Search Results - (Author, Cooperation:C. L. Creasy)
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1Latest Papers from Table of Contents or Articles in PressM. T. McCabe ; H. M. Ott ; G. Ganji ; S. Korenchuk ; C. Thompson ; G. S. Van Aller ; Y. Liu ; A. P. Graves ; A. Della Pietra, 3rd ; E. Diaz ; L. V. LaFrance ; M. Mellinger ; C. Duquenne ; X. Tian ; R. G. Kruger ; C. F. McHugh ; M. Brandt ; W. H. Miller ; D. Dhanak ; S. K. Verma ; P. J. Tummino ; C. L. Creasy
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Silencing/drug effects ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors/genetics/metabolism ; Histones/chemistry/metabolism ; Humans ; Indoles/*pharmacology/*therapeutic use ; Lymphoma, Follicular/*drug therapy/enzymology/genetics/pathology ; Lymphoma, Large B-Cell, Diffuse/*drug therapy/enzymology/genetics/pathology ; Methylation/drug effects ; Mice ; Mutation/*genetics ; Neoplasm Transplantation ; Polycomb Repressive Complex 2/*antagonists & inhibitors/genetics/metabolism ; Pyridones/*pharmacology/*therapeutic use ; Repressor Proteins/chemistry/metabolism ; Transcriptional Activation/drug effects ; Transplantation, HeterologousPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. C. Mack ; H. Witt ; R. M. Piro ; L. Gu ; S. Zuyderduyn ; A. M. Stutz ; X. Wang ; M. Gallo ; L. Garzia ; K. Zayne ; X. Zhang ; V. Ramaswamy ; N. Jager ; D. T. Jones ; M. Sill ; T. J. Pugh ; M. Ryzhova ; K. M. Wani ; D. J. Shih ; R. Head ; M. Remke ; S. D. Bailey ; T. Zichner ; C. C. Faria ; M. Barszczyk ; S. Stark ; H. Seker-Cin ; S. Hutter ; P. Johann ; S. Bender ; V. Hovestadt ; T. Tzaridis ; A. M. Dubuc ; P. A. Northcott ; J. Peacock ; K. C. Bertrand ; S. Agnihotri ; F. M. Cavalli ; I. Clarke ; K. Nethery-Brokx ; C. L. Creasy ; S. K. Verma ; J. Koster ; X. Wu ; Y. Yao ; T. Milde ; P. Sin-Chan ; J. Zuccaro ; L. Lau ; S. Pereira ; P. Castelo-Branco ; M. Hirst ; M. A. Marra ; S. S. Roberts ; D. Fults ; L. Massimi ; Y. J. Cho ; T. Van Meter ; W. Grajkowska ; B. Lach ; A. E. Kulozik ; A. von Deimling ; O. Witt ; S. W. Scherer ; X. Fan ; K. M. Muraszko ; M. Kool ; S. L. Pomeroy ; N. Gupta ; J. Phillips ; A. Huang ; U. Tabori ; C. Hawkins ; D. Malkin ; P. N. Kongkham ; W. A. Weiss ; N. Jabado ; J. T. Rutka ; E. Bouffet ; J. O. Korbel ; M. Lupien ; K. D. Aldape ; G. D. Bader ; R. Eils ; P. Lichter ; P. B. Dirks ; S. M. Pfister ; A. Korshunov ; M. D. Taylor
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Brain Neoplasms/drug therapy/genetics ; CpG Islands/*genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy/*genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor AssaysPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Keywords: Key words Transcription factors ; Gene expression ; Protein-protein interaction PHO4 ; PHO2 Saccharomyces cerevisiaeSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract In Saccharomyces cerevisiae, expression of acid phosphatase, encoded by the PHO5 gene, requires two positive regulatory factors, Pho4 and Pho2 (also called Bas2 or Grf10). Using GAL4-PHO4 fusions, we demonstrate that a functional interaction between these two proteins is necessary for transcriptional activation to occur. This functional interaction between Pho4 and Pho2 is independent of the presence of the negative regulatory factor, Pho80, which also interacts with Pho4. Interestingly, truncations of Pho4 missing amino acids 252–265, which encompass the basic region of the basic helix-loop-helix (bHLH) DNA binding motif, exhibit high transcriptional activation that is independent of the Pho2 molecule. Single amino acid mutations of highly conserved residues within this area all display this Pho2-independent phenotype. A region near the C-terminus of Pho2 appears to be critical for this interaction with Pho4. A model to account for the requirement for Pho2 in Pho4-dependent transcriptional activation is proposed.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Keywords: Transcription factors ; Gene expression ; Protein-protein interactionPHO4 ; PHO2 Saccharomyces cerevisiaeSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract InSaccharomyces cerevisiae, expression of acid phosphatase, encoded by thePHO5 gene, requires two positive regulatory factors, Pho4 and Pho2 (also called Bas2 or Grf10). UsingGAL4-PHO4 fusions, we demonstrate that a functional interaction between these two proteins is necessary for transcriptional activation to occur. This functional interaction between Pho4 and Pho2 is independent of the presence of the negative regulatory factor, Pho80, which also interacts with Pho4. Interestingly, truncations of Pho4 missing amino acids 252–265, which encompass the basic region of the basic helix-loop-helix (bHLH) DNA binding motif, exhibit high transcriptional activation that is independent of the Pho2 molecule. Single amino acid mutations of highly conserved residues within this area all display this Pho2-independent phenotype. A region near the C-terminus of Pho2 appears to be critical for this interaction with Pho4. A model to account for the requirement for Pho2 in Pho4-dependent transcriptional activation is proposed.Type of Medium: Electronic ResourceURL: