism ; GTP Phosphohydrolases/genetics/metabolism ; Gene Expression Regulation, Enzymologic ; Gene Knock-In Techniques ; Hypoglycemia/genetics ; Kaplan-Meier Estimate ; Mice ; Multiprotein Complexes/genetics/metabolism ; TOR Serine-Threonine Kinases/genetics/metabolism ; Time Factors
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

9

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

S. A. Kang ; M. E. Pacold ; C. L. Cervantes ; D. Lim ; H. J. Lou ; K. Ottina ; N. S. Gray ; B. E. Turk ; M. B. Yaffe ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2013

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Publication Date:	2013-07-28
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Amino Acid Motifs ; Amino Acids/metabolism ; Animals ; Cell Line ; Culture Media ; Humans ; Mice ; Multiprotein Complexes ; Naphthyridines/pharmacology ; Peptides/chemistry/metabolism ; Phosphorylation ; Proteins/antagonists & inhibitors/chemistry/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors/chemistry/metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

10

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

L. Bar-Peled ; L. Chantranupong ; A. D. Cherniack ; W. W. Chen ; K. A. Ottina ; B. C. Grabiner ; E. D. Spear ; S. L. Carter ; M. Meyerson ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2013

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Publication Date:	2013-06-01
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Amino Acids/metabolism ; Carrier Proteins/antagonists & inhibitors/genetics/metabolism ; Cell Line, Tumor ; GTPase-Activating Proteins ; HEK293 Cells ; Humans ; Lysosomes/enzymology ; Monomeric GTP-Binding Proteins/metabolism ; Multiprotein Complexes ; Mutation ; Neoplasms/enzymology/genetics ; Nuclear Proteins/antagonists & inhibitors/genetics/metabolism ; Proteins/metabolism ; RNA, Small Interfering/genetics ; TOR Serine-Threonine Kinases ; Tumor Suppressor Proteins/antagonists & inhibitors/genetics/*metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

11

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

S. Wang ; Z. Y. Tsun ; R. L. Wolfson ; K. Shen ; G. A. Wyant ; M. E. Plovanich ; E. D. Yuan ; T. D. Jones ; L. Chantranupong ; W. Comb ; T. Wang ; L. Bar-Peled ; R. Zoncu ; C. Straub ; C. Kim ; J. Park ; B. L. Sabatini ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-01-09
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Amino Acid Sequence ; Amino Acid Transport Systems/chemistry/genetics/metabolism ; Arginine/deficiency/metabolism ; HEK293 Cells ; Humans ; Lysosomes/enzymology ; Molecular Sequence Data ; Monomeric GTP-Binding Proteins/metabolism ; Multiprotein Complexes/metabolism ; Protein Structure, Tertiary ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

12

Identification of an oncogenic RAB protein

D. B. Wheeler ; R. Zoncu ; D. E. Root ; D. M. Sabatini ; C. L. Sawyers
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-09-05
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Alleles ; Cell Line, Tumor ; Gene Deletion ; Humans ; Immunoprecipitation ; Lysosomal-Associated Membrane Protein 2/metabolism ; Multiprotein Complexes/metabolism ; Mutation ; Neoplasms/genetics/metabolism/pathology ; Oncogene Proteins/genetics/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/genetics ; Protein Transport ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; TOR Serine-Threonine Kinases/metabolism ; rab GTP-Binding Proteins/genetics/metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

13

Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

P. Katajisto ; J. Dohla ; C. L. Chaffer ; N. Pentinmikko ; N. Marjanovic ; S. Iqbal ; R. Zoncu ; W. Chen ; R. A. Weinberg ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-04-04
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Cell Aging/genetics/physiology ; Cell Division/genetics/physiology ; Cell Line ; Humans ; Mitochondria/physiology/ultrastructure ; Stem Cells/physiology/*ultrastructure
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

14

Sestrin2 is a leucine sensor for the mTORC1 pathway

R. L. Wolfson ; L. Chantranupong ; R. A. Saxton ; K. Shen ; S. M. Scaria ; J. R. Cantor ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-10-10
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	GTPase-Activating Proteins/metabolism ; HEK293 Cells ; Humans ; Leucine/metabolism ; Metabolic Networks and Pathways ; Multiprotein Complexes/metabolism ; Nuclear Proteins/chemistry/genetics/metabolism ; Protein Binding ; Proteins/chemistry/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

15

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

R. A. Saxton ; K. E. Knockenhauer ; R. L. Wolfson ; L. Chantranupong ; M. E. Pacold ; T. Wang ; T. U. Schwartz ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-11-21
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Amino Acid Sequence ; Binding Sites ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Leucine/chemistry/metabolism ; Metabolic Networks and Pathways ; Molecular Sequence Data ; Multiprotein Complexes/chemistry/genetics/metabolism ; Mutation ; Nuclear Proteins/chemistry/metabolism ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; TOR Serine-Threonine Kinases/chemistry/genetics/metabolism
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

16

Identification and characterization of essential genes in the human genome

T. Wang ; K. Birsoy ; N. W. Hughes ; K. M. Krupczak ; Y. Post ; J. J. Wei ; E. S. Lander ; D. M. Sabatini
American Association for the Advancement of Science (AAAS)
Published 2015

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Publication Date:	2015-10-17
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	CRISPR-Cas Systems ; Cell Line, Tumor ; Cell Nucleolus/metabolism ; Gene Expression Profiling ; Gene Knockout Techniques ; Genes, Essential ; Genetic Testing/methods ; Genome, Human/*genetics ; Genomic Library ; Humans ; Neoplasms/genetics ; RNA Processing, Post-Transcriptional/genetics ; RNA, Guide/genetics
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

17

Genetic screens in human cells using the CRISPR-Cas9 system

T. Wang ; J. J. Wei ; D. M. Sabatini ; E. S. Lander
American Association for the Advancement of Science (AAAS)
Published 2013

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Publication Date:	2013-12-18
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Antigens, Neoplasm/genetics ; Antimetabolites, Antineoplastic/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Caspase 9/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats ; DNA Mismatch Repair/genetics ; DNA Topoisomerases, Type II/genetics ; DNA-Binding Proteins/antagonists & inhibitors/genetics ; Drug Resistance, Neoplasm/genetics ; Etoposide/pharmacology ; Gene Knockout Techniques ; Gene Library ; Genetic Testing ; Genome-Wide Association Study/methods ; Humans ; RNA/genetics ; Thioguanine/pharmacology
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

18

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

D. Kim ; B. P. Fiske ; K. Birsoy ; E. Freinkman ; K. Kami ; R. L. Possemato ; Y. Chudnovsky ; M. E. Pacold ; W. W. Chen ; J. R. Cantor ; L. M. Shelton ; D. Y. Gui ; M. Kwon ; S. H. Ramkissoon ; K. L. Ligon ; S. W. Kang ; M. Snuderl ; M. G. Vander Heiden ; D. M. Sabatini
Nature Publishing Group (NPG)
Published 2015

Staff View

Publication Date:	2015-04-10
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Acetone/analogs & derivatives/metabolism/toxicity ; Animals ; Brain Neoplasms/blood supply/enzymology/metabolism/pathology ; Cell Hypoxia ; Cell Line, Tumor ; Cell Survival ; Female ; Glioblastoma/blood supply/enzymology/metabolism/pathology ; Glycine/metabolism ; Glycine Dehydrogenase (Decarboxylating)/antagonists & inhibitors/metabolism ; Glycine Hydroxymethyltransferase/metabolism ; Humans ; Ischemia/enzymology/*metabolism/pathology ; Mice ; Necrosis ; Oxygen Consumption ; Pyruvaldehyde/metabolism/toxicity ; Pyruvate Kinase/metabolism ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

19

Nutrient-sensing mechanisms and pathways

A. Efeyan ; W. C. Comb ; D. M. Sabatini
Nature Publishing Group (NPG)
Published 2015

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Publication Date:	2015-01-17
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Amino Acids/metabolism ; Animals ; Autophagy ; Glucose/metabolism ; Homeostasis ; Humans ; *Lipid Metabolism ; Metabolic Diseases/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

20

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

R. Possemato ; K. M. Marks ; Y. D. Shaul ; M. E. Pacold ; D. Kim ; K. Birsoy ; S. Sethumadhavan ; H. K. Woo ; H. G. Jang ; A. K. Jha ; W. W. Chen ; F. G. Barrett ; N. Stransky ; Z. Y. Tsun ; G. S. Cowley ; J. Barretina ; N. Y. Kalaany ; P. P. Hsu ; K. Ottina ; A. M. Chan ; B. Yuan ; L. A. Garraway ; D. E. Root ; M. Mino-Kenudson ; E. F. Brachtel ; E. M. Driggers ; D. M. Sabatini
Nature Publishing Group (NPG)
Published 2011

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Publication Date:	2011-07-16
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/enzymology/genetics/metabolism/pathology ; Cell Line, Tumor ; Cell Proliferation ; Citric Acid Cycle/physiology ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Genomics ; Glutamic Acid/metabolism ; Humans ; Ketoglutaric Acids/metabolism ; Melanoma/enzymology/genetics ; Mice ; Neoplasm Transplantation ; Phosphoglycerate Dehydrogenase/genetics/metabolism ; RNA Interference ; Serine/biosynthesis
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

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