Search Results - (Author, Cooperation:C. Yee)
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1Zou, L., Stecula, A., Gupta, A., Prasad, B., Chien, H.-C., Yee, S. W., Wang, L., Unadkat, J. D., Stahl, S. H., Fenner, K. S., Giacomini, K. M.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-06-02Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0026-895XElectronic ISSN: 1521-0111Topics: Chemistry and PharmacologyMedicinePublished by: -
2Michael D. Glidden, Khadijah Aldabbagh, Nelson B. Phillips, Kelley Carr, Yen-Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P. Wickramasinghe, Nischay Rege, Mamuni Swain, Yi Peng, Yanwu Yang, Michael C. Lawrence, Vivien C. Yee, Faramarz Ismail-Beigi, Michael A. Weiss
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-01-06Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
3K. G. Paulson; V. Voillet; M. S. McAfee; D. S. Hunter; F. D. Wagener; M. Perdicchio; W. J. Valente; S. J. Koelle; C. D. Church; N. Vandeven; H. Thomas; A. G. Colunga; J. G. Iyer; C. Yee; R. Kulikauskas; D. M. Koelle; R. H. Pierce; J. H. Bielas; P. D. Greenberg; S. Bhatia; R. Gottardo; P. Nghiem; A. G. Chapuis
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-09-25Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
4Nischay K. Rege, Nalinda P. Wickramasinghe, Alisar N. Tustan, Nelson F. B. Phillips, Vivien C. Yee, Faramarz Ismail-Beigi, Michael A. Weiss
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-07-14Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
5A. Gould ; A. Udalski ; I. G. Shin ; I. Porritt ; J. Skowron ; C. Han ; J. C. Yee ; S. Kozlowski ; J. Y. Choi ; R. Poleski ; L. Wyrzykowski ; K. Ulaczyk ; P. Pietrukowicz ; P. Mroz ; M. K. Szymanski ; M. Kubiak ; I. Soszynski ; G. Pietrzynski ; B. S. Gaudi ; G. W. Christie ; J. Drummond ; J. McCormick ; T. Natusch ; H. Ngan ; T. G. Tan ; M. Albrow ; D. L. DePoy ; K. H. Hwang ; Y. K. Jung ; C. U. Lee ; H. Park ; R. W. Pogge ; F. Abe ; D. P. Bennett ; I. A. Bond ; C. S. Botzler ; M. Freeman ; A. Fukui ; D. Fukunaga ; Y. Itow ; N. Koshimoto ; P. Larsen ; C. H. Ling ; K. Masuda ; Y. Matsubara ; Y. Muraki ; S. Namba ; K. Ohnishi ; L. Philpott ; N. J. Rattenbury ; T. Saito ; D. J. Sullivan ; T. Sumi ; D. Suzuki ; P. J. Tristram ; N. Tsurumi ; K. Wada ; N. Yamai ; P. C. Yock ; A. Yonehara ; Y. Shvartzvald ; D. Maoz ; S. Kaspi ; M. Friedmann
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
6E. E. Kenny ; N. J. Timpson ; M. Sikora ; M. C. Yee ; A. Moreno-Estrada ; C. Eng ; S. Huntsman ; E. G. Burchard ; M. Stoneking ; C. D. Bustamante ; S. Myles
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-05-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Substitution ; Gene Frequency ; Genes, Recessive ; Genome-Wide Association Study ; Genotype ; Hair Color/*genetics ; Humans ; Melanesia ; Membrane Glycoproteins/*genetics/metabolism ; *Mutation, Missense ; Oxidoreductases/*genetics/metabolism ; Polymorphism, Single NucleotidePublished by: -
7G. D. Poznik ; B. M. Henn ; M. C. Yee ; E. Sliwerska ; G. M. Euskirchen ; A. A. Lin ; M. Snyder ; L. Quintana-Murci ; J. M. Kidd ; P. A. Underhill ; C. D. Bustamante
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-08-03Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: African Continental Ancestry Group/genetics ; Chromosomes, Human, Y/*classification/*genetics ; Evolution, Molecular ; Female ; *Genetic Variation ; Genome, Mitochondrial/genetics ; Haploidy ; Humans ; Male ; Mutation ; Phylogeny ; Sequence Analysis, DNA ; Time FactorsPublished by: -
8A. C. Vitari ; K. G. Leong ; K. Newton ; C. Yee ; K. O'Rourke ; J. Liu ; L. Phu ; R. Vij ; R. Ferrando ; S. S. Couto ; S. Mohan ; A. Pandita ; J. A. Hongo ; D. Arnott ; I. E. Wertz ; W. Q. Gao ; D. M. French ; V. M. Dixit
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-05-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Motifs ; Animals ; Carrier Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic ; DNA-Binding Proteins/genetics/metabolism ; Humans ; Male ; Mice ; Nuclear Proteins/deficiency/*metabolism ; PTEN Phosphohydrolase/deficiency ; Prostatic Neoplasms/metabolism/pathology ; Protein Binding ; Proto-Oncogene Proteins c-ets/*metabolism ; Transcription Factors/genetics/metabolism ; Tumor Suppressor Proteins/*metabolism ; Ubiquitin-Protein Ligases/deficiency/genetics/*metabolism ; UbiquitinationPublished by: -
9Staff View
Type of Medium: bookPublication Date: 1988Keywords: Künstliche Intelligenz ; Lernen ; Evolutionstheorie ; Mathematisches Modell ; Neurologie ; PhysiologieLanguage: English -
10Rowe, J. H., Delmonte, O. M., Keles, S., Stadinski, B. D., Dobbs, A. K., Henderson, L. A., Yamazaki, Y., Allende, L. M., Bonilla, F. A., Gonzalez-Granado, L. I., Celikbilek Celik, S., Guner, S. N., Kapakli, H., Yee, C., Pai, S.-Y., Huseby, E. S., Reisli, I., Regueiro, J. R., Notarangelo, L. D.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-05-25Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Immunobiology and ImmunotherapyPublished by: -
11Staff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The clustering and percolation of particles in binary mixtures of randomly centered spheres are examined based on a selective particle connectivity criterion in which only particles of different species are allowed to form directly connected bonds. This problem is different from the usually studied "simple'' percolation problem in which pairs of particles form directly connected bonds as long as they are separated by a distance σ or less. The percolation threshold and pair-connectedness function of the binary mixture are determined based on the connectivity Ornstein–Zernike integral equation in the Percus–Yevick (PY) approximation. It is shown that, within the PY closure, the present system can be mapped into the Widom–Rowlinson model in the theory of liquid state. The percolation thresholds and the pair–connectedness functions of the particles are numerically computed for a wide range of particle densities and number fractions. It is found that their percolation densities differ considerably from those found in the simple percolation problem for a binary mixture of randomly centered spheres. To our knowledge, this is the first study of selective particle clustering and percolation in multicomponent mixtures of particles.Type of Medium: Electronic ResourceURL: -
12Fanti, Lisa A. ; Glandt, Eduardo D. ; Chiew, Yee C.
College Park, Md. : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The complete description of a homogeneous, multiphase dispersion is contained within the infinite set of n-body density distribution functions g(rn) which have been used to calculate macroscopic properties such as interfacial area and specific volume. Certain quantities of interest, however, must take the connectedness of the individual phases into account. This requires the introduction of a complete set of n-body connectedness functions g+n(rn). Until now, only the pair-connectedness function g+2(r2) has been computed. Here, a formalism for the estimation of higher-order connectedness functions from lower order ones is presented. Results are given for the average volume and interfacial area per cluster for a dispersion of randomly placed spheres.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The intermolecular site–site correlation function gij(r) of freely jointed athermal tangent hard-sphere chains (HSC) are determined based on a particle–particle description of the chain system. We developed a mathematical framework through which the functions gij(r) can be obtained within the context of the Percus–Yevick (PY) integral equation theory. The computational scheme involves the analytic solution to the structure of a multicomponent particle mixture that is subject to some specified connectivity constraints. In particular, we determined the site–site correlation functions gij(r) of homonuclear 4-mer chains, and homonuclear 4-mer chains in a hard-sphere solvent. Analytic expressions for the site–site and site–solvent correlation functions at contact, i.e., gij(σ+), are obtained. Site–site correlation functions determined from the PY theory show the "correlation hole'' behavior at low density. Comparison of the PY results with computer simulation data shows that the theory yields accurate values for an averaged "total'' correlation function, and captures the essential features of the site–site correlation functions gij(r). In addition the effect of hard-sphere solvent particles on the structure of HSC molecules is also investigated.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The connectivity and percolation behavior of a system of one-component randomly centered spheres is studied based on a new approximation scheme which goes beyond the Percus–Yevick closure. This new closure corrects the Percus–Yevick direct-connectedness function. The percolation density determined from this approximation agrees with the simulation result to within 4% (compared with a 43% deviation in the Percus–Yevick approximation). Good agreement for the pair-connectedness function is also obtained.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The percolation and clustering behaviors of a system of one-component attractive square-well hard-core fluid are studied through Monte Carlo simulation. The percolation densities of the square-well particles at different temperatures are determined for particles of different well widths. Comparison of the Monte Carlo data with the Percus–Yevick solution is made. The Percus–Yevick approximation is found to yield fairly good estimates of the percolation threshold except at low temperatures and high densities. The pair-connectedness functions at different temperatures and particle densities are also obtained. A new conditional probability of particle connectedness is defined and determined from this Monte Carlo study.Type of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The steady state diffusion-controlled reaction or trapping rate k2 in binary mixtures of impenetrable, nonoverlapping static sinks or traps are determined through random-walk simulations. The simulations are carried out using the first passage time technique. Exact values of the reaction rate k2 are obtained as a function of the total sink volume fraction φ, sink size ratio β, and sink number fraction xA. The reaction rate k2 is found to increase with increasing surface area of the sinks. Specifically, for dispersions at low volume fraction φ and small values of β, we observe from our data that the ratio of the reaction rate in a binary sink dispersion to that of the monodisperse system is directly proportional to the square of the ratio of the specific surface areas of the two systems. In addition, it is found that the quantity l=〈R3〉/〈R2〉 serves as an appropriate scaling parameter for the reaction rate k2.Type of Medium: Electronic ResourceURL: -
17Zheng, Li Hua ; Chiew, Yee C.
College Park, Md. : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The diffusion-controlled reaction rate of dispersions of overlapping (fully penetrable) and nonoverlapping static sinks are determined through computer simulations. The diffusive or random-walk motions of the solutes are simulated in continuum space based on the first passage time probability distribution. This method yields accurate results for the reduced diffusion-controlled reaction rate k/ks where ks represents the dilute concentration Smoluchowski limit. Values of k/ks over a wide range of sink concentrations are obtained. These "exact'' data are compared with a number of approximate theories. The merits and the regimes of validity of these theories are determined.Type of Medium: Electronic ResourceURL: -
18Lipp, Michael M. ; Lee, Ka Yee C. ; Zasadzinski, Joseph A.
[S.l.] : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: We describe an integrated fluorescence, polarized fluorescence, and Brewster angle microscope/Langmuir trough assembly. This apparatus was specifically designed for the study of lung surfactant (LS) monolayers, and is well suited for the study of other lipid/protein monolayer systems. The apparatus can be operated simultaneously in both the fluorescence and Brewster angle modes under a wide range of conditions, including physiological subphases and temperatures. The combination of information obtained from these microscopy techniques facilitates the identification of the composition of coexisting phases, allows us to systematically study the effects of specific proteins on lipid monolayers, and eliminates possible artifacts inherent to fluorescence. To demonstrate this system we present images of mixed monolayers of the anionic and unsaturated lipid components of LS and show that synergistic interactions between certain LS proteins and these lipids hold the key to the proper functioning of LS monolayers. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
19Li, Xiao-Jian ; Chiew, Yee C.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Thermodynamical properties of "infinitely stiff'' freely jointed Lennard-Jones chains are obtained through Monte Carlo simulation technique in the canonical (NVT) ensemble. A force-bias sampling scheme is used in the simulation. The compressibility factor, energy, and constant-volume heat capacity of 8-, 16-, and 32-mer Lennard-Jones chains over wide ranges of densities and temperatures are obtained. It is known that the virial pressure of infinitely stiff freely jointed Lennard-Jones chains depends on two- and three-body correlations between segments. We determine, for the first time, these two contributions to the virial pressure of Lennard-Jones chains, and found that their relative magnitudes are comparable with each other. While the three-body term remains positive for all temperatures and densities examined, the two-body term adopts negative values at low temperatures and densities and positive values at high temperatures and densities. Our simulation results reveal the importance of three-body intrachain correlations that arise from chain connectivity and provide a quantitative basis for the assessment and development of theories for chain fluids.Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The effective conductivity σe of a dispersion of long, parallel cylinders (or two-dimensional systems), distributed in a second continuous matrix phase, is determined as a function of its microscopic structure. We obtained an expression for the effective conductivity of two-dimensional systems (based on an approximate scheme) that includes the one-body and two-body terms in the cluster expansion for σe. The effective conductivities of two-dimensional hard disks and square-well particles are computed. It is found that this expression yields excellent estimates for the effective conductivity over a wide range of cylinder volume fractions, and for cases in which the cylinder to matrix phase conductivity ratios are high.Type of Medium: Electronic ResourceURL: