Search Results - (Author, Cooperation:Colmers)

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  1. 1
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Neuropeptide Y (NPY) potently inhibits glutamate release and seizure activity in rodent hippocampus in vitro and in vivo, but the nature of the receptor(s) mediating this action is controversial. In hippocampal slices from rats and several wild-type mice, a Y2-preferring agonist mimicked, and the Y2-specific antagonist BIIE0246 blocked, the NPY-mediated inhibition both of glutamatergic transmission and of epileptiform discharges in two different slice models of temporal lobe epilepsy, stimulus train-induced bursting (STIB) and 0-Mg2+ bursting. Whereas Y5 receptor-preferring agonists had small but significant effects in vitro, they were blocked by BIIE0246, and a Y5 receptor-specific antagonist did not affect responses to any agonist tested in any preparation. In slices from 〈inlineGraphic alt="inline image" href="urn:x-wiley:0953816X:EJN4338:EJN_4338_mu1" location="equation/EJN_4338_mu1.gif"/〉 mice, NPY was without effect on evoked potentials or in either of the two slice seizure models. In vivo, intrahippocampal injections of Y2- or Y5-preferring agonists inhibited seizures caused by intrahippocampal kainate, but again the Y5 agonist effects were insensitive to a Y5 antagonist. Neither Y2- nor Y5-preferring agonists affected kainate seizures in 〈inlineGraphic alt="inline image" href="urn:x-wiley:0953816X:EJN4338:EJN_4338_mu2" location="equation/EJN_4338_mu2.gif"/〉 mice. A Y5-specific antagonist did not displace the binding of two different NPY ligands in WT or 〈inlineGraphic alt="inline image" href="urn:x-wiley:0953816X:EJN4338:EJN_4338_mu3" location="equation/EJN_4338_mu3.gif"/〉 mice, whereas all NPY binding was eliminated in the 〈inlineGraphic alt="inline image" href="urn:x-wiley:0953816X:EJN4338:EJN_4338_mu4" location="equation/EJN_4338_mu4.gif"/〉 mouse. Thus, we show that Y2 receptors alone mediate all the anti-excitatory actions of NPY seen in the hippocampus, whereas our findings do not support a role for Y5 receptors either in vitro or in vivo. The results suggest that agonists targeting the Y2 receptor may be useful anticonvulsants.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  2. 2
    COLMERS, WILLIAM F.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  3. 3
    KLAPSTEIN, G. J. ; TREHERNE, K. A. ; COLMERS, W. F.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
  7. 7
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Mäckel, H. G. ; Foerster ; Reich ; Meixner ; Colmers ; Armuzzi, G. ; Monacelli ; Roscher
    Springer
    Published 1930
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses