Search Results - (Author, Cooperation:D. Hsu)
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1Latest Papers from Table of Contents or Articles in PressS. Konermann ; M. D. Brigham ; A. E. Trevino ; J. Joung ; O. O. Abudayyeh ; C. Barcena ; P. D. Hsu ; N. Habib ; J. S. Gootenberg ; H. Nishimasu ; O. Nureki ; F. Zhang
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-12-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: CRISPR-Associated Proteins/genetics/metabolism ; CRISPR-Cas Systems/*genetics ; Cell Line, Tumor ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; DNA, Complementary/biosynthesis/genetics ; Drug Resistance, Neoplasm/drug effects/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Gene Library ; Genetic Engineering/*methods ; Genetic Loci/genetics ; Genetic Testing ; Genome, Human/*genetics ; Humans ; Indoles/pharmacology ; Melanoma/drug therapy/*genetics ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; RNA, Untranslated/biosynthesis/genetics/metabolism ; Reproducibility of Results ; Sulfonamides/pharmacology ; Transcriptional Activation/*genetics ; Up-Regulation/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. Song ; C. Zhong ; M. A. Bonaguidi ; G. J. Sun ; D. Hsu ; Y. Gu ; K. Meletis ; Z. J. Huang ; S. Ge ; G. Enikolopov ; K. Deisseroth ; B. Luscher ; K. M. Christian ; G. L. Ming ; H. Song
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Cell Lineage/drug effects ; Cell Proliferation/drug effects ; Dentate Gyrus/cytology/drug effects/metabolism ; Female ; GABA Modulators/pharmacology ; GABA-A Receptor Agonists/pharmacology ; GABA-A Receptor Antagonists/pharmacology ; Interneurons/cytology/drug effects/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/drug effects/*physiology ; Neural Stem Cells/*cytology/drug effects/metabolism ; *Neurogenesis/drug effects ; Neuroglia/cytology/drug effects/metabolism ; Parvalbumins/metabolism ; Receptors, GABA-A/metabolism ; Signal Transduction/drug effects ; Somatostatin/metabolism ; Stem Cell Niche/drug effects/physiology ; Vasoactive Intestinal Peptide/metabolism ; gamma-Aminobutyric Acid/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-10Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-10-03Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressS. Konermann ; M. D. Brigham ; A. E. Trevino ; P. D. Hsu ; M. Heidenreich ; L. Cong ; R. J. Platt ; D. A. Scott ; G. M. Church ; F. Zhang
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-07-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arabidopsis Proteins/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cells, Cultured ; Chromatin/genetics/radiation effects ; Cryptochromes/metabolism ; Epigenesis, Genetic/*genetics/*radiation effects ; Gene Expression Regulation/genetics/*radiation effects ; Genetic Vectors/genetics ; *Light ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism/radiation effects ; Optogenetics/*methods ; Time Factors ; Transcription, Genetic/genetics/*radiation effects ; Two-Hybrid System Techniques ; WakefulnessPublished by: -
6Latest Papers from Table of Contents or Articles in PressL. Cong ; F. A. Ran ; D. Cox ; S. Lin ; R. Barretto ; N. Habib ; P. D. Hsu ; X. Wu ; W. Jiang ; L. A. Marraffini ; F. Zhang
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-01-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; Caspase 9/*chemistry/genetics ; DNA/chemistry/genetics ; *DNA Cleavage ; Genetic Engineering/*methods ; Genetic Loci ; Genome/*genetics ; Humans ; Inverted Repeat Sequences/*genetics ; Mice ; Microarray Analysis/*methods ; Molecular Sequence Data ; Mutagenesis ; RNA/chemistry/genetics ; Recombinational DNA Repair ; Streptococcus pyogenes/enzymology/geneticsPublished by: -
7Latest Papers from Table of Contents or Articles in PressHsu, D. C., Sunyakumthorn, P., Wegner, M., Schuetz, A., Silsorn, D., Estes, J. D., Deleage, C., Tomusange, K., Lakhashe, S. K., Ruprecht, R. M., Lombardini, E., Im-Erbsin, R., Kuncharin, Y., Phuang-Ngern, Y., Inthawong, D., Chuenarom, W., Burke, R., Robb, M. L., Ndhlovu, L. C., Ananworanich, J., Valcour, V., O'Connell, R. J., Spudich, S., Michael, N. L., Vasan, S.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-05-15Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
8Articles: DFG German National LicensesYao, Y. D. ; Wu, K. T. ; Chen, Y. Y. ; Hsu, D. N.
[S.l.] : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The optical, electrical, and magnetic properties of magnetic Nd15Fe77B8 and nonmagnetic Nd5Fe62B33 films have been investigated. It has been found that within the visible (wavelengths 4400–6400 A(ring)) the films are transparent with thickness less than 800 A(ring) for magnetic films and 1500 A(ring) for nonmagnetic films. This is due to the difference of the magnetic permeability μ between films. The oscillatory behavior with thickness of the films is observed in the film samples. The anomalous behaviors near the Curie temperature for both bulk- and film-type samples are similar to that of the type-III ferromagnets. The temperature at which the electrical resistance of the film-type samples increases abruptly varies from 620 K for 1000 A(ring) to 650 K for 2000 A(ring).Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesHsu, D. S. Y. ; Squire, D. W. ; Lin, M. C.
College Park, Md. : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Rotational energy distributions of the desorbing NO product from the NH3+O2 reaction on a Pt(111) single crystal have been measured using the laser-induced fluorescence technique in conjunction with an UHV apparatus. Over the surface temperature range 800–1300 K, the rotational temperature of NO was found to remain virtually constant near 400 K.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We propose a variation on the wave-packet interpretation of quantum mechanics introduced by Heller, here using the Dirac variational principle to optimize the time evolution of all the parameters that enter our basis set. We solve the general one-dimensional problem, and test our method on the Morse oscillator and the symmetric quartic double well.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesMa, Jianpeng ; Hsu, D. ; Straub, John E.
College Park, Md. : American Institute of Physics (AIP)
Published 1993Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: An approximate method for integrating the Liouville equation to obtain the time-dependent classical phase space density distribution at constant energy or temperature is presented. The density distribution of each degree of freedom is represented by a single Gaussian phase packet (GPP) whose center and width obey variationally optimized equations of motion. The constant energy dynamics is applied to the calculation of equilibrium thermodynamic averages for a Lennard-Jones cluster and fluid to demonstrate the feasibility and utility of this approximate method for the simulation of many-body condensed phase systems. The rate of kinetic energy equipartitioning is examined for GPP dynamics using a generalization of the ergodic measure and found to be significantly faster than for standard molecular dynamics simulation. A global optimization algorithm is developed based on simulated annealing of the phase space density distribution. This method is applied to the global energy minimization of Lennard-Jones clusters and found to be superior to simulated annealing methods employing classical point particles.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesDinsmore, A. D. ; Hsu, D. S. ; Qadri, S. B. ; Cross, J. O. ; Kennedy, T. A. ; Gray, H. F. ; Ratna, B. R.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Structural and light-emitting properties of nanoparticles of ZnS:Mn annealed in vacuum at temperatures up to 525 °C are presented. Annealing the 3.5 nm particles at temperatures up to 350 °C caused growth of some particles without substantial change in the luminescence or ZnS lattice. After annealing at 400–525 °C, the high-temperature wurtzite phase of ZnS appeared, accompanied by an increase of the average particle diameter to approximately 100 nm and a rearrangement of the Mn ions. Dramatic increase in cathodoluminescence emission was also observed and is compared to the structural information obtained from electron microscopy, x-ray diffraction, x-ray absorption fine structure, and electron paramagnetic resonance measurements. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesHsu, D. K. ; Margetan, F. J. ; Thompson, D. O.
Woodbury, NY : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We report experimental results from a first-of-a-kind ultrasonic transducer that generates a beam with a Bessel function profile. Using a technique of nonuniform poling, an axially symmetric Bessel function pattern is "polarized into'' a piezoelectric ceramic element. The resulting circular-disk transducer has the usual full-plating electrode configuration, but produces an ultrasonic beam with a radial displacement profile approximating that of the Bessel function J0 (r), both in amplitude and in phase. The radiation field of a 1-in.-diam, 2.25 MHz Bessel transducer mapped out with a point probe shows good agreement with calculated results using a Gauss-Hermite model. Bessel transducers are of particular interest in attempts to achieve "diffractionless'' beams.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesThompson, D. O. ; Wormley, S. J. ; Hsu, D. K.
[S.l.] : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: An automated multiviewing ultrasonic apparatus and signal processing routine have been developed for utilization in nondestructive evaluation (NDE) of materials. The instrument has been developed to take advantage of recent advances in long and intermediate wavelength inverse scattering of elastic waves, and provides a 3-D reconstruction of a flaw. Although the reconstruction obtained does not contain fine details of the flaw's structure, it provides sufficient information about the flaw (size, orientation, and selected materials properties) so that failure-predictive decisions can be made.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesDinsmore, A. D. ; Hsu, D. S. ; Gray, H. F. ; Qadri, S. B. ; Tian, Y. ; Ratna, B. R.
Woodbury, NY : American Institute of Physics (AIP)
Published 1999Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We have synthesized nanoparticles of ZnS doped with Mn for potential use as cathodoluminescent phosphors in field-emission displays (FEDs). We show that the cathodoluminescent efficiency of particles ≤100 nm in diameter is within 40% of that of a commercial (micron-sized) phosphor when the electron-beam energy ranges between 500 and 3500 eV. The nanoparticles exhibit less current saturation than larger-sized phosphors, an important feature for use in FEDs. Furthermore, the nanoparticles were annealed at just 535 °C, hundreds of degrees below the processing temperatures of standard phosphors. Finally, we discuss the effect of the particle surface on low-voltage luminous efficiency. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We continue our study of the optical dephasing of impurities by phonons. The pure dephasing contribution to the homogeneous linewidth is calculated to all orders in the excitation–phonon interaction. We introduce a microscopic model for the pseudolocal phonon spectral density when the impurity is in the ground electronic state. This microscopic model improves upon our previous phenomenological model. The model is applied to several experimental systems—in all cases, the theoretical results provide a reasonably accurate description of the temperature-dependent linewidth with no adjustable parameters.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We continue our discussion of the nonperturbative theory of zero-phonon impurity lines in crystals formulated by Osad'ko and more recently by us. In Paper I of this series we evaluated our general results for the linewidth and shift for models of electronic coupling to both acoustic and optical phonons. Here we evaluate our general results for a simple model of electronic coupling to a pseudolocal phonon. The pseudolocal phonon is characterized by its frequency and lifetime in both the ground and excited electronic states. In addition to providing exact analytic expressions (reduced to quadrature) for the width and shift, we derive an approximate analytic expression for the linewidth that is bi-Arrhenius, with activation energies corresponding to the ground and excited state pseudolocal phonon frequencies. We discuss how our theoretical approach and results are related to the exchange theory of Harris, the optical Redfield theory of deBree and Wiersma, and the perturbation theory of Small and Jones and Zewail. In Paper III of this series, we compare the results of this paper and of Paper I to experiment.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: We have applied the results of the nonperturbative theory of zero-phonon linewidths of impurities in crystals discussed by Osad'ko and us, and further developed by us in papers I and II of this series, to the analysis of several absorption, photon echo, and hole burning experiments. Two (relatively) high temperature absorption experiments on 1,3-diazaazulene in naphthalene and dilute ruby were analyzed with a model of Debye acoustic phonons. In both cases the Debye temperature was obtained from independent experiment or theory, and a one-parameter fit was performed on the temperature-dependent linewidth. It was found that (especially for diazaazulene) the systems are not in the weak coupling limit. For several low temperature experiments, where the dephasing is presumably due to pseudolocal phonons, the nonperturbative theory, coupled with the results of deBree and Wiersma, provides a reasonably complete understanding of the observed dephasing rates.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesHoffbauer, M. A. ; Hsu, D. S. Y. ; Lin, M. C.
College Park, Md. : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Boltzmann-like rotational energy distributions were obtained for desorbing OH radials formed in the oxidation of hydrogen on a Pt(111) single crystal and polycrystalline Pt foil by using the laser-induced fluorescence method in conjunction with an UHV apparatus. For an O/H=1 reactant gas mixture, relatively high rotational energy accommodation was indicated by the rotational to surface temperature ratios Tr/Ts of 0.85±0.03 over the temperature range 1227–1479 K for the Pt(111) single crystal, and of 0.86±0.04 over 1283–1475 K for the polycrystalline Pt foil. Tr seemed to be proportional to Ts over these temperature ranges. The lack of noticeable dependence of Tr/Ts on the O/H reactant gas mixture ratio suggests that the rotational energy accommodation is not sensitive to the apparent Pt–OH bond strength.Type of Medium: Electronic ResourceURL: