Search Results - (Author, Cooperation:C. Moran)
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1Latest Papers from Table of Contents or Articles in PressTesti, A. M., Pession, A., Diverio, D., Grimwade, D., Gibson, B., de Azevedo, A. C., Moran, L., Leverger, G., Elitzur, S., Hasle, H., ten Bosch, J. v. d. W., Smith, O., De Rosa, M., Piciocchi, A., Lo Coco, F., Foa, R., Locatelli, F., Kaspers, G. J. L.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-07-27Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Myeloid Neoplasia, Clinical Trials and ObservationsPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. E. Green ; E. L. Braun ; J. Armstrong ; D. Earl ; N. Nguyen ; G. Hickey ; M. W. Vandewege ; J. A. St John ; S. Capella-Gutierrez ; T. A. Castoe ; C. Kern ; M. K. Fujita ; J. C. Opazo ; J. Jurka ; K. K. Kojima ; J. Caballero ; R. M. Hubley ; A. F. Smit ; R. N. Platt ; C. A. Lavoie ; M. P. Ramakodi ; J. W. Finger, Jr. ; A. Suh ; S. R. Isberg ; L. Miles ; A. Y. Chong ; W. Jaratlerdsiri ; J. Gongora ; C. Moran ; A. Iriarte ; J. McCormack ; S. C. Burgess ; S. V. Edwards ; E. Lyons ; C. Williams ; M. Breen ; J. T. Howard ; C. R. Gresham ; D. G. Peterson ; J. Schmitz ; D. D. Pollock ; D. Haussler ; E. W. Triplett ; G. Zhang ; N. Irie ; E. D. Jarvis ; C. A. Brochu ; C. J. Schmidt ; F. M. McCarthy ; B. C. Faircloth ; F. G. Hoffmann ; T. C. Glenn ; T. Gabaldon ; B. Paten ; D. A. Ray
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-12-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alligators and Crocodiles/classification/*genetics ; Animals ; Biological Evolution ; Birds/classification/*genetics ; Conserved Sequence ; DNA Transposable Elements ; Dinosaurs/classification/*genetics ; *Evolution, Molecular ; Genetic Variation ; *Genome ; Molecular Sequence Annotation ; Molecular Sequence Data ; Phylogeny ; Reptiles/classification/genetics ; Sequence Alignment ; Sequence Analysis, DNA ; TranscriptomePublished by: -
3Latest Papers from Table of Contents or Articles in PressJ. Zhang ; J. Fujimoto ; D. C. Wedge ; X. Song ; S. Seth ; C. W. Chow ; Y. Cao ; C. Gumbs ; K. A. Gold ; N. Kalhor ; L. Little ; H. Mahadeshwar ; C. Moran ; A. Protopopov ; H. Sun ; J. Tang ; X. Wu ; Y. Ye ; W. N. William ; J. J. Lee ; J. V. Heymach ; W. K. Hong ; S. Swisher ; Wistuba, II ; P. A. Futreal
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adenocarcinoma/*genetics/pathology ; DNA Mutational Analysis ; Exome/genetics ; Genes, Neoplasm ; *Genetic Heterogeneity ; Humans ; Lung Neoplasms/*genetics/pathology ; Mutation ; Neoplasm Recurrence, Local/*genetics/pathologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-10-11Publisher: Royal SocietyElectronic ISSN: 2054-5703Topics: Natural Sciences in GeneralKeywords: cellular biologyPublished by: -
5Articles: DFG German National LicensesStaff View
ISSN: 0066-6742Topics: ArchaeologyNotes: VARIAURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1475-2743Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesAgriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Abstract. A method is presented for compiling a manual for the estimation of crop residue cover in the field. The crop residue is a combination of standing stubble and the straw remaining on the ground after harvest. Field assessment of crop residue is important so that management decisions may be made in the field. Such decisions include selection of cultivation or sowing machinery, irrigation scheduling (for crusting materials), soil temperature control and grazing of crop residue. The manual consists of a graded set of colour photographs, taken from an overhead boom, and a sampling rate nomogram to determine the number of 1 m quadrats required in a given field to estimate the cover with a predetermined level of error. Two methods for calibration of the photographs are compared: (a) projection of slides onto a screen with manual counting, and (b) digital image analysis of the photographs. Image analysis is efficient, rapid and gives less error than counting from the projections because many more points are counted. The use of the manual in the field is described. It is an inexpensive piece of equipment for the field agronomist or farmer, and gives a reliable, rapid and semi-quantitative estimate of residue cover.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesMoran, C. ; Ni Bhuinneain, M. ; Geary, M. ; Cunningham, S. ; McKenna, P. ; Gardiner, J.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Incidence rates of electrocardiographic changes during Caesarean section vary from 25 to 60%. To date, no investigator has identified myocardial ischaemia resulting from these changes. We investigated patients undergoing elective Caesarean section using peripartum Holter monitoring and serum analysis of cardiac troponin I (cTnI). Twenty-six patients presenting for elective Caesarean section were studied. Peroperative Holter monitoring continued for 12 h postoperatively, at which time blood samples for cTnI levels were taken. Significant ST changes were recorded in 42% of patients peroperatively and 38.5% of patients postoperatively. Forty-two per cent of patients experienced peroperative chest pain requiring opioid analgesia. Chest pain was significantly associated with abnormal electrocardiogram (ECG) findings. Ischaemic levels of cTnI were recorded in two patients. This study reports, for the first time, myocardial ischaemia (7.69% of patients) arising in conjunction with the ECG changes seen during elective Caesarean section. We also report episodes of significant postoperative ST-segment changes.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesBARRETT, A. M. ; WALSHE, K. ; KAVANAGH, P. V. ; McNAMARA, S. M. ; MORAN, C. ; BURDETT, J. ; SHATTOCK, A. G.
Oxford, UK : Blackwell Publishing Ltd
Published 1999Staff ViewISSN: 1369-1600Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Five commercially available immunoassay test kits (SYVA EMIT® d.a.uTM, SYVA EMIT® II assay, Abbott FPIA, Cozart Auto-Lyte® and Roche Abuscreen® OnlineTM, all used for the benzodiazepine group of drugs) were evaluated for their ability to detect flunitrazepam, its major urinary metabolite, 7-aminoflunitrazepam, and several other benzodiazepines at serial dilutions (final concentration 25–1000 ng/ml) in drug-free urine and in urines following oral administration of flunitrazepam (1–3 mg). For comparison, gas chromatography/mass spectrometry was used to measure urinary levels of 7-aminoflunitrazepam. Levels of drug detected in the study were compared with the cross-reactivities presented by the manufacturers for each individual kit. One to three mg doses of flunitrazepam were taken by volunteers and levels excreted in urine analysed over several hours. A positive response was obtained in several samples from volunteers who had taken 2 mg or 3 mg doses, but not a 1 mg dose. Thirty-five clinical samples from the individuals suspected of benzodiazepine abuse were also examined. The results were not consistent among the kits evaluated.We conclude that the test kits evaluated in this study do not detect flunitrazepam reliably, due primarily to their poor sensitivities.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 8755-4615Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Computer ScienceEducationType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 8755-4615Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Computer ScienceEducationType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1460-9592Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: Autistic children are very difficult to manage in the hospital setting because they react badly to any change in routine. Methods: We have developed a unique management program for autistic children admitted for medical and surgical procedures requiring a general anaesthetic. Details of each patient managed according to this program have been prospectively entered into an Autistic Register. Results: An audit of this database shows that we have administered anaesthesia on 87 occasions for 59 autistic children over 4 years. Conclusions: There is great variation in the severity of autism and hospital needs of these children. The focus is on early communication with the patient’s families, flexibility to individualize the admission process and anaesthetic plan with admission and early discharge on the day of surgery whenever possible. Oral midazolam is an effective premedication for the milder cases and oral ketamine is the most reliable for moderate and severe cases. Comparison of oral midazolam and ketamine shows no significant different postoperative recovery and hospital discharge times. Routine intravenous fluids and antiemesis prophylaxis with removal of the i.v. cannula before return to the ward are also seen as important steps to decrease stress and smooth the postoperative phase. This program has also successfully been extended to the management of problem children due to other causes.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims: To present three cases of sclerosing haemangioma of the lung (SHL) with prominent cystic changes.Methods and results: The patients were three women, 27, 35, and 64 years of age. In two cases, the lesion was found on routine chest X-ray and in both instances the diagnosis of SHL was not entertained in the radiological differential diagnosis. In one case, the finding was discovered on post mortem examination. Grossly, the lesions were well-circumscribed and cystic. Histologically, the tumours were characterized by a dual population of small and large bland-appearing neoplastic cells growing in a predominantly cystic pattern. Immunohistochemical staining for epithelial membrane antigen by tumour cells was consistently positive in all three cases. All tumours were negative for keratin, CD34, factor VIII, and S100. The two patients in whom the lesion was identified ante-mortem are alive and free of disease 4 and 7 years after surgical excision.Conclusions: The present cases indicate that sclerosing haemangioma may present as a cystic pulmonary neoplasm; such a presentation should be taken into consideration when assessing cystic pulmonary lesions.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesCastro, C Y ; Moran, C A ; Flieder, D G ; Suster, S
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Primary signet ring cell adenocarcinomas of the lung: a clinicopathological study of 15 cases Aims: We describe the clinicopathological characteristics of 15 cases of primary signet ring cell adenocarcinoma of the lung and highlight the importance of recognizing that not all adenocarcinomas with signet ring cell features represent metastatic adenocarcinomas. Methods and results: We evaluated the clinicopathological and immunohistochemical features of 15 cases of signet ring cell adenocarcinoma of the lung. The patients were 12 men and three women, age 30–75 years (mean 52.5 years). No evidence of a primary tumour elsewhere could be found on thorough clinical examination. Nine patients underwent resection and the remainder were biopsied. The tumours ranged from 18 to 80 mm in greatest dimension. Microscopically, two distinct patterns of growth were recognized: acinar and diffuse. The tumours were characterized by the presence of 〉75% signet ring cells. Periodic acid–Schiff and mucicarmine showed strong intracellular positive staining. Immunohistochemical stains for TTF-1 (6/6) and CEA (9/9) showed strong positive reaction in all cases evaluated. Three out of six cases were also positive for cytokeratin 7. All the tumours (6/6) were negative for cytokeratin 20, ER, PR and GCDFP-15. Follow-up information was obtained in 11 patients; six patients died within 1 year and five patients were alive from 3 to 36 months after initial diagnosis. Conclusion: These cases highlight an unusual histological growth pattern of primary lung adenocarcinoma that may be mistaken for a metastasis from an occult primary. The recognition of this pattern of lung tumours is important for proper treatment.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims : To report three cases of primary carcinoma of the neck arising in multilocular thymic cysts (MTC).Methods and results : The patients were three men aged 47, 50 and 52 years who presented with a painless neck mass of several weeks' duration. The patients had no history of previous surgical procedures or of malignancy elsewhere. The tumours in all three patients were located on the right lateral side of the neck; all patients underwent complete surgical resection of the mass. Grossly, the tumours were cystic and measured between 20 and 30 mm in greatest diameter. Histologically, the tumours showed cyst walls lined by squamous epithelium. The cyst walls contained prominent germinal centres with lymphoid hyperplasia, cholesterol cleft granulomas, and scattered keratinized structures reminiscent of Hassall's corpuscles. In addition, a neoplastic cellular proliferation composed of round to oval cells arranged in sheets and originating from the lining of the cystic structures was present. The neoplastic cells showed moderate amounts of eosinophilic cytoplasm, round nuclei, and, in some areas, prominent nucleoli. Mitotic figures were easily found, and cellular pleomorphism was present in several areas. In two cases the tumours showed features of basaloid carcinoma of the thymus, while in one case the pattern was that of squamous cell carcinoma. Immunohistochemical studies for keratin showed a strong positive reaction in the tumour cells, while leucocyte common antigen strongly stained the lymphoid background. Follow-up information obtained in two patients showed them to be alive 6 months after initial diagnosis. One patient was lost to follow-up.Conclusion : The cases described here represent an unusual variant of carcinoma arising in multilocular thymic cyst in the neck region.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0005-2760Keywords: (Human epidermis) ; Confluence ; Injury ; Keratinocyte ; Prostaglandin E"2 synthesis ; Ultraviolet light BSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0304-3878Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Political ScienceEconomicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0304-3878Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Political ScienceEconomicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0305-750XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: GeographyPolitical ScienceSociologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0378-4320Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionType of Medium: Electronic ResourceURL: