Search Results - (Author, Cooperation:C. P. Crum)

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  1. 1
    A. I. Ojesina ; L. Lichtenstein ; S. S. Freeman ; C. S. Pedamallu ; I. Imaz-Rosshandler ; T. J. Pugh ; A. D. Cherniack ; L. Ambrogio ; K. Cibulskis ; B. Bertelsen ; S. Romero-Cordoba ; V. Trevino ; K. Vazquez-Santillan ; A. S. Guadarrama ; A. A. Wright ; M. W. Rosenberg ; F. Duke ; B. Kaplan ; R. Wang ; E. Nickerson ; H. M. Walline ; M. S. Lawrence ; C. Stewart ; S. L. Carter ; A. McKenna ; I. P. Rodriguez-Sanchez ; M. Espinosa-Castilla ; K. Woie ; L. Bjorge ; E. Wik ; M. K. Halle ; E. A. Hoivik ; C. Krakstad ; N. B. Gabino ; G. S. Gomez-Macias ; L. D. Valdez-Chapa ; M. L. Garza-Rodriguez ; G. Maytorena ; J. Vazquez ; C. Rodea ; A. Cravioto ; M. L. Cortes ; H. Greulich ; C. P. Crum ; D. S. Neuberg ; A. Hidalgo-Miranda ; C. R. Escareno ; L. A. Akslen ; T. E. Carey ; O. K. Vintermyr ; S. B. Gabriel ; H. A. Barrera-Saldana ; J. Melendez-Zajgla ; G. Getz ; H. B. Salvesen ; M. Meyerson
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-01-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenocarcinoma/genetics/virology ; Carcinoma, Squamous Cell/genetics/virology ; Case-Control Studies ; Cell Cycle Proteins/genetics ; Core Binding Factor beta Subunit/genetics ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; E1A-Associated p300 Protein/genetics ; Exome/genetics ; F-Box Proteins/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Genome, Human/*genetics ; Genomics ; HLA-B Antigens/genetics ; Humans ; Mitogen-Activated Protein Kinase 1/genetics ; Mutation/*genetics ; NF-E2-Related Factor 2/genetics ; Papillomaviridae/genetics/physiology ; Papillomavirus Infections/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins c-ets ; Receptor, ErbB-2/genetics ; Transcription Factors/genetics ; Transcriptome/genetics ; Tumor Suppressor Protein p53/genetics ; Ubiquitin-Protein Ligases/genetics ; Uterine Cervical Neoplasms/*genetics/virology ; Virus Integration/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2015-06-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Bacterial Toxins/pharmacology ; Cell Differentiation/drug effects ; Cell Lineage ; Cells, Cultured ; Clone Cells/cytology/metabolism ; Clostridium difficile/physiology ; Colon/cytology/drug effects ; Enterocolitis, Pseudomembranous/microbiology/pathology ; Epigenesis, Genetic/genetics ; Epithelium/drug effects/metabolism ; Fetus/cytology ; Genomic Instability/genetics ; Humans ; Intestine, Small/cytology ; Intestines/*cytology/drug effects ; Organoids/cytology/growth & development ; Stem Cells/*cytology/*metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    W. Zuo ; T. Zhang ; D. Z. Wu ; S. P. Guan ; A. A. Liew ; Y. Yamamoto ; X. Wang ; S. J. Lim ; M. Vincent ; M. Lessard ; C. P. Crum ; W. Xian ; F. McKeon
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-11-11
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bronchioles/cytology/virology ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Dogs ; Humans ; Influenza A Virus, H1N1 Subtype/pathogenicity ; Keratin-5/*metabolism ; Lung/*cytology/pathology/*physiology/virology ; Madin Darby Canine Kidney Cells ; Mice ; Orthomyxoviridae Infections/metabolism/pathology/virology ; Oxygen/metabolism ; Pedigree ; Phosphoproteins/*metabolism ; Pneumonia/metabolism/pathology/virology ; Pulmonary Alveoli/cytology/pathology/virology ; Re-Epithelialization ; *Regeneration ; Stem Cell Transplantation ; Stem Cells/*cytology/*metabolism ; Trans-Activators/*metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    ISSN:
    1432-2307
    Keywords:
    Keywords MUC2 ; MUC5AC ; ACIS ; Adenocarcinoma ; Tubal metaplasia ; Endometriosis ; Cervix uteri
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  The expression of mucin genes in the normal glandular epithelium of the endocervix has been well characterized. However, mucin gene expression in neoplastic or particular non-neoplastic glandular cervical lesions has not been addressed. This immunohistochemical study was carried out to analyze the expression of MUC2 and MUC5AC in neoplastic and non-neoplastic glandular lesions of the cervix. Monoclonal antibodies were used on paraffin-embedded sections from 41 adenocarcinomas, 2 adenosquamous carcinomas, 13 adenocarcinomas in situ (ACIS), 3 glandular dysplasias, 8 endometrioses, 5 tubal metaplasias, 17 squamous metaplasias, 3 microglandular hyperplasias and normal tissue of the endocervix, endometrium and fallopian tube. The patterns of expression of MUC2 and MUC5AC were different and in principle contrary. Focal MUC2 expression was observed almost exclusively in neoplastic lesions (36%) and not in normal epithelia and non-neoplastic lesions, the one notable exception being immature metaplasia. In contrast, strong expression of MUC5AC was observed in both normal endocervical epithelium (100%) and neoplastic lesions (73%). The expression of MUC5AC, however, was diminished in most neoplastic glandular lesions. Co-expression of MUC2 and MUC5AC was consistently documented in the lesions with intestinal differentiation. In contrast, cases of tubal metaplasia and endometriosis were negative for MUC2 and MUC5AC. These results indicate that discrimination of mucin gene expression may be helpful in discriminating lesions of the cervix.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004280000273

    Articles: DFG German National Licenses