Search Results - (Author, Cooperation:C. Winkler)

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  1. 1
    S. DebRoy ; M. Gebbie ; A. Ramesh ; J. R. Goodson ; M. R. Cruz ; A. van Hoof ; W. C. Winkler ; D. A. Garsin
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-08-26
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Base Sequence ; Cobamides/*metabolism ; Enterococcus faecalis/*genetics/metabolism ; Ethanolamine/*metabolism ; *Gene Expression Regulation, Bacterial ; Molecular Sequence Data ; Nucleic Acid Conformation ; RNA, Messenger/chemistry/genetics/*metabolism ; *Response Elements ; Riboswitch/genetics/*physiology ; *Transcription, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    P. H. Sudmant ; S. Mallick ; B. J. Nelson ; F. Hormozdiari ; N. Krumm ; J. Huddleston ; B. P. Coe ; C. Baker ; S. Nordenfelt ; M. Bamshad ; L. B. Jorde ; O. L. Posukh ; H. Sahakyan ; W. S. Watkins ; L. Yepiskoposyan ; M. S. Abdullah ; C. M. Bravi ; C. Capelli ; T. Hervig ; J. T. Wee ; C. Tyler-Smith ; G. van Driem ; I. G. Romero ; A. R. Jha ; S. Karachanak-Yankova ; D. Toncheva ; D. Comas ; B. Henn ; T. Kivisild ; A. Ruiz-Linares ; A. Sajantila ; E. Metspalu ; J. Parik ; R. Villems ; E. B. Starikovskaya ; G. Ayodo ; C. M. Beall ; A. Di Rienzo ; M. F. Hammer ; R. Khusainova ; E. Khusnutdinova ; W. Klitz ; C. Winkler ; D. Labuda ; M. Metspalu ; S. A. Tishkoff ; S. Dryomov ; R. Sukernik ; N. Patterson ; D. Reich ; E. E. Eichler
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-08-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    African Continental Ancestry Group/classification/genetics ; Animals ; *DNA Copy Number Variations ; *Evolution, Molecular ; *Gene Duplication ; Genome, Human/*genetics ; Hominidae/genetics ; Humans ; Oceanic Ancestry Group/classification/genetics ; Phylogeny ; Polymorphism, Single Nucleotide ; Population/*genetics ; Selection, Genetic ; *Sequence Deletion
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    S. A. Grebenev ; A. A. Lutovinov ; S. S. Tsygankov ; C. Winkler
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-10-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    ISSN:
    1435-165X
    Keywords:
    Epidemiology ; behavioral and emotional problems ; children ; adolescents
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract In an epidemiological sample of children aged 6 to 17 a total of 1964 parents responded to the Child Behavior Check List (CBCL). A subgroup of 399 parents were interviewed with the Diagnostic Interview Schedule for Children (DISC). The mean syndrome scale scores in the various sex/age groups were in the lower range of several international studies using the CBCL. Effect analyses revealed sex to be more important than nationality (indigenous vs. immigrant) and age. All effects had to be considered as being small. Convergence between syndrome scales of the CBCL and interview-derived DSMIII-R diagnoses was good for three major groups of disorders.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00538985

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1435-165X
    Keywords:
    Key words Epidemiology ; behavioral and emotional problems ; children ; adolescents
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract In an epidemiological sample of children aged 6 to 17 a total of 1964 parents responded to the Child Behavior Check List (CBCL). A subgroup of 399 parents were interviewed with the Diagnostic Interview Schedule for Children (DISC). The mean syndrome scale scores in the various sex/age groups were in the lower range of several international studies using the CBCL. Effect analyses revealed sex to be more important than nationality (indigenous vs. immigrant) and age. All effects had to be considered as being small. Convergence between syndrome scales of the CBCL and interview-derived DSM-III-R diagnoses was good for three major groups of disorders.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00538985

    Articles: DFG German National Licenses
  6. 6
    Staff View
    Publication Date:
    2018-01-09
    Publisher:
    The American Association of Immunologists (AAI)
    Print ISSN:
    0022-1767
    Electronic ISSN:
    1550-6606
    Topics:
    Medicine
    Published by:
    http://www.aai.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Buchenau, H. ; Knuth, E. L. ; Northby, J. ; Toennies, J. P. ; Winkler, C.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    Liquid helium clusters are produced by expanding gaseous 4 He into a vacuum from a cold source with temperatures between 5 and 20 K at stagnation pressures from P0 =8 to 20 bar and are studied by time-of-flight (TOF) and mass spectrometry. At low temperatures, T0 〈12 K, the mass spectra show several anomalies which can be attributed to pick-up of residual gases. At T0 〈10K, there is evidence for a very intense peak at m=16 amu which is attributed to He+4 . Depending on the temperatures, the TOF spectra reveal ions with three different velocities. These TOF observations are analyzed using isentropic lines in the known phase diagram of 4 He, which take into account deviations from ideal gas behavior. Three qualitatively different expansion regimes are identified: (I) the expansion proceeds through a region on the high temperature side of the critical point, (II) the expansion passes through or near the critical point, and (III) the expansion passes through a region on the low temperature side of the critical point. The mass spectra, peak velocities and speed ratios, when analyzed with the aid of the phase diagram, indicate that (a) two of the TOF peaks are due to clusters, (b) the fastest cluster peak is due to clusters formed by condensation of gas phase atoms, and (c) the slowest cluster peak is due to either separation into two phases (regime II) or disintegration of a liquid phase (regime III). Measured conversions of initial enthalpy into free jet kinetic energy suggest that the cluster temperature undergoes a sharp drop to a very low temperature approaching 0 K at T0 〈6.5 K where the expansion isentrope intersects the liquid–vapor line upstream from the source orifice.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.458275

    Articles: DFG German National Licenses
  8. 8
    SCHÖNFELDER, V. ; BENNETT, K. ; BLOEMEN, H. ; COLLMAR, W. ; DIEHL, R. ; HERMSEN, W. ; KUIPER, L. ; LICHTI, G. ; MCCONNELL, M. ; RYAN, J. ; STRONG, A. ; WINKLER, C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1995.tb17533.x

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1749-6632
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Natural Sciences in General
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1749-6632.1995.tb17578.x

    Articles: DFG German National Licenses
  10. 10
    Schroecksnadel, K. ; Frick, B. ; Winkler, C. ; Wirleitner, B. ; Schennach, H. ; Fuchs, D.

    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Moderate hyperhomocysteinaemia is established as an independent risk factor for atherosclerosis, thrombosis, stroke and dementia. Hyperhomocysteinaemia is mostly caused by the deficiency of B-vitamins folate and vitamin B12, which are essential cofactors in the remethylation of homocysteine to methionine. Interestingly, moderate hyperhomocysteinaemia is also often observed in chronic diseases, in which also elevated immune activation markers such as neopterin or sTNFR-II are found. In order to simulate immune activation in vitro, human peripheral blood mononuclear cells (PBMC) were stimulated with mitogens. Stimulation significantly increased homocysteine production in comparison with unstimulated PBMC; in parallel also neopterin formation was induced. Homocysteine formation was due to cell proliferation, proliferating T lymphocytes, and also the myelomonocytic cell line U-937 produced homocysteine. Treatment with the anti-inflammatory drug aspirin dose-dependently inhibited homocysteine production and also neopterin formation in human PBMC. Treatment with salicylic acid showed similar effects as aspirin; FACS analysis showed that both compounds inhibited cell proliferation by arresting cells in the G0/G1-phase. In U-937, both compounds also slightly induced apoptosis at 5 mm. Proliferation-induced homocysteine formation and in parallel also monocyte activation can be suppressed effectively by aspirin and salicylic acid in vitro, suggesting that also in vivo aspirin may downregulate not only inflammation but also formation of homocysteine.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.2005.01654.x

    Articles: DFG German National Licenses
  11. 11
    Lundblad, M. ; Andersson, M. ; Winkler, C. ; Kirik, D. ; Wierup, N. ; Cenci, M. A.

    Oxford, UK : Blackwell Science, Ltd
    Published 2002
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    In an attempt to define clinically relevant models of akinesia and dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, we have examined the effects of drugs with high (l-DOPA) vs. low (bromocriptine) dyskinesiogenic potential in Parkinson's disease on three types of motor performance, namely: (i) abnormal involuntary movements (AIMs) (ii) rotational behaviour, and (iii) spontaneous forelimb use (cylinder test). Rats with unilateral 6-OHDA lesions received single daily i.p. injections of l-DOPA or bromocriptine at therapeutic doses. During 3 weeks of treatment, l-DOPA but not bromocriptine induced increasingly severe AIMs affecting the limb, trunk and orofacial region. Rotational behaviour was induced to a much higher extent by bromocriptine than l-DOPA. In the cylinder test, the two drugs initially improved the performance of the parkinsonian limb to a similar extent. However, l-DOPA-treated animals showed declining levels of performance in this test because the drug-induced AIMs interfered with physiological limb use, and gradually replaced all normal motor activities. l-DOPA-induced axial, limb and orolingual AIM scores were significantly reduced by the acute administration of compounds that have antidyskinetic efficacy in parkinsonian patients and/or nonhuman primates (−91%, yohimbine 10 mg/kg; −19%, naloxone 4–8 mg/kg; −37%, 5-methoxy 5-N,N-dimethyl-tryptamine 2 mg/kg; −30%, clozapine 8 mg/kg; −50%, amantadine 40 mg/kg). l-DOPA-induced rotation was, however, not affected. The present results demonstrate that 6-OHDA-lesioned rats do exhibit motor deficits that share essential functional similarities with parkinsonian akinesia or dyskinesia. Such deficits can be quantified using novel and relatively simple testing procedures, whereas rotometry cannot discriminate between dyskinetic and antiakinetic effects of antiparkinsonian treatments.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.0953-816x.2001.01843.x

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1365-2516
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2516.2005.01119.x

    Articles: DFG German National Licenses
  13. 13
    Birkholz, W. ; Winkler, C. ; Baumbach, H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    1359-0189
    Keywords:
    CR-39 ; Cf-252 source ; calibration ; microton ; solid state nuclear track detectors
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/1359-0189(91)90242-A

    Articles: DFG German National Licenses
  14. 14
    Birkholz, W. ; Winkler, C. ; Langrock, E.-J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    1359-0189
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/1359-0189(91)90006-4

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1546-170X
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nm0496-405

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Nearly 400 years have passed since a supernova was last observed directly in the Milky Way (by Kepler, in 1604). Numerous Galactic supernovae are expected to have occurred since then, but only one (Cassiopeia A) may have been seen. The historical record of supernovae is therefore incomplete, as ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/24106

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The Milky Way is known to be an abundant source of γ-ray photons, now determined to be mainly diffuse in nature and resulting from interstellar processes. In the soft γ-ray domain, point sources are expected to dominate, but the lack of sensitive high-resolution observations did not ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nature02407

    Articles: DFG German National Licenses
  18. 18
    Schorn, H. ; Winkler, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0021-9673
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)80321-6

    Articles: DFG German National Licenses
  19. 19
    Walder, G. ; Winkler, C. ; Mark, T.D.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0009-2614
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0009-2614(89)87238-0

    Articles: DFG German National Licenses
  20. 20
    Martini, K. ; Toennies, J.P. ; Winkler, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0009-2614
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0009-2614(91)90277-G

    Articles: DFG German National Licenses