Search Results - (Author, Cooperation:D. Griggs)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2014-04-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Advisory Committees/*organization & administration ; *Authorship ; *Climate Change/statistics & numerical data ; Computer Graphics ; Conflict of Interest ; *Environmental Policy ; Group Processes ; *Policy Making ; Research Design ; *Research Personnel/psychology ; *Research Report/trends ; Workload ; WritingPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. Griggs ; M. Stafford-Smith ; O. Gaffney ; J. Rockstrom ; M. C. Ohman ; P. Shyamsundar ; W. Steffen ; G. Glaser ; N. Kanie ; I. Noble
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Climate Change ; *Conservation of Natural Resources ; *Economics ; *Environmental Policy ; Humans ; PovertyPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1439-0973Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Die Pharmakokinetik und Gewebepenetration von vier Chinolonen wurde bestimmt. Die untersuchten Verbindungen waren Norfloxacin (400 mg p.o.), Enoxacin (600 mg p.o. und 400 mg i.v.), Ciprofloxacin (100 mg i.v. und 500 mg p.o.) sowie Ofloxacin (600 mg p.o.). Die Untersuchungen wurden an gesunden freiwilligen Probanden durchgeführt. Von den untersuchten oralen Substanzen wurden Ofloxacin und Ciprofloxacin am schnellsten resorbiert (Tmax 1,2 Stunden) und Enoxacin am langsamsten (Tmax 1,9 Stunden). Ofloxacin erreichte die höchsten Serumspiegel (nach Gabe der höheren Dosis). Die Serumhalbwertszeiten betrugen für Norfloxacin 3,75 Stunden, für Ciprofloxacin 3,9 Stunden (p.o.), 4,0 Stunden (i.v.), für Ofloxacin 7,0 Stunden und für Enoxacin 6,2 Stunden (p.o.) und 5,1 Stunden (i.v.). Alle Substanzen penetrierten rasch in Hautblasenflüssigkeit. Die Wiederfindungsrate im 24-Stunden-Urin (gemessen mittels mikrobiologischem Assay) betrug für Enoxacin 62% (p.o.), 46,1% nach i.v.-Gabe (plus 11,6% Oxoenoxacin, bestimmt mittels HPLC) und für Norfloxacin 27%, für orales Ciprofloxacin 30,6%, für i.v. appliziertes Ciprofloxacin 75,7%, sowie für Ofloxacin 73%.Notes: Summary The pharmacokinetics and tissue penetration of four quinolones were studied. The compounds were norfloxacin (400 mg p.o.), enoxacin (600 mg p.o. and 400 mg i.v.), ciprofloxacin (100 mg i.v. and 500 mg p.o.) and ofloxacin (600 mg p.o.) given to healthy volunteers. Of the oral agents studied ofloxacin and ciprofloxacin were the most rapidly absorbed (Tmax 1.2 h) and enoxacin the least (Tmax 1.9 h). The serum levels attained were highest in the case of ofloxacin (after allowing for the higher dose administered). The serum half-lives were norfloxacin 3.75 h, ciprofloxacin 3.9 h (p.o.), 4.0 h (i.v.), ofloxacin 7.0 h and enoxacin 6.2 h (p.o.) and 5.1 h (i.v.). All agents penetrated the blister fluid readily. The 24 h urine recovery (as measured by a microbiological assay) was 62% for enoxacin (p.o.), 46.4% following i.v. enoxacin (plus 11.6% oxo-enoxacin, measured by HPLC) 27% for norfloxacin, 30.6% for oral ciprofloxacin, 75.7% for i.v. ciprofloxacin and 73% for ofloxacin.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The susceptibility of 47 clinical isolates of methicillin-resistantStaphylococcus aureus (MRSA) to cefpirome, ceftazidime and methicillin was determined with Isosensitest media, with/without 5 % NaCl and incubation at 30°, 37° and 44°C for 24 and 48 h. At 24 h the MIC50 of cefpirome was 8 mg/l compared to 64 mg/l ceftazidime; at 48 h this increased to 32 mg/l cefpirome. The addition of 10 mg/l clavulanic acid or sulbactam lowered the MIC of cefpirome (at 48 h) by greater than four-fold in 23 % and 11 % of the strains, respectively. Cefpirome had primary affinity for penicillin-binding protein (PBP) 1 and 2 in five MRSA and one methicillin-susceptibleStaphylococcus aureus. PBP 2a was present in all MRSA and was not saturated by 64 mg/l cefpirome. Clavulanic acid at a concentration of 10 mg/l bound to PBP 2 by 〉 50 % in all strains, and when combined with cefpirome, the density of PBP 2a was also reduced but not completely abolished. The data from this study suggests that the mechanism of synergy of a β-lactamase inhibitor plus a cephalosporin for MRSA may be due to an additive effect against PBPs and not just inhibition of a β-lactamase. No cefpirome-resistant mutants could be selected from a methicillin-susceptibleStaphylococcus aureus, but mutants were selected from an MRSA (expressing homogeneous methicillin resistance) for which MICs of cefpirome were 8 to 32 mg/l.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: coronary driving pressure ; vascular waterfall ; acute coronary insufficiencySource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: