Search Results - (Author, Cooperation:D. J. Garry)

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  1. 1
    A. Sharma ; V. Sebastiano ; C. T. Scott ; D. Magnus ; N. Koyano-Nakagawa ; D. J. Garry ; O. N. Witte ; H. Nakauchi ; J. C. Wu ; I. L. Weissman ; S. M. Wu
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-11-07
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; *Bioethical Issues ; Blastocyst ; *Chimera ; Financial Management/ethics ; Humans ; Mice ; National Institutes of Health (U.S.)/economics/ethics ; Pluripotent Stem Cells/*transplantation ; Stem Cell Research/economics/*ethics ; United States
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Garry, D. J. ; Sorenson, R. L. ; Coulter, H. D.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-0428
    Keywords:
    GABA ; insulin ; immunohistochemistry ; islet of Langerhans ; electron microscopy ; Lowicryl K4M
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The purpose of this study was to determine the ultrastructural localization of gamma amino butyric acid (GABA) within the B cell of isolated rat islets, particularly with respect to the B cell secretion granules. GABA immunoreactivity was localized ultrastructurally, with colloidal gold, in the B cells and absent in the A cells and D cells. Quantitative analysis of the colloidal gold particle distribution in the B cell revealed 29.5±5.2 gold particles/μm2 in the nuclei, 29.3±6.9 gold particles/μm2 in the mitochondria and 4.9±1.0gold particles/μrn2 in the secretion granules. Particle density in the remainder of the cytoplasm was 41.9±4.1 particles/μm2. The paucity of gamma amino butyric acid in the B cell secretion granules differs from observations on gamma amino butyric acidergic neurons, where there is an accumulation of gamma amino butyric acid within the neurosecretory vesicles. These findings indicate that if gamma amino butyric acid is released from the islet, then it is by a nongranular mechanism. In addition, the results are compatible with the hypotheses that gamma amino butyric acid within the B cell functions in the regulation of insulin biosynthesis, and/or functions as an alternative energy source for the B cell through the gamma amino butyric acid shunt.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00274582

    Articles: DFG German National Licenses
  3. 3
    Garry*, D. J. ; Meeson, A. ; Yan, Z. ; Williams, R. S.
    Springer
    Published 2000
    Staff View
    ISSN:
    1420-9071
    Keywords:
    Key words. Myoglobin; oxygen transport; heart; skeletal muscle; transgenic mice.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. Hemoproteins are widely distributed among prokaryotes, unicellular eukaryotes, plants and animals . Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria . This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists . Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin . This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/PL00000732

    Articles: DFG German National Licenses