Search Results - (Author, Cooperation:D. Eberhard)
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1Latest Papers from Table of Contents or Articles in PressM. M. Savitski ; F. B. Reinhard ; H. Franken ; T. Werner ; M. F. Savitski ; D. Eberhard ; D. Martinez Molina ; R. Jafari ; R. B. Dovega ; S. Klaeger ; B. Kuster ; P. Nordlund ; M. Bantscheff ; G. Drewes
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-04Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adenosine Triphosphatases/metabolism ; Antineoplastic Agents/*pharmacology ; Hot Temperature ; Humans ; K562 Cells ; Ligands ; Protein Binding ; Protein Denaturation ; Protein Stability ; Proteome/*drug effects ; Proteomics/*methodsPublished by: -
2Latest Papers from Table of Contents or Articles in PressL. Kruidenier ; C. W. Chung ; Z. Cheng ; J. Liddle ; K. Che ; G. Joberty ; M. Bantscheff ; C. Bountra ; A. Bridges ; H. Diallo ; D. Eberhard ; S. Hutchinson ; E. Jones ; R. Katso ; M. Leveridge ; P. K. Mander ; J. Mosley ; C. Ramirez-Molina ; P. Rowland ; C. J. Schofield ; R. J. Sheppard ; J. E. Smith ; C. Swales ; R. Tanner ; P. Thomas ; A. Tumber ; G. Drewes ; U. Oppermann ; D. J. Patel ; K. Lee ; D. M. Wilson
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Enzyme Inhibitors/*pharmacology ; Humans ; Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors ; Macrophages/*drug effects/*immunologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressL. Kruidenier ; C. W. Chung ; Z. Cheng ; J. Liddle ; K. Che ; G. Joberty ; M. Bantscheff ; C. Bountra ; A. Bridges ; H. Diallo ; D. Eberhard ; S. Hutchinson ; E. Jones ; R. Katso ; M. Leveridge ; P. K. Mander ; J. Mosley ; C. Ramirez-Molina ; P. Rowland ; C. J. Schofield ; R. J. Sheppard ; J. E. Smith ; C. Swales ; R. Tanner ; P. Thomas ; A. Tumber ; G. Drewes ; U. Oppermann ; D. J. Patel ; K. Lee ; D. M. Wilson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Biocatalysis/drug effects ; Catalytic Domain ; Cells, Cultured ; Enzyme Inhibitors/metabolism/*pharmacology ; Evolution, Molecular ; Histones/chemistry/metabolism ; Humans ; Inhibitory Concentration 50 ; Jumonji Domain-Containing Histone Demethylases/*antagonists & ; inhibitors/chemistry/classification/metabolism ; Lysine/metabolism ; Macrophages/*drug effects/enzymology/*immunology/metabolism ; Methylation/drug effects ; Mice ; Models, Molecular ; Substrate Specificity ; Tumor Necrosis Factor-alpha/biosynthesisPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: The ability of cholinergic agonists to activate phospholipase C in bovine adrenal chromaffin cells was examined by assaying the production of inositol phosphates in cells prelabeled with [3H]inositol. We found that both nicotinic and muscarinic agonists increased the accumulation of [3H]inositol phosphates (mainly inositol monophos-phate) and that the effects mediated by the two types of receptors were independent of each other. The production of inositol phosphates by nicotinic stimulation required extracellular Ca2+ and was maximal at 0.2 mMCa2+. Increasing extracellular Ca2+ from 0.22 to 2.2 mM increased the sensitivity of inositol phosphates formation to stimulation by submaximal concentrations of 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) but did not enhance the response to muscarine. Elevated K+ also stimulated Ca2+-dependent [3H]inositol phosphate production, presumably by a non-receptor-mediated mechanism. The Ca2+ channel antagonists D600 and nifedipine inhibited the effects of DMPP and elevated K+ to a greater extent than that of muscarine. Ca2+ (0.3–10 μM) directly stimulated the release of inositol phosphates from digitonin-permeabilized cells that had been prelabeled with [3H]inositol. Thus, cholinergic stimulation of bovine adrenal chromaffin cells results in the activation of phospholipase C by distinct muscarinic and nicotinic mechanisms. Nicotinic receptor stimulation and elevated K+ probably increased the accumulation of inositol phosphates through Ca2+ influx and a rise in cytosolic Ca2+. Because Ba2+ caused catechol-amine secretion but did not enhance the formation of inositol phosphates, phospholipase C activation is not required for exocytosis. However, diglyceride and wyo-inositol 1,4,5-trisphosphate produced during cholinergic stimulation of chromaffin cells may modulate secretion and other cellular processes by activating protein kinase C and/or releasing Ca2+ from intracellular stores.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesKaiser, E. ; Hu, B. ; Becher, S. ; Eberhard, D. ; Schray, B. ; Baack, M. ; Hameister, H. ; Knippers, R.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-2048Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Zusammenfassung 1. Bei dem WasserpilzFusarium aquaeductuum wurde der Einfluß von Lichtintensität und Lichtmenge auf die Carotinoidbildung untersucht. 2. 2 1/2 Tage alte Pilze wurden in Phosphatpuffer suspendiert, in Gaswaschflaschen unter ständiger Durchlüftung belichtet und nach verschiedenen Zeiten der Gesamtfarbstoffgehalt bestimmt. 3. Die im Dauerlicht gebildete Farbstoffmenge ist von der Lichtintensität abhängig und erreicht bereits nach etwa 8 Std den höchsten Wert, der sich auch bei längerer Belichtungszeit nicht mehr ändert. 4. Die Farbstoffbildung läuft nach kurzer Belichtung auch im Dunkeln weiter. Gleiche Lichtmengen bewirken die Bildung gleicher Farbstoffmengen im Bereich zwischen 1500 und 48 000 Lux-Stunden. Dies gilt bei allen angewandten Lichtintensitäten allerdings nur bis zu einer Belichtungszeit von etwa 4 Std; eine Weiterbelichtung nach der 4. Std ist wirkungslos. 5. Diese Begrenzung auf 4 Std beruht nicht auf einer Selbstvergiftung der Pilze. Gegen die Möglichkeit einer Verarmung an Reservestoffen spricht, daß Proben, die erst nach 4stündiger Dunkelheit belichtet wurden, noch etwa 80% der Farbstoffmenge sofort belichteter Pilze bildeten.Type of Medium: Electronic ResourceURL: