Search Results - (Author, Cooperation:C. Olsson)

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  1. 1
    Staff View
    Publication Date:
    2011-03-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cell Line ; Cellular Reprogramming/*genetics ; Chromosome Fragile Sites/genetics ; DNA Copy Number Variations/*genetics ; Embryonic Stem Cells/cytology/metabolism ; Fibroblasts/cytology/metabolism ; Haplotypes/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Induced Pluripotent Stem Cells/cytology/*metabolism/pathology ; Mosaicism ; Mutagenesis/genetics ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide/genetics ; *Selection, Genetic/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    D. Shungin ; T. W. Winkler ; D. C. Croteau-Chonka ; T. Ferreira ; A. E. Locke ; R. Magi ; R. J. Strawbridge ; T. H. Pers ; K. Fischer ; A. E. Justice ; T. Workalemahu ; J. M. Wu ; M. L. Buchkovich ; N. L. Heard-Costa ; T. S. Roman ; A. W. Drong ; C. Song ; S. Gustafsson ; F. R. Day ; T. Esko ; T. Fall ; Z. Kutalik ; J. Luan ; J. C. Randall ; A. Scherag ; S. Vedantam ; A. R. Wood ; J. Chen ; R. Fehrmann ; J. Karjalainen ; B. Kahali ; C. T. Liu ; E. M. Schmidt ; D. Absher ; N. Amin ; D. Anderson ; M. Beekman ; J. L. Bragg-Gresham ; S. Buyske ; A. Demirkan ; G. B. Ehret ; M. F. Feitosa ; A. Goel ; A. U. Jackson ; T. Johnson ; M. E. Kleber ; K. Kristiansson ; M. Mangino ; I. Mateo Leach ; C. Medina-Gomez ; C. D. Palmer ; D. Pasko ; S. Pechlivanis ; M. J. Peters ; I. Prokopenko ; A. Stancakova ; Y. Ju Sung ; T. Tanaka ; A. Teumer ; J. V. Van Vliet-Ostaptchouk ; L. Yengo ; W. Zhang ; E. Albrecht ; J. Arnlov ; G. M. Arscott ; S. Bandinelli ; A. Barrett ; C. Bellis ; A. J. Bennett ; C. Berne ; M. Bluher ; S. Bohringer ; F. Bonnet ; Y. Bottcher ; M. Bruinenberg ; D. B. Carba ; I. H. Caspersen ; R. Clarke ; E. W. Daw ; J. Deelen ; E. Deelman ; G. Delgado ; A. S. Doney ; N. Eklund ; M. R. Erdos ; K. Estrada ; E. Eury ; N. Friedrich ; M. E. Garcia ; V. Giedraitis ; B. Gigante ; A. S. Go ; A. Golay ; H. Grallert ; T. B. Grammer ; J. Grassler ; J. Grewal ; C. J. Groves ; T. Haller ; G. Hallmans ; C. A. Hartman ; M. Hassinen ; C. Hayward ; K. Heikkila ; K. H. Herzig ; Q. Helmer ; H. L. Hillege ; O. Holmen ; S. C. Hunt ; A. Isaacs ; T. Ittermann ; A. L. James ; I. Johansson ; T. Juliusdottir ; I. P. Kalafati ; L. Kinnunen ; W. Koenig ; I. K. Kooner ; W. Kratzer ; C. Lamina ; K. Leander ; N. R. Lee ; P. Lichtner ; L. Lind ; J. Lindstrom ; S. Lobbens ; M. Lorentzon ; F. Mach ; P. K. Magnusson ; A. Mahajan ; W. L. McArdle ; C. Menni ; S. Merger ; E. Mihailov ; L. Milani ; R. Mills ; A. Moayyeri ; K. L. Monda ; S. P. Mooijaart ; T. W. Muhleisen ; A. Mulas ; G. Muller ; M. Muller-Nurasyid ; R. Nagaraja ; M. A. Nalls ; N. Narisu ; N. Glorioso ; I. M. Nolte ; M. Olden ; N. W. Rayner ; F. Renstrom ; J. S. Ried ; N. R. Robertson ; L. M. Rose ; S. Sanna ; H. Scharnagl ; S. Scholtens ; B. Sennblad ; T. Seufferlein ; C. M. Sitlani ; A. Vernon Smith ; K. Stirrups ; H. M. Stringham ; J. Sundstrom ; M. A. Swertz ; A. J. Swift ; A. C. Syvanen ; B. O. Tayo ; B. Thorand ; G. Thorleifsson ; A. Tomaschitz ; C. Troffa ; F. V. van Oort ; N. Verweij ; J. M. Vonk ; L. L. Waite ; R. Wennauer ; T. Wilsgaard ; M. K. Wojczynski ; A. Wong ; Q. Zhang ; J. Hua Zhao ; E. P. Brennan ; M. Choi ; P. Eriksson ; L. Folkersen ; A. Franco-Cereceda ; A. G. Gharavi ; A. K. Hedman ; M. F. Hivert ; J. Huang ; S. Kanoni ; F. Karpe ; S. Keildson ; K. Kiryluk ; L. Liang ; R. P. Lifton ; B. Ma ; A. J. McKnight ; R. McPherson ; A. Metspalu ; J. L. Min ; M. F. Moffatt ; G. W. Montgomery ; J. M. Murabito ; G. Nicholson ; D. R. Nyholt ; C. Olsson ; J. R. Perry ; E. Reinmaa ; R. M. Salem ; N. Sandholm ; E. E. Schadt ; R. A. Scott ; L. Stolk ; E. E. Vallejo ; H. J. Westra ; K. T. Zondervan ; P. Amouyel ; D. Arveiler ; S. J. Bakker ; J. Beilby ; R. N. Bergman ; J. Blangero ; M. J. Brown ; M. Burnier ; H. Campbell ; A. Chakravarti ; P. S. Chines ; S. Claudi-Boehm ; F. S. Collins ; D. C. Crawford ; J. Danesh ; U. de Faire ; E. J. de Geus ; M. Dorr ; R. Erbel ; J. G. Eriksson ; M. Farrall ; E. Ferrannini ; J. Ferrieres ; N. G. Forouhi ; T. Forrester ; O. H. Franco ; R. T. Gansevoort ; C. Gieger ; V. Gudnason ; C. A. Haiman ; T. B. Harris ; A. T. Hattersley ; M. Heliovaara ; A. A. Hicks ; A. D. Hingorani ; W. Hoffmann ; A. Hofman ; G. Homuth ; S. E. Humphries ; E. Hypponen ; T. Illig ; M. R. Jarvelin ; B. Johansen ; P. Jousilahti ; A. M. Jula ; J. Kaprio ; F. Kee ; S. M. Keinanen-Kiukaanniemi ; J. S. Kooner ; C. Kooperberg ; P. Kovacs ; A. T. Kraja ; M. Kumari ; K. Kuulasmaa ; J. Kuusisto ; T. A. Lakka ; C. Langenberg ; L. Le Marchand ; T. Lehtimaki ; V. Lyssenko ; S. Mannisto ; A. Marette ; T. C. Matise ; C. A. McKenzie ; B. McKnight ; A. W. Musk ; S. Mohlenkamp ; A. D. Morris ; M. Nelis ; C. Ohlsson ; A. J. Oldehinkel ; K. K. Ong ; L. J. Palmer ; B. W. Penninx ; A. Peters ; P. P. Pramstaller ; O. T. Raitakari ; T. Rankinen ; D. C. Rao ; T. K. Rice ; P. M. Ridker ; M. D. Ritchie ; I. Rudan ; V. Salomaa ; N. J. Samani ; J. Saramies ; M. A. Sarzynski ; P. E. Schwarz ; A. R. Shuldiner ; J. A. Staessen ; V. Steinthorsdottir ; R. P. Stolk ; K. Strauch ; A. Tonjes ; A. Tremblay ; E. Tremoli ; M. C. Vohl ; U. Volker ; P. Vollenweider ; J. F. Wilson ; J. C. Witteman ; L. S. Adair ; M. Bochud ; B. O. Boehm ; S. R. Bornstein ; C. Bouchard ; S. Cauchi ; M. J. Caulfield ; J. C. Chambers ; D. I. Chasman ; R. S. Cooper ; G. Dedoussis ; L. Ferrucci ; P. Froguel ; H. J. Grabe ; A. Hamsten ; J. Hui ; K. Hveem ; K. H. Jockel ; M. Kivimaki ; D. Kuh ; M. Laakso ; Y. Liu ; W. Marz ; P. B. Munroe ; I. Njolstad ; B. A. Oostra ; C. N. Palmer ; N. L. Pedersen ; M. Perola ; L. Perusse ; U. Peters ; C. Power ; T. Quertermous ; R. Rauramaa ; F. Rivadeneira ; T. E. Saaristo ; D. Saleheen ; J. Sinisalo ; P. E. Slagboom ; H. Snieder ; T. D. Spector ; U. Thorsteinsdottir ; M. Stumvoll ; J. Tuomilehto ; A. G. Uitterlinden ; M. Uusitupa ; P. van der Harst ; G. Veronesi ; M. Walker ; N. J. Wareham ; H. Watkins ; H. E. Wichmann ; G. R. Abecasis ; T. L. Assimes ; S. I. Berndt ; M. Boehnke ; I. B. Borecki ; P. Deloukas ; L. Franke ; T. M. Frayling ; L. C. Groop ; D. J. Hunter ; R. C. Kaplan ; J. R. O'Connell ; L. Qi ; D. Schlessinger ; D. P. Strachan ; K. Stefansson ; C. M. van Duijn ; C. J. Willer ; P. M. Visscher ; J. Yang ; J. N. Hirschhorn ; M. C. Zillikens ; M. I. McCarthy ; E. K. Speliotes ; K. E. North ; C. S. Fox ; I. Barroso ; P. W. Franks ; E. Ingelsson ; I. M. Heid ; R. J. Loos ; L. A. Cupples ; A. P. Morris ; C. M. Lindgren ; K. L. Mohlke
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adipocytes/metabolism ; Adipogenesis/genetics ; Adipose Tissue/*metabolism ; Age Factors ; *Body Fat Distribution ; Body Mass Index ; Continental Population Groups/genetics ; Epigenesis, Genetic ; Europe/ethnology ; Female ; Genome, Human/genetics ; *Genome-Wide Association Study ; Humans ; Insulin/*metabolism ; Insulin Resistance/genetics ; Male ; Models, Biological ; Neovascularization, Physiologic/genetics ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/*genetics ; Sex Characteristics ; Transcription, Genetic/genetics ; Waist-Hip Ratio
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-11-06
    Publisher:
    Rockefeller University Press
    Print ISSN:
    0022-1007
    Electronic ISSN:
    1540-9538
    Topics:
    Medicine
    Keywords:
    Cardiovascular Biology
    Published by:
    http://www.rupress.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Debruyne, F. ; Yoshida, O. ; Olsson, C. ; Bauer, J. ; Hold, W. ; Kakehi, Y. ; Schalken, JA ; Borkowsky, A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1442-2042
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1442-2042.1995.tb00485.x

    Articles: DFG German National Licenses
  5. 5
    BERGMAN, B. ; HUGOSON, A. ; OLSSON, C.-O.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1995
    Staff View
    ISSN:
    1365-2842
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    summary A 25 year longitudinal study was carried out on a number of patients fitted with removable partial dentures (RPDs) in 1969. Before the prosthetic treatment all patients were given oral hygiene motivation and instructions in order to create a high level of co-operation. The RPDs, most of which were lower bilateral distal extension dentures, were carefully planned and designed. During the first 10 years the patients were examined in our clinic at yearly intervals at which time encouragement and reinstruction regarding oral hygiene were given and various treatment procedures were performed as required. After the initial 10 years the patients were advised, for practical reasons, to continue to have yearly controls on their own initiative. Of the initial 30 patients from 1969, 23 were still alive in 1994, all of whom were examined. In five of those 23 the original RPD situation had changed more or less due mainly to general illness contracted and/or change to other therapies. In the remaining 18 patients wearing in total 20 RPDs, 13 (65%) of the original RPDs were still functioning. Seven RPDs were new with principally the same design as the original ones. Among these 18 patients the number of lost teeth, the number of new DF surfaces and the increased number of endodontically treated teeth were few. No apparent changes took place regarding the periodontal condition during the follow-up period. These favourable biological conditions in the RPD jaws, in combination with the patients' satisfaction with the comfort and chewing ability, reinforce the conclusions drawn at our 10 year control – that an RPD is a valuable treatment procedure for patients with a markedly reduced number of teeth.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2842.1995.tb01055.x

    Articles: DFG German National Licenses
  6. 6
    OLSSON, C. N. ; SMITH, ALEX G.

    [s.l.] : Nature Publishing Group
    Published 1967
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] Recently we reported2 that char. 3 pulses are received most often when source B is on the central meridian, a result supported by Baart, Barrow, and Lee3. In analyses in which no distinction is made between pulse types it is the main source, A, that shows the highest probability of emission. Our ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/214999a0

    Articles: DFG German National Licenses
  7. 7
    Eriksson, S.G. ; Johansson, L.G. ; Olsson, C.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0921-4534
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0921-4534(88)80146-1

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    0012-1606
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0012-1606(85)90326-4

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    0022-0248
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Geosciences
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-0248(91)90568-P

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    0022-0248
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Geosciences
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-0248(91)90579-T

    Articles: DFG German National Licenses
  11. 11
    Cecchinato, D. ; Olsson, C. ; Lindhe, J.

    Oxford, UK : Munksgaard International Publishers
    Published 2004
    Staff View
    ISSN:
    1600-051X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Objective: To evaluate bone-level alterations that occurred at implants of the Astra Tech® System that were placed in the load carrying, posterior parts of the dentition using either a submerged (two-stage) or a non-submerged (one-stage) installation protocol.Material and Methods: Eighty-four patients that required 115 fixed partial dentures (FPDs or cases) entered the prospective study. All subjects were assigned one patient and 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE527:ges" location="ges.gif"/〉one case numbers. For the randomization of cases, a custom-made program based on balanced random permuted blocks was utilized. The cases were assigned to two treatment groups, namely one-stage installation procedure, non-submerged technique (group A) and two-stage installation procedure, submerged technique (group B). Several subjects contributed with cases to both groups A and B. Periodontal, endodontal and open caries lesions were treated prior to implant installation. All patients received careful oral hygiene instruction and training in self-performed plaque control measures.The surgical technique used for fixture installation followed the outline described in the manual for the Astra Tech® System. The FPDs were placed 3 months (mandible) and 6 months (maxilla) following implant installation. Immediately following FPD placement, a baseline examination was performed that included assessment of plaque, soft-tissue inflammation and bone level. Clinicians who were otherwise not involved in the study performed the radiographic measurements. Clinical and radiographical examinations were repeated once a year after the baseline examination.Data analysis: The primary outcome variable was the change in the bone level at the implants from the time of placement of the bridge (FPD) to the 1- and 2-year reexaminations. Fisher's permutation test was used to test if differences existed between groups A and B, and between patients (men/women, smokers/non-smokers, age), sites (maxilla/mandible) and implants (length, diameter). Pitman's test was used to study correlations between bone shape and quality data and different radiographic bone-level data.Results: It was demonstrated that tissue healing following implant installation appeared to be independent of the surgical protocol, i.e. whether the marginal portions of the implants during surgery were fully or only partly submerged under the ridge mucosa. Thus, (i) in both treatment groups the number of implants that failed to osseointegrate (early failures) was small (〈2%); (ii) at the end of the recommended periods of bone healing prior to loading, – in both groups, maxilla=6 months and mandible=3 months – the level of the marginal bone was close to the coronal rim of the fixture; group A: 1.54±0.92 mm, group B: 1.31±0.77 mm. The current study also demonstrated that irrespective of surgical protocol (two-stage, one-stage), implants supporting the FPDs exhibited only small amount of radiographic bone loss during the first year of function (group A: 0.02±038 mm, group B: 0.17±0.64 mm). Moreover, during the second year of function, the amount of additional bone loss that occurred in the two treatment groups was close to zero.Conclusion: Periimplant bone-level change during function seemed to be unrelated to whether initial soft- and hard-tissue healing following implant installation had occurred under submerged or non-submerged conditions.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-051X.2004.00527.x

    Articles: DFG German National Licenses
  12. 12
    Olsson, C. ; Emilson, C. G. ; Birkhed, D.
    Springer
    Published 2000
    Staff View
    ISSN:
    1436-3771
    Keywords:
    Keywords Fluoride release ; Resin-modified glass ionomer cement ; pH ; Sodium fluoride ; Toothpaste
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract . The aim of the study was to evaluate the fluoride release from an aged resin-modified glass ionomer (Vitremer) after exposure to five toothpaste slurries with different pH values. Cylindrical specimens of the material were leached in de-ionized water for 3 months and then exposed for 30 min daily for 10 days to three dentifrice slurries (20 specimens/group) containing 0.05% fluoride with pH values of 2.6, 5.7 and 8.3 and two non-fluoridated slurries with pH values of 2.5 and 5.7. A neutral NaF solution (0.05% F) was used as a control. During the 30 min exposure time, the fluoride concentration was gradually decreased in order to imitate the clinical situation. Thereafter, specimens were immersed individually in de-ionized water and the fluoride release determined. After the first day of exposure, all groups except one without fluoride (pH 5.7) showed significantly (P〈0.05) increased fluoride release. After exposure to the fluoridated toothpaste slurry with pH 5.7, significantly (P〈0.05) more fluoride was released compared to the toothpaste slurry with pH 8.3. Low pH (2.5 or 2.6) of the slurry resulted in a significantly (P〈0.05) higher fluoride release, regardless of whether it was fluoridated or not. The total amount of fluoride released after exposure to the more acidic fluoride toothpaste slurry was greater than that released from the more acidic non-fluoride toothpaste and the less acidic fluoride toothpaste. Our data indicate that the fluoride release from the resin-modified glass ionomer studied may be in-creased after treament with an acidified NaF-toothpaste.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s007840000084

    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1433-8726
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Prostate-specific antigen (PSA) is the most accurate serum marker for cancer of the prostate (CaP). However, its sensitivity and specificity are suboptimal, especially at values ranging between 4.1 and 10.0 ng/ml (monoclonal), because benign prostatic hypertrophy and hyperplasia (BPH) and CaP frequently coexist in this range. This study was undertaken to determine the value of incorporating prostate volume measurements with serum PSA levels in a quotient (PSA/volume) entitled PSA density (PSAD). A total of 3140 patients were analyzed and stratified by serum PSA, digital rectal examination (DRE), transrectal prostate ultrasound (TRUS), TRUS volume determination and PSAD. All patients were referred for evaluation and therefore do not represent a screened population. Patients underwent prostate biopsies when abnormalities in TRUS or DRE were detected. Although both PSA and PSAD have statistical significance when the serum PSA value is ≦4.0 ng/ml, neither has clinical significance in differentiating BPH from CaP. At serum levels ranging between 4.1 and 10.0 ng/ml, PSA has no ability to differentiate BPH from CaP, whereas PSAD does so with statistical and clinical significance. When the PSA value is between 10.1 and 20.0 ng/ml, only PSAD is statistically significant. When PSA exceeds 20 ng/ml, PSAD is redundant. We conclude that all patients with an abnormality on DRE or TRUS should undergo prostate biopsy. If the PSA value is ≦4.0 ng/ml, TRUS and PSAD are not warranted and routine biopsy is not recommended. For intermediate PSA levels, 4.1–10.0 ng/ml, TRUS, TRUS prostate volume, and PSAD are important. The use of PSAD provides unique information regarding the need for biopsy and the likelihood of CaP. At PSA levels ranging between 10.1 and 20.0 ng/ml, PSAD will identify those patients who are less likely to have CaP, but all should undergo biopsy. If the PSA value is 〉20 ng/ml, all patients should undergo a biopsy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00185070

    Articles: DFG German National Licenses
  14. 14
    Olsson, C. A.
    Springer
    Published 1985
    Staff View
    ISSN:
    1433-8726
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00326994

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1434-0879
    Keywords:
    Bladder carcinoma ; Keyhole limpet haemocyanin (KLH) ; Immunotherapy
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The antigenicity of transitional cell carcinoma of the bladder has stimulated the search for effective immunotherapeutic agents in the treatment of this disease. Non-specific immunotherapy with local (intravesical/intralesional) and systemic Keyhole Limpet Haemocyanin (KLH) in a FANFT induced murine bladder tumor model was studied. Results showed no difference between control or treated groups in either tumor growth or animal survival.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00256343

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1434-0879
    Keywords:
    Cytoreductive surgery ; Chemotherapy ; Renal adenocarcinoma ; Rats
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The potential ability of cytoreductive surgery to increase the effectiveness of chemotherapy (vindesine) was tested utilizing male Wistar Lewis rats transplanted simulataneously with intraperitoneal and flank implants of a spontaneously arising renal adenocarcinoma. Cytoreduction was accomplished in some animals by removing the flank tumor 5–7 weeks following implantation; all animals received vindesine (IP injection of 0.5 mg/kg on two successive weeks). While vindesine reduced tumor growth, in no case did the addition of cytoreductive surgery enhance the effect of chemotherapy. The addition of cytoreductive surgery to marginally effective chemotherapy was found to be ineffective or even detrimental.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00571754

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1434-0879
    Keywords:
    Renal carcinoma ; Chemosensitivity ; Animal model
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary A non-endocrine dependent, spontaneous carcinoma of the kidney in a Wistar-Lewis rat has been studied for sensitivity to chemotherapeutic agents. Two tumour models have been employed. Subcutaneously transplanted flank nodules were used to screen single agents for antitumour activity. A model of intraperitoneal metastatic disease was employed to test further agents which had demonstrated some effectiveness in the nodule model. Single agents that proved ineffective were streptozotocin, neocarzinostatin, chlorozotocin and carminomycin. 5-FU, bleomycin and hydroxyurea were also ineffective at the doses tested. Agents that were effective included cyclophosphamide, adriamycin, vinblastine, vindesin, and maytansine. The most effective combination therapy appeared to be cyclophosphamide with vindesin and cisplatin.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00256520

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1433-8726
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary We have examined the reproducibility of DNA histograms produced by flow cytometry in two strains of the Dunning R3327 rat prostatic tumor model, determining the extent of variability between tumors in the same animal, from animal to animal within the same strain and from strain to strain. We have also investigated the ability of flow cytometry to monitor changes in DNA histograms produced by tumor age and hormonal manipulation. We have found that there is a considerable difference in aneuploidy in tumors from the two strains, and also much variability in its extent within each strain. While orchiectomy (ORCH) tended to decrease the extent of aneuploidy, this could only be reliably detected if each tumor acted as its own control, with sampling being done pre- and post-ORCH.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00326863

    Articles: DFG German National Licenses
  19. 19
    Allhoff, E. P. ; Olsson, C. A.
    Springer
    Published 1993
    Staff View
    ISSN:
    1433-8726
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00185065

    Articles: DFG German National Licenses
  20. 20
    Olsson, C. A.
    Springer
    Published 1985
    Staff View
    ISSN:
    1433-8726
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00326979

    Articles: DFG German National Licenses