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Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging/genetics ; Apoptosis/genetics ; Brain/*anatomy & histology ; Caudate Nucleus/anatomy & histology ; Child ; Female ; Gene Expression Regulation, Developmental/genetics ; Genetic Loci/genetics ; Genetic Variation/*genetics ; *Genome-Wide Association Study ; Hippocampus/anatomy & histology ; Humans ; Magnetic Resonance Imaging ; Male ; Membrane Proteins/genetics ; Middle Aged ; Organ Size/genetics ; Putamen/anatomy & histology ; Sex Characteristics ; Skull/anatomy & histology ; Young AdultPublished by: -
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Publication Date: 2018-05-31Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Semiconductors II: surfaces, interfaces, microstructures, and related topicsPublished by: -
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ISSN: 1432-1912Keywords: Supersensitivity to Catecholamines ; Block of COMT-U-0521 ; V-0521 ; Isolated Nictitating MembraneSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The sensitivity of various isolated organs to catecholamines was tested before and after block of catechol-O-methyl transferase (COMT) by U-0521 (3′,4′-dihydroxy-2-methyl propiophenone; 18 μg/ml for 20 min). Isolated Nictitating Membrane of the Cat. The sensitivity to catecholamines was increased by inhibition of COMT whenever the experimental conditions resulted in a high potency of the amine, i.e., when the ED50 of the amine (in the absence of U-0521) was below about 10−6 M. Thus, block of COMT potentiated the effects of (−)-noradrenaline and (−)-adrenaline after denervation (or in the presence of cocaine) but not on muscles with an intact adrenergic innervation; it also increased the sensitivity to theβ-effects but not to theα-effects of isoprenaline. No potentiation was observed for dopamine which has a low potency even after denervation. The relation between potency of the catecholamine and the degree of the sensitizing effect of U-0521 was not due to saturation of COMT or of access to the enzyme. Measurements in denervated muscles of the production of O-methylated metabolites from (±)-noradrenaline-H3 (added to the bath for 20 min in concentrations of about 10−7 to 10−4 M), and of the extraneuronal accumulation of noradrenaline-H3 did not reveal any saturation of either the enzyme or the extraneuronal accumulation of the amine. When block of COMT resulted in supersensitivity to a catecholamine, the time required to reach steady-state responses was usually increased. This is consistent with the view that block of the enzyme impaired a site of loss. Block of COMT failed to produce any substantial potentiation of the effects of the indirectly acting amines, tyramine and mephentermine. O-methylation of the released transmitter seems to occur after the amine has reached the receptors of the effector cells. Isolated Strips of Cat and Bat Spleen. Results were quantitatively similar, since block of COMT potentiated the effects of (−)-noradrenaline and (−)-adrenaline in the presence but not (or only very little) in the absence of cocaine. However, the degree of supersensitivity after block of COMT (in the presence of cocaine) was smaller than in the nictitating membrane. In the cat spleen, cocaine causes a small but significant degree of supersensitivity to isoprenaline but not to methoxamine. Isolated Sat Aorta, Block of COMT did not increase the effect of cocaine. It is suggested that differences in the morphology of the adrenergic innervation contribute to the observed organ differences.Type of Medium: Electronic ResourceURL: -
4Bräuninger, H. ; Einighammer, H. J. ; Feitzinger, J. V. ; Fink, H. H. ; Höhn, D. H. ; Koops, H. ; Krämer, G. ; Mayer, U. ; Möllenstedt, G. ; Mozer, M.
Springer
Published 1971Staff ViewISSN: 1573-093XSource: Springer Online Journal Archives 1860-2000Topics: PhysicsType of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 1435-2451Keywords: Permanent cardiac pacemaker ; Electrode dislocation ; Electrode crack ; Infections ; Herzschrittmachertherapie ; Elektrodendislokation ; Elektrodenbruch ; Infektiase KomplikationenSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung 2118 Erstimplantationen, 1579 Aggregatwechsel von 1963–1984, mittlere Beobachtungszeit 3,1 Jahre. 2613 Elektrodenanlagen. 19 Elektroden epicardial. 81% uber V. cephalica, Rest uber V. jugularis externa und V. jugularis interna (7%). Nur ventriculäre Systeme. Von 1974–1984: 87% Schulterelektroden, 11% Schraubelektroden. Von 1981–1984: 58% 4-fach gewendelte Schulterelektroden, 39,2% 4fach gewendelte Schraubelektroden (Osypka SX u. PY).Notes: Summary From 1963 to 1984 there have been 218 primary implantations and 1579 generator changes. The median observation time for 2613 electrode implantations was 3.1 years. Nineteen epicardial electrodes have been implanted: 81% via the cephalic vein, the rest via the external and internal jugular vein (7%). From 1981 to 1984, 58% atraumatic fourfold coil electrodes were used and 39.2% fourfold coild screwin electrodes (Osypka SX and PY).Type of Medium: Electronic ResourceURL: -
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ISSN: 1435-2451Keywords: Cancer of the rectum ; Anterior resection ; Enteral anastomosis by clamps ; Rectumcarcinom ; anteriore Rectumresektion ; KlammernahtgerdteSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Im Februar 1983 wurden 125 zwischen Mai 1980 und Mai 1982 operierten Rectum-CA-Patienten nachuntersucht. 33%=42 waren durch anteriore Resektion behandelt. Diese Gruppe hatte innerhalb 33 Monaten 33% Rezidive, bei primärem Tumor im Stadium Dukes B und C gleichermaßen. 28% waren inoperable Rezidive. Die postoperative Krankenhausletalität dieser Operierten hatte 7,14% betragen, gegenüber 12% der rectumexstirpierten Patienten. Die 3-Jahres-Rezidivquote der 690 rectumexstirpierten Patienten zwischen 60 und 78,1981 nachuntersucht, betrug 18,2 %. Zur Indikationsstellung ob anteriore Resektion oder Rectumexstirpation müssen darum der Allgemeinzustand, die Lebenserwartung und die Möglichkeit der Anus praeter-Versorgung abgewogen werden.Notes: Summary The recurrence rate over 3 years after extirpation of the rectum in 690 patients operated between 1960 and 1978 is compared with the recurrence in 42 patients with an anterior resection out of 125 patients who underwent rectum carcinoma surgery. In this group there was 33% recurrency with primary tumor in stage Dukes B and C. The extirpated group showed carcinoma recurrencies in 18.2%. Although hospital mortality after anterior resection (7%) is much lower than in the extirpation group (12%), the high recurrency rate of anterior resection should be considered when deciding upon the procedure.Type of Medium: Electronic ResourceURL: