Search Results - (Author, Cooperation:D. Kwiatkowski)
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1Latest Papers from Table of Contents or Articles in PressD. Gurdasani ; T. Carstensen ; F. Tekola-Ayele ; L. Pagani ; I. Tachmazidou ; K. Hatzikotoulas ; S. Karthikeyan ; L. Iles ; M. O. Pollard ; A. Choudhury ; G. R. Ritchie ; Y. Xue ; J. Asimit ; R. N. Nsubuga ; E. H. Young ; C. Pomilla ; K. Kivinen ; K. Rockett ; A. Kamali ; A. P. Doumatey ; G. Asiki ; J. Seeley ; F. Sisay-Joof ; M. Jallow ; S. Tollman ; E. Mekonnen ; R. Ekong ; T. Oljira ; N. Bradman ; K. Bojang ; M. Ramsay ; A. Adeyemo ; E. Bekele ; A. Motala ; S. A. Norris ; F. Pirie ; P. Kaleebu ; D. Kwiatkowski ; C. Tyler-Smith ; C. Rotimi ; E. Zeggini ; M. S. Sandhu
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa ; Africa South of the Sahara ; Asia/ethnology ; Europe/ethnology ; Genetic Variation/*genetics ; Genetics, Medical/*trends ; Genome, Human/*genetics ; Genomics/*trends ; Humans ; Risk Factors ; Selection, Genetic/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressChen, F., Zhang, Y., Gibbons, D. L., Deneen, B., Kwiatkowski, D. J., Ittmann, M., Creighton, C. J.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-05-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Latest Papers from Table of Contents or Articles in PressAisner, D. L., Sholl, L. M., Berry, L. D., Rossi, M. R., Chen, H., Fujimoto, J., Moreira, A. L., Ramalingam, S. S., Villaruz, L. C., Otterson, G. A., Haura, E., Politi, K., Glisson, B., Cetnar, J., Garon, E. B., Schiller, J., Waqar, S. N., Sequist, L. V., Brahmer, J., Shyr, Y., Kugler, K., Wistuba, I. I., Johnson, B. E., Minna, J. D., Kris, M. G., Bunn, P. A., Kwiatkowski, D. J., for the LCMC2 investigators
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-03-06Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressTessema, S. K., Utama, D., Chesnokov, O., Hodder, A. N., Lin, C. S., Harrison, G. L. A., Jespersen, J. S., Petersen, B., Tavul, L., Siba, P., Kwiatkowski, D., Lavstsen, T., Hansen, D. S., Oleinikov, A. V., Mueller, I., Barry, A. E.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-07-24Publisher: The American Society for Microbiology (ASM)Print ISSN: 0019-9567Electronic ISSN: 1098-5522Topics: MedicinePublished by: -
5Articles: DFG German National LicensesSHORT, M. P. ; HAINES, J. ; JEWELL, A. ; BEJJANI, B. ; YANG, C. H. ; WYANDT, H. ; MacFARLANE, H. ; ANDERMANN, E. ; KWIATKOWSKI, D. ; AMOS, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesGoetghebuer, T. ; Isles, K. ; Moore, C. ; Thomson, A. ; Kwiatkowski, D. ; Hull, J.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background The nature of the association between severe respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing remains unknown. In a previous study, we showed that genetic variation in the IL-8-promoter region is associated with susceptibility to severe bronchiolitis.Objective The purpose of this study was to assess the association between wheezing post-bronchiolitis and the genetic variant of IL-8 gene.Methods We collected data from 134 children who had suffered from bronchiolitis, enrolled in our previous study. The occurrence of wheezing post-bronchiolitis was recorded from a questionnaire sent by post. The association between the genotype and wheezing phenotype was assessed by family-based and case–control approaches.Results Family-based association showed that the IL-8 variant was transmitted significantly more often than expected in the children who wheezed after the episode of bronchiolitis (transmission=56%, P=0.02). This effect was not observed in the group of children who had bronchiolitis but did not go on to wheeze. Moreover, the variant was significantly more frequent in post-bronchiolitis wheezers compared with the general population (odds ratio=1.6, 95% confidence interval 1.0–2.6).Conclusion These preliminary results suggest that there is a genetic predisposition to wheeze following severe RSV bronchiolitis.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0169-4758Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesKandt, R. S. ; Haines, J. L. ; Smith, M. ; Northrup, H. ; Gardner, R. J. M. ; Short, M. P. ; Dumars, K. ; Roach, E. S. ; Steingold, S. ; Wall, S. ; Blanton, S. H. ; Flodman, P. ; Kwiatkowski, D. J. ; Jewell, A. ; Weber, J. L. ; Roses, A. D. ; Pericak-Vance, M. A.
[s.l.] : Nature Publishing Group
Published 1992Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Tuberous sclerosis complex (TSC) is an autosomal dominant disorder of unknown aetiology that affects numerous body systems including skin, brain and kidneys. Some TSC has been linked to chromosome 9, additional TSC genes on chromosomes 11 and 12 have been proposed, but the majority of TSC families ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesRuwende, C. ; Khoo, S. C. ; Snow, R. W. ; Yates, S. N. R. ; Kwiatkowski, D. ; Gupta, S. ; Warn, P. ; Allsopp, C. E. M. ; Gilbert, S. C. ; Peschu, N. ; Newbold, C. I. ; Greenwood, B. M. ; Marsh, K. ; Hill, A. V. S.
[s.l.] : Nature Publishing Group
Published 1995Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Despite the extensive heterogeneity of G6PD deficiency, a single molecular variant, G6PD A-, seems predominant in sub-Saharan Africa12 14. It differs from the normal G6PD B allele at two amino-acid positions, one at position 376 encoding the B to A change and the other at position 202 that ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHill, A.V.S. ; Bennett, S. ; Allsopp, C.E.M. ; Kwiatkowski, D. ; Anstey, N.M. ; Twumasi, P. ; Rowe, P.A. ; Brewster, D. ; McMichael, A.J. ; Greenwood, B.M.
Amsterdam : ElsevierStaff ViewISSN: 0169-4758Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesAttwood, J. ; Chiano, M. ; Collins, A. ; Donis-Keller, H. ; Dracopoli, N. ; Fountain, J. ; Falk, C. ; Goudie, D. ; Retief, A. ; Jeffreys, A.J. ; Kwiatkowski, D. ; Shields, D. ; Robson, E. ; Vergnaud, G. ; Northrup, H. ; Gusella, J. ; Haines, J. ; Phillips, J. ; Weber, J. ; Weissenbach, J. ; Yates, J. ; Armour, J.A.L. ; Lathrop, M. ; Pericak-Vance, M.A. ; White, R.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1238Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A fundamental question for the intensivist is why some individuals but not others succumb to life-threatening infection. A growing body of evidence indicates that both the risk of acquiring infection and the risk of developing severe complications are determined by host genetic factors. These include a number of single gene defects with devastating consequences, e. g. interferon-gamma receptor mutations that lead to fatal infections with ubiquitous mycobacteria, but such examples are relatively rare. Of greater importance for routine clinical practice is the potentially vast number of genetic variants with subtle effects on the regulation or function of specific immunological, physiological and metabolic mediators. Such polygenic traits do not obey simple patterns of familial segregation seen for monogenic disorders, and their clinical investigation is further complicated by the environmental variability of infectious exposure. Recent advances in this field have therefore largely stemmed from hospital-based case-controlled studies that have uncovered disease associations with specific DNA polymorphisms in candidate gene regions. For example, tumour necrosis factor polymorphisms have been associated with susceptibility to malaria and other infections; chemokine receptor polymorphisms with susceptibility to HIV; natural resistance-associated macrophage protein 1 with tuberculosis; and mannose binding lectin polymorphisms with meningococcal disease. A much greater number of genetic associations will emerge as the full extent of human genomic diversity becomes known. The challenge for clinical investigators is to generate an epidemiological framework for population- and family-based association studies, which is sufficiently robust to exclude population artifacts and sufficiently powerful to be able to dissect true disease-causing polymorphisms from linked genetic markers. In the long term this approach promises to identify host mediators that are critical for pathogenesis and immunity and to yield molecular insights into the complex processes of human gene regulation. This information is likely to be of considerable value in designing more effective approaches to the treatment and prevention of life-threatening infectious disease.Type of Medium: Electronic ResourceURL: