Search Results - (Author, Cooperation:D. A. Mitchell)

2015-03-13

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Antigens, Neoplasm/immunology ; CD4-Positive T-Lymphocytes/drug effects/immunology ; Cancer Vaccines/administration & dosage/*immunology/therapeutic use ; Cell Movement/drug effects ; Chemokine CCL3/*immunology ; Dendritic Cells/cytology/*drug effects/immunology ; Female ; Glioblastoma/drug therapy/*immunology/pathology/*therapy ; Humans ; Immunotherapy/methods ; Lymph Nodes/cytology/drug effects/immunology ; Mice ; Mice, Inbred C57BL ; Phosphoproteins/chemistry/genetics/immunology ; Substrate Specificity ; Survival Rate ; Tetanus Toxoid/*administration & dosage/*pharmacology/therapeutic use ; Treatment Outcome ; Viral Matrix Proteins/chemistry/genetics/immunology

2018-08-16

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

1469-8986

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Psychology

In many cases where SCR half-recovery time cannot be measured because of post-peak activity, quarter-recovery time is measurable. Prediction of half from quarter recovery times is examined and the calculation of loge t/2 values for loge t/4 values is recommended.

Electronic Resource

1469-7610

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Psychology

Summary Data from Rutter's ‘Children's Behaviour’ questionnaire derived from the use of the scale in a developing country suggest that its factor structure is stable over sex and over racial groups. However, when analysis is undertaken on potentially pathological groups, then a more differentiated factor structure is apparent.

Electronic Resource

1600-051X

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Abstract The increasing awareness of the role of obligate anaerobic bacteria in the aetiology of oral disease has led to an interest in their chemotherapeutic control. Many drugs are capable of eliminating anaerobes but in instances where these bacteria are acting as sole or major pathogens it is desirable to remove these specifically. The nitroimidazole group of drugs is specifically anti-anaerobic in nature and includes metronidazole, nimorazole and tinidazole. This paper reviews the literature on metronidazole. This drug is absorbed well from the gastrointestinal tract and can be detected at batericidal levels in blood and saliva within 1 h of ingestion. The mode of action of metronidazole is unknown but thought to concern intracellular reduction of the molecule. The drug acts specifically against anaerobes and does not disturb the commensal aerobic flora; resistance very rarely develops. The dosage recommended for use in dentistry would appear to be very safe. Metronidazole has important interactions with alcohol, disulfiram and warfarin and there are containdications to its use. Metronidazole has been proved to be efficacious in treating: acute ulcerative gingivitis may infections, some cases of osteomyelitis and infected socket. The drug may be of use in cases of chronic progressive periodontitis where anaerobes are implicated as pathogens.

Electronic Resource

1573-6776

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary Metal ions and cassava extracts stimulated growth ofRhizopus oligosporus on a model solid substrate. A large improvement in protein content was obtained by simultaneously increasing the nitrogen content and decreasing the particle size of the substrate. No improvement occurred when these conditions were applied to cassava, however, because of the sticky consistency of the cassava after gelatinization.

Electronic Resource

1573-6784

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary A model solid substrate was developed, consisting of cassava starch and other nutrients embedded in kappa-carrageenan. A suitable fermentation system and analytical techniques were also developed to cope with the constraints imposed by solid-state fermentation.

Electronic Resource

1573-6784

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary Membrane filters overlaid on slabs of a model solid substrate enabled recovery of biomass ofRhizopus oligosporus. Although the presence of the membrane filter affects the growth ofRhizopus oligosporus it provides a useful tool for studying solid-state fermentation.

Electronic Resource

1573-0972

Springer Online Journal Archives 1860-2000

Biology

Process Engineering, Biotechnology, Nutrition Technology

Abstract Protein enrichment of sago starch of three different diameters was investigated both in flask culture and under forced aeration in a packed-bed fermenter using two strains of Rhizopus. Protein production by R. oligosporus UQM 145F was superior to Rhizopus sp. UQM 186F in the flask culture without aeration, with both preferring larger diameter (3 to 4 mm) spherical sago-beads. In the packed-bed fermenter with forced aeration, Rhizopus sp. UQM 186F led to more rapid protein production compared to R. ollgosporus UQM 145F and produced equivalent final yields (about 10% protein on a dry wt basis).

Electronic Resource

1573-6776

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary A standing column packed bed bioreactor was constructed to enable packed bed operation during solid-state cultivation (SSC) of sago starch byR. oligosporus UQM 145F, to be followed byin situ drying of the microbial product. The essential amino acid composition of the microbial product was determined from the samples obtained from the cultivation with a substrate loading of 250g.

Electronic Resource

1573-6776

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary A model substrate consisting of cassava starch embedded in kappa-carrageenan was used to mimic the growth ofRhizopus oligosporus on cassava tubers. Growth on the model substrate was similar to that during solid-state fermentation of the actual cassava. However, protein production and starch utilization were slower on the model substrate.

Electronic Resource

1573-6784

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary Membrane filter culture was used as a model system for the investigation of the growth of Rhizopus oligosporus in solid-state fermentation. The biuret method gave more accurate estimations of protein than the Folin-Lowry method. However, due to the change in the protein content of the biomass during the fermentation, protein cannot be considered to be a reliable index of growth in solid-state fermentation.

Electronic Resource

1573-6784

Springer Online Journal Archives 1860-2000

Process Engineering, Biotechnology, Nutrition Technology

Summary A simple method using non-linear regression is developed to analyse experimental data from plasmid stability studies of recombinantSaccharomyces cerevisiae grown in continuous cultures with non-selective and selective media. This method simultaneously provides quantitative information on the probability of plasmid loss due to segregation during cell division and the specific growth rates of plasmid-containing and plasmid-free cells at particular dilution rates. The method is applied to a set of experimental data. The three-parameter model, together with the estimated parameter values, provides a good fit to the experimental data.

Electronic Resource

1573-0972

Protease ; Rhizopus ; solid-state fermentation

Springer Online Journal Archives 1860-2000

Biology

Process Engineering, Biotechnology, Nutrition Technology

Abstract Rice bran was superior to other proteinaceous substrates for protease production by Rhizopus oligosporus ACM 145F in solid-state fermentation. Maximum protease yield was after 72 h. The optimal initial moisture content was 47% (a w=0.97). Dried, ground and resuspended fermented rice was the most pratical and effective inoculum preparation, although, in the laboratory, spore suspensions prepared directly from agar slants were more convenient. Inoculum density (from 102 to 107 spores/g substrate) and age (3, 5, 7 and 9 days) had little effect on protease yield.

Electronic Resource

1573-0972

Springer Online Journal Archives 1860-2000

Biology

Process Engineering, Biotechnology, Nutrition Technology

Abstract The growth ofRhizopus oligosporus on a model solid substrate consisting of cassava starch and other nutrients embedded in a kappa-carrageenan matrix was followed microscoplcally. There were two distinct growth phases: (1) germination of spores and development of mycellum to form a loose network over the whole substrate surface; (2) increase in the density of the mycellum. Although some penetrative hyphae were produced, the biomass was malnly restricted to the surface. Consequently, starch utilization was greatest near the surface. Based on these observations a descriptive model for the growth ofRhizopus ollgosporus on the model substrate was proposed. The five steps are: (1) release of glucoamylase by the mycelium; (2) diffusion of the glucoamylase to the starch; (3) hydrolysis of the starch by the glucoamylase, releasing glucose; (4) diffusion of glucose; (5) absorption of glucose by the mycellum at the surface to produce new blomass.

Electronic Resource

0897-3806

levator ani muscle ; nerve supply ; puborectalis component ; Life and Medical Sciences ; Miscellaneous Medical

Wiley InterScience Backfile Collection 1832-2000

Medicine

This study of 50 embalmed and 4 unembalmed cadavers was undertaken to try to better understand the rationale for the varied descriptions of the levator ani muscle and its components. Our findings are in harmony with those which have determined M. puborectalis to be the caudal component of the levator ani and to have superior and inferior laminae. The inferior lamina contributes significantly to the mass of the puborectalis, forming the major part of its so-called sling component that angulates the anorectal junction. The more superficial of the anterior fibers of both the M. pubococcygeus and M. puborectalis insert prerectally and contribute to what is called M. levator prostatae (pubovaginalis). Their fused borders bound the levator (urogenital) hiatus. The deeper fibers insert into the posterolateral wall of the vagina in the female. Both M. pubococcygeus and M. puborectalis also insert between the Ms. sphincter ani externus and internus, and both contribute to the postanal levator plate. The nerve supply of M. puborectalis is from the nerve to the levator ani (S 3,4) on its superior aspect, but it frequently receives an auxiliary supply from the inferior rectal and perineal branches of the pudendal nerve on its inferior aspect. The surgical significance of M. levator ani is commented on.

7 Ill.

Electronic Resource