Search Results - (Author, Cooperation:C. Schulze)

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  1. 1
    S. Sawcer ; G. Hellenthal ; M. Pirinen ; C. C. Spencer ; N. A. Patsopoulos ; L. Moutsianas ; A. Dilthey ; Z. Su ; C. Freeman ; S. E. Hunt ; S. Edkins ; E. Gray ; D. R. Booth ; S. C. Potter ; A. Goris ; G. Band ; A. B. Oturai ; A. Strange ; J. Saarela ; C. Bellenguez ; B. Fontaine ; M. Gillman ; B. Hemmer ; R. Gwilliam ; F. Zipp ; A. Jayakumar ; R. Martin ; S. Leslie ; S. Hawkins ; E. Giannoulatou ; S. D'Alfonso ; H. Blackburn ; F. Martinelli Boneschi ; J. Liddle ; H. F. Harbo ; M. L. Perez ; A. Spurkland ; M. J. Waller ; M. P. Mycko ; M. Ricketts ; M. Comabella ; N. Hammond ; I. Kockum ; O. T. McCann ; M. Ban ; P. Whittaker ; A. Kemppinen ; P. Weston ; C. Hawkins ; S. Widaa ; J. Zajicek ; S. Dronov ; N. Robertson ; S. J. Bumpstead ; L. F. Barcellos ; R. Ravindrarajah ; R. Abraham ; L. Alfredsson ; K. Ardlie ; C. Aubin ; A. Baker ; K. Baker ; S. E. Baranzini ; L. Bergamaschi ; R. Bergamaschi ; A. Bernstein ; A. Berthele ; M. Boggild ; J. P. Bradfield ; D. Brassat ; S. A. Broadley ; D. Buck ; H. Butzkueven ; R. Capra ; W. M. Carroll ; P. Cavalla ; E. G. Celius ; S. Cepok ; R. Chiavacci ; F. Clerget-Darpoux ; K. Clysters ; G. Comi ; M. Cossburn ; I. Cournu-Rebeix ; M. B. Cox ; W. Cozen ; B. A. Cree ; A. H. Cross ; D. Cusi ; M. J. Daly ; E. Davis ; P. I. de Bakker ; M. Debouverie ; B. D'Hooghe M ; K. Dixon ; R. Dobosi ; B. Dubois ; D. Ellinghaus ; I. Elovaara ; F. Esposito ; C. Fontenille ; S. Foote ; A. Franke ; D. Galimberti ; A. Ghezzi ; J. Glessner ; R. Gomez ; O. Gout ; C. Graham ; S. F. Grant ; F. R. Guerini ; H. Hakonarson ; P. Hall ; A. Hamsten ; H. P. Hartung ; R. N. Heard ; S. Heath ; J. Hobart ; M. Hoshi ; C. Infante-Duarte ; G. Ingram ; W. Ingram ; T. Islam ; M. Jagodic ; M. Kabesch ; A. G. Kermode ; T. J. Kilpatrick ; C. Kim ; N. Klopp ; K. Koivisto ; M. Larsson ; M. Lathrop ; J. S. Lechner-Scott ; M. A. Leone ; V. Leppa ; U. Liljedahl ; I. L. Bomfim ; R. R. Lincoln ; J. Link ; J. Liu ; A. R. Lorentzen ; S. Lupoli ; F. Macciardi ; T. Mack ; M. Marriott ; V. Martinelli ; D. Mason ; J. L. McCauley ; F. Mentch ; I. L. Mero ; T. Mihalova ; X. Montalban ; J. Mottershead ; K. M. Myhr ; P. Naldi ; W. Ollier ; A. Page ; A. Palotie ; J. Pelletier ; L. Piccio ; T. Pickersgill ; F. Piehl ; S. Pobywajlo ; H. L. Quach ; P. P. Ramsay ; M. Reunanen ; R. Reynolds ; J. D. Rioux ; M. Rodegher ; S. Roesner ; J. P. Rubio ; I. M. Ruckert ; M. Salvetti ; E. Salvi ; A. Santaniello ; C. A. Schaefer ; S. Schreiber ; C. Schulze ; R. J. Scott ; F. Sellebjerg ; K. W. Selmaj ; D. Sexton ; L. Shen ; B. Simms-Acuna ; S. Skidmore ; P. M. Sleiman ; C. Smestad ; P. S. Sorensen ; H. B. Sondergaard ; J. Stankovich ; R. C. Strange ; A. M. Sulonen ; E. Sundqvist ; A. C. Syvanen ; F. Taddeo ; B. Taylor ; J. M. Blackwell ; P. Tienari ; E. Bramon ; A. Tourbah ; M. A. Brown ; E. Tronczynska ; J. P. Casas ; N. Tubridy ; A. Corvin ; J. Vickery ; J. Jankowski ; P. Villoslada ; H. S. Markus ; K. Wang ; C. G. Mathew ; J. Wason ; C. N. Palmer ; H. E. Wichmann ; R. Plomin ; E. Willoughby ; A. Rautanen ; J. Winkelmann ; M. Wittig ; R. C. Trembath ; J. Yaouanq ; A. C. Viswanathan ; H. Zhang ; N. W. Wood ; R. Zuvich ; P. Deloukas ; C. Langford ; A. Duncanson ; J. R. Oksenberg ; M. A. Pericak-Vance ; J. L. Haines ; T. Olsson ; J. Hillert ; A. J. Ivinson ; P. L. De Jager ; L. Peltonen ; G. J. Stewart ; D. A. Hafler ; S. L. Hauser ; G. McVean ; P. Donnelly ; A. Compston
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-08-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Cell Differentiation/immunology ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genome-Wide Association Study ; HLA-A Antigens/genetics ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Immunity, Cellular/genetics/*immunology ; Major Histocompatibility Complex/genetics ; Multiple Sclerosis/*genetics/*immunology ; Polymorphism, Single Nucleotide/genetics ; Sample Size ; T-Lymphocytes, Helper-Inducer/cytology/immunology
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    W. F. Laurance ; D. C. Useche ; J. Rendeiro ; M. Kalka ; C. J. Bradshaw ; S. P. Sloan ; S. G. Laurance ; M. Campbell ; K. Abernethy ; P. Alvarez ; V. Arroyo-Rodriguez ; P. Ashton ; J. Benitez-Malvido ; A. Blom ; K. S. Bobo ; C. H. Cannon ; M. Cao ; R. Carroll ; C. Chapman ; R. Coates ; M. Cords ; F. Danielsen ; B. De Dijn ; E. Dinerstein ; M. A. Donnelly ; D. Edwards ; F. Edwards ; N. Farwig ; P. Fashing ; P. M. Forget ; M. Foster ; G. Gale ; D. Harris ; R. Harrison ; J. Hart ; S. Karpanty ; W. J. Kress ; J. Krishnaswamy ; W. Logsdon ; J. Lovett ; W. Magnusson ; F. Maisels ; A. R. Marshall ; D. McClearn ; D. Mudappa ; M. R. Nielsen ; R. Pearson ; N. Pitman ; J. van der Ploeg ; A. Plumptre ; J. Poulsen ; M. Quesada ; H. Rainey ; D. Robinson ; C. Roetgers ; F. Rovero ; F. Scatena ; C. Schulze ; D. Sheil ; T. Struhsaker ; J. Terborgh ; D. Thomas ; R. Timm ; J. N. Urbina-Cardona ; K. Vasudevan ; S. J. Wright ; G. J. Arias ; L. Arroyo ; M. Ashton ; P. Auzel ; D. Babaasa ; F. Babweteera ; P. Baker ; O. Banki ; M. Bass ; I. Bila-Isia ; S. Blake ; W. Brockelman ; N. Brokaw ; C. A. Bruhl ; S. Bunyavejchewin ; J. T. Chao ; J. Chave ; R. Chellam ; C. J. Clark ; J. Clavijo ; R. Congdon ; R. Corlett ; H. S. Dattaraja ; C. Dave ; G. Davies ; M. Beisiegel Bde ; N. da Silva Rde ; A. Di Fiore ; A. Diesmos ; R. Dirzo ; D. Doran-Sheehy ; M. Eaton ; L. Emmons ; A. Estrada ; C. Ewango ; L. Fedigan ; F. Feer ; B. Fruth ; J. G. Willis ; U. Goodale ; S. Goodman ; J. C. Guix ; P. Guthiga ; W. Haber ; K. Hamer ; I. Herbinger ; J. Hill ; Z. Huang ; I. F. Sun ; K. Ickes ; A. Itoh ; N. Ivanauskas ; B. Jackes ; J. Janovec ; D. Janzen ; M. Jiangming ; C. Jin ; T. Jones ; H. Justiniano ; E. Kalko ; A. Kasangaki ; T. Killeen ; H. B. King ; E. Klop ; C. Knott ; I. Kone ; E. Kudavidanage ; J. L. Ribeiro ; J. Lattke ; R. Laval ; R. Lawton ; M. Leal ; M. Leighton ; M. Lentino ; C. Leonel ; J. Lindsell ; L. Ling-Ling ; K. E. Linsenmair ; E. Losos ; A. Lugo ; J. Lwanga ; A. L. Mack ; M. Martins ; W. S. McGraw ; R. McNab ; L. Montag ; J. M. Thompson ; J. Nabe-Nielsen ; M. Nakagawa ; S. Nepal ; M. Norconk ; V. Novotny ; S. O'Donnell ; M. Opiang ; P. Ouboter ; K. Parker ; N. Parthasarathy ; K. Pisciotta ; D. Prawiradilaga ; C. Pringle ; S. Rajathurai ; U. Reichard ; G. Reinartz ; K. Renton ; G. Reynolds ; V. Reynolds ; E. Riley ; M. O. Rodel ; J. Rothman ; P. Round ; S. Sakai ; T. Sanaiotti ; T. Savini ; G. Schaab ; J. Seidensticker ; A. Siaka ; M. R. Silman ; T. B. Smith ; S. S. de Almeida ; N. Sodhi ; C. Stanford ; K. Stewart ; E. Stokes ; K. E. Stoner ; R. Sukumar ; M. Surbeck ; M. Tobler ; T. Tscharntke ; A. Turkalo ; G. Umapathy ; M. van Weerd ; J. V. Rivera ; M. Venkataraman ; L. Venn ; C. Verea ; C. V. de Castilho ; M. Waltert ; B. Wang ; D. Watts ; W. Weber ; P. West ; D. Whitacre ; K. Whitney ; D. Wilkie ; S. Williams ; D. D. Wright ; P. Wright ; L. Xiankai ; P. Yonzon ; F. Zamzani
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-07-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Agriculture/statistics & numerical data ; Animals ; *Biodiversity ; Conservation of Natural Resources/*statistics & numerical data ; Data Collection ; Ecology/statistics & numerical data ; Endangered Species/*statistics & numerical data ; Environmental Pollution/adverse effects/statistics & numerical data ; Fires/statistics & numerical data ; Forestry/statistics & numerical data ; Interviews as Topic ; Mining/statistics & numerical data ; Population Growth ; Rain ; Reproducibility of Results ; Research Personnel ; Surveys and Questionnaires ; Temperature ; Trees/*physiology ; *Tropical Climate
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    Measurements have been made on the National Synchrotron Light Source Coronary Angiography X17B2 beamline under ideal and real imaging conditions to investigate the optimal imaging conditions for spatial resolution and spectral purity. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1145966

    Articles: DFG German National Licenses
  4. 4
    Schulze, C. ; Chapman, D.

    [S.l.] : American Institute of Physics (AIP)
    Published 1995
    Staff View
    ISSN:
    1089-7623
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Electrical Engineering, Measurement and Control Technology
    Notes:
    pepo is a program for the calculation of the reflection profiles of cylindrically bent Laue crystal monochromators based on the Penning and Polder theory of x-ray diffraction in slightly strained crystals. The creation of new wave fields as well as an anisotropic model for the crystal deformation has been added to the original theory. The program runs under the computing environment IDL and is widget based. The calculation of perfect flat crystal reflectivity curves in Bragg and Laue geometry using the formulas presented by Zachariasen is included. The agreement with experimental results is excellent, allowing the derivation of focal properties from the calculated reflectivity curves. © 1995 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.1145712

    Articles: DFG German National Licenses
  5. 5
    BRUMM, C. ; SCHULZE, C. ; CHARELS, K. ; MOROHOSHI, T. ; KLÖPPEL, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1989
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    One hundred benign and malignant primary liver tumours were screened immunocytochemically for alpha-fetoprotein (AFP), α1-antitrypsin, alpha-human chorionic gonadotropin, carcinoembryonic antigen (CEA), keratin and vimentin. Alphafetoprotein was found in 16/63 (24%) hepatocellular carcinomas and in two hepatoblastomas. When comparing tissue positivity for AFP with tumour differentiation, grade 1 hepatocellular carcinomas were found to be negative, while 21% of grade 2, 36% of grade 3 and 16% of grade 4, respectively, stained positively. Alphafetoprotein positive cells were present in 9/10 hepatocellular carcinomas with serum levels exceeding 5000 ng/ml, but were absent in 17 tumours with serum AFP levels below 5000 ng/ml. All tumours other than hepatocellular carcinomas and hepatoblastomas were AFP negative. Carcinoembryonic antigen was present in 72% of cholangiocarcinomas, but was demonstrated in only one hepatocellular carcinoma. This exception was a combined hepatocellular-cholangiocarcinoma in which CEA expression was restricted to the cholangiocellular part. α1-antitrypsin was found in 4/63 hepatocellular carcinomas, in 2/2 fibrolamellar carcinomas and in 2/18 cholangiocarcinomas. Alpha-human chorionic gonadotropin was detected in one hepatocellular carcinoma and was strongly expressed in both fibrolamellar carcinomas. Weak staining for keratin was seen in most tumours with hepatocellular differentiation. All cholangiocarcinomas, in contrast, were strongly labelled with the keratin antibody. Co-expression of keratin and vimentin was observed in seven poorly differentiated hepatocellular carcinomas and three cholangiocarcinomas as well as in the two hepatoblastomas. The findings suggest that AFP is a diagnostic but rather insensitive immunocytochemical marker for hepatocellular differentiation in malignant liver tumours; CEA and keratin may help in discriminating cholangiocarcinomas from hepatocellular carcinomas.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2559.1989.tb02186.x

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    0027-5107
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0027-5107(87)90191-6

    Articles: DFG German National Licenses
  7. 7
    Schulze, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-5320
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-5320(79)80027-1

    Articles: DFG German National Licenses
  8. 8
    Goebel, M. ; Spalthoff, G. ; Schulze, C. ; Florin, I.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-3999
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Psychology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-3999(89)90090-1

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    0196-9781
    Keywords:
    CCK analogues ; CCK receptors ; Gallbladder contraction ; Pancreatic enzyme secretion
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0196-9781(93)90191-I

    Articles: DFG German National Licenses
  10. 10
    Schulze, C. ; Schwartz, H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0168-1176
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0168-1176(89)85024-4

    Articles: DFG German National Licenses
  11. 11
    Schulze, C.

    Berlin : Periodicals Archive Online (PAO)
    Published 1982
    Staff View
    ISSN:
    0012-1045
    Topics:
    Philosophy
    Description / Table of Contents:
    Aus Anlass des 65. Jahrestages der Grossen Sozialistischen Revolution und des 60. Jahrestages der Gründung der Union der Union der Sozialistischen Sowjetrepubliken
    Abstract:
    BEMERKUNGEN UND BERICHTE
    Notes:
    Philosophische und rechtstheoretische Probleme des sozialistischen Staates
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1982-030-10-000008

    Articles: DFG German National Licenses
  12. 12
    Ritter, R. ; Schulte, U. ; Schulze, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0143-8166
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Physics
    Technology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0143-8166(88)90003-6

    Articles: DFG German National Licenses
  13. 13
    Suortti, P. ; Lienert, U. ; Schulze, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0168-9002
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0168-9002(94)90157-0

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    0168-9002
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0168-9002(94)91945-3

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    0168-9002
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0168-9002(93)91114-3

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1432-2277
    Keywords:
    Key words Transplantation ; Nitric oxide ; Endothelial function ; Gene expression ; Cytokines
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Endothelial dysfunction anticipates the development of transplant coronary artery disease (TxCAD) observed more than 1 year after transplantation (HTx). We investigated whether in patients early after HTx myocardial inducible and constitutive nitric oxide synthases (iNOS; cNOS) are expressed and cardiac nitric oxide production occurs. Moreover, a possible relationship to alterations in endothelium dependent and independent vasomotor function was assessed. Forty-two transplant recipients were studied 37 ± 5 days after HTx. Microvascular coronary flow velocity reserve (CFVR) was tested endothelium dependent (acetylcholine; 30 μg/min × 5 min/i.c.) and independent (adenosine; 160 μg/min × 5 min/i.c.) by Doppler flow wire. Flow velocity increase by a factor greater than 2 was considered normal. Quantitative coronary angiography was used to assess epicardial vasomotor function in response to the same stimuli. Myocardial iNOS and cNOS gene expression were detected by semiquantitative reversed transcriptase polymerase chain reaction. Plasma nitrite levels (μM) were measured by spectrophotometry. Cytokines (TNF-a, IL-6; pg/ml) were measured by enzyme linked immunosorbent assay. In 26.1 % of patients (n = 11; group A) an impaired endothelium dependent CFVR (1.65 ± 0.23 increase) was observed; in 73.9 % (n = 31, group B) a normal endothelium dependent CFVR (3.0 ± 0.7 increase; P = 0.003) was observed. Myocardial iNOS and cNOS gene expression did not differ between the two groups. Transcardiac cytokine production was noted in 58.8 % of patients for IL-6 and in 53.3 % for TNF-α. Coronary sinus (CS) levels of TNF-α, IL-6 and nitrite were higher in group A. A significant increase in nitrite production was found only in patients with impaired endothelium dependent CFVR (aorta: 43.9 ± 3.7 vs CS: 52.8 ± 5.6, P = 0.05), suggesting transcardiac nitric oxide production. In addition, CS nitrite levels correlated with CS TNF-a levels in patients with impaired CFVR (r = 0.44, P = 0.003). Microvascular endothelium dependent CFVR is impaired in 26 % of patients early after HTx. Activation of cytokines and the NO pathway seem to be involved in this vasomotor dysfunction The association between cardiac nitric oxide production and TNF-a in this group indicates a chronic high immunologic process, which may represent an early and important target for therapy and prevention of TxCAD.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001470050330

    Articles: DFG German National Licenses
  17. 17
    Schulze, C. J. ; Mayer, H. M.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-0932
    Keywords:
    Exogenous lumbar spondylodiscitis ; Vertebral body fracture ; Stab wound ; Computed tomography ; Magnetic resonance imaging
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Exogenous spondylodiscitis is a rare event and is usually iatrogenic. Non-iatrogenic exogenous spondylodiscitis has been described in the literature following transabdominal gunshot wounds associated with injury to the intestines and spine. Several cases of traumatic meningitis and one of a traumatic meningocele following an injury of the spinal sac have been reported. No report of exogenous spondylodiscitis complicating a stabwound has been published. This is a report of exogenous spondylodiscitis following a paravertebral stabwound with a knife in association with a superior wedge fracture of L2.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00300297

    Articles: DFG German National Licenses
  18. 18
    Horisberger, M. ; Schulze, C.
    Springer
    Published 1974
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Two RNA-dependent RNA polymerase activities are detected in the cytoplasm of influenza Ao/NWS infected cells; one activity has properties similar to the RNA-dependent RNA polymerase activity associated with the influenza Ao/NWS virion and is stimulated by Mn2+ at high ionic strength. The other activity is stimulated by Mg2+ at low ionic strength. Both cellular activities are associated with a heavy complex which sediments heterogeneously in the region of monosomes in a sucrose gradient; this polymerase complex is not bound to ribosomes. The polymerase complex contains one main protein which corresponds to the nucleocapsid protein (NP) of the virus; it also contains segmented viral RNA. The polymerase complex and the ribonucleoprotein of the virus have similar components and sedimentation properties.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01240214

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-2277
    Keywords:
    Key words Cardiac transplantation ; Myocardial preservation ; Endothelin ; Nitric oxide synthases ; Humans
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Optimal preservation of the myocardium remains a major concern in clinical and experimental heart transplantation. The present study compared the efficacy of University of Wisconsin (UW) and Celsior preservation solution with respect to myocardial performance, epicardial and microvascular endothelial vasomotor function and myocardial expression of endothelin and nitric oxide synthases in humans. Forty-one cardiac transplant recipients received either UW (n = 20) or Celsior (n = 21) preserved hearts. Catecholamine and vasodilator requirements were assessed within the first 5 postoperative days. Left ventricular performance and endothelial function was assessed 1 month after transplantation. Endothelin and nitric oxide synthase gene expression were detected in myocardial biopsy samples. Celsior preserved hearts required significantly more catecholamines and vasodilators within the first 5 postoperative days. Myocardial performance and endothelial function were comparable 1 month after transplantation. Total ischemic time correlated with impaired endothelial function in the Celsior but not in the UW group. Endothelin and inducible nitric oxide synthase gene expression were significantly higher in the Celsior group. The results of the study show that both solutions provide myocardial protection with regard to left ventricular performance and endothelial function 1 month after cardiac transplantation. The necessity for higher vasodilator and catecholamine therapy in Celsior preserved hearts suggests post-ischemic myocardial stunning within the first 5 postoperative days. The positive correlation between impaired endothelial function and total ischemic time in the Celsior group requires longitudinal investigation in particular with regard to the development of allograft vasculopathy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001470050326

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1432-2277
    Keywords:
    Key words Nitric oxide ; Endothelin ; Humans ; Heart transplantation ; Endothelial function
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001470050532

    Articles: DFG German National Licenses