Search Results - (Author, Cooperation:C. Sander)
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1Latest Papers from Table of Contents or Articles in PressC. G. Buffie ; V. Bucci ; R. R. Stein ; P. T. McKenney ; L. Ling ; A. Gobourne ; D. No ; H. Liu ; M. Kinnebrew ; A. Viale ; E. Littmann ; M. R. van den Brink ; R. R. Jenq ; Y. Taur ; C. Sander ; J. R. Cross ; N. C. Toussaint ; J. B. Xavier ; E. G. Pamer
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anti-Bacterial Agents/pharmacology ; Bile Acids and Salts/*metabolism ; Biological Evolution ; Clostridium/metabolism ; Clostridium difficile/drug effects/*physiology ; Colitis/metabolism/microbiology/prevention & control/therapy ; Disease Susceptibility/*microbiology ; Feces/microbiology ; Female ; Humans ; Intestines/drug effects/*metabolism/*microbiology ; Metagenome/genetics ; Mice ; Mice, Inbred C57BL ; Microbiota/drug effects/genetics/*physiology ; SymbiosisPublished by: -
2Latest Papers from Table of Contents or Articles in PressN. A. Rizvi ; M. D. Hellmann ; A. Snyder ; P. Kvistborg ; V. Makarov ; J. J. Havel ; W. Lee ; J. Yuan ; P. Wong ; T. S. Ho ; M. L. Miller ; N. Rekhtman ; A. L. Moreira ; F. Ibrahim ; C. Bruggeman ; B. Gasmi ; R. Zappasodi ; Y. Maeda ; C. Sander ; E. B. Garon ; T. Merghoub ; J. D. Wolchok ; T. N. Schumacher ; T. A. Chan
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-03-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Antibodies, Monoclonal, Humanized/*therapeutic use ; Antineoplastic Agents/*therapeutic use ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Non-Small-Cell Lung/*drug therapy/*genetics/immunology ; Cohort Studies ; DNA Repair/genetics ; Disease-Free Survival ; Drug Resistance, Neoplasm/*genetics ; Humans ; Lung Neoplasms/*drug therapy/*genetics/immunology ; Mutation ; Programmed Cell Death 1 Receptor/*antagonists & inhibitors ; Smoking/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressG. Iyer ; A. J. Hanrahan ; M. I. Milowsky ; H. Al-Ahmadie ; S. N. Scott ; M. Janakiraman ; M. Pirun ; C. Sander ; N. D. Socci ; I. Ostrovnaya ; A. Viale ; A. Heguy ; L. Peng ; T. A. Chan ; B. Bochner ; D. F. Bajorin ; M. F. Berger ; B. S. Taylor ; D. B. Solit
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-08-28Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Antineoplastic Agents/*therapeutic use ; Clinical Trials, Phase II as Topic ; Codon, Nonsense ; Disease-Free Survival ; Drug Resistance, Neoplasm/*genetics ; Everolimus ; Genome, Human ; Genome-Wide Association Study ; Humans ; Molecular Targeted Therapy ; Multiprotein Complexes ; Neoplasm Metastasis ; Neurofibromin 2/genetics ; Proteins/antagonists & inhibitors ; Sequence Deletion ; Sirolimus/*analogs & derivatives/therapeutic use ; TOR Serine-Threonine Kinases ; Tumor Suppressor Proteins/*genetics ; Urinary Bladder Neoplasms/*drug therapy/genetics/pathologyPublished by: -
4Articles: DFG German National LicensesHelsper, Johannes P. F. G. ; Ric de Vos, C. H. ; Maas, Frank M. ; Jonker, Harry H. ; Van Den Broeck, Hetty C. ; Jordi, Wilco ; Pot, C. Sander ; Keizer, L. C. Paul ; Schapendonk, Ad H. C. M.
Oxford, UK : Munksgaard International Publishers
Published 2003Staff ViewISSN: 1399-3054Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The effect of supplemental UV-A (320–400 nm) radiation on tissue absorption at 355 nm, levels of various antioxidants (ascorbate, glutathione, carotenoids and flavonoids) and of antioxidant scavenging capacity were investigated with leaves and petals of Rosa hybrida, cv. Honesty and with leaves, petals and sepals of Fuchsia hybrida, cv. Dollarprinzessin. Supplemental UV-A did not result in visible changes in plant morphology of either species. In leaves it induced small increases in levels of chlorophylls a and b, the carotenoids antheraxanthin, lutein and β-carotene, and high increases in the flavonols quercetin and kaempferol. Petals hardly responded, while the coloured sepals of fuchsia showed an increase in quercetin derivatives. HPLC of unhydrolysed flavonoids showed that individual quercetin derivatives in leaves of both species and kaempferol derivatives in rose leaves increased 2-fold. Some kaempferol derivatives in fuchsia leaves were more than 2-fold enhanced or were newly induced by supplemental UV-A. Increases in l-ascorbic acid levels in fuchsia leaves, and decreases in rose leaves as result of supplemental UV-A were observed, but differences appeared statistically not significant, while l-ascorbate levels remained unchanged in the other tissues investigated. Anthocyanins and reduced glutathione levels were unaffected in all tissues. The combined UV-A induced increases in concentrations of these antioxidant species, did not lead to significant increases in antioxidant capacity of tissues, measured as Trolox equivalents in 50%-ethanol extracts. Light absorption at 355 nm of leaf extracts was significantly increased upon UV-A exposure. Our results indicate that the major protection towards UV-A exposure, in particular in the leaves, will originate from absorption of irradiation, and not from scavenging reactive oxygen species.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesHERBST, H. ; SANDER, C. ; TRONNIEK, M. ; KUTZNER, H. ; HÜGEL, H. ; KAUDEWITZ, P.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary The prevalence of the t(2:5)(p23;q35) and/or anaplastic lymphoma kinase (ALK) gene products in cutaneous anaplastic large cell (ALC) lymphomas and a potential precursor lesion, lymphomatoid papulosis (LyP). is controversial. ALK gene products, which are absent from normal lymphohae-matopoietic cells, are a phenotypic marker of lymphomas carrying the t(2:5). We used in situ hybridization and immunohistology to screen 14 cutaneous ALC lymphomas, 21 cases of LyP, and one nodal ALC lymphoma associated with LyP for ALK gene products. ALK gene products were not detectable in these cases. In contrast, ALK gene products were found in a lymphonodal ALC lymphoma with subsequent extension to the skin and in t(2:5)-positive cell lines. Detection of the Epstein-Barr virus (EBV)-encoded small nuclear transcripts (EBER), and of immunoglobulin light chain transcripts served to check for the presence of cellular RNA in the tissue sections. EBER transcripts were found in scattered reactive lymphoid cells, but not in atypical or tumour cells. ALK gene expression and EBV infection seem to be a rare finding in cutaneous ALC lymphomas and LyP. This points to a molecular aetiology of primary cutaneous ALC lymphomas and LyP distinct from that of extracutaneous CD30+ lymphoproliferative disease. Detection of the t(2;5) or ALK gene products in cutaneous lymphoproliferative lesions therefore requires exclusion of extracutaneous ALC lymphoma in such patients.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesSummer, B. ; Sander, C. A. ; Przybilla, B. ; Thomas, P.
Copenhagen : Munksgaard International Publishers
Published 2001Staff ViewISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: The peripheral blood mononuclear cells (PBMC) of individuals with nickel contact allergy are reported to proliferate to a varying degree upon nickel stimulation in vitro. Different phenotypes of the T cells involved are described. With regard to preferential use of the T-cell receptor (TCR), analysis of the several families of the TCR-γ gene allows rearrangement evaluation of all T cells regardless of predominant surface expression of TCR α/β. Methods: The PBMC of 10 nickel-allergic and five nonallergic individuals were cultured for 4 days in the presence of either medium, PHA, NiSO4, or tetanus toxoid (TT). Proliferation was measured by radioactive thymidine uptake and expressed as stimulation index (SI). T-cell clonality was assessed by analysis of the TCR-γ chain gene, including the use of PCR with a primer combination covering the four main groups (Vγ1-8, Vγ9, Vγ10, and Vγ11) of the variable region of the TCR-β chain gene. Results: In the allergic individuals, proliferation to NiSO4 was significantly (P〈0.05) higher than in nonallergics (mean SI: 18.05/17.87 vs 0.67/2.27). In unstimulated and PHA-stimulated cultures, there was a random TCR spectrum in both groups. In contrast, in nickel-allergic individuals or individuals with recent TT-booster, oligoclonality could be observed in the correspondingly stimulated cultures. Conclusions: In addition to proliferation assay, analysis of T-cell clonality may be a further means to characterize clinical hypersensitivity reactions on the basis of antigen-dependent oligoclonal T-cell expansion, as in the case of tissue-infiltrating lymphocytes.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesWOLLENBERG, A. ; HÄNEL, S. ; SPANNAGL, M. ; SANDER, C. ; PLEWIG, G.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Substantial subcutaneous haemorrhage without preceding trauma or underlying bleeding disorder is a rare occurrence in dermatological practice, essentially restricted to early childhood (acute haemorrhagic oedema of childhood). We report an adolescent with a morphologically unique bleeding manifestation. A 16-year-old presented with two episodes of massive subcutaneous haemorrhage in association with urticarial vasculitis. There was no history of preceding trauma or haemorrhagic disorder. Haemorrhage was observed in areas typically affected by angioedema, such as the periorbital, perioral, lingual, sublingual and laryngeal areas. History revealed an atopic diathesis with hay fever and examination showed alopecia areata. An antinuclear antibody titre and the presence of lupus anticoagulant indicated transient antiphospholipid antibodies. As urticaria corresponds to urticaria profunda angioedema, we hypothesize a pathophysiological relationship between superficial urticarial vasculitis and the deep variant of urticarial vasculitic disease, leading to the unique morphology present in our patient.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0962-8924Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0005-2787Keywords: 5-Bromodeoxyuridine ; Pisatin induction ; l-Phenylalanine ammonia-lyaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0926-6550Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0926-6550Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0926-6569Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Ankyrin-like repeat ; Domain ; Homology ; Protein kinase ; RNaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Dimerization ; Gene regulation ; Sequence analysis ; Transcription factor ; Zn-bindingSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Homology ; Mosaic protein ; Sperm receptor: TGF-receptor ; UromodulinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Primary structural repeat ; TFIIIA ; Transcription factorSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0022-2836Keywords: evaluation ; homologous proteins ; prediction accuracy ; secondary structure prediction ; secondary structure segmentsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0022-2836Keywords: adenovirus fibre ; computer model ; triple helixSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: