Search Results - (Author, Cooperation:D. Julius)

2018-01-12

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Geosciences

Computer Science

Medicine

Natural Sciences in General

Physics

Biochemistry

2013-12-07

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Ankyrin Repeat ; *Cryoelectron Microscopy ; HEK293 Cells ; Humans ; *Models, Molecular ; Protein Structure, Tertiary ; Rats ; TRPV Cation Channels/*chemistry

2015-04-10

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Allosteric Regulation ; Analgesics ; Ankyrin Repeat ; Anti-Inflammatory Agents ; Binding Sites ; Calcium Channels/*chemistry/metabolism/*ultrastructure ; *Cryoelectron Microscopy ; Cytosol/metabolism ; Humans ; Models, Molecular ; Nerve Tissue Proteins/antagonists & ; inhibitors/*chemistry/metabolism/*ultrastructure ; Polyphosphates/metabolism/pharmacology ; Protein Stability/drug effects ; Protein Subunits/chemistry/metabolism ; Structure-Activity Relationship ; Transient Receptor Potential Channels/antagonists &

2011-08-05

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Alternative Splicing/*genetics ; Amino Acid Sequence ; Animals ; Cattle ; Chiroptera/anatomy & histology/classification/*genetics/*physiology ; Face/anatomy & histology/innervation ; Feeding Behavior/physiology ; HEK293 Cells ; Hot Temperature ; Humans ; *Infrared Rays ; Molecular Sequence Data ; Organ Specificity/genetics ; Phylogeny ; Predatory Behavior/physiology ; Protein Isoforms/chemistry/genetics/metabolism ; Protein Structure, Tertiary ; Sensation/*physiology ; TRPV Cation Channels/chemistry/*genetics/metabolism ; Trigeminal Ganglion/*metabolism

2015-07-23

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2011-11-19

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Acid Sensing Ion Channels ; Amino Acid Sequence ; Animals ; Capsaicin/pharmacology ; Cells, Cultured ; Elapid Venoms/*chemistry/*pharmacology ; *Elapidae ; Hindlimb/drug effects/physiopathology ; Humans ; Hydrogen-Ion Concentration ; Ion Channel Gating/drug effects ; Male ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Nerve Tissue Proteins/agonists/deficiency/genetics/*metabolism ; Nociception/drug effects/physiology ; Oocytes ; Pain/*chemically induced/metabolism/physiopathology ; *Protein Multimerization ; Protein Structure, Quaternary ; Protons ; Rats ; Sensory Receptor Cells/drug effects/metabolism ; Sodium Channel Agonists ; Sodium Channels/deficiency/genetics/*metabolism ; TRPV Cation Channels/metabolism ; Xenopus laevis

2013-12-07

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; *Models, Molecular ; Mutation ; Protein Structure, Tertiary ; Rats ; TRPV Cation Channels/*chemistry/genetics/*physiology

1471-4159

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Birds are indifferent to the pain-producing effects of capsaicin. However, avian primary sensory neurons exhibit heat-evoked membrane currents resembling those carried by mammalian capsaicin receptors. We aimed to identify an avian capsaicin receptor homolog, and to map structural determinants for vanilloid sensitivity. We cloned the avian capsaicin receptor ortholog, cVR1 (68% identity to rat VR1), from a chicken DRG library. cVR1 currents responded to noxious heat and acidity, but were insensitive to capsaicin. Structural domains essential for vanilloid interaction were mapped by chimeric analysis, ligand binding assays, mutagenesis and chemical labeling. Vanilloid sensitivity can be conferred to vanilloid-insensitive capsaicin receptor homologs (cVR1, VRL1 and TRPV4) by a domain within the transmembrane moiety of rat VR1. Genetic and chemical modification studies suggest that capsaicin or the endogenous ligand, anandamide, bind to the receptor from the intracellular side of the plasma membrane and interact with residues near the third putative transmembrane region.

Electronic Resource

0014-4827

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Medicine

Electronic Resource

0550-3213

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Physics

Electronic Resource

1435-1463

Springer Online Journal Archives 1860-2000

Medicine

Summary 1. Our experiments confirm the thesis that the lungs move actively by the impulse which is conveyed by the vegetative nervous system. Atelectasis and emphysema are the consequence of contraction or dilatation of the smooth pulmonary musculature. The center for the movement of this musculature is lying in the brains. It depends on the intensity of the stimulation in which manner the periphery, i. e., the lungs and the blood vessels, react. 2. We could convince ourselves that insuline exerts a vivid effect on the movements of the pulmonary tissue and on the blood circulation in the lungs. 3. The described changes may be the basis for subsequent pulmonary complications, such as pneumonia, pulmonary abscess or pulmonary gangrene. 4. In our opinion, aspiration plays an important part. Saliva and also remnants of food damage the tissue, the ability of which to resist detrimental influences is lowered in consequence of neuroparalytic hyperemia of the mucous membrane: this is the increase in stimulation in the sense ofReinhardt's theory.

Résumé 1. Nos expériences confirment la thèse que les poumons se mouvent activement par l'impulsion transmise par le système nerveux végétatif. L'atélectasie et l'emphysème sont causés par la contraction ou par la dilatation de la musculature pulmonaire lisse. Le centre pour le mouvement de cette musculature se trouve dans le cerveau. De l'intensité de la stimulation dépend la réaction de la périphérie, c'est-à-dire des poumons et des vaisseaux. 2. Nous avons pu nous convaincre que l'insuline exerce un effet fort sur les mouvements du tissu pulmonaire et sur la circulation sanguine dans les poumons. 3. Les changements décrits peuvent être la base pour des complications pulmonaires, comme la pneumonie, l'abcès ou la gangrène pulmonaires. 4. Nous sommes d'avis que l'aspiration joue un rôle important. La salive et des restes de la nourriture lèsent le tissu dont la capacité de résister à des influences malsaines est diminuée par suite de l'hyperémie névroparalytique de la membrane muqueuse: c'est l'augmentation de stimulations dans le sens de la théorie deReinhardt.

Zusammenfassung 1. Unsere Versuche bestätigen die These, daß sich die Lunge aktiv durch den Impuls bewegt, den das vegetative Nervensystem überträgt. Die Atelektase und das Emphysem sind die Folge von Kontraktion oder Dilatation der glatten Lungenmuskulatur; das Zentrum für die Bewegungen dieser Muskulatur befindet sich im Gehirn. Von der Stärke der Reizung hängt es ab, auf welche Art und Weise die Peripherie, d. h. die Lunge und die Blutgefäße in ihr reagieren. 2. Wir konnten uns davon überzeugen, daß das Insulin eine lebhafte Wirkung auf die Bewegungen des Lungengewebes und auf den Blutkreislauf in der Lunge ausübt. 3. Die beschriebenen Veränderungen können die Grundlage für spätere Lungenkomplikationen, wie Pneumonie, Lungenabszeß oder-gangrän bilden. 4. Die Aspiration spielt unserer Meinung nach eine große Rolle. Der Speichel oder auch Speisereste schädigen das Gewebe, dessen Widerstandsfähigkeit infolge der neuroparalytischen Hyperämie der Schleimhaut gesunken ist. Das ist der Reizzuwachs im SinneReinhardts.

Electronic Resource

1432-1041

Key words REM sleep ; Clonidine ; Yohimbine; α2-adrenoceptors ; man

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Abstract Objective: To study the acute effect of clonidine, an α2-adrenoceptor agonist, and yohimbine, an α2-adrenoceptor antagonist, on nocturnal sleep in healthy men. Setting: McGuire Veteran Affairs Medical Center, Richmond, Virginia, USA. Subjects: Eight healthy male volunteers. Methods: Each subject slept in the sleep laboratory for 2 consecutive nights on three separate sessions, at 3-week intervals. On the 2nd night of each session, the subjects received yohimbine (5.4 mg), clonidine (0.1 mg), or placebo in a double-blind, randomized, placebo-controlled, crossover design. Results: There were no apparent effects of yohimbine. In contrast, clonidine completely suppressed rapid eye movement (REM) sleep in one subject and reduced REM sleep in the remaining seven subjects. Conclusion: Our study confirms that clonidine markedly decreases REM, even at a low single dose, and supports the hypothesis of the important role of α2-receptors in controlling REM sleep.

Electronic Resource

1612-4677

Springer Online Journal Archives 1860-2000

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

1573-6903

Springer Online Journal Archives 1860-2000

Medicine

Abstract Plasma levels of 14 amino acids were determined in 44 probands with 3/sec spike-wave epilepsy, 27 of their first-degree relatives, and 22 controls. Six ratios of metabolically related amino acids were also calculated. Statistically significant differences were found for 7/20 variables when the experimental and control probands were compared, and for 6/20 variables when the relatives were compared with controls. Tau, Asp, and Tau/Glu were decreased and Glu was increased in both the experimental probands and their first degree relatives. When discriminant analysis was used, age- and sex-matched epileptic probands could be distinguished from the age- and sex-matched control probands with 100% accuracy employing only 3 amino acids (Asp, Glu, Val) and one ratio (Thr/Ser).

Electronic Resource

1572-9931

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract Serotonin (5-hydroxytryptamine) functions as a neurotransmitter and a hormone. Its diverse actions are mediated by at least seven distinct cell surface receptor subtypes. The serotonin receptor subtype 2 (gene symbolHTR2) is a G-protein-coupled receptor, expressed primarily in the cerebral cortex, where upon stimulation it stimulates the hydrolysis of inositol phospholipids. We have mapped theHTR2 locus to human chromosome 13 and to mouse chromosome 14 by somatic cell hybrid analysis. Linkage studies in CEPH families, using a PvuII RFLP detected with the HTR2 probe, revealed tight linkage betweenHTR2 andESD, the locus for esterase D. The most likely position forHTR2 is betweenESD andRB1, the retinoblastoma-1 gene. The homologous loci in mouse,Rb-1 andEsd(Es-10) are on mouse chromosome 14, close toag, agitans, a recessive neurological mutation. Having mappedHtr-2 to mouse chromosome 14, we predict that it falls into this known conserved gene cluster.

Electronic Resource