Search Results - (Author, Cooperation:C. Metcalfe)
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1Latest Papers from Table of Contents or Articles in PressM. J. Ridd, D. M. Gaunt, R. H. Guy, N. M. Redmond, K. Garfield, S. Hollinghurst, N. Ball, L. Shaw, S. Purdy, C. Metcalfe
Wiley-Blackwell
Published 2018Staff ViewPublication Date: 2018-02-25Publisher: Wiley-BlackwellPrint ISSN: 0007-0963Electronic ISSN: 1365-2133Topics: MedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressPoffenberger, M. C., Metcalfe-Roach, A., Aguilar, E., Chen, J., Hsu, B. E., Wong, A. H., Johnson, R. M., Flynn, B., Samborska, B., Ma, E. H., Gravel, S.- P., Tonelli, L., Devorkin, L., Kim, P., Hall, A., Izreig, S., Loginicheva, E., Beauchemin, N., Siegel, P. M., Artyomov, M. N., Lum, J. J., Zogopoulos, G., Blagih, J., Jones, R. G.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Immunology, Medicine, DiseasesPublished by: -
3Latest Papers from Table of Contents or Articles in PressE. E. Storm ; S. Durinck ; F. de Sousa e Melo ; J. Tremayne ; N. Kljavin ; C. Tan ; X. Ye ; C. Chiu ; T. Pham ; J. A. Hongo ; T. Bainbridge ; R. Firestein ; E. Blackwood ; C. Metcalfe ; E. W. Stawiski ; R. L. Yauch ; Y. Wu ; F. J. de Sauvage
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-12-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies/immunology/pharmacology/therapeutic use ; Cell Differentiation/*drug effects ; Cell Division/drug effects ; Colorectal Neoplasms/*drug therapy/metabolism/*pathology ; Disease Progression ; Female ; Gene Expression Regulation/drug effects ; Humans ; Intestines/cytology/drug effects/metabolism/pathology ; Male ; Mice ; *Molecular Targeted Therapy ; Neoplastic Stem Cells/*drug effects/metabolism/*pathology ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/*metabolism ; Stem Cells/cytology/metabolism ; Thrombospondins/antagonists & inhibitors/immunology/*metabolism ; Xenograft Model Antitumor AssaysPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1095-8649Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Testosterone induced papillomata in 85% (11/13) of initially non-papillomatous white suckers Catostomus commersoni and increased papillomata growth in 100% (16/16) of initially papillomatous suckers. 17β-oestradiol induced papillomata in 83% (10/12) of initially nonpapillomatous suckers and increased papillomata growth in 100% (16/16) of initially papillomatous suckers. Less than 29% (4/14) of white suckers injected with tamoxifen developed papillomata, while complete papillomata regression was observed in 71% (10/14) of initially papillomatous suckers. In control groups 59% (27/46) of suckers either retained or developed papillomata and 27% (6/24) of suckers exhibited tumour regression. Protein kinase C (PKC) activity was significantly depressed and ornithine decarboxylase (ODC) activity was significantly elevated in steroid-treated papillomata v. normal lip epidermis. ODC activity was significantly depressed in tamoxifen-injected, regressing papillomata. There were no significant differences in plasma oestrogen and testosterone levels between papillomatous and nonpapillomatous female fish from a site contaminated with persistent organic chemicals and an uncontaminated reference site. Similarly, no significant differences in testosterone and 11-ketotestosterone levels were observed between papillomatous and non-papillomatous male fish.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] IT is a well-known fact that the common nettle (Urtica dioica) yieldsa very strong bast fibre which was used in Great Britain until about 1860 for the manufacture of cloth. Since then its use has been discontinuedbecause other cheaper, imported materials became available. In the past,nettles have ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] ON May 7, Lord Florey, president of the Royal Society of London, opened the new Jodrell Laboratory at Kew. The ceremony was attended by the Minister of Agriculture and other distinguished guests. This bald statement of fact covers an event of very great significance in the history of the Royal ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract The concentration of PCB, as Aroclor 1254®, accumulated from sandy sediment byNereis virens is directly related to PCB concentration in sediment and to exposure time, and is inversely related to worm size. There was no indication of equilibrium concentrations being attained during 32 days' exposure. Concentration factors at 32 days ranged from 10.8 for 0.6-g worms to 3.8 for 4.7-g worms. There was no obvious excretion of PCB byN. virens during 26 days' post exposure. Accumulation of PCB byCrangon septemspinosa is directly related to PCB concentration in sediment and inversely related to animal size. Concentration factors at 32 days ranged from 3.5 for 0.1-g shrimp to 1.9 for 2.9-g shrimp. Field collectedN. virens ranging in weight from 1.3 to 20.0 g were analyzed for PCB, ΣDDT and dieldrin. Smaller worms had accumulated more per unit weight of each compound than larger worms.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesMcLeese, D. W. ; Sergeant, D. B. ; Metcalfe, C. D. ; Zitko, V. ; Burridge, L. E.
Springer
Published 1980Staff ViewISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Conclusions (IR)-cis-permethrin, decamethrin, and NRDC 168S are extremely lethal to salmon and lobster. The increase in lethality relative to that of permethrin follows qualitatively the patterns established in toxicity studies with insects: (IR)-cis isomers are more lethal than (IR)-trans, and the presence of an αcyano group in the phenoxybenzyl moiety increases the lethality. The latter effect is very pronounced for lobsters. The octanol/water partition coefficient alone is not sufficient for predicting the lethality of pyrethroids to salmon or lobster.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Conclusions Permethrin is extremely toxic to juvenile Atlantic salmon and has a lethal threshold of approximately 9 μg/ℓ. It is relatively much more persistent than pyrethrins and allethrin. Fish accumulate permethrin from water and the accumulation coefficient of 55 indicates an intermediate degree of accumulation under the used experimental conditions.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Conclusions Comparison of the Freundlich isotherms for adsorption and desorption of Aroclor 1254 indicate that adsorbed PCB does not desorb readily. The Freundlich exponent and K value for desorption, based on the organic carbon content of the sediment, may be of practical use in predicting PCB concentrations in the pore water of settled dredge spoil, provided that the replacement rate of pore water is slow enough to allow establishment of equilibrium conditions. It is assumed that these coefficients may apply to other sediments with different combinations of organic and inorganic components. However, further study to check this and whether the Freundlich isotherms apply at lower concentrations of PCB is required.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesMenone, M. L. ; Aizpún de Moreno, J. E. ; Moreno, V. J. ; Lanfranchi, A. L. ; Metcalfe, T. L. ; Metcalfe, C. D.
Springer
Published 2000Staff ViewISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract. A freshwater fish species, silverside (Odontesthes bonariensis) from Mar Chiquita coastal lagoon, Argentina, was analyzed for concentrations of several organochlorine pesticides (OCs) and polychlorinated biphenyls (PCBs) in liver, gonads, mesenteric fat and muscle, and the contents of the digestive tract over several stages of sexual maturation. PCBs and OCs were detected at ng/g concentrations (wet weight) in pooled samples, with levels generally in the order of fat 〉 liver 〉 gonad 〉 muscle, reflecting the differences in tissue lipid content. Lipid-normalized concentrations of the analytes were relatively consistent among tissues, except for significantly higher concentrations of PCBs (e.g., 447.7 ng/g lipid wt) in the ovaries of female silverside. DDT and its metabolites, γ-HCH, and several insecticides from the cyclodiene class, including endosulfan and endosulfan sulfate, were the predominant OCs in fish tissues and the contents of the digestive tract, reflecting recent and past pesticide use in this region. The ratio of OCs to PCBs in all tissues was 〉1; consistent with contamination of the region with OC pesticides. However, PCBs were dominated by penta- and hexachlorobiphenyls, which is consistent with direct (i.e., nonatmospheric) inputs. Biomagnification of penta- and hexachlorobiphenyl PCB congeners was noted in fish tissues relative to the contents of the digestive tract. Total OC and PCB concentrations in the ovaries and muscle of silverside were below concentrations associated with reproductive impairment in fish or the limits for human consumption, respectively.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1573-2932Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Abstract Studies in temperate regions indicate that the carbamate insecticide aldicarb and its metabolites leach readily through agricultural soils into groundwater. However, little is known about the fate of this nematicide in tropical regions, where its leaching potential may be even greater because of high annual rainfall and the acidic nature and low organic content of many tropical soils. Examination of the leaching behaviour of aldicarb and its metabolites in columns containing soil from Belize, Central America, indicated that total carbamate residues (TCR) could rapidly reach concentrations 〉 15 mg L−1 in porewater 1 m below the soil surface within 70 days of application. These values are well in excess of the US EPA Health Advisory level of 0.01 mg L−1. TCR retention within a given depth interval in the soil columns relative to incoming TCR flux was greatest between 0 and 0.1 m, reflecting high organic matter contents in the upper soil. Retention below 0.1 m was relatively consistent with depth, while differences in relative retention between columns were due to a greater duration of leaching for the second column. Aldicarb was rapidly oxidized to aldicarb sulfoxide and aldicarb sulfone in these soils. The high concentration and mobility of TCR in this acidic soil is attributed to the transformation of the parent compound to the sulfoxide metabolite, which has a lower degradation rate and organic carbon partioning coefficient than aldicarb.Type of Medium: Electronic ResourceURL: