Search Results - (Author, Cooperation:C. Wirbelauer)

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  1. 1
    T. Baubec ; D. F. Colombo ; C. Wirbelauer ; J. Schmidt ; L. Burger ; A. R. Krebs ; A. Akalin ; D. Schubeler
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-01-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Line ; Chromatin/chemistry/genetics/metabolism ; CpG Islands/genetics ; DNA (Cytosine-5-)-Methyltransferase/chemistry/*metabolism ; DNA Methylation/*genetics ; Embryonic Stem Cells/enzymology/metabolism ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic/*genetics ; Genome/*genetics ; Genomics ; Histone-Lysine N-Methyltransferase/deficiency/genetics/metabolism ; Histones/chemistry/metabolism ; Lysine/metabolism ; Mice ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Structure, Tertiary ; Protein Transport ; Transcription, Genetic/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2011-12-16
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Differentiation ; CpG Islands ; Cytosine/*metabolism ; *DNA Methylation ; DNA-Binding Proteins/*metabolism ; Embryonic Stem Cells/cytology ; *Epigenomics ; Mice ; Neurons/cytology ; Promoter Regions, Genetic/genetics ; Protein Binding ; Stem Cells/cytology ; Transcription Factors/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1435-702X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  · Background: The purpose of this prospective, controlled, clinical study was to investigate corneal shape changes due to pars plana vitrectomy (PPV) in patients with potential visual improvement postoperatively. · Methods: A total of 36 consecutive patients undergoing conventional PPV combined with or without macular surgery were studied. Sequential determinations of the corneal curvature by manual keratometry and corneal topography were performed preoperatively, during the first postoperative week, at 4 weeks and after 2–8 months (mean 4 months). · Results: The mean surgically induced keratometric astigmatism was 2.92±1.98 diopters (D) (P〈0.0001) during the first postoperative week. After 4 weeks and 4 months the values decreased to 1.01±0.97 D and 0.67±0.43 D, respectively. Videokeratographic analysis confirmed significant curvature changes, with corneal steepening (P〈0.008) which corresponded to the superonasal and temporal semimeridian, and flattening (P〈0.008) along the inferior and inferonasal semimeridians. Corneal changes persisted in some cases for several weeks, partly in an asymmetric and irregular configuration. Shifts in axis to against-the-rule and oblique meridians were noted postoperatively with redistribution within preoperative values in 53% of the cases at 4 weeks after surgery. Subgroup analysis revealed that suture diameter, as well as the use of gas endotamponade, influenced the induced astigmatism. · Conclusion: A substantial increase of the corneal astigmatism and distinct shape changes can occur after PPV in the immediate postoperative period. Consecutive stabilization at preoperative values was observed after several weeks. The time course of the corneal curvature alterations should be considered in the postoperative management to detect refractive causes of inadequate visual acuity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004170050166

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1435-702X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  · Purpose: To evaluate the diagnostic potential of a slit-lamp-adapted optical coherence tomography (OCT) system as an in vivo imaging device for routine clinical examination of the anterior segment of the eye. · Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a slit-lamp-adapted OCT system using 100–200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue. · Results: The slit-lamp-adapted OCT system allowed direct biomicroscopic imaging of the measured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epithelium could be visualized with high accuracy. Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possible. Complete demonstration of the chamber angle was difficult due to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris. · Conclusions: Slit-lamp-adapted OCT is a useful diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular structures.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004170050002

    Articles: DFG German National Licenses