Search Results - (Author, Cooperation:C. M. Robinson)

Showing 1 - 2 results of 2, query time: 0.11s Refine Results
  1. 1
    C. M. Robinson ; J. K. Pfeiffer
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-11-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; B-Lymphocytes/*virology ; Caliciviridae Infections/*immunology ; Enterobacteriaceae/*physiology ; Gastroenteritis/*immunology ; Humans ; Intestines/*microbiology ; Norovirus/*physiology ; *Virus Replication
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Dempster, R. P. ; Robinson, C. M. ; Harrison, G. B. L.
    Springer
    Published 1996
    Staff View
    ISSN:
    1432-1955
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract  Genetically modified Escherichia coli expressing the Taenia ovis fusion protein GST-45W(B/X) as inclusion bodies were grown in volumes ranging up to 1000 l. Bacteria were inactivated by heat or chemical treatment without affecting immunogenicity. The fusion protein was recovered in a highly immunogenic form from washed inclusion bodies and from urea-solubilised inclusion bodies. The fusion protein was found to be stable in solution after storage at 4°C for up to 2 years. Vaccines formulated with fusion protein from urea-soluble inclusion bodies gave consistently high protection (89–100%) against challenge infection. The methods described enabled the production of sufficient vaccine for large field trials. These trials generated the data required for product registration and manufacture of a vaccine to prevent T. ovis infection in sheep.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses