Search Results - (Author, Cooperation:C. Picard)
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1Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damageI. Angulo ; O. Vadas ; F. Garcon ; E. Banham-Hall ; V. Plagnol ; T. R. Leahy ; H. Baxendale ; T. Coulter ; J. Curtis ; C. Wu ; K. Blake-Palmer ; O. Perisic ; D. Smyth ; M. Maes ; C. Fiddler ; J. Juss ; D. Cilliers ; G. Markelj ; A. Chandra ; G. Farmer ; A. Kielkowska ; J. Clark ; S. Kracker ; M. Debre ; C. Picard ; I. Pellier ; N. Jabado ; J. A. Morris ; G. Barcenas-Morales ; A. Fischer ; L. Stephens ; P. Hawkins ; J. C. Barrett ; M. Abinun ; M. Clatworthy ; A. Durandy ; R. Doffinger ; E. R. Chilvers ; A. J. Cant ; D. Kumararatne ; K. Okkenhaug ; R. L. Williams ; A. Condliffe ; S. Nejentsev
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-10-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Class I Phosphatidylinositol 3-Kinases ; *Genetic Predisposition to Disease ; Humans ; Immunologic Deficiency Syndromes/*genetics/immunology/*pathology ; Lymphocytes/immunology ; Mutation ; Pedigree ; Phosphatidylinositol 3-Kinases/*genetics ; Phosphatidylinositol Phosphates/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Respiratory Tract Infections/*genetics/immunology/*pathologyPublished by: -
2M. J. Ciancanelli ; S. X. Huang ; P. Luthra ; H. Garner ; Y. Itan ; S. Volpi ; F. G. Lafaille ; C. Trouillet ; M. Schmolke ; R. A. Albrecht ; E. Israelsson ; H. K. Lim ; M. Casadio ; T. Hermesh ; L. Lorenzo ; L. W. Leung ; V. Pedergnana ; B. Boisson ; S. Okada ; C. Picard ; B. Ringuier ; F. Troussier ; D. Chaussabel ; L. Abel ; I. Pellier ; L. D. Notarangelo ; A. Garcia-Sastre ; C. F. Basler ; F. Geissmann ; S. Y. Zhang ; H. W. Snoeck ; J. L. Casanova
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-03-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Child ; Dendritic Cells/immunology ; Female ; Fibroblasts/immunology ; Genes, Recessive ; *Heterozygote ; Humans ; Induced Pluripotent Stem Cells/immunology ; *Influenza A Virus, H1N1 Subtype ; Influenza, Human/complications/genetics/*immunology ; Interferon Regulatory Factor-7/*genetics ; Interferon Type I/*biosynthesis/genetics ; Leukocytes/immunology ; Lung/immunology ; Mutation ; Respiratory Distress Syndrome, Adult/genetics/*immunology/virology ; Respiratory Mucosa/immunologyPublished by: -
3A. Bolze ; N. Mahlaoui ; M. Byun ; B. Turner ; N. Trede ; S. R. Ellis ; A. Abhyankar ; Y. Itan ; E. Patin ; S. Brebner ; P. Sackstein ; A. Puel ; C. Picard ; L. Abel ; L. Quintana-Murci ; S. N. Faust ; A. P. Williams ; R. Baretto ; M. Duddridge ; U. Kini ; A. J. Pollard ; C. Gaud ; P. Frange ; D. Orbach ; J. F. Emile ; J. L. Stephan ; R. Sorensen ; A. Plebani ; L. Hammarstrom ; M. E. Conley ; L. Selleri ; J. L. Casanova
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-04-13Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: DNA Mutational Analysis ; Genetic Loci ; *Haploinsufficiency ; Heterotaxy Syndrome/*genetics ; Humans ; Mutation ; Pedigree ; Penetrance ; Receptors, Laminin/*genetics ; Ribosomal Proteins/*genetics ; Spleen/*abnormalities/growth & developmentPublished by: -
4S. Okada ; J. G. Markle ; E. K. Deenick ; F. Mele ; D. Averbuch ; M. Lagos ; M. Alzahrani ; S. Al-Muhsen ; R. Halwani ; C. S. Ma ; N. Wong ; C. Soudais ; L. A. Henderson ; H. Marzouqa ; J. Shamma ; M. Gonzalez ; R. Martinez-Barricarte ; C. Okada ; D. T. Avery ; D. Latorre ; C. Deswarte ; F. Jabot-Hanin ; E. Torrado ; J. Fountain ; A. Belkadi ; Y. Itan ; B. Boisson ; M. Migaud ; C. S. Arlehamn ; A. Sette ; S. Breton ; J. McCluskey ; J. Rossjohn ; J. P. de Villartay ; D. Moshous ; S. Hambleton ; S. Latour ; P. D. Arkwright ; C. Picard ; O. Lantz ; D. Engelhard ; M. Kobayashi ; L. Abel ; A. M. Cooper ; L. D. Notarangelo ; S. Boisson-Dupuis ; A. Puel ; F. Sallusto ; J. Bustamante ; S. G. Tangye ; J. L. Casanova
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-07-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Candida albicans/*immunology ; Candidiasis, Chronic Mucocutaneous/complications/*genetics/immunology ; Cattle ; Child ; Child, Preschool ; DNA Mutational Analysis ; Exome/genetics ; Female ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Humans ; Immunity/*genetics ; Interferon-gamma/immunology ; Interleukin-17/immunology ; Mice ; Mutation ; Mycobacterium bovis/immunology/isolation & purification ; Mycobacterium tuberculosis/immunology/isolation & purification ; Nuclear Receptor Subfamily 1, Group F, Member 3/*genetics ; Pedigree ; Receptors, Antigen, T-Cell, alpha-beta/genetics/immunology ; Receptors, Antigen, T-Cell, gamma-delta/genetics/immunology ; Severe Combined Immunodeficiency/*genetics ; T-Lymphocytes/immunology ; Thymus Gland/abnormalities/immunology ; Tuberculosis, Bovine/*genetics/immunology ; Tuberculosis, Pulmonary/*genetics/immunologyPublished by: -
5E. Martin ; N. Palmic ; S. Sanquer ; C. Lenoir ; F. Hauck ; C. Mongellaz ; S. Fabrega ; P. Nitschke ; M. D. Esposti ; J. Schwartzentruber ; N. Taylor ; J. Majewski ; N. Jabado ; R. F. Wynn ; C. Picard ; A. Fischer ; P. D. Arkwright ; S. Latour
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antigens, CD3/immunology ; B-Lymphocytes/cytology/immunology/metabolism ; Carbon-Nitrogen Ligases/*deficiency/genetics/*metabolism ; Cell Proliferation ; Child, Preschool ; Cytidine Triphosphate/metabolism ; Female ; Humans ; Immunologic Deficiency Syndromes/enzymology/genetics ; Infant ; Infant, Newborn ; *Lymphocyte Activation/genetics ; Lymphocytes/*cytology/immunology/metabolism ; Male ; Mutation/genetics ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes/cytology/immunology/metabolismPublished by: -
6A. Puel ; S. Cypowyj ; J. Bustamante ; J. F. Wright ; L. Liu ; H. K. Lim ; M. Migaud ; L. Israel ; M. Chrabieh ; M. Audry ; M. Gumbleton ; A. Toulon ; C. Bodemer ; J. El-Baghdadi ; M. Whitters ; T. Paradis ; J. Brooks ; M. Collins ; N. M. Wolfman ; S. Al-Muhsen ; M. Galicchio ; L. Abel ; C. Picard ; J. L. Casanova
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-02-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Candida albicans ; Candidiasis, Chronic Mucocutaneous/*genetics/*immunology ; Child ; Child, Preschool ; Female ; Genes, Dominant ; Genes, Recessive ; Humans ; Interleukin-17/*immunology ; Male ; Molecular Sequence Data ; Mutation ; Pedigree ; Receptors, Interleukin-17/genetics ; Signal Transduction/genetics ; Th17 Cells/immunologyPublished by: -
7Bernstein, P. ; Picard, C. ; Becker, V. ; Flament, S. ; Beaudet, N.
[S.l.] : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: We present a mean-field model for the mixed state of superconducting microbridges with low pinning forces which accounts for the I–V characteristics measured on superconducting flux flow transistors (SFFTs) as well as the improvement of the performances of these devices when they include several microbridges. From the model it turns out that the vortex motion is not mostly driven by the bias current as is assumed in classical flux flow descriptions but by a diffusion process. Moreover, it is shown that due to the magnetic coupling between bridges, the critical current of a device with n bridges is larger than n times the critical current of a single bridge. Expressions for this increase in the critical current and the current gain of these devices are given. The model also accounts for the dynamic resistance modulation of SFFTs when an external magnetic field is applied. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
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ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: In order to develop superconducting thin films or multilayer structures suitable for Abrikosov vortex flux flow transistors, we propose a model to describe the current–voltage characteristics measured on microbridges operating in the flux creep regime and we show how the effective superconducting thickness of the samples, as well as the pinning potential range, the maximum velocity, the pinning energy, and the depinning current of the vortices can be determined. This model is applied to microbridges with structures containing one or several YBa2Cu3O7−δ layers which were deposited either on LaAlO3 or on SrTiO3 substrates. The results demonstrate that most YBa2Cu3O7−δ microbridges exhibit very similar properties and are not suitable for flux flow devices. However, bilayer structures comprised of a YBa2Cu3O7−δ film and a conductive capping layer display interesting properties. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
9Picard, C. ; Ksas, B. ; Griffiths, N. M. ; Fioramonti, J.
Oxford UK : Blackwell Science Ltd.
Published 2002Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Radiation-induced diarrhoea is attributed to both mucosal injury and alterations of intestinal motility. Previous reports have indicated that 5-hydroxytryptamine is released following irradiation, which may contribute to these changes.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:To investigate the effects of granisetron (5-hydroxytryptamine type-3 receptor antagonist) on colonic motility, fluid absorption and 5-hydroxytryptamine colonic content following abdominal irradiation (10 Gy) in rats.〈section xml:id="abs1-3"〉〈title type="main"〉Methods: In vivo measurements of motility and fluid absorption in the proximal and distal colon, respectively, diarrhoea score and 5-hydroxytryptamine tissue levels were performed 3 and 7 days after abdominal irradiation. The effects of post-irradiation granisetron (0.3 mg/kg subcutaneously) were also evaluated.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Colonic motility and fluid/Na+ absorption were reduced 3 and 7 days after irradiation. All rats developed diarrhoea (3 days) concomitant with increased colonic mucosal 5-hydroxytryptamine levels. Granisetron prevented diarrhoea, attenuated decreased colonic motility and reduced 5-hydroxytryptamine levels on day 3, although fluid absorption was only slightly improved. On day 7, colonic motility and fluid/Na+ absorption were restored in granisetron-dosed animals.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:These results indicate that radiation-induced diarrhoea involves alterations of both colonic motility and fluid/Na+ absorption. 5-Hydroxytryptamine could be one of the mediators implicated in these alterations, as post-irradiation dosage with a 5-hydroxytryptamine type-3 receptor antagonist improved colonic motility and prevented diarrhoea on day 3.Type of Medium: Electronic ResourceURL: -
10PICARD, C. ; FIORAMONTI, J. ; FRANCOIS, A. ; ROBINSON, T. ; NEANT, F. ; MATUCHANSKY, C.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Bifidobacteria, naturally present in the dominant colonic microbiota, represent up to 25% of the cultivable faecal bacteria in adults and 80% in infants. As probiotic agents, bifidobacteria have been studied for their efficacy in the prevention and treatment of a broad spectrum of animal and/or human gastrointestinal disorders, such as colonic transit disorders, intestinal infections, and colonic adenomas and cancer. The aim of this review is to focus on the gastrointestinal effects of bifidobacteria as probiotic agents in animal models and man. The traditional use of bifidobacteria in fermented dairy products and the GRAS (‘Generally Recognised As Safe’) status of certain strains attest to their safety. Some strains, especially Bifidobacterium animalis strain DN-173 010 which has long been used in fermented dairy products, show high gastrointestinal survival capacity and exhibit probiotic properties in the colon. Bifidobacteria are able to prevent or alleviate infectious diarrhoea through their effects on the immune system and resistance to colonization by pathogens. There is some experimental evidence that certain bifidobacteria may actually protect the host from carcinogenic activity of intestinal flora. Bifidobacteria may exert protective intestinal actions through various mechanisms, and represent promising advances in the fields of prophylaxis and therapy.Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 0022-3697Keywords: Cobalt monoxide ; high temperature microcalorimetry ; non-stoichiometry ; thermodynamic propertiesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0921-4534Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0003-2697Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 0038-1098Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0038-1098Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: