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1Latest Papers from Table of Contents or Articles in PressG. B. Ehret ; P. B. Munroe ; K. M. Rice ; M. Bochud ; A. D. Johnson ; D. I. Chasman ; A. V. Smith ; M. D. Tobin ; G. C. Verwoert ; S. J. Hwang ; V. Pihur ; P. Vollenweider ; P. F. O'Reilly ; N. Amin ; J. L. Bragg-Gresham ; A. Teumer ; N. L. Glazer ; L. Launer ; J. H. Zhao ; Y. Aulchenko ; S. Heath ; S. Sober ; A. Parsa ; J. Luan ; P. Arora ; A. Dehghan ; F. Zhang ; G. Lucas ; A. A. Hicks ; A. U. Jackson ; J. F. Peden ; T. Tanaka ; S. H. Wild ; I. Rudan ; W. Igl ; Y. Milaneschi ; A. N. Parker ; C. Fava ; J. C. Chambers ; E. R. Fox ; M. Kumari ; M. J. Go ; P. van der Harst ; W. H. Kao ; M. Sjogren ; D. G. Vinay ; M. Alexander ; Y. Tabara ; S. Shaw-Hawkins ; P. H. Whincup ; Y. Liu ; G. Shi ; J. Kuusisto ; B. Tayo ; M. Seielstad ; X. Sim ; K. D. Nguyen ; T. Lehtimaki ; G. Matullo ; Y. Wu ; T. R. Gaunt ; N. C. Onland-Moret ; M. N. Cooper ; C. G. Platou ; E. Org ; R. Hardy ; S. Dahgam ; J. Palmen ; V. Vitart ; P. S. Braund ; T. Kuznetsova ; C. S. Uiterwaal ; A. Adeyemo ; W. Palmas ; H. Campbell ; B. Ludwig ; M. Tomaszewski ; I. Tzoulaki ; N. D. Palmer ; T. Aspelund ; M. Garcia ; Y. P. Chang ; J. R. O'Connell ; N. I. Steinle ; D. E. Grobbee ; D. E. Arking ; S. L. Kardia ; A. C. Morrison ; D. Hernandez ; S. Najjar ; W. L. McArdle ; D. Hadley ; M. J. Brown ; J. M. Connell ; A. D. Hingorani ; I. N. Day ; D. A. Lawlor ; J. P. Beilby ; R. W. Lawrence ; R. Clarke ; J. C. Hopewell ; H. Ongen ; A. W. Dreisbach ; Y. Li ; J. H. Young ; J. C. Bis ; M. Kahonen ; J. Viikari ; L. S. Adair ; N. R. Lee ; M. H. Chen ; M. Olden ; C. Pattaro ; J. A. Bolton ; A. Kottgen ; S. Bergmann ; V. Mooser ; N. Chaturvedi ; T. M. Frayling ; M. Islam ; T. H. Jafar ; J. Erdmann ; S. R. Kulkarni ; S. R. Bornstein ; J. Grassler ; L. Groop ; B. F. Voight ; J. Kettunen ; P. Howard ; A. Taylor ; S. Guarrera ; F. Ricceri ; V. Emilsson ; A. Plump ; I. Barroso ; K. T. Khaw ; A. B. Weder ; S. C. Hunt ; Y. V. Sun ; R. N. Bergman ; F. S. Collins ; L. L. Bonnycastle ; L. J. Scott ; H. M. Stringham ; L. Peltonen ; M. Perola ; E. Vartiainen ; S. M. Brand ; J. A. Staessen ; T. J. Wang ; P. R. Burton ; M. Soler Artigas ; Y. Dong ; H. Snieder ; X. Wang ; H. Zhu ; K. K. Lohman ; M. E. Rudock ; S. R. Heckbert ; N. L. Smith ; K. L. Wiggins ; A. Doumatey ; D. Shriner ; G. Veldre ; M. Viigimaa ; S. Kinra ; D. Prabhakaran ; V. Tripathy ; C. D. Langefeld ; A. Rosengren ; D. S. Thelle ; A. M. Corsi ; A. Singleton ; T. Forrester ; G. Hilton ; C. A. McKenzie ; T. Salako ; N. Iwai ; Y. Kita ; T. Ogihara ; T. Ohkubo ; T. Okamura ; H. Ueshima ; S. Umemura ; S. Eyheramendy ; T. Meitinger ; H. E. Wichmann ; Y. S. Cho ; H. L. Kim ; J. Y. Lee ; J. Scott ; J. S. Sehmi ; W. Zhang ; B. Hedblad ; P. Nilsson ; G. D. Smith ; A. Wong ; N. Narisu ; A. Stancakova ; L. J. Raffel ; J. Yao ; S. Kathiresan ; C. J. O'Donnell ; S. M. Schwartz ; M. A. Ikram ; W. T. Longstreth, Jr. ; T. H. Mosley ; S. Seshadri ; N. R. Shrine ; L. V. Wain ; M. A. Morken ; A. J. Swift ; J. Laitinen ; I. Prokopenko ; P. Zitting ; J. A. Cooper ; S. E. Humphries ; J. Danesh ; A. Rasheed ; A. Goel ; A. Hamsten ; H. Watkins ; S. J. Bakker ; W. H. van Gilst ; C. S. Janipalli ; K. R. Mani ; C. S. Yajnik ; A. Hofman ; F. U. Mattace-Raso ; B. A. Oostra ; A. Demirkan ; A. Isaacs ; F. Rivadeneira ; E. G. Lakatta ; M. Orru ; A. Scuteri ; M. Ala-Korpela ; A. J. Kangas ; L. P. Lyytikainen ; P. Soininen ; T. Tukiainen ; P. Wurtz ; R. T. Ong ; M. Dorr ; H. K. Kroemer ; U. Volker ; H. Volzke ; P. Galan ; S. Hercberg ; M. Lathrop ; D. Zelenika ; P. Deloukas ; M. Mangino ; T. D. Spector ; G. Zhai ; J. F. Meschia ; M. A. Nalls ; P. Sharma ; J. Terzic ; M. V. Kumar ; M. Denniff ; E. Zukowska-Szczechowska ; L. E. Wagenknecht ; F. G. Fowkes ; F. J. Charchar ; P. E. Schwarz ; C. Hayward ; X. Guo ; C. Rotimi ; M. L. Bots ; E. Brand ; N. J. Samani ; O. Polasek ; P. J. Talmud ; F. Nyberg ; D. Kuh ; M. Laan ; K. Hveem ; L. J. Palmer ; Y. T. van der Schouw ; J. P. Casas ; K. L. Mohlke ; P. Vineis ; O. Raitakari ; S. K. Ganesh ; T. Y. Wong ; E. S. Tai ; R. S. Cooper ; M. Laakso ; D. C. Rao ; T. B. Harris ; R. W. Morris ; A. F. Dominiczak ; M. Kivimaki ; M. G. Marmot ; T. Miki ; D. Saleheen ; G. R. Chandak ; J. Coresh ; G. Navis ; V. Salomaa ; B. G. Han ; X. Zhu ; J. S. Kooner ; O. Melander ; P. M. Ridker ; S. Bandinelli ; U. B. Gyllensten ; A. F. Wright ; J. F. Wilson ; L. Ferrucci ; M. Farrall ; J. Tuomilehto ; P. P. Pramstaller ; R. Elosua ; N. Soranzo ; E. J. Sijbrands ; D. Altshuler ; R. J. Loos ; A. R. Shuldiner ; C. Gieger ; P. Meneton ; A. G. Uitterlinden ; N. J. Wareham ; V. Gudnason ; J. I. Rotter ; R. Rettig ; M. Uda ; D. P. Strachan ; J. C. Witteman ; A. L. Hartikainen ; J. S. Beckmann ; E. Boerwinkle ; R. S. Vasan ; M. Boehnke ; M. G. Larson ; M. R. Jarvelin ; B. M. Psaty ; G. R. Abecasis ; A. Chakravarti ; P. Elliott ; C. M. van Duijn ; C. Newton-Cheh ; D. Levy ; M. J. Caulfield ; T. Johnson
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa/ethnology ; Asia/ethnology ; Blood Pressure/*genetics/physiology ; Cardiovascular Diseases/*genetics ; Coronary Artery Disease/genetics ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Humans ; Hypertension/genetics ; Kidney Diseases/genetics ; Polymorphism, Single Nucleotide/*genetics ; Stroke/geneticsPublished by: -
2Articles: DFG German National LicensesElzen, H. J. ; Cohen-Overbeek, T. E. ; Grobbee, D. E. ; Wladimiroff, J. W.
Oxford, UK : Blackwell Publishing Ltd
Published 1993Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objective To determine whether uterine artery blood flow velocity measurements can predict miscarriage in older women.Design Prospective study.Subjects Three hundred and ninety-three women aged 35 years and older in the first trimester of pregnancy.Main outcome measures Miscarriage, genetic abortion, pulsatility index (PI), maternal age, gestational age at intake.Results Twenty women miscarried; 10 pregnancies were terminated because of chromosomal anomalies. Maternal age and gestational age at intake were significantly associated with miscarriage rate (P= 0.01 and P= 0.001, respectively). Uterine artery PI values declined significantly during the first trimester (P= 0.001). However, no association was found between uterine artery PI values and miscarriage rate. PI, maternal age and gestational age at intake were not essentially different between women who miscarried before or after chorionic villus sampling. No association was found between PI, maternal age, and gestational age at intake and genetic abortion rate.Conclusions Uterine artery blood flow velocity waveforms, as expressed by the pulsatility index, bear no relation to miscarriage.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesArbous, M. S. ; Grobbee, D. E. ; Van Kleef, J. W. ; De Lange, J. J. ; Spoormans, H. H. A. J. M. ; Touw, P. ; Werner, F. M. ; Meursing, A. E. E.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: From a prospectively defined cohort of patients who underwent either general, regional or combined anaesthesia from 1 January 1995 to 1 January 1997 (n = 869 483), all consecutive patients (n = 811) who died within 24 h or remained unintentionally comatose 24 h after anaesthesia were classified to determine a relationship with anaesthesia. These deaths (n = 119; 15%) were further analysed to identify contributing aspects of the anaesthetic management, other factors and the appropriateness of care. The incidence of 24-h peri-operative death per 10 000 anaesthetics was 8.8 (95% CI 8.2–9.5), of peri-operative coma was 0.5 (0.3–0.6) and of anaesthesia-related death 1.4 (1.1–1.6). Of the 119 anaesthesia-related deaths, 62 (52%) were associated with cardiovascular management, 57 (48%) with other anaesthetic management, 12 (10%) with ventilatory management and 12 (10%) with patient monitoring. Inadequate preparation of the patient contributed to 30 (25%) of the anaesthesia-related deaths. During induction of anaesthesia, choice of anaesthetic technique (n = 18 (15%)) and performance of the anaesthesiologist (n = 8 (7%)) were most commonly associated with death. During maintenance, the most common factors were cardiovascular management (n = 43 (36%)), ventilatory management (n = 12 (10%)) and patient monitoring (n = 12 (10%)). In both the recovery and the postoperative phases, patient monitoring was the most common factor (n = 12 (10%) for both). For cardiovascular, ventilatory and other anaesthetic management, human failure contributed to 89 (75%) deaths and organisational factors to 12 (10%). For inadequate patient monitoring, human factors contributed to 71 (60%) deaths and organisational factors to 48 (40%). Other contributing factors were inadequate communication (30 deaths (25%) for all four aspects of the anaesthetic management) and lack of supervision (particularly for ventilatory management). Inadequate care was delivered in 19 (16%) of the anaesthesia-related deaths with respect to cardiovascular management, in 20 (17%) with respect to ventilatory management, in 18 (15%) with respect to patient monitoring and in 23 (19%) with respect to other anaesthetic management.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesArbous, M. S. ; Grobbee, D. E. ; Van Kleef, J. W. ; Meursing, A. E. E.
Oxford : Blackwell Science Ltd, UK
Published 1998Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: To date, anaesthesia-related mortality, morbidity and risk factors have almost exclusively been studied qualitatively rather than quantitatively. Therefore, knowledge of the relative risk associated with many anaesthesia-related factors is still lacking. Recently, a quantitative study of the determinants and prevention of morbidity and mortality in anaesthesia was started in the Netherlands. Its objective is to study severe peri-operative morbidity and mortality as a function of anaesthesia-related risk factors. The study is designed as a case-control study within a prospectively defined cohort. The cohort comprises all patients undergoing an anaesthetic procedure, either general, regional or a combination, in one of 61 hospitals between 1 January 1995 and 1 January 1997. A ‘case’ is a patient who dies within 24 h of undergoing an anaesthetic procedure or who remains comatose 24 h after an anaesthetic procedure. A ‘control’ patient is a randomly chosen patient who has undergone anaesthesia and is matched for gender and age. The present report discusses the study protocol.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesVERMEER, C. ; KNAPEN, M. H. J. ; JIE, K.-S. G. ; GROBBEE, D. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesDijk, K. ; Fischer, K. ; Bom, J. G. ; Grobbee, D. E. ; Berg, H. M.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. To quantify variation in clinical phenotype of severe haemophilia we performed a single centre cohort study among 171 severe haemophilia patients. Age at first joint bleed, treatment requirement (i.e. annual clotting factor use), annual bleeding frequency and arthropathy were documented. Because treatment strategies intensified during follow-up, patients were stratified in two age groups: patients born 1968–1985 (n = 91), or 1985–2002 (n = 80). A total of 2166 patient-years of follow-up were available (median 12.0 years per patient). Age at first joint bleed ranged from 0.2 to 5.8 years. Patients who had their first joint bleed later needed less treatment and developed less arthropathy. In patients born 1968–1985 during both on-demand and prophylactic treatment, the 75th percentile of annual joint bleed frequency was consistently four times as high as the 25th percentile. In both age groups variation in annual clotting factor use between 25th and 75th percentiles was 1.4–1.5 times for prophylaxis and 3.8 times for on-demand treatment. To conclude, the onset of joint bleeding is inversely related with treatment requirement and arthropathy and may serve as an indicator of clinical phenotype. Thus, providing a starting point for aetiological research and individualization of treatment.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesFischer, K. ; Van Der Bom, J. G. ; Mauser-Bunschoten, E. P. ; Roosendaal, G. ; Prejs, R. ; Grobbee, D. E. ; Van Den Berg, H. M.
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A cohort study was performed among 214 patients with severe haemophilia, born 1944–1994, to describe changes in treatment over the last 3 decades and its effects on clotting factor consumption and haemophilic arthropathy. Data on treatment strategy, clotting factor consumption, and outcome were collected for 3567 patient years (from 1972 to 1998), and 493 Pettersson scores were analysed. Median follow up was 17 years (range 6–27 years), and median age in 1998 was 27.6 years. Since 1965, replacement therapy, prophylaxis, and home treatment have been used and treatment intensified. Over the last 3 decades, annual clotting factor consumption increased by 260%, for both prophylactic and on-demand treatment. Annual clotting factor consumption kg–1 increased during childhood and appeared to stabilize in early adulthood for patients born 1965–79, who were treated with early replacement therapy or early prophylaxis. In contrast, clotting factor consumption increased continuously for patients born before 1965, who had had no access to replacement therapy during the early years of their life. The annual number of joint bleeds decreased over the years. Arthropathy as measured by the Pettersson score generally became apparent around the age of 15 years and was lowest in patients treated with primary prophylaxis. In conclusion, clotting factor consumption has increased and haemophilic arthropathy has decreased due to the intensification of treatment for severe haemophilia over the last 3 decades. Annual clotting factor consumption stabilizes in adulthood for patients who receive early intensive treatment.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesFischer, K. ; Van der Bom, J. G. ; Molho, P. ; Negrier, C. ; Mauser-Bunschoten, E. P. ; Roosendaal, G. ; De Kleijn, P. ; Grobbee, D. E. ; Van Den Berg, H. M.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. A multicentre study was performed to compare clotting factor use and outcome between on-demand and prophylactic treatment strategies for patients with severe haemophilia. Data on treatment and outcome of 49 Dutch patients with severe haemophilia, born 1970–80, primarily treated with prophylaxis, were compared with those of 106 French patients, who were primarily treated on demand. Dutch patients received intermediate dose prophylaxis, for a median duration of 12.7 years. Patients primarily treated with prophylaxis had fewer joint bleeds per year (median 2.8 vs. 11.5), a higher proportion of patients without joint bleeds (29% vs. 9%), lower clinical scores (median 2.0 vs. 8.0), and less arthropathy as measured by the Pettersson score (median 7 points vs. 16 points). Mean annual clotting factor use was equal at 1488 ± 783 IU kg−1 year−1 (mean ± standard deviation) for patients primarily treated with prophylaxis and 1612 ± 1442 IU kg−1 year−1 for patients primarily treated on demand. These findings suggest that, compared with a primarily on-demand treatment strategy, a primarily prophylactic treatment strategy leads to better outcome at equal treatment costs in young adults with severe haemophilia.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesFischer, K. ; Astermark, J. ; Van Der Bom, J. G. ; Ljung, R. ; Berntorp, E. ; Grobbee, D. E. ; Van Den Berg, H. M.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. A multicentre study was performed in Sweden and the Netherlands, comparing effects of two prophylactic regimens in 128 patients with severe haemophilia, born 1970–90. 42 Swedish patients (high-dose prophylaxis), were compared with 86 Dutch patients (intermediate-dose prophylaxis). Patients were evaluated at the date of their last radiological score according to Pettersson. Annual clotting factor consumption and bleeding frequency were registered for a period of three years before evaluation. Patients in the high-dose group were younger at evaluation (median 15.2 vs. 17.9 years), started prophylaxis earlier (median 2 vs. 5 years), and used 2.19 times more clotting factor kg−1 year−1. Patients treated with high-dose prophylaxis had fewer joint bleeds (median 0.3 year−1 vs. 3.3 year−1) and the proportion of patients without arthropathy as measured by the Pettersson score was higher (69% vs. 32%), however, the age-adjusted difference in scores (median 0 points vs. 4 points) was small and at present not statistically significant. Clinical scores and quality of life were similar. These findings suggest that, compared with intermediate-dose prophylaxis, high-dose prophylaxis significantly increases treatment costs and reduces joint bleeds over a period of 3 years, but only slightly reduces arthropathy after 17 years of follow-up.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesFischer, K. ; Van Der Bom, J. G. ; Prejs, R. ; Mauser-Bunschoten, E. P. ; Roosendaal, G. ; Grobbee, D. E. ; Van Den Berg, H. M.
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A cohort study was performed to assess adherence to early prophylactic therapy and its effects on outcome in 49 patients with severe haemophilia born 1970–1980. Median age at start of prophylaxis was 5.5 years. The majority (69%) of patients interrupted prophylactic treatment one or more times of their own accord (median total interruption 2.2 years). Patients who discontinued prophylaxis at any point tended to have more arthropathy as measured by the Pettersson scale (median 8 points versus 4 points). One-third of these patients interrupted prophylaxis for longer periods and had permanently stopped taking prophylaxis at a mean age of 20.1 years (mean ± SD duration 4.1 ± 4 years) and consequently experienced 5.4 ± 3.4) joint bleeds per year. This subgroup could be identified by a predictive score based on age at start of prophylaxis, weekly dose of prophylaxis, and joint bleed frequency on prophylaxis. In conclusion, while on prophylaxis, more than two-thirds of patients with severe haemophilia try to discontinue treatment, resulting in slightly more arthropathy. One-third of these patients permanently discontinue prophylaxis in adulthood, while maintaining a low number of joint bleeds.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesVan Den Bosch, J. E. ; Kalkman, C. J. ; Vergouwe, Y. ; Van Klei, W. A. ; Bonsel, G. J. ; Grobbee, D. E. ; Moons, K. G. M.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We have validated two scoring systems for predicting postoperative nausea and vomiting, derived by Apfel et al. and Koivuranta et al. from 1388 adult inpatients undergoing a wide range of surgical procedures. The predictive accuracy of the scoring systems was evaluated in terms of the ability to discriminate between patients with and without postoperative nausea and vomiting (discrimination) and agreement between observed and predicted outcomes (calibration). Discrimination and calibration were less than expected based on previous reports, with both scoring systems providing risk predictions that were too extreme. The area under the ROC curve was 0.63 for Apfel et al.'s scoring system and 0.66 for Koivuranta et al.'s scoring system. Neither of the scoring systems provided a risk threshold for administering anti-emetic prophylaxis that yielded satisfying results in terms of predictive values, sensitivity and specificity. Hence, in their original forms, the scoring systems do not guarantee accurate prediction of the risk of postoperative nausea and vomiting in other patient populations. Koivuranta et al.'s scoring system appears to be more robust across different populations.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesDaele, P. L. A. ; Burger, H. ; Laet, C. E. D. H. ; Hofman, A. ; Grobbee, D. E. ; Birkenhäger, J. C. ; Pols1, H. A. P.
Springer
Published 1997Staff ViewISSN: 1433-2965Keywords: Broadband ultrasound attenuation (BUA) ; Epidemiology ; Longitudinal ; Osteoporosis ; Speed of sound (SOS) ; Stiffness ; UltrasoundSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We examined with a median follow-up of 1.4 years (range 1.0–2.0 years) the rates of change per year in ultrasound parameters of the calcaneus. Speed of sound (SOS), Broadband ultrasound attenuation (BUA) and Stiffness were measured twice in 543 subjects (224 men) participating in the Rotterdam Study. SOS fell by −2.5 m/s per year in both sexes (95% CI −4.0 to −1.1 m/s per year in men and −3.6 to −1.4 m/s per year in women). Stiffness decreased by −0.62 (−1.33 to 0.09) per year in men and −0.66 (−1.24 to −0.08) per year in women. In men the rate of change in SOS and Stiffness tended to increase with age. BUA did not change significantly during follow-up in either sex. The prospectively assessed rates of loss differed considerably from those observed cross-sectionally, especially for SOS in men (cross-sectional −0.7 m/s per year, longitudinal −2.5 m/s per year). There was substantial variation between individuals both in changes per year in SOS and in changes per year in BUA. With a median follow-up time of 1.4 years, approximately 27% of the variation in the rate of change for SOS could be explained by measurement error while for BUA this was approximately 9% and for Stiffness 11%. Only a small percentage of subjects had changes larger than could be accounted for by measurement error (SOS: men 26.8%, women 21.6%; BUA: men 28.5%, women: 38.8%; Stiffness: men 32.6%, women 35.1%). The latter may limit the use of ultrasound measurements as a follow-up tool in individuals rather than in populations.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National Licensesvan Popele, N. M. ; Westendorp, I. C. D. ; Bots, M. L. ; Reneman, R. S. ; Hoeks, A. P. G. ; Hofman, A. ; Grobbee, D. E. ; Witteman, J. C. M.
Springer
Published 2000Staff ViewISSN: 1432-0428Keywords: Keywords Insulin resistance ; arterial stiffness ; healthy subjects ; women ; population.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Aims/hypothesis. The insulin resistance syndrome is related to arterial stiffness in diabetic subjects. Whether the insulin resistance syndrome is also related to arterial stiffness in non-diabetic subjects is less clear. We studied the association between variables of the insulin resistance syndrome in relation to arterial distensibility in healthy middle-aged non-diabetic women. Methods. This study was done in 180 non-diabetic women, aged 43–55, selected from the general population. Arterial distensibility was assessed in the carotid artery. The associations were evaluated using linear regression analyses. Results. Strong associations were found between arterial distensibility and the variables of the insulin resistance syndrome: body mass index, waist-to-hip ratio, high-density-lipoprotein-cholesterol, triglycerides, glucose, insulin, apolipoprotein A1, plasminogen activator inhibitor-1-antigen and tissue-type plasminogen activator-antigen. After additional adjustment for mean arterial pressure, common carotid arterial distensibility remained associated with body mass index: β-coefficient (95 % confidence interval) per kg/m2: –0.24 (–0.42; –0.06); waist-to-hip ratio: –26.62 (–40.59; –12.65) per m/m; triglycerides: –1.42(–2.77; –0.08) per mmol/l; plasminogen activator inhibitor–1-antigen: –0.01 (–0.02; –0.00) per ng/ml and borderline significant associated with high-density-lipoprotein-cholesterol: 1.93 (–0.01; 3.87; p = 0.07) per mmol/l. Clustering of variables of the insulin resistance syndrome was strongly related to decreased arterial distensibility which remained after adjustment for mean arterial pressure. No association was found between arterial distensibility and variables that are not part of the insulin resistance syndrome: total cholesterol, LDL-cholesterol and apolipoprotein B. Conclusion/interpretation. The results of this study show that variables of the insulin resistance syndrome are associated with decreased arterial distensibility of the common carotid artery in healthy non-diabetic subjects. [Diabetologia (2000) 43: 665–672]Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National Licenses’t Hart, L. M. ; de Knijff, P. ; Dekker, J. M. ; Stolk, R. P. ; Nijpels, G. ; van der Does, F. E. E. ; Ruige, J. B. ; Grobbee, D. E. ; Heine, R. J. ; Maassen, J. A.
Springer
Published 1999Staff ViewISSN: 1432-0428Keywords: Keywords Type II diabetes ; diabetes ; genetics ; sulphonylurea receptor ; prevalence.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Aims/hypothesis. We have analysed to what extent two previously reported single nucleotide polymorphisms in the sulphonylurea receptor gene (SUR1) are associated with Type II (non-insulin-dependent) diabetes mellitus in The Netherlands. Furthermore, we estimated haplotype frequencies in control and diabetic populations, including data extracted from three other studies. Methods. Subjects with Type II diabetes (n = 388) and normoglycaemic subjects (n = 336) were randomly selected from two population-based studies, the Hoorn and Rotterdam studies. DNA was typed for variants in exon 16 (-3c→t variant in the splice acceptor site) and exon 18 (Thr759Thr, ACC→ACT). Results. The genotype frequencies in both populations were similar. We observed an association of the exon 16–3t variant with Type II diabetes (allele frequencies 0.41 % vs 0.48 % in NGT and Type II diabetes, respectively, p = 0.01). There was no association between Type II diabetes and the variant in exon 18 or the combination of both variants (p 〉 0.5). A strong linkage disequilibrium between the exon 16 and exon 18 variants was observed in the diabetic groups but not, or less pronounced, in the control groups from the different studies. Haplotype estimation shows that several different risk haplotypes exist in different Caucasian populations. Conclusion/interpretation. The exon 16–3t allele of the SUR1 gene is associated with Type II diabetes in the Netherlands. Based on estimated haplotype frequencies in different Caucasian populations we conclude that multiple haplotypes on the SUR1 gene seem to confer a risk for developing Type II diabetes in Caucasians. [Diabetologia (1999) 42: 617–620]Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesOtt, A. ; Stolk, R. P. ; Hofman, A. ; van Harskamp, F. ; Grobbee, D. E. ; Breteler, M. M. B.
Springer
Published 1996Staff ViewISSN: 1432-0428Keywords: Keywords Diabetes mellitus ; insulin treatment ; dementia ; Alzheimer's disease ; vascular dementia ; aged ; epidemiology.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam Study, a large population-based study in the elderly. Of 6330 participants, aged 55 to 99 years old, complete information on diabetes and presence of dementia was available. Diabetes was diagnosed as use of anti-diabetes medication or random or post-load serum glucose over 11 mmol/l. Dementia was diagnosed through a stepped approach, including a sensitive screening of all participants and a comprehensive diagnostic work-up. Diabetes was present in 724 (11.4 %) subjects. Of the 265 dementia patients 59 (22.3 %) had diabetes. Multiple logistic regression analyses, adjusting for age and sex differences, revealed a positive association between diabetes and dementia (odds ratio: 1.3, 95 % confidence interval: 1.0–1.9). In particular, strong associations were found between dementia and diabetes treated with insulin (odds ratio: 3.2, 95 % confidence interval: 1.4–7.5). The relation was strongest with vascular dementia, but was also observed with Alzheimer's disease. These associations were independent of educational attainment, smoking, body mass index, atherosclerosis, blood pressure and antihypertensive drug treatment, and could not be explained by clinical cerebral infarctions. The results suggest that NIDDM is associated with dementia. Alzheimer's disease may be more frequent in elderly diabetic patients treated with insulin. [Diabetologia (1996) 39: 1392–1397]Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesJie, K.-S. G. ; Bots, M. L. ; Vermeer, C. ; Witteman, J. C. M. ; Grobbee, D. E.
Springer
Published 1996Staff ViewISSN: 1432-0827Keywords: Key words: Vitamin K – Gammacarboxyglutamate — Osteocalcin — Calcification — Atherosclerosis — Bone mass.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsNotes: Abstract. Gammacarboxyglutamate (Gla) is an uncommon amino acid formed by vitamin K action. Increasing evidence indicates that Gla-proteins are involved in the regulation of calcification processes in both bone tissue and atherosclerotic vessel wall. In a population-based study we have previously shown that in a group of 113 postmenopausal women the presence of abdominal aortic calcifications is associated with a reduced vitamin K status. In the present study we investigated whether this reduced vitamin K status was also associated with differences in bone mass or circulating calciotropic hormone levels. Serum immunoreactive osteocalcin with low affinity for hydroxyapatite (irOCfree) was used as a marker for vitamin K status. After correction for age it was found that women with atherosclerotic calcifications had a 7% lower bone mass as measured by metacarpal radiogrammetry (mean difference: 3.2 mm2, 95% CI: −0.2–6.5, P= 0.06). No differences between both groups of women were observed for serum intact parathyroid hormone (PTH) and serum 25-hydroxyvitamin D levels. In the atherosclerotic women (n = 34), markers for vitamin K status were inversely associated with bone mass (r =−0.47, P= 0.013), whereas no such association was found in the nonatherosclerotic women (n = 79). It is concluded that the atherosclerotic women in this study may be at higher risk for osteoporotic fractures as evidenced by their lower bone mass and higher serum irOCfree levels. The finding that in atherosclerotic women vitamin K status is associated with bone mass supports our hypothesis that vitamin K status affects the mineralization processes in both bone and in atherosclerotic plaques.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesLawson, D. H. ; Bridgman, K. ; Bock, G. H. ; Grobbee, D. E. ; Hense, H. W. ; Block, P. ; Paterson, K. R. ; Stonier, P.
Springer
Published 1995Staff ViewISSN: 1432-1041Keywords: Postmarketing surveillance ; Ramipril ; HypertensionSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Abstract A prospective observational cohort study of the angiotensin inhibitor, ramipril, was undertaken in four countries within the European Community-Netherlands, United Kingdom, Germany and Belgium. A total of 10,377 consecutive patients with essential hypertension were recruited to the study with the aim of follow-up for one year. Overall 37% of doctors who agreed to participate in the study actually enrolled at least one patient. One third of the doctors who enrolled patients in the study entered two thirds of patients studied. Some 15% of participating males and 27% of females were aged over 70 years. Newly diagnosed hypertensives comprised 22% of the study cohort, the proportion being highest in UK and Netherlands, whereas 53% were established hypertensives of two or more years' duration, the proportion being highest in Germany and Belgium. There were substantial differences among the participating countries in the concurrent treatment these patients were receiving for hypertension, with two or more co-therapies being most frequent in Germany and Belgium. There were also substantial differences in co-therapies for concurrent diseases among the participating countries, reflecting both standard therapeutic practices in local areas and differences in marketing of drugs in the different countries. This report describes the initial findings of this multinational study and emphasises the need to consider several major potentially confounding variables in the analysis of the outcome events both in this study and in other collaborative observational international monitoring schemes for adverse drug reactions.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesOttervanger, J. P. ; Stricker, B. H. C. ; Witsen, T. B. ; Valkenburg, H. A. ; Grobbee, D. E.
Springer
Published 1994Staff ViewISSN: 1432-1041Keywords: Sumatriptan ; Migraine ; pharmacoepidemiology ; adverse reaction ; angina pectoris ; postmarketing surveillance ; general practitionerSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Abstract There are several reports on cardiac adverse reactions attributed to the antimigraine drug sumatriptan in the recent literature. In order to assess the frequency and the character of adverse reactions to sumatriptan, a postmarketing cohort study was performed one year after registration of the drug in The Netherlands. With assistance of 86% of the drug dispensing general practitioners in The Netherlands, 1727 patients who had received sumatriptan were traced in July, 1992. Via their general practitioners, a questionnaire about use of sumatriptan, adverse reactions and other medication was sent to the patients in December 1992. During the study period, seven patients were lost to follow-up. Of the 1720 remaining patients, 1202 (70%) responded to the questionnaire, of whom 1187 had actually used sumatriptan. The most frequently reported suspected adverse reactions were paraesthesiae (139 patients, 95% CI 9.9%–13.5%) and dizziness (96 patients, 95% CI 6.5%–9.7%). Chest pain after use of sumatriptan was reported by 94 patients (7.9%, 95% CI 6.4%–9.4%), and according to the close temporal relationship with the intake of sumatriptan and a positive rechallenge, a causal relationship was probable in most of those patients. The frequency of chest pain attributed to sumatriptan was higher in females (9.0% vs 4.6%; relative risk 1.9, 95% CI 1.1–3.4). Age and hypertension were not associated with chest pain attributed to sumatriptan. Dyspnoea attributed to sumatriptan was reported by 26 patients (2.2%), and was associated with obstructive lung disease (relative risk 5.4 95% CI 1.7–16.9). Thus, in view of the high frequency of chest pain after use of sumatriptan and reports in the literature of cardiac disturbances, including myocardial infarction, cautious use of the drug is advised.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesOttervanger, J. P. ; Valkenburg, H. A. ; Grobbee, D. E. ; Stricker, B. H. C.
Springer
Published 1996Staff ViewISSN: 1432-1041Keywords: Key words Sumatriptan ; Postmarketing surveillance ; Migraine; overuse ; pharmacoepidemiologySource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Abstract Objective: To investigate the frequency of use and misuse of sumatriptan, and to explore the characteristics of patients reporting overuse. Setting: A postmarketing cohort study on adverse reactions to sumatriptan, performed with the assistance of drug-dispensing general practitioners in the Netherlands. Methods: Questionnaires were sent to patients on sumatriptan of drug-dispensing general practitioners in the Netherlands. Use of sumatriptan was classified into five groups: 〈 1, 1–10, 11–20 and 21–30 times per month and a group of patients who reported daily use of sumatriptan more than 10 times per week. Patients in the latter group were regarded as “overusers”. Results: The request to the 1720 patients yielded a response rate of 1202 (70%). Of 952 (79%) of these patients, details of their sumatriptan intake were available. Most patients (718, 75%) took sumatriptan 1–10 times each month. However, 36 patients (4%, 95% CI 2.8–5.2%) took sumatriptan daily or more than 10 times each week. The group with the highest intake consisted mainly of males, and many patients who reported a poor efficacy of sumatriptan. Age was not related to use of sumatriptan. Conclusions: A small group of patients (4%) used sumatriptan too often. A high intake was associated with both male gender and a reported poor efficacy of sumatriptan, but not with age, reported adverse reactions, or headache attributed to sumatriptan. It is important to explain to patients that sumatriptan is only for the treatment of acute attacks, and not for prophylactic use. Drug consumption patterns have to be evaluated, in particular in patients who report low efficacy of sumatriptan.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesClaus, J. J. ; Breteler, M. M. B. ; Hasan, D. ; Krenning, E. P. ; Bots, M. L. ; Grobbee, D. E. ; Swieten, J. C. ; Harskamp, F. ; Hofman, A.
Springer
Published 1996Staff ViewISSN: 1619-7089Keywords: Vascular risk factors ; Atherosclerosis ; Cerebral white matter lesions ; Cerebral blood flow ; Elderly populationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We studied risk factors for cerebral vascular disease (blood pressure and hypertension, factor VIIc, factor VIIIc, fibrinogen), indicators of atherosclerosis (intima-media thickness and plaques in the carotid artery) and cerebral white matter lesions in relation to regional cerebral blood flow (rCBF) in 60 persons (aged 65–85 years) recruited from a population-based study. rCBF was assessed with single-photon emission tomography using technetium-99md,l-hexamethylpropylene amine oxime (99mTc-HMPAO). Statistical analysis was performed with multiple linear regression with adjustment for age, sex and ventricle-to-brain ratio. A significant positive association was found between systolic and diastolic blood pressure and temporo-parietal rCBF. In analysis with quartiles of the distribution, we found a threshold effect for the relation of low diastolic blood pressure (≤60 mmHg) and low temporo-parietal rCBF. Levels of plasma fibrinogen were inversely related to parietal rCBF, with a threshold effect of high fibrinogen levels (〉3.2 g/1) and low rCBF. Increased atherosclerosis was related to low rCBF in all cortical regions, but these associations were not significant. No consistent relation was observed between severity of cerebral white matter lesions and rCBF. Our results may have implications for blood pressure control in the elderly population.Type of Medium: Electronic ResourceURL: