Search Results - (Author, Cooperation:C. L. Baker)
-
1Latest Papers from Table of Contents or Articles in PressV. M. Narasimhan ; K. A. Hunt ; D. Mason ; C. L. Baker ; K. J. Karczewski ; M. R. Barnes ; A. H. Barnett ; C. Bates ; S. Bellary ; N. A. Bockett ; K. Giorda ; C. J. Griffiths ; H. Hemingway ; Z. Jia ; M. A. Kelly ; H. A. Khawaja ; M. Lek ; S. McCarthy ; R. McEachan ; A. O'Donnell-Luria ; K. Paigen ; C. A. Parisinos ; E. Sheridan ; L. Southgate ; L. Tee ; M. Thomas ; Y. Xue ; M. Schnall-Levin ; P. M. Petkov ; C. Tyler-Smith ; E. R. Maher ; R. C. Trembath ; D. G. MacArthur ; J. Wright ; R. Durbin ; D. A. van Heel
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-03-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; *Consanguinity ; DNA Mutational Analysis ; Drug Prescriptions ; Exome/genetics ; Female ; Fertility ; Gene Knockout Techniques ; Genes, Lethal ; Genetic Loci ; Genome, Human ; Great Britain ; *Health ; Histone-Lysine N-Methyltransferase/*genetics ; Homologous Recombination ; Homozygote ; Humans ; Male ; Mothers ; Pakistan/ethnology ; PhenotypePublished by: -
2Latest Papers from Table of Contents or Articles in PressL. F. Larrondo ; C. Olivares-Yanez ; C. L. Baker ; J. J. Loros ; J. C. Dunlap
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-01-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adenine/analogs & derivatives/pharmacology ; Alleles ; *Circadian Clocks ; *Circadian Rhythm ; Feedback, Physiological ; Fungal Proteins/biosynthesis/*genetics/*metabolism ; Half-Life ; Neurospora crassa/*physiology ; Phosphorylation ; Proteasome Endopeptidase Complex/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Stability ; Proteolysis ; Signal TransductionPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract Nonlinear input-output behavior of the repetitive firing mechanism in crayfish tonic stretch receptor cells was studied using white-noise analysis; the latter technique allows estimation of Wiener kernel functions which provide a complete description of the system input-output behavior, at least for the conditions under which the experiment is performed. 200 ms-long steps of Gaussian-distributed current levels were injected through a microelectrode as the input. Nerve impulse (spike) frequency was used as the output variable. Analysis was restricted to signal frequency components less than or equal to the cell's firing frequency. For this frequency range, the Wiener kernels can be related directly to previously known physiological properties of neurons, such as pacemaker sensitivities, thresholds, and adaptation. Different measures of “spike frequency” (instantaneous frequency, average frequency, and convolution of the spike train with a Sinc function) were tested and gave approximately the same results, with the major differences being at high frequencies. At normal carrier frequencies (approx. 10 Hz) and small modulation depths (cell never shut off for long periods), the stretch receptor behaved very linearly; the first kernel had a peak at the origin followed by a negative decaying undershoot, as would be expected for a neuron with “refractory” (spike-dependent) adaptation; higher kernels made negligible contributions. In this range, the first kernel peak corresponded approximately to the cell's pacemaker sensitivity, as would be expected. When a high modulation depth was employed, the cell was silent for appreciable periods, indicating nonlinear behavior (half-wave rectification). The first kernels were qualitatively unchanged, but second kernels now made a significant contribution.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract Simulated white noise analysis experiments on a simple integrate-and-fire neuron model with adaptation yields Wiener kernels comparable to those found for a crayfish stretch receptor neuron, for low modulation depths (linear range). At high modulation depths (nonlinear range), this model corresponds well to the neuron only if the “membrane potential” variable is constrained to positive values. An alternative kind of neural model considered is one in which spike initiation processes are ignored, and instead a time-continuous spike frequency variable is used. Such an analytic differential equation model can be represented by a half-wave rectifier with low-pass feedback; simulated white noise analysis of this model shows good correspondence with the stretch receptor, except at the higher frequencies approaching the cell's carrier frequency. The analytic system model is amenable to mathematical analysis using linear and nonlinear systems theory, resulting in equations which relate features of Wiener kernels (peaks, undershoots, time constants, etc.) to previously described features of neurons (threshold, pacemaker sensitivity, adaptation or post-inhibitory rebound).Type of Medium: Electronic ResourceURL: