Search Results - (Author, Cooperation:D. Coppola)

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  1. 1
    Staff View
    Publication Date:
    2018-02-09
    Publisher:
    BMJ Publishing Group
    Print ISSN:
    0017-5749
    Electronic ISSN:
    1468-3288
    Topics:
    Medicine
    Published by:
    http://www.bmj.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Q. Fu ; C. Posth ; M. Hajdinjak ; M. Petr ; S. Mallick ; D. Fernandes ; A. Furtwangler ; W. Haak ; M. Meyer ; A. Mittnik ; B. Nickel ; A. Peltzer ; N. Rohland ; V. Slon ; S. Talamo ; I. Lazaridis ; M. Lipson ; I. Mathieson ; S. Schiffels ; P. Skoglund ; A. P. Derevianko ; N. Drozdov ; V. Slavinsky ; A. Tsybankov ; R. G. Cremonesi ; F. Mallegni ; B. Gely ; E. Vacca ; M. R. Morales ; L. G. Straus ; C. Neugebauer-Maresch ; M. Teschler-Nicola ; S. Constantin ; O. T. Moldovan ; S. Benazzi ; M. Peresani ; D. Coppola ; M. Lari ; S. Ricci ; A. Ronchitelli ; F. Valentin ; C. Thevenet ; K. Wehrberger ; D. Grigorescu ; H. Rougier ; I. Crevecoeur ; D. Flas ; P. Semal ; M. A. Mannino ; C. Cupillard ; H. Bocherens ; N. J. Conard ; K. Harvati ; V. Moiseyev ; D. G. Drucker ; J. Svoboda ; M. P. Richards ; D. Caramelli ; R. Pinhasi ; J. Kelso ; N. Patterson ; J. Krause ; S. Paabo ; D. Reich
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-05-03
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Murthy, S. ; Murthy, N. S. ; Coppola, D. ; Wood, D. L.
    Springer
    Published 1997
    Staff View
    ISSN:
    1420-908X
    Keywords:
    Key words: 5-lipoxygenase inhibition — Five lipoxygenase activating protein (FLAP) — Dextran sulfate — Experimental colitis — Leukotriene B4— Inflammatory bowel disease
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract. Objective and Design: There is crucial evidence that leukotrienes are significant mediators of inflammation in inflammatory bowel diseases (IBD). Thus, selective inhibition of leukotriene synthesis is believed to provide a novel approach to therapy of IBD. The aim of the study is to study the efficacy of a potent 5-lipoxygenase activating protein inhibitor (FLAP), BAY y 1015 in a dextran sulfate model of mouse colitis.¶Material: Outbred female mice weighing approximately 25 grams were used to produce acute or chronic colitis by feeding 5% dextran sulfate in drinking water.¶Treatment: Colitic mice were treated with placebo (3% starch suspension, 0.1 ml. p.o., bid) or BAY y 1015 at 8 or 24 mg/kg, p.o., bid or olsalazine, 150 mg/kg/day, p.o.¶Methods: Efficacy was determined by measuring daily disease activity index (DAI), quantitative histological scores, qualitative histology and measurement of tissue myeloperoxidase (MPO) and leukotriene B4 (LTB4) levels.¶Results: BAY y 1015 was significantly more effective in improving the qualitative histology, inhibiting the DAI, inflammation scores (37–79%), crypt scores (28–71%), MPO (49–57%) and LTB4 levels (56–63%) compared to placebo treatment at all levels of colitis. The two doses of BAY y 1015 were equipotent in decreasing TLB4 levels. BAY y 1015 was significantly better than olsalazine in two of the three protocols used in this study. In the advanced disease level both doses of BAY y 1015 were equipotent in inhibiting crypt and (28–32%) inflammation scores (34–36%), LTB4 (34–56%) and MPO 41–49%) compared to olsalazine.¶Conclusion: This study suggests the possibility of investigating the use of this compound for the treatment of human inflammatory bowel diseases.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s000110050177

    Articles: DFG German National Licenses
  4. 4
    Kocab, M.A. ; Coppola, D. ; Hiotis, S. ; Karl, R.C. ; Barthel, J.S.
    Springer
    Published 2000
    Staff View
    ISSN:
    1432-2218
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004640020082

    Articles: DFG German National Licenses