Search Results - (Author, Cooperation:D. J. Lee)

2013-03-02

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics/metabolism ; Antimicrobial Cationic Peptides/genetics/metabolism ; Humans ; Interferon-beta/genetics/*immunology/metabolism ; Interferon-gamma/genetics/*immunology/metabolism ; Interleukin-10/genetics/metabolism ; Leprosy, Lepromatous/genetics/*immunology/metabolism ; Leprosy, Tuberculoid/genetics/*immunology/metabolism ; Microbial Viability ; Monocytes/immunology/metabolism ; Mycobacterium leprae/*immunology/physiology ; RNA, Messenger/genetics/metabolism ; Receptors, Calcitriol/genetics/metabolism ; Transcriptome ; Tuberculosis/genetics/immunology ; Up-Regulation ; beta-Defensins/genetics/metabolism

2013-12-24

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Acyl Carrier Protein/*chemistry/*metabolism ; Binding Sites ; Catalytic Domain ; Cross-Linking Reagents/chemistry ; Crystallography, X-Ray ; Escherichia coli/*chemistry ; Fatty Acid Synthase, Type II/chemistry/metabolism ; Fatty Acids/*biosynthesis ; Histidine/metabolism ; Hydro-Lyases/chemistry/metabolism ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Protein Interaction Maps

2018-01-10

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2018-03-14

Royal Society

2054-5703

Natural Sciences in General

palaeontology, ecology, evolution

2018-11-27

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2018-09-25

Institute of Physics (IOP)

1367-2630

Physics

2018-08-02

American Association for the Advancement of Science (AAAS)

2375-2548

Natural Sciences in General

2018-12-11

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

A numerical investigation of the macromixing effect on the bistable ClO−2+I− reaction based on the global fluid flow field was undertaken in this work. Results obtained in this study indicated that the mixing intensity has a significant effect on the location and transition point of the thermodynamic branch, but has nearly no effect on the flow branch.

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

A modified version of the Cormack and Lehane scoring system was prospectively evaluated in 663 patients requiring tracheal intubation. In the modified system, grade 2 (only part of the glottis visible) was divided into 2a (part of the cords visible) and 2b (only the arytenoids or the very posterior origin of the cords visible). One hundred and sixty-two intubations (24.4%) were scored as grade 2a and 43 (6.5%) as grade 2b, of which seven (4.3%) and 29 (67.4%), respectively, were difficult, defined as requiring more than one laryngoscopy or the use of specialist equipment. Grade 2b denotes a laryngoscopic view that is relatively common and is often associated with difficulty passing a tracheal tube. The modified scoring system thus provides more information than the original Cormack and Lehane system and its use should be considered when recording the ease of tracheal intubation in the anaesthetic record or in studies of tracheal intubation.

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

We have studied the interfacial properties of droplets of (cutoff and shifted) Lennard-Jones fluids in the canonical ensemble, using mean field theory. We have examined the effects of system size, overall density (supersaturation) and temperature on the density profiles, density and pressure at the center of the droplet, and surface tension. The numerical accuracy of the theory was tested by extensive comparisons of the results with the molecular dynamics simulations of Thompson et al. Good agreement was found. We have used the theory to calculate the energy of formation of a droplet and the stability temperature Ts for droplet formation as a function of the system size and overall density. We find Ts to be lower than the coexistence temperature for the planar surface, and to fall as the drop size falls.

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Sevoflurane, desflurane and isoflurane were compared using a circle system in 97 patients undergoing short surgical procedures. Using initial high flows, the time intervals to equilibration between inspired and end-expired agent concentrations were measured; equilibration was defined as FE/F1 =0.8. The mean (SD) times obtained for sevoflurane, desflurane and isoflurane were 8.2 (2.1) min, 3.8 (0.7) min and 19.7 (6.5) min, respectively. These times were significantly different from each other (p 〈0.0001). After equilibration total flows were reduced to 500 ml.min−1; at these flows the initial decline in end-expired agent concentration was minimal with desflurane, intermediate with sevoflurane and greatest with isoflurane. Both desflurane and sevoflurane are appropriate for efficient use of the circle system during short anaesthetics.

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Three comparisons were made between vitamin E-deficient and control rats and one between normal and deficient rabbits. In experiments 1 and 2, control groups of 5?6 weanling female rats of the Sprague-Dawley strain were fed a basal vitamin E-deficient diet for 20 weeks. This diet contained the ...

Electronic Resource

1437-9813

Key words Bacterial translocation ; Probiotics ; Neonate

Springer Online Journal Archives 1860-2000

Medicine

Abstract  The clinical use of probiotic agents such as enteral Lactobacillus to enhance intestinal defense against potential luminal pathogens has been tested in vivo; however, an understanding of the mechanisms responsible for the observed protection is lacking. The purpose of this study was to evaluate the effects of Lactobacillus on bacterial translocation (BT) in a neonatal animal model. Newborn New Zealand white rabbit pups were enterally fed a 10% Formulac solution inoculated with or without a 108 suspension of ampicillin-resistant Escherichia coli K1 (E. coli K1A) and/or Lactobacillus casei GG (Lacto GG). Pups received either no bacteria (n = 10), Lacto GG (n = 8), E. coli K1A (n = 26), or a combination of Lacto GG and E. coli K1A (n = 33). On day 3, representative tissue specimens from the mesenteric lymph nodes (MLN), spleen (SPL), and liver (LIV) were aseptically harvested in addition to a small-bowel (SB) sample that was rinsed to remove luminal contents. The specimens were then cultured in organism-specific media. Statistical analysis was by one-way ANOVA with P values less than 0.05 considered significant. Neonatal rabbits receiving Lacto GG-supplemented formula exhibited a 25% decrease (P 〈 0.05) in small-bowel colonization by E. coli K1A. In addition, Lacto GG decreased the frequency of extraintestinal BT by 46% (P 〈 0.05), 61% (P 〈 0.05), and 23%, respectively, in the MLN, SPL, and LIV. We have shown that enterally-administered Lacto GG decreases the frequency of E. coli K1A translocation in a neonatal rabbit model. These results may have significant implications for the treatment of BT and sepsis in the human neonate and provide a model for further studies.

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Geochemical and hydrogeological evidence shows that the thermal springs at Bath originate from the Mendip Hills. A maximum subsurface temperature of 80±16 °C is attained during circulation to between 2.7 and 4.3 km within the Carboniferous Limestone. The residence time of the bulk of the ...

Electronic Resource

1432-1181

Springer Online Journal Archives 1860-2000

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Physics

Abstract This work theoretically investigated the thermal performance and stability characteristics of a straight pin fin subject to boiling considering a temperature-dependent thermal conductivity of fin, k=k sat(1+b(T−T sat)). Steady-state temperature distribution and the associated fin base heat flow were for the first time analytically found, whose stability characteristics were evaluated by linear stability analysis. A positive temperature coefficient b will raise both the fin's temperature and base heat flow. The corresponding stability for stable fin boiling was enhanced. A negative b results in an opposite trend. The use of a mean thermal conductivity in fin boiling calculations is discussed.

Electronic Resource

1432-2242

Alfalfa ; Biparental plastid inheritance ; Chlorophyll deficient mutants ; ctDNA

Springer Online Journal Archives 1860-2000

Biology

Summary Mapping of chloroplast DNA (ctDNA) restriction fragment patterns from a chlorophyll deficient mutant and two phenotypically normal alfalfa genotypes (Medicago sativa L.) has demonstrated the existence of a distinct ctDNA genotype from each source. These unique restriction fragment patterns were utilized to identify maternal or paternal origin of ctDNA in hybrid plants from crosses involving the normal alfalfa genotypes as females and the yellow-green chlorophyll deficient sectors as males. Progeny from these crosses expressing the yellow-green sectored phenotypes contained paternal ctDNA in the chlorophyll deficient sectors and maternal ctDNA in the normal sectors, confirming biparental plastid inheritance. The existence of mixed cells containing both mutant and normal plastids at various stages of sorting-out was observed by transmission electron microscopy of mesophyll cells in mosaic tissue from hybrid plants. This observation verified the biparental transmission of plastids in alfalfa.

Electronic Resource

1432-2242

Glycine max ; Chloroplast DNA ; RFLP ; Population ; Male-sterile

Springer Online Journal Archives 1860-2000

Biology

Summary Restriction fragment length polymorphisms (RFLPs) were used to assess chloroplast DNA (cpDNA) variation in a population of soybeans subjected to continuous cycles of forced outcrossing. This population was derived by crossing 39 female lines with four male-sterile (Ms2ms2) maintainer lines and advancing each generation by selecting only outcrossed seed borne on male-sterile (ms2ms2) plants. Analysis of the original 39 female lines revealed three groups based on cpDNA RFLPs. These three groups had been previously documented in soybeans, and the distribution of these groups among the female parents of this population was similar to that observed in germ plasm surveys of soybean. Thirty-four of the female parents had group I cpDNA, 3 had group II, and 2 had group III. Plants collected from this population after seven cycles of outcrossing were scored for four morphological traits (flower color, pubescence color, seed color, and pubescence type) known to be controlled by alleles at single nuclear loci. The frequencies of the phenotypes observed in this study indicated that the population underwent random mating with respect to flower and pubescence color, but deviated from random mating at the other two loci. Analysis of 158 of these same plants collected from the population after seven cycles of outcrossing revealed no individuals with group II or group III cpDNAs. The fixation of the group I cpDNA marker in this outcrossing population was judged to result primarily from selection against individuals in the population with the rare cpDNAs.

Electronic Resource

1435-1536

Enthalpy-entropy compensation ; ionic surfactant ; critical micelle concentration ; reference temperature ; temperature effect

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract The enthalpy-entropy compensation in ionic surfactant micellization process over a large temperature range is examined. The surfactants SDS and C16TAB are investigated experimentally, and the enthalpy and entropy changes are evaluated based on phase separation or mass action models together with the other three surfactant systems. The relationship between compensation temperature and the reference temperatures is discussed.

Electronic Resource

1435-1536

Enthalpy-entropy compensation ; cosolvent effects ; critical micelle concentration ; reference temperature ; temperature effects

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Abstract The enthalpy-entropy compensation in micellization of sodium dodecyl sulphate (SDS) in binary mixtures of water/methanol (MeOH), water/ethylene glycol (EG) and water/glycerol (GL) over a temperature range of 10–60°C was examined. When the cosolvent concentration was low, the critical micelle concentration (CMC) depended only on the total amount of the hydroxyl group added. When the cosolvent concentration was high, the increase in CMC followed the sequence: MeOH〉EG〉GL. Enthalpy and entropy changes were evaluated from which the compensation temperature was determined. Both enthalpy and entropy changes decreased on the addition of the cosolvents, indicating a lowering of solution hydrophobicity. The compensation temperature was found as a constant over the cosolvent concentration range, as a result, was not a good index for characterizing the solute/solvent interactions. The two reference temperatures at which the enthalpy-entropy change respectively became zero were strongly influenced by the cosolvent addition, therefore could serve as a proper index for solution hydrophobicity.

Electronic Resource