Search Results - (Author, Cooperation:D. Clever)
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1Latest Papers from Table of Contents or Articles in PressR. Roychoudhuri ; K. Hirahara ; K. Mousavi ; D. Clever ; C. A. Klebanoff ; M. Bonelli ; G. Sciume ; H. Zare ; G. Vahedi ; B. Dema ; Z. Yu ; H. Liu ; H. Takahashi ; M. Rao ; P. Muranski ; J. G. Crompton ; G. Punkosdy ; D. Bedognetti ; E. Wang ; V. Hoffmann ; J. Rivera ; F. M. Marincola ; A. Nakamura ; V. Sartorelli ; Y. Kanno ; L. Gattinoni ; A. Muto ; K. Igarashi ; J. J. O'Shea ; N. P. Restifo
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-06-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autoimmunity/immunology ; Basic-Leucine Zipper Transcription Factors/deficiency/genetics/*metabolism ; CD4-Positive T-Lymphocytes/cytology/immunology/metabolism ; Cell Differentiation/genetics/immunology ; Female ; Forkhead Transcription Factors/genetics/metabolism ; Homeostasis/genetics/*immunology ; Humans ; Immune Tolerance/genetics/immunology ; Inflammation/genetics/immunology/mortality/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; T-Lymphocytes, Regulatory/cytology/drug effects/*immunology/metabolism ; Transforming Growth Factor beta/pharmacologyPublished by: -
2Articles: DFG German National LicensesNair, X. ; Nettleton, D. ; Clever, D. ; Tramposch, K. M. ; Ghosh, S. ; Franson, R. C.
Springer
Published 1993Staff ViewISSN: 1573-2576Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract A predictive animal model of skin inflammation is needed for the development of potential therapeutic agents. The existing models of inflammation rely on animals whose skin physiology or biochemistry differs significantly from human. The objective of this investigation was to evaluate the swine as a potential model of inflammation, because its skin has been recognized to exhibit morphologic and functional similarities to human skin. In the swine, an inflammatory response was produced following intradermal injection of snake venom phospholipase A2 (PLA2). This response was characterized by transient erythema (2–3 h) and microscopic changes of cell infiltration, epidermal hyperplasia, and dermal damage, which were apparent two days after PLA2 and peaked by day 7. In general, these microscopic changes persisted up to 21 days. Treatment with the antiinflammatory steroid, betamethasone dipropionate (Diprolene), gave a significant reduction of the inflammatory responses. Heat-inactivated PLA2, ovalbumin, or saline did not provoke this reaction, although PLA2 inactivated by bromophenacyl bromide alkylation did produce an inflammatory response. The alkylated PLA2 was also able to provoke an inflammatory response in the mouse paw edema assay. These results demonstrate that PLA2 can stimulate an inflammatory response in the swine skin, but that phospholipid hydrolytic activity is not required.Type of Medium: Electronic ResourceURL: