Search Results - (Author, Cooperation:D. Finkelstein)
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1A. Rodriguez-Fernandez, V. Esposito, D. F. Sanchez, K. D. Finkelstein, P. Juranic, U. Staub, D. Grolimund, S. Reiche, B. Pedrini
Wiley-Blackwell
Published 2018Staff ViewPublication Date: 2018-02-24Publisher: Wiley-BlackwellTopics: Chemistry and PharmacologyGeosciencesPhysicsPublished by: -
2S. L. Finkelstein ; C. Papovich ; M. Dickinson ; M. Song ; V. Tilvi ; A. M. Koekemoer ; K. D. Finkelstein ; B. Mobasher ; H. C. Ferguson ; M. Giavalisco ; N. Reddy ; M. L. Ashby ; A. Dekel ; G. G. Fazio ; A. Fontana ; N. A. Grogin ; J. S. Huang ; D. Kocevski ; M. Rafelski ; B. J. Weiner ; S. P. Willner
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-10-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3G. Robinson ; M. Parker ; T. A. Kranenburg ; C. Lu ; X. Chen ; L. Ding ; T. N. Phoenix ; E. Hedlund ; L. Wei ; X. Zhu ; N. Chalhoub ; S. J. Baker ; R. Huether ; R. Kriwacki ; N. Curley ; R. Thiruvenkatam ; J. Wang ; G. Wu ; M. Rusch ; X. Hong ; J. Becksfort ; P. Gupta ; J. Ma ; J. Easton ; B. Vadodaria ; A. Onar-Thomas ; T. Lin ; S. Li ; S. Pounds ; S. Paugh ; D. Zhao ; D. Kawauchi ; M. F. Roussel ; D. Finkelstein ; D. W. Ellison ; C. C. Lau ; E. Bouffet ; T. Hassall ; S. Gururangan ; R. Cohn ; R. S. Fulton ; L. L. Fulton ; D. J. Dooling ; K. Ochoa ; A. Gajjar ; E. R. Mardis ; R. K. Wilson ; J. R. Downing ; J. Zhang ; R. J. Gilbertson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; CREB-Binding Protein/genetics ; Cadherins/genetics ; Cdh1 Proteins ; Cell Cycle Proteins/deficiency/genetics ; Cell Lineage ; Cerebellar Neoplasms/*classification/*genetics/pathology ; Child ; DEAD-box RNA Helicases/genetics ; DNA Copy Number Variations ; DNA Helicases/genetics ; DNA Mutational Analysis ; Disease Models, Animal ; Genome, Human/genetics ; Genomics ; Hedgehog Proteins/metabolism ; Histone Demethylases/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/*classification/*genetics/pathology ; Methylation ; Mice ; Mutation/*genetics ; Nuclear Proteins/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/geneticsPublished by: -
4M. Parker ; K. M. Mohankumar ; C. Punchihewa ; R. Weinlich ; J. D. Dalton ; Y. Li ; R. Lee ; R. G. Tatevossian ; T. N. Phoenix ; R. Thiruvenkatam ; E. White ; B. Tang ; W. Orisme ; K. Gupta ; M. Rusch ; X. Chen ; P. Nagahawhatte ; E. Hedlund ; D. Finkelstein ; G. Wu ; S. Shurtleff ; J. Easton ; K. Boggs ; D. Yergeau ; B. Vadodaria ; H. L. Mulder ; J. Becksfort ; P. Gupta ; R. Huether ; J. Ma ; G. Song ; A. Gajjar ; T. Merchant ; F. Boop ; A. A. Smith ; L. Ding ; C. Lu ; K. Ochoa ; D. Zhao ; R. S. Fulton ; L. L. Fulton ; E. R. Mardis ; R. K. Wilson ; J. R. Downing ; D. R. Green ; J. Zhang ; D. W. Ellison ; R. J. Gilbertson
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/genetics/metabolism ; Animals ; Base Sequence ; Brain Neoplasms/genetics/metabolism/pathology ; Cell Line ; Cell Nucleus/metabolism ; *Cell Transformation, Neoplastic/genetics ; Chromosomes, Human, Pair 11/genetics ; Ependymoma/*genetics/*metabolism/pathology ; Female ; Humans ; Mice ; Models, Genetic ; Molecular Sequence Data ; NF-kappa B/genetics/*metabolism ; Neural Stem Cells/metabolism/pathology ; Oncogene Proteins, Fusion/genetics/metabolism ; Phosphoproteins/genetics/metabolism ; Proteins/genetics/*metabolism ; *Signal Transduction ; Transcription Factor RelA/genetics/*metabolism ; Translocation, Genetic/geneticsPublished by: -
5G. M. Delgoffe ; S. R. Woo ; M. E. Turnis ; D. M. Gravano ; C. Guy ; A. E. Overacre ; M. L. Bettini ; P. Vogel ; D. Finkelstein ; J. Bonnevier ; C. J. Workman ; D. A. Vignali
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-08-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autoimmunity/immunology ; Cell Survival ; Colitis/immunology ; Female ; Forkhead Transcription Factors/metabolism ; HEK293 Cells ; Homeostasis/immunology ; Humans ; Immune Tolerance/immunology ; Immunological Synapses ; Lymphocytes, Tumor-Infiltrating/cytology/immunology/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasms/genetics/immunology/pathology ; Neuropilin-1/deficiency/*metabolism ; PTEN Phosphohydrolase/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Semaphorins/*metabolism ; Signal Transduction ; T-Lymphocytes, Regulatory/cytology/*immunology/*metabolism ; TOR Serine-Threonine Kinases/metabolismPublished by: -
6Harwood, F. C., Klein Geltink, R. I., OHara, B. P., Cardone, M., Janke, L., Finkelstein, D., Entin, I., Paul, L., Houghton, P. J., Grosveld, G. C.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-13Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
7Roberts, K. G., Janke, L. J., Zhao, Y., Seth, A., Ma, J., Finkelstein, D., Smith, S., Ebata, K., Tuch, B. B., Hunger, S. P., Mullighan, C. G.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-08-24Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Lymphoid NeoplasiaPublished by: -
8Stanic, D. ; Parish, C. L. ; Zhu, W. M. ; Krstew, E. V. ; Lawrence, A. J. ; Drago, J. ; Finkelstein, D. I. ; Horne, M. K.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
9Lawrence, A. J. ; Parish, C. L. ; Chen, F. ; Lodge, D. J. ; Krstew, E. V. ; Card, K. ; Finkelstein, D. I. ; Horne, M. K.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Corticotropin-releasing factor is a neuropeptide associated with the integration of physiological and behavioural responses to stress and also in the modulation of affective state and drug reward. The selective, centrally acting corticotropin-releasing factor type 1 receptor antagonist, antalarmin, is a potent anxiolytic and reduces volitional ethanol consumption in Fawn-Hooded rats. The efficacy of antalarmin to reduce ethanol consumption increased with time, suggestive of adaptation to reinforcement processes and goal-directed behaviour. The aim of the present study was to examine the effects of chronic antalarmin treatment on reward-related regions of Fawn-Hooded rat brain. Bi-daily antalarmin treatment (20 mg/kg, i.p.) for 10 days increased tyrosine hydroxylase messenger RNA expression throughout the ventral mesencephalon. Following chronic antalarmin the density of dopaminergic terminals within the basal ganglia and amygdaloid complex were reduced, as was dopamine transporter binding within the striatum. Receptor autoradiography indicated an up-regulation of dopamine D2, but no change in D1, binding in striatum, and Golgi-Cox analysis of striatal medium spiny neurones indicated that chronic antalarmin treatment increased spine density. Thus, chronic antalarmin treatment modulates dopaminergic pathways and implies that chronic treatment with drugs of this class may ultimately alter postsynaptic signaling mechanisms within the basal ganglia.Type of Medium: Electronic ResourceURL: -
10Stanic, D. ; Parish, C. L. ; Zhu, W. M. ; Krstew, E. V. ; Lawrence, A. J. ; Drago, J. ; Finkelstein, D. I. ; Horne, M. K.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Following partial substantia nigra lesions, remaining dopaminergic neurones sprout, returning terminal density in the dorsal striatum to normal by 16 weeks. This suggests regeneration and maintenance of terminal density is regulated to release appropriate levels of dopamine. This study examined the structure and function of these reinnervated terminals, defining characteristics of dopamine uptake and release, density and affinity of the dopamine transporter (DAT) and ultrastructural morphology of dopamine terminals in the reinnervated dorsal striatum. Finally, rotational behaviour of animals in response to amphetamine was examined 4 and 16 weeks after substantia nigra pars compacta (SNpc) lesions. Dopamine transport was markedly reduced 16 weeks after lesioning along with reduced density and affinity of DAT. Rate of dopamine release and peak concentration, measured electrochemically, was similar in lesioned and control animals, while clearance was prolonged after lesioning. Ultrastructurally, terminals after lesioning were morphologically distinct, having increased bouton size, vesicle number and mitochondria, and more proximal contacts on post-synaptic cells. After 4 weeks, tendency to rotate in response to amphetamine was proportional to lesion size. By 16 weeks, rotational behaviour returned to near normal in animals where lesions were less than 70%, although some animals demonstrated unusual rotational patterns at the beginning and end of the amphetamine effect. Together, these changes indicate that sprouted terminals are well compensated for dopamine release but that transport mechanisms are functionally impaired. We discuss these results in terms of implications for dyskinesia and other behavioural states.Type of Medium: Electronic ResourceURL: -
11FINKELSTEIN, D. B. ; SOLIDAY, C. L. ; CRAWFORD, M. S. ; RAMBOSEK, J. ; MCADA, P. C. ; LEACH, J.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
12Stanic, D. ; Finkelstein, D. I. ; Bourke, D. W. ; Drago, J. ; Horne, M. K.
Oxford, UK : Blackwell Science, Ltd
Published 2003Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Previously we described the extent of sprouting that axons of the rat substantia nigra pars compacta (SNpc) undergo to grow new synapses and re-innervate the dorsal striatum 16 weeks after partial lesions. Here we provide insights into the timing of events related to the re-innervation of the dorsal striatum by regenerating dopaminergic nigrostriatal axons over a 104-week period after partial SNpc lesioning. Density of dopamine transporter and tyrosine hydroxylase immunoreactive axonal varicosities (terminals) decreased up to 80% 4 weeks after lesioning but returned to normal by 16 weeks, unless SNpc lesions were greater than 75%. Neuronal tracer injections into the SNpc revealed a 119% increase in axon fibres (4 mm rostral to the SNpc) along the medial forebrain bundle 4 weeks after lesioning. SNpc cells underwent phenotypic changes. Four weeks after lesioning the proportion of SNpc neurons that expressed tyrosine hydroxylase fell from 90% to 38% but returned to 78% by 32 weeks. We discuss these phenotype changes in the context of neurogenesis. Significant reductions in dopamine levels in rats with medium (30–75%) lesions returned to normal by 16 weeks whereas recovery was not observed if lesions were larger than 75%. Finally, rotational behaviour of animals in response to amphetamine was examined. The clear rightward turning bias observed after 2 weeks recovered by 16 weeks in animals with medium (30–75%) lesions but was still present when lesions were larger. These studies provide insights into the processes that regulate sprouting responses in the central nervous system following injury.Type of Medium: Electronic ResourceURL: -
13Parish, C. L. ; Stanic, D. ; Drago, J. ; Borrelli, E. ; Finkelstein, D. I. ; Horne, M. K.
Oxford, UK : Blackwell Science, Ltd
Published 2002Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: This study demonstrates that pharmacological manipulation of the dopamine (DA) receptors can modulate the size of the axonal tree of substantia nigra pars compacta (SNpc) neurons in mice. Pharmacological blockade or genetic ablation of the D2 receptor (D2R) resulted in sprouting of DA SNpc neurons whereas treatment with a D2 agonist resulted in pruning of the terminal arbor of these neurons. Agents such as cocaine, that indirectly stimulate D2R, also resulted in reduced terminal arbor. Specific D1 agonists or antagonists had no effect on the density of DA terminals in the striatum. We conclude that the D2 receptor has a central role in regulating the size of the terminal arbor of nigrostriatal neurons. These findings have implications relating to the use of dopaminergic agonists in the management of Parkinson's disease and in controlling plasticity following injury, loss or transplantation of DA neurons.Type of Medium: Electronic ResourceURL: -
14Tripanichkul, W. ; Stanic, D. ; Drago, J. ; Finkelstein, D. I. ; Horne, M. K.
Oxford, UK : Blackwell Science, Ltd
Published 2003Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Recently it was demonstrated that sprouting of dopaminergic neurons and a microglial and astrocyte response follows both partial lesions of the substantia nigra pars compacta and blockade of the D2 dopamine receptor. We therefore studied the effects of the combination of these two treatments (lesioning and D2 dopamine receptor blockade). Haloperidol administration caused a 57% increase in dopaminergic terminal tree size (measured as terminal density per substantia nigra pars compacta neuron) and an increase of glia in the striatum. Following small to medium nigral lesions (less than 60%), terminal tree size increased by 51% on average and returned density of dopaminergic terminals to normal. In contrast, administration of haloperidol for 16 weeks following lesioning resulted in reduced dopaminergic terminal density and terminal tree size (13%), consistent with absent or impaired sprouting. Glial cell numbers increased but were less than with lesions alone. When haloperidol was administered after the striatum had been reinnervated through sprouting (16–32 weeks after lesioning), terminal tree size increased up to 150%, similar to the effect of haloperidol in normal animals. By examining the effect of administering haloperidol at varying times following a lesion, we concluded that a switch in the effect of D2 dopamine receptor blockade occurred after dopaminergic synapses began to form in the striatum. We postulate that when synapses are present, D2 dopamine receptor blockade results in increased terminal density, whereas prior to synapse formation D2 dopamine receptor blockade causes attenuation of a sprouting response. We speculate that D2 dopamine receptors located on growth cones ‘push’ neurites toward their targets, and blockade of these receptors could lead to attenuation of sprouting.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0003-4916Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0167-2789Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 1432-0983Keywords: Saccharomyces cerevisiae ; Translation ; Coordinate regulation ; ElectrophoresisSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary The products of protein synthesis from exponential phase cultures of Saccharomyces cerevisiae grown at 23 °C or at 36 °C appear to be essentially identical. However, yeast cells respond to a shift in culture temperature from 23 °C to 36 °C with the rapid de novo synthesis of a polypeptide species of molecular weight 100,000. Within 60–90 min after the shift this polypeptide represents approximately 2.5% of the total cellular protein, a 5–10 fold increase over the preshift level. The level of this polypeptide then decreases with continued growth of the cells at 36 °C. Analyses by SDS-polyacrylamide gel electrophoresis of polypeptides obtained from cells pulse labeled with [35S]methionine demonstrate that following a temperature shift from 23 °C to 36 °C the synthetic rate of the 100,000 molecular weight polypeptide (as well as a number of other polypeptide species) increases to a level at least 10 fold higher than that observed prior to the shift. A concomittant decrease is observed in the synthesis of a large number of polypeptide species which were actively synthesized before the shift. Maximum changes in synthetic rates are observed 20–30 min after the shift and preshift synthetic patterns are regained within 60–90 min. Synthetic changes of the same magnitude and time course can be produced by short (20–30 min) exposures to 36 °C implicating a heat shock response. Several of the transiently induced polypeptides, including the 100,000 molecular weight species, show an affinity for DNA as determined by DNA-cellulose chromatography.Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 1432-1106Keywords: Muscle ; Motor units ; Partial denervation ; Motoneurone sprouting ; Force-velocity ; HistochemistrySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The fast-twitch flexor digitorum longus (FDL) muscle was partially denervated by a unilateral section of the L7 ventral root. After approximately 100 days the isometric, force-velocity and histochemical properties of single motor units from the partially denervated muscle were determined. The diameter of the nerve axons supplying the muscle were also examined. The extrapolated maximum speed of sarcomere shortening (Vmax) of the enlarged motor units was significantly less than that of the control whole muscle Vmax. It is concluded that the motoneurone is capable of expanding its territory and therefore its tension generating capability without any apparent change in axonal diameter. In addition, the intrinsic properties of the muscle fibres are altered.Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 1432-2013Keywords: Retina ; Frosch ; Bewegungsdetektoren ; Frog ; Movement DetectorsSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary 1. By means of metal-filled micropipettes the action potentials of 4 different classes of optic nerve fibers were recorded in Rana esculenta. The relationship between the angular velocity of the stimuli and the neuronal response was determined. 2. If an object smaller than the excitatory receptive field (ERF) was moved through the receptive field of the different classes of retinal units the response depended on the angular velocity, contrast and size of the stimulus. The response was measured as the average impulses frequency (R) during the traverse of the ERF. Between R and the angular velocity (v) the equation R=k·v c [impulses · sec−1] was found. The exponent c was 0.5 for class 1 neurons, 0.7 for class 2 neurons, and 0.95 for class 3 neurons. In class 4 neurons the response to large stimuli increased linearly with the increase of the angular velocity, while no systematic relationship between R and v was valid for small moving stimuli (〈5°) 3. If the contrast or the size of the stimuli was changed the exponent c was not changed; but k depended on both parameters and on the direction of the contrast against the background. The power function was no longer valid if stimuli considerably larger than the ERF were used. The exponent c was independent of the type of the movement (linear, non-linear, irregular movement); it was also independent of the direction of the motion. 4. A model of the receptive field is demonstrated. In this model an RC-filter function within the bipolar cells is assumed. The bipolar cells with different filter function activate different classes of ganglion cells. Different time constants of the bandpass filter at the bipolar cell level are the main cause for the different exponents of the power function between angular velocity and neuronal response.Notes: Zusammenfassung 1. Von Opticusfasern des europäischen Wasserfrosches wurden mit metallgefüllten Mikroelektroden die Aktionspotentiale 4 verschiedener Neuronenklassen registriert. die Abhängigkeit der neuronalen Aktivierung von der Winkelgeschwindigkeit der bewegten Reizmuster wurde untersucht. 2. Als Maß für die neuronale Aktivierung wurde die mittlere Impulsfrequenz (R) gewählt, die ein kleines Objekt während der Durchquerung des excitatorischen receptiven Feldes (ERF) auslöste. Zwischen R und v wurde innerhalb weiter Grenzen (0.05–20° · sec−1) eine Potenzfunktion gefunden: R=k·v c (Impulse · sec−1). Der Exponent c war 0,5 für Neurone der Klasse 1, 0,7 für Neurone der Klasse 2 und 0,95 für Neurone der Klasse 3. Die off-Neurone (Klasse 4) zeigten für kleine bewegte Objekte (〈5°) keine regelhafte Beziehung zwischen R und v; für große dunkle, auf weißem Hintergrund bewegte Objekte wurde eine lineare Beziehung zwischen R und v gefunden. 3. Eine Änderung des Kontrastes der bewegten Reize gegen den Hintergrund beeinflußte den Exponenten c nicht, während k mit Abnahme des Kontrastes kleiner wurde. Der Exponent c war unabhängig von der Richtung und der Art der Bewegung (linear, nichtlinear, unregelmäßig) und von der Größe der bewegten Reize, so lange diese kleiner als das ERF waren. 4. Ein einfaches Modell des receptiven Feldes, das auf dem Analogrechner simuliert werden kann, wird erläutert. Es wird angenommen, daß die Signalübertragung durch die verschiedenen Bipolarzellen durch verschiedene Bandpassfilter dargestellt werden kann. Mit dem Analogmodell kann gezeigt werden, daß die untere Grenzfrequenz dieser Bandpaßfilter den Exponenten c in der Potenzfunktion zwischen R und v bestimmt.Type of Medium: Electronic ResourceURL: -
20Grüsser, O. -J. ; Grüsser-Cornehls, Ursula ; Finkelstein, D. ; Henn, V. ; Patutschnik, Margrit ; Butenandt, E.
Springer
Published 1967Staff ViewISSN: 1432-2013Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary In the frog's retina (Rana esculenta, Rana pipiens) two classes of neurons which are especially sensitive to stimuli moved through the receptive fields were investigated. It was found that the following stimulus parameters determine the response of these class-2 and class-3 neurons: angular velocity (v), stimulus size (A), contrast of stimulus against a white or a black background (c), position of the path of traverse in the receptive field (P), and the time (t) between the movement of identical stimuli along the same path through the receptive field. These parameters were changed within a considerable range; the relation between the parameter change and the neuronal response is given in different equations. A final formula, which allows one to calculate the average response of a class-2 or a class-3 neurons to a stimulus moved through the excitatory receptive field is given in equations 6a and 6b.Notes: Zusammenfassung In der Froschretina (Rana esculenta, Rana pipiens) gibt es zwei Klassen bewegungsspezifischer Neurone. Ihre Aktionspotentiale wurden mit metallgefüllten Mikropipetten von den Endigungen der Opticusfasern in den oberflächlichen Tectumschichten registriert. Durch maschinelle visuelle Reizung mit einer Perimeterapparatur wurde gefunden, daß die folgenden Reizparameter in gesetzmäßiger Weise die Reaktionen dieser retinalen Neurone bestimmen: Winkelgeschwindigkeit (v), Größe des bewegten Reizes (A), Kontrast des Reizes gegen einen weißen oder schwarzen Hintergrund (c), Position (P) der Strecke im rezeptiven Feld, entlang welcher der Reiz durch das rezeptive Feld bewegt wurde und die Zeit (t), die zwischen der Reizung mit gleichen bewegten Mustern auf derselben Strecke durch das rezeptive Feld verstrichen ist. Auf Grund der experimentellen Befunde konnten Gleichungen aufgestellt werden (1–6), welche die Antwort der bewegungsspezifischen Neurone der Klasse 2 und der Klasse 3 der Froschnetzhaut beschreiben.Type of Medium: Electronic ResourceURL: