Search Results - (Author, Cooperation:D. J. Stein)
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1C. Rotimi ; A. Abayomi ; A. Abimiku ; V. M. Adabayeri ; C. Adebamowo ; E. Adebiyi ; A. D. Ademola ; A. Adeyemo ; D. Adu ; D. Affolabi ; G. Agongo ; S. Ajayi ; S. Akarolo-Anthony ; R. Akinyemi ; A. Akpalu ; M. Alberts ; O. Alonso Betancourt ; A. M. Alzohairy ; G. Ameni ; O. Amodu ; G. Anabwani ; K. Andersen ; F. Arogundade ; O. Arulogun ; D. Asogun ; R. Bakare ; N. Balde ; M. L. Baniecki ; C. Beiswanger ; A. Benkahla ; L. Bethke ; M. Boehnke ; V. Boima ; J. Brandful ; A. I. Brooks ; F. C. Brosius ; C. Brown ; B. Bucheton ; D. T. Burke ; B. G. Burnett ; S. Carrington-Lawrence ; N. Carstens ; J. Chisi ; A. Christoffels ; R. Cooper ; H. Cordell ; N. Crowther ; T. Croxton ; J. de Vries ; L. Derr ; P. Donkor ; S. Doumbia ; A. Duncanson ; I. Ekem ; A. El Sayed ; M. E. Engel ; J. C. Enyaru ; D. Everett ; F. M. Fadlelmola ; E. Fakunle ; K. H. Fischbeck ; A. Fischer ; O. Folarin ; J. Gamieldien ; R. F. Garry ; S. Gaseitsiwe ; R. Gbadegesin ; A. Ghansah ; M. Giovanni ; P. Goesbeck ; F. X. Gomez-Olive ; D. S. Grant ; R. Grewal ; M. Guyer ; N. A. Hanchard ; C. T. Happi ; S. Hazelhurst ; B. J. Hennig ; C. Hertz ; Fowler ; W. Hide ; F. Hilderbrandt ; C. Hugo-Hamman ; M. E. Ibrahim ; R. James ; Y. Jaufeerally-Fakim ; C. Jenkins ; U. Jentsch ; P. P. Jiang ; M. Joloba ; V. Jongeneel ; F. Joubert ; M. Kader ; K. Kahn ; P. Kaleebu ; S. H. Kapiga ; S. K. Kassim ; I. Kasvosve ; J. Kayondo ; B. Keavney ; A. Kekitiinwa ; S. H. Khan ; P. Kimmel ; M. C. King ; R. Kleta ; M. Koffi ; J. Kopp ; M. Kretzler ; J. Kumuthini ; S. Kyobe ; C. Kyobutungi ; D. T. Lackland ; K. A. Lacourciere ; G. Landoure ; R. Lawlor ; T. Lehner ; M. Lesosky ; N. Levitt ; K. Littler ; Z. Lombard ; J. F. Loring ; S. Lyantagaye ; A. Macleod ; E. B. Madden ; C. R. Mahomva ; J. Makani ; M. Mamven ; M. Marape ; G. Mardon ; P. Marshall ; D. P. Martin ; D. Masiga ; R. Mason ; M. Mate-Kole ; E. Matovu ; M. Mayige ; B. M. Mayosi ; J. C. Mbanya ; S. A. McCurdy ; M. I. McCarthy ; H. McIlleron ; S. O. Mc'Ligeyo ; C. Merle ; A. O. Mocumbi ; C. Mondo ; J. V. Moran ; A. Motala ; M. Moxey-Mims ; W. S. Mpoloka ; C. L. Msefula ; T. Mthiyane ; N. Mulder ; G. Mulugeta ; D. Mumba ; J. Musuku ; M. Nagdee ; O. Nash ; D. Ndiaye ; A. Q. Nguyen ; M. Nicol ; O. Nkomazana ; S. Norris ; B. Nsangi ; A. Nyarko ; M. Nyirenda ; E. Obe ; R. Obiakor ; A. Oduro ; S. F. Ofori-Acquah ; O. Ogah ; S. Ogendo ; K. Ohene-Frempong ; A. Ojo ; T. Olanrewaju ; J. Oli ; C. Osafo ; O. Ouwe Missi Oukem-Boyer ; B. Ovbiagele ; A. Owen ; M. O. Owolabi ; L. Owolabi ; E. Owusu-Dabo ; G. Pare ; R. Parekh ; H. G. Patterton ; M. B. Penno ; J. Peterson ; R. Pieper ; J. Plange-Rhule ; M. Pollak ; J. Puzak ; R. S. Ramesar ; M. Ramsay ; R. Rasooly ; S. Reddy ; P. C. Sabeti ; K. Sagoe ; T. Salako ; O. Samassekou ; M. S. Sandhu ; O. Sankoh ; F. S. Sarfo ; M. Sarr ; G. Shaboodien ; I. Sidibe ; G. Simo ; M. Simuunza ; L. Smeeth ; E. Sobngwi ; H. Soodyall ; H. Sorgho ; O. Sow Bah ; S. Srinivasan ; D. J. Stein ; E. S. Susser ; C. Swanepoel ; G. Tangwa ; A. Tareila ; O. Tastan Bishop ; B. Tayo ; N. Tiffin ; H. Tinto ; E. Tobin ; S. M. Tollman ; M. Traore ; M. J. Treadwell ; J. Troyer ; M. Tsimako-Johnstone ; V. Tukei ; I. Ulasi ; N. Ulenga ; B. van Rooyen ; A. P. Wachinou ; S. P. Waddy ; A. Wade ; M. Wayengera ; J. Whitworth ; L. Wideroff ; C. A. Winkler ; S. Winnicki ; A. Wonkam ; M. Yewondwos ; T. sen ; N. Yozwiak ; H. Zar
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-06-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Africa ; Disease/*genetics ; England ; Genetics, Medical/trends ; Genome-Wide Association Study/*trends ; Genomics/*trends ; Health ; Humans ; National Institutes of Health (U.S.) ; United StatesPublished by: -
2P. Y. Collins ; V. Patel ; S. S. Joestl ; D. March ; T. R. Insel ; A. S. Daar ; W. Anderson ; M. A. Dhansay ; A. Phillips ; S. Shurin ; M. Walport ; W. Ewart ; S. J. Savill ; I. A. Bordin ; E. J. Costello ; M. Durkin ; C. Fairburn ; R. I. Glass ; W. Hall ; Y. Huang ; S. E. Hyman ; K. Jamison ; S. Kaaya ; S. Kapur ; A. Kleinman ; A. Ogunniyi ; A. Otero-Ojeda ; M. M. Poo ; V. Ravindranath ; B. J. Sahakian ; S. Saxena ; P. A. Singer ; D. J. Stein
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-07-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Global Health ; Humans ; Mental Disorders/economics/epidemiology/prevention & control ; Mental Health/*statistics & numerical data ; Substance-Related Disorders/economics/epidemiology ; World Health OrganizationPublished by: -
3Staff View
Publication Date: 2018-06-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, Medicine, Diseases, Online OnlyPublished by: -
4Doruyter, A. G., Dupont, P., Stein, D. J., Lochner, C., Warwick, J. M.
The Society of Nuclear Medicine (SNM)
Published 2018Staff ViewPublication Date: 2018-12-04Publisher: The Society of Nuclear Medicine (SNM)Print ISSN: 0022-3123Topics: MedicinePublished by: -
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ISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A new wide-annulus Couette-type viscometer/rheometer has been designed, fabricated, and tested with the objective of measuring the shear flow properties of silicate melts and magmatic suspensions containing vapor bubbles and/or solid particles at 10−4 GPa and temperatures from 600 to 1500 °C. The goal of this development has been to advance the precision of high-temperature multiphase silicate rheometry in the viscosity regime of 104–1010 Pa s, and to attempt experiments on multiphase magmatic mixtures that have heretofore been difficult to perform in the concentric cylinder geometry. With this instrument, fluids with viscosities in the design viscosity range may be tested at shear rates from 10−5 to 1 s−1, employing a series of interchangeable torque transducers capable of measurements from 0.003 to 3 N m, preserving precision of the stress measurement across the entire dynamic span. A microprocessor-controlled motor drive enables precisely specified rotational motions (position and/or speed of the sample container) for accurate constant-shear-rate or finite-strain experiments. Use of high-purity cast ceramic components rather than platinum alloy for the rotating sample container (cup) and fixed cylindrical bob permit sectioning of the sample following an experiment to inspect and analyze textural characteristics of the magmatic suspensions. Computerized data acquisition is accomplished via a standard microcomputer interface and commercially available software system that allows data to be recorded, visualized, and statistically modeled as an experiment progresses. The instrument has been tested using NIST (NBS) reference material 717 (a borosilicate glass) at viscosities from 104 to 109 Pa s. Value of the standard viscosity has been recovered within the published precision (0.03 log units) at temperatures between 650 and 850 °C. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
6STEIN, D. J. ; EL-SERAG, H. B. ; KUCZYNSKI, J. ; KRAMER, J. R. ; SAMPLINER, R. E.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: Obesity has been linked to gastro-oesophageal reflux disease symptoms and oesophageal adenocarcinoma; however, there is no published evidence for an association with Barrett's oesophagus.Aim: To investigate the association between obesity and Barrett's oesophagus.Methods: We conducted a retrospective cross-sectional study of patients who underwent upper endoscopy at the Southern Arizona Veteran's Affairs Healthcare System between 1998 and 2004. We examined male patients without malignancy, with available information on weight and height. Based on endoscopic and histological findings, patients were classified as cases with Barrett's oesophagus or non-cases without Barrett's oesophagus. Multivariable logistic regression analysis was conducted to examine the association of body mass index and obesity with Barrett's oesophagus and Barrett's oesophagus length while adjusting for age and race.Results: There were 65 cases with Barrett's oesophagus and 385 non-cases without Barrett's oesophagus. The mean body mass index was significantly higher in cases than in non-cases (29.8 vs. 28.0, P = 0.03). Cases had significantly greater mean weight than controls (206 lb vs. 190,P = 0.005). The proportions of cases with body mass index 25–30 and body mass index ≥30 were greater than those in non-cases (44.6% vs. 37.7%) and (40.0% vs. 33.5%), respectively (P = 0.08). In the multivariable logistic regression model adjusting for race and age, when compared with body mass index 〈 25, the odds ratio was 2.43 (95% confidence interval: 1.12–5.31) for body mass index 25–30 and 2.46 (1.11–5.44) for body mass index ≥30. When examined as a continuous variable the adjusted odd ratio for each five-point increase in body mass index was 1.35 (95% confidence interval: 1.06–1.71, P = 0.01). The association between weight and Barrett's oesophagus was also statistically significant (adjusted odd ratio for each 10 pound increase = 1.10, 1.03–1.17, P =0.002). Among the 65 cases of Barrett's oesophagus, there was no correlation between the length of Barrett's oesophagus at the time of diagnosis and the body mass index (correlation coefficient = 0.03, P = 0.79).Conclusion: This retrospective cross-sectional study in male veterans shows that overweight is associated with a two-and-half-fold increased risk of Barrett's oesophagus. Larger studies of the underlying mechanism are warranted to better understand how and why obese patients are at greater risk for Barrett's oesophagus.Type of Medium: Electronic ResourceURL: -
7Hollander, E. ; Stein, D. J. ; Saoud, J. B. ; DeCaria, C. M. ; Cooper, T. B. ; Islam, M. N. ; Liebowitz, M. R. ; Stanley, M.
Springer
Published 1992Staff ViewISSN: 1435-1463Keywords: Fenfluramine ; plasma homovanillic acid ; serotonin ; dopamineSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The specificity of fenfluramine as a pharmacological probe of the serotonin system has been questioned, since animal studies with high dose 1-fenfluramine show increases in striatal levels of the dopamine metabolite homo-vanillic acid. To test the specificity of fenfluramine in humans with clinical doses, we compared plasma homovanillic acid (pHVA) concentration in healthy volunteers after administration of fenfluramine (60 mg) and placebo. There were no significant effects on pHVA, which supports previous findings that at doses used in pharmacological challenge paradigms, the effect of fenfluramine on the dopamine system is insufficient to alter measures of its change.Type of Medium: Electronic ResourceURL: -
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ISSN: 1435-1536Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: -
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ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0003-3146Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: Saturated and unsaturated oligomers are formed by a side reaction during the thermal polymerization of styrene. MAYO has suggested that these oligomers are closely associated with the initiation step.Recently the structures of the dimer fraction were published by BROWN. By independent synthesis of the dimers we could confirm his results. The main components of the dimer fraction are trans- and cis-1.2-diphenylcyclobutane in a ratio of 3:1 ; also smaller amounts of 1.3-diphenylbutene-(3) and I-phenyltetralin were found.The aim of this work was to clarify the structures of the trimers. The trimer fraction contains about 30% of 1.3.5-triphenylhexene-(5), the structure of which was confirmed by independent synthesis. Furthermore we were able to show, that about 65% of the trimer fraction consists of the 4 optical inactive isomers of 1-phenyl-4-[1′-phenyläthyl-(1′)]-1.2.3.4.-tetrahydronaphthalene. Their structures were confirmed by dehydrogenation to 1-phenyl-4-[1′-phenyläthyl-(1′)]-naphthalene, which was identical to an independently synthesized sample.Notes: Bei der thermischen Polymerisation von Styrol entstehen in einer Nebenreaktion gesättigte und ungesättigte Oligomere, die nach MAYO in engem Zusammenhang mit der Startreaktion stehen.Durch unabhängige Synthese der Dimeren konnten wir die kürzlich von BROWN veröffentlichten Strukturen bestätigen. Hauptkomponenten der Dimerenfraktion sind trans- und cis-1.2-Diphenylcyclobutan im Verhältnis etwa 3:1; in kleineren Mengen wurden noch 1.3-Diphenylbuten-3 und 1-Phenyltetralin nachgewiesen.Hauptaufgabe dieser Arbeit war die Strukturaufklärung der trimeren Styrole. Das Auftreten von 1.3.5-Triphenylhexen-5 konnte durch Synthese gesichert werden; es ist zu etwa 30% in der Trimerenfraktion enthalten.Weiterhin konnten wir zeigen, daß etwa 65% der Trimerenfraktion aus den vier isomeren, optisch inaktiven 1-Phenyl-4-[1′-phenyläthyl-(1′)]-1.2.3.4.-tetrahydronaphthalinen bestehen. Die Struktur wurde durch Dehydrierung zum optisch inaktiven 1-Phenyl-4-[1′-phenyläthyl-(1′)]-naphthalin und dessen Vergleich mit einer unabhängig synthetisierten Probebewiesen.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
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ISSN: 0025-116XKeywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: Chain branching reactions influence the molecular weight distribution; the latter can therefore be used to calculate the number of branch points if the mechanism of the polymerization reaction is known. Instead of the complete molecular weight distribution the “ununiformity” (P̄w/P̄n-1), which is more readily accessible both theoretically and experimentally, can be used.In radical polymerizations, two kinds of branching reactions occur (viz. branching at end groups and at other groups) which have a different influence on the distribution width. On the basis of papers by STOCKMAYER and by BAMFORD and TOMPA, the influence of these reactions can be calculated. The combination of both effects allows the calculation of the distribution width as a function of conversion, using the characteristic velocity constants of the branching reaction as parameters. Comparison with experimentally determined values of the distribution width (obtainable from measurements of M̄w and M̄n) allows a determination of the numerical values of these velocity constants.Notes: Verzweigungsreaktionen beeinflussen die Molekulargewichtsverteilung; aus dieser kann man daher die Zahl der Verzweigungspunkte berechnen, wenn der Bildungsmechanismus des Polymeren bekannt ist. Statt der Molekulargewichtsverteilung kann man die aus dieser abgeleitete Uneinheitlichkeit verwenden, die theoretisch und experimentell leichter zugänglich ist.Bei der Radikalpolymerisation treten zwei Arten von Verzweigungsreaktionen auf (Mittelgruppen- bzw. Endgruppenverzweigung), deren Einfluß auf die Uneinheitlichkeit verschieden ist. Der Einfluß dieser Reaktionen kann - fußend auf Arbeiten von STOCKMAYER sowie BAMFORD und TOMPA - rechnerisch erfaßt werden. Die Kombination der beiden Effekte erlaubt die Berechnung der Uneinheitlichkeit als Funktion des Umsatzes, wobei die charakteristischen Geschwindigkeitskonstanten der Verzweigungsreaktionen als Parameter benutzt werden. Der Vergleich mit experimentellen Werten der Uneinheitlichkeit - erhältlich aus Messungen von M̄w und M̄n - erlaubt die Ermittlung der Zahlenwerte dieser Geschwindigkeitskonstanten.Additional Material: 2 Ill.Type of Medium: Electronic ResourceURL: -
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ISSN: 0025-116XKeywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: The transfer constant (Cp) of the polymer was obtained by determination of the modification of the degree of polymerisation of „β-polymer“ in the presence of relatively short chain „α-polymer“, and calculation of Cp with the use of the general transfer equation. The degree of polymerisation was determined from viscosity measurements using the calibration obtained by MATSUMOTO et al. account being taken of the type of the average. From these measurements a new value of kab/kw2 resulted. The individual values of the propagation and termination constants proved to lie considerably higher than previously accepted. The value of Cp obtained was (2,5 ± 0,5)·10-4, agreeing well with corresponding results obtained with model substances of low molecular weight.Especial care was required in the preparation of the α-polymer and the carrying out of the polymerisation experiments. Traces of O increase the apparent value of Cp to an unpredictable extent. Moreover double bonds of allyl type which have a strong inhibitor effect, are easily formed in the PVAc chain.Notes: Die Übertragungskonstante (Cp) am Polymeren wird ermittelt, indem der Einfluß relativ kurzkettiger „α-Polymerer“ auf den Polymerisationsgrad des „α-Polymeren“ gemessen und daraus Cp mit Hilfe der Reglergleichung berechnet wird. Der Polymerisationsgrad wird viskosimetrisch auf Grund der Eichmessungen von MATSUMOTO u.a. unter Berücksichtigung der Mittelwertbildung bestimmt. Aus den Messungen ergibt sich ein neuer Wert für das Konstantenverhältnis kab/Kw2; die Einzelwerte der Wachstums- und der Abbruchskonstante liegen danach erheblich höher als bisher angenommen wurde. Für Cp ergibt sich (2,5 ± 0,5)·10-4 in guter Übereinstimmung mit entsprechenden Meßergebnissen an niedermolekularen Modellsubstanzen.Die Herstellung der α-Polymeren und die Durchführung der Polymerisationsversuche erfordert die Anwendung besonderer Vorsichtsmaßregeln. Spuren von Sauerstoff erhöhen den scheinbaren Wert von Cp in unkontrollierbarer Weise; ferner bilden sich in der PVAc-Kette leicht Doppelbindungen in Allylkonfiguration, die starke Inhibitorwirkungen ausüben.Additional Material: 6 Ill.Type of Medium: Electronic ResourceURL: -
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ISSN: 0025-116XKeywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: A series of 11 polyvinylacetates was prepared by polymerization to different degrees of conversion under the same conditions. On these samples, measurements of osmotic pressure and light scattering were made to obtain the number- and weight-average molecular weights. From the variation of these averages with increasing conversion, the coefficient of transfer to polymer Cp, and the velocity constant of growth of the terminal double bonds, kN were calculated. At 60°C. the values Cp = 1.8.10-4, kN/kW = 0,80 were obtained.Using these values, the number of branch points per polymer molecule was calculated as a function of degree of conversion.Notes: Eine Serie von 11 Polyvinylacetaten wurde unter konstanten Reaktionsbedingungen bis zu verschiedenen Umsätzen polymerisiert. An diesen Präparaten wurden osmotische Messungen und Streulichtmessungen durchgeführt. Die Messungen liefern das Zahlen- und das Gewichtsmittel der Polymeren. Aus der Änderung der Mittelwerte mit steigendem Umsatz werden die Übertragungskonstante Cp zum Polymeren und die Wachstumskonstante kN der endständigen Doppelbindung berechnet. Die erhaltenen Zahlenwerte sind für 60°C: Cp = 1,8.10-4, kN/kW = 0,80.Unter Benutzung dieser Zahlenwerte wurde die Zahl der Verzweigungspunkte pro Polymermolekül als Funktion des Umsatzes berechnet.Additional Material: 7 Ill.Type of Medium: Electronic ResourceURL: