Search Results - (Author, Cooperation:C. Kern)
-
1Latest Papers from Table of Contents or Articles in PressR. E. Green ; E. L. Braun ; J. Armstrong ; D. Earl ; N. Nguyen ; G. Hickey ; M. W. Vandewege ; J. A. St John ; S. Capella-Gutierrez ; T. A. Castoe ; C. Kern ; M. K. Fujita ; J. C. Opazo ; J. Jurka ; K. K. Kojima ; J. Caballero ; R. M. Hubley ; A. F. Smit ; R. N. Platt ; C. A. Lavoie ; M. P. Ramakodi ; J. W. Finger, Jr. ; A. Suh ; S. R. Isberg ; L. Miles ; A. Y. Chong ; W. Jaratlerdsiri ; J. Gongora ; C. Moran ; A. Iriarte ; J. McCormack ; S. C. Burgess ; S. V. Edwards ; E. Lyons ; C. Williams ; M. Breen ; J. T. Howard ; C. R. Gresham ; D. G. Peterson ; J. Schmitz ; D. D. Pollock ; D. Haussler ; E. W. Triplett ; G. Zhang ; N. Irie ; E. D. Jarvis ; C. A. Brochu ; C. J. Schmidt ; F. M. McCarthy ; B. C. Faircloth ; F. G. Hoffmann ; T. C. Glenn ; T. Gabaldon ; B. Paten ; D. A. Ray
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-12-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Alligators and Crocodiles/classification/*genetics ; Animals ; Biological Evolution ; Birds/classification/*genetics ; Conserved Sequence ; DNA Transposable Elements ; Dinosaurs/classification/*genetics ; *Evolution, Molecular ; Genetic Variation ; *Genome ; Molecular Sequence Annotation ; Molecular Sequence Data ; Phylogeny ; Reptiles/classification/genetics ; Sequence Alignment ; Sequence Analysis, DNA ; TranscriptomePublished by: -
2Articles: DFG German National LicensesMarino, M. M. ; Ermler, W. C. ; Kern, C. W. ; Bondybey, V. E.
College Park, Md. : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Ab initio spin–orbit full configuration-interaction calculations in the context of relativistic effective core potentials are reported for the weakly bound metal dimer LiBe, a three-valence-electron system. The effects of basis set on the energies of valence and Rydberg states of the cluster are discussed, as are the effects of configuration space selection on the energy of the latter states. Results at the dissociative limit are compared to the experimental atomic spectra. Potential-energy curves and spectroscopic constants are presented for the ground state and fourteen excited states, which includes the Li and Be 2p valence states, the Li 3s, 3p, 3d, and 4s Rydberg states, as well as three low-lying states of the molecular cation.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesTang, Shaoping ; Freeman, A. J. ; Ross, R. B. ; Kern, C. W.
College Park, Md. : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Results of extensive studies of metallic beryllium modeled with 135 atoms are reported using a first-principles total energy molecular cluster approach based on the local density approximation. Binding energy, ionization potential, charge density, Mulliken populations, density of states and atomic forces are calculated. The results show that the ground state of Be135 is of a″ symmetry. The binding energy is 77.5 kcal/mol which is very close to the binding energy of bulk Be (75.3 kcal/mol). Comparison with earlier results from Hartree-Fock calculations shows significant differences in the calculated binding energy, ionization potential, and Mulliken populations. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesErmler, W. C. ; Kern, C. W. ; Pitzer, R. M. ; Winter, N. W.
College Park, Md. : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: A cluster of 13 beryllium atoms has been studied in ab initio Hartree–Fock calculations. The chosen geometric configuration has D3h symmetry and corresponds to a central Be with 12 atoms situated at the hexagonal close-packed, nearest-neighbor positions. The lowest energy electronic state among those investigated is 5A‘1 and the first excited state is 5E‘ lying at 1.12 eV. A total of 14 states were identified below 2.0 eV. The 5A''1 Hartree–Fock ground state has a binding energy of 12.0 kcal/mol relative to the separated atoms and an ionization potential of 0.54 eV. Total valence energies, orbital energies, binding energies, electric field gradients, diamagnetic shielding constants, nuclear–electron potentials, second moments, and Mulliken populations are reported. In addition, the cluster calculations give a reasonable estimate for the Sternheimer correction to the electric field gradient of the bulk metal.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesFrei, F. J. ; Haemmerle, M. H. ; Brunner, R. ; Kern, C.
Oxford, UK : Blackwell Science Ltd
Published 1997Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Children with cerebral palsy and severe mental retardation who present for operation may require lower concentrations of inhalational anaesthetics than healthy children. The minimum alveolar concentration (MAC) for halothane was measured in 36 children and adolescents, aged 4–18 years, who underwent orthopaedic surgery. The control group consisted of 12 healthy children (group 1). Children with cerebral palsy and severe mental retardation were allocated to one of two groups: those taking chronic anticonvulsant medication (group 2) (n = 12) and those who did not take any drugs (group 3) (n = 12). The mean (SEM) MAC value for halothane (expressed in volume per cent) was 0.90 (0.02) for healthy children. Children with cerebral palsy had significantly lower MAC values whether they took anticonvulsant drugs or not (0.62 (0.03) and 0.71 (0.10), respectively).Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesKERN, C. ; TASSONYI, E. ; ROUGE, J.-C. ; WILDER-SMITH, O. H. G. ; PITTET, J.-F.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED 50 and ED90 of doxacurium during halothane (n = 9), isoflurane (n= 12) or alfentanil (n = 9) based anaesthesia in children aged 2–10 years. Both isoflurane and halothane potentiated the effects of doxacurium compared to alfentanil. The ED50for doxacurium/halothane was 23.9μg.kg-1 compared to 32.7 μg.kg-1 for doxacurium/alfentanil. The ED90, for doxacurium j isoflurane was 32.7 μg.kg-1 compared to 48.2 μg.kg-1 doxacurium/alfentanil (p〈0.05). There were no significant time course differences between the groups. When equipotent doses of doxacurium were used to provide muscle relaxation the duration of the neuromuscular block was similar in children who received qflentanil, halothane or isoflurane supplementation of N2O/O2 anaesthesia.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1460-9592Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We studied the haemodynamic changes during induction of anaesthesia in 50 ASA I and II children (1–12 yrs) undergoing minor elective surgery. The patients were randomly divided into two groups to receive either halothane (n=25) or sevoflurane (n=25) in a mixture of O2 and N2O (40:60) for mask induction of anaesthesia. Induction of anaesthesia was performed with an overpressure technique by administering rapid increases of gas concentrations, in increments of 1% up to 7% for sevoflurane and of 0.5% up to 3% for halothane. Induction was smooth and rapid in both groups but characterized by increases in heart rate and systolic blood pressure up to 20% especially in the sevoflurane group (P〈0.05); these increases in the latter group were significant compared with baseline and the halothane group (P〈0.05). No serious complications were observed. The authors conclude that more children experienced heart rate and blood pressure increases during the early stage of inhalational induction with sevoflurane compared with halothane.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesKATARIA, B. ; EPSTEIN, R. ; BAILEY, A. ; SCHMITZ, M. ; BACKUS, W.W. ; SCHOECK, D. ; HACKL, W. ; GOVAERTS, M.J.M. ; ROUGE, J.C. ; KERN, C. ; ACKERN, K. ; HATCH, D.J.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1460-9592Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Induction, emergence and recovery characteristics were compared during sevoflurane or halothane anaesthetic in a large (428) multicentre, international study of children undergoing elective inpatient surgical procedures. Two hundred and fourteen children in each group underwent inhalation induction with nitrous oxide/oxygen and sevoflurane or halothane. Incremental doses of either study drug were added until loss of eyelash reflex was achieved. Steady state concentrations of anaesthesia were maintained until the end of surgery when anaesthetic agents were terminated simultaneously. Time variables were recorded for induction, emergence and the first need for analgesia in the recovery room. In addition, in 86 of the children in both groups, venous blood samples were drawn for plasma fluoride levels during and after surgery. There was a trend toward smoother induction (induction of anaesthesia without coughing, breath holding, excitement laryngospasm, bronchospasm, increased secretion, and vomiting) in the sevoflurane group with faster induction (2.1 min vs 2.9 min, P= 0.037) and rapid emergence times (10.3 min vs 13.9 min, P= 0.003). Among the children given sevoflurane, 2% developed bradycardia compared with 11% in the halothane group. Postoperatively, 46% of the children in the halothane group developed nausea and or vomiting versus 31% in the sevoflurane group (P= 0.002). Two children in the halothane group developed cardiac dysrhythmia and were dropped from the study. In addition, a child in the halothane group developed malignant hyperthermia, received dantrolene, and had an uneventful recovery. Mean maximum inorganic fluoride concentration was 18.3 μM˙l−1. The fluoride concentrations peaked within one h of termination of sevoflurane anaesthetic and returned rapidly to baseline within 48 h. This study suggests that sevoflurane may be the drug of choice for the anaesthetic management of children.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1572-8862Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Abstract Ab initio calculations are reported for the simplest heteronuclear metal cluster, LiBe. Full spin-orbit configuration interaction calculations in the context of relativistic effective core potentials lead to accurate potential energy curves for low-lying states. Results are compared with recent experimental observations and with all electron multi-reference configuration interaction calculations.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1433-0458Keywords: Schlüsselwörter Tonsillektomie ; Schmerz ; Blutverlust ; Bupivacain ; Epinephrin ; Key words Tonsillectomy ; Pain ; Blood loss ; Bupivacaine ; EpinephrineSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary The effects of peritonsillar injections of epinephrine and local anesthetics before tonsillectomy on blood loss and postoperative pain were evaluated in a prospective, randomized double-blind trial on 103 children. Patients were randomly assigned into one of three groups: controls given injections of 0.9% NaCl (n=34), patients injected with 0.4 ml/kg (1:200,000) epinephrine combined with 0.25% bupivacaine (n=33) and patients given only 1:200,000 epinephrine (n=36). All injections and operations were performed by the same surgeon (KS). Blood loss was calculated by weighing all blood aspirated perioperatively and swabs used during surgery. Postoperative pain was assessed at regular intervals by using three methods: (1) use of a visual analogue scale by parents and nurses to estimate pain; (2) postoperative need for nalbuphin as analgesic; (3) the Hannallah-Broadman semi-objective pain score (including crying, anxiety, restlessness, and changes in blood pressure). The mean blood loss in the control group (given NaCl) was 132 g, which was significantly increased when compared with the epinephrine/bupivacaine group (85 g) and the group treated with only epinephrine (90 g). However, analysis of the postoperative pain scores did not reveal any significant differences among groups. These findings indicate that the peritonsillar injection of bupivacaine does not decrease postoperative pain, but peritonsillar injections of epinephrine will significantly reduce blood loss during tonsillectomy.Notes: Zusammenfassung Anhand einer randomisierten prospektiven, doppelblinden, placebokontrollierten Studie mit 103 Kindern untersuchten wir, ob durch eine peritonsilläre Infiltration von Epinephrin und Lokalanästhetika vor Tonsillektomie der Blutverlust und die postoperativen Schmerzen vermindert werden können. Die Kinder wurden in 3 Gruppen eingeteilt: 1. NaCl-Infiltration als Kontrollgruppe, 2. Epinephrin und Bupivacain und 3. nur Epinephrin. Alle Operationen wurden durch den Erstautor ausgeführt. Der Blutverlust wurde durch Messen des Gewichts der Tupfer und des Inhalts des Absaugglases quantifiziert. Der postoperative Schmerzverlauf wurde in regelmäßigen Intervallen mittels 3 verschiedenen Methoden evaluiert: 1. Schmerzbeurteilung durch die Eltern und Kinderkrankenschwestern anhand einer “visual analogue scale”, 2. postoperativen Nalbuphin-Bedarf und 3. semiobjektiven Schmerzscore nach Hannallah und Broadman (Anaesthesiology 66:832–834, 1987). Der Median des Blutverlustes betrug in der Kontrollgruppe (NaCl) 132 g, und reduzierte sich signifikant in der Gruppe mit Epinephrin und Bupivacain auf 85 g und in der Gruppe mit nur Epinephrin auf 90 g. Die Auswertung der postoperativen Schmerzparameter zeigte keine signifikante Unterschiede zwischen den Gruppen, womit sich keine postoperative analgetische Wirkung von Bupivacain nachweisen ließ. Wir empfehlen deshalb zur Verminderung des Blutverlusts die peritonsilläre Infiltration mit 0,4 ml/kg KG Epinephrin (1:200'000), jedoch ohne Zusatz von Lokalanästhetika.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1573-0832Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The extent to which veterinary pathogenic and human opportunistic species of thermophilic and thermotolerant fungi disseminate in aerosols from heated effluents of nuclear production reactors of the Savannah River Plant (SRP), South Carolina, has been measured. Aerosol samples were taken at 140 sites, from directly over thermal effluents to more than 100 kilometers from the SRP boundary. Sampling methods included settle plates (134 sites, 1, 103 plates for a total of 2, 805 hrs.), liquid impingement (78 sites, 1 cubic meter each), filtration (79 sites, 1 cubic meter each), and a particle sizing cascade impactor (Andersen Sampler) (17 sites, 1 cubic meter each). Soils, foams, and microbial mats from thermal effluents (a total of 191 samples), and vegetation (560 samples) were sampled to study distribution of particular species. Sampling was done under a variety of conditions: hot weather and cold, wet and dry, day and night, windy and calm, reactor(s) operating and not, disturbed vegetation and undisturbed. At 102 of the aerosol sampling sites, sophisticated meterological analyses were used to allow sampling of air in the plume which originated from thermal effluents. Soil, foam, microbial mat, vegetation, and aerosol samples were quantitatively plated for detection of viable units; filters were halved and then both plated and observed microscopically. Significant dissemination of thermophilic and thermotolerant fungi from thermal effluents was not detected. Thermophilic and thermotolerant fungi were widely distributed in soil, air, and on vegetation. Dactylaria gallopava, the indicator species and dominant fungus in microbial mats lining SRP thermal effluents and the cause of epidemic fatal phaeohyphomycosis in flocks of turkeys and chickens in South Carolina, Georgia, and elsewhere, was isolated from air at a maximum of 50 meters from effluents (8 viable units per cubic meter of air in the plume of an effluent during a strong wind).Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesRoss, R. B. ; Ermler, W. C. ; Luañta, V. ; Pitzer, R. M. ; Kern, C. W.
New York, NY : Wiley-Blackwell
Published 1990Staff ViewISSN: 0020-7608Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical PhysicsSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Ab initio self-consistent field calculations are reported for electronic states of beryllium clusters comprised of 81 and 87 atoms. The clusters correspond to the tenth and eleventh coordination shells of a central Be with internuclear separations derived from the lattice constants of the bulk metal. Ab initio effective core potentials have been employed to replace the 1s electrons, therey reducing the complexity of the calculations. In addition, the use of the full D3h point group symmetry of the clusters results in a substantial reduction of the number of two-electron integrals that must be computed and processed. Binding energies, orbital energies, electric field gradient, nuclear-electrostatic potential, diamagnetic shielding constant, second moments, and Mulliken populations are calculated for selected electronic states. Systematic trends toward bulk behavior with increasing cluster size, as found in earlier cluster studies, continue to appear for the electric field gradient and quadrupole moment of Be81. Anomalous behavior, however, is observed in Be87. This is attributed to distortional effects due to the addition of atoms in planes above and below the Be81 cluster along the principal axis of symmetry.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesRoss, R. B. ; Ermler, W. C. ; Kern, C. W. ; Pitzer, R. M.
New York, NY : Wiley-Blackwell
Published 1992Staff ViewISSN: 0020-7608Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical PhysicsSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Hartree-Fock-Roothaan studies are reported for low-lying electronic states of metallic beryllium as modeled by a moiety of 135 beryllium atoms. The system corresponds to 16 coordination shells of a central Be with internuclear separations derived from the lattice constants of the bulk metal. The calculations become tractable by use of the full D3h symmetry of the system at both the integrals and self-consistent-field stages and by employing ab initio effective potentials for the 1s electrons of each beryllium atom. Ionization potentials, binding energies, orbital energies, electric field gradients, nuclear-electrostatic potentials, diamagnetic shielding constants, second moments, and Mulliken populations are calculated for selected electronic states. The calculated ionization potential for the lowest state agrees to within 10% of the experimental bulk work function. A density-of-states analysis for that state is reported and compared with band structure calculations.Additional Material: 5 Ill.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1618-2650Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesRoss, R. B. ; Kern, C. W. ; Pitzer, R. M. ; Ermler, W. C.
New York, NY : Wiley-Blackwell
Published 1995Staff ViewISSN: 0020-7608Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical PhysicsSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Ab initio self-consistent-field calculations are reported for electronic states of beryllium clusters comprised of 93, 105, 111, and 123 atoms. The respective clusters correspond to coordination shells 12-15 of a central Be atom with internuclear separations derived from the lattice constants of the bulk metal. Ab initio effective core potentials have been employed to replace the 1 s electrons, thereby reducing the complexity of the calculations. In addition, use of the full D3h point group symmetry of the clusters results in a substantial reduction of the numbers of two-electron integrals that must be computed and processed. Binding energies, orbital energies, electric field gradient, nuclear-electrostatic potential, diamagnetic shielding constant, second moments, and Mulliken populations are calculated for selected electronic states. Calculated binding energies when compared among the different clusters as well as to smaller and larger fragments from earlier studies provide evidence for the onset of convergence to the Hartree-Fock limit of the bulk. Lowest-state ionization potentials are consistently above and agree to within 14% of the experimental workfunction. The net charge on the central beryllium atom decreases toward zero. The variability of observed bulklike behavior for the different properties indicates that the transition between cluster and bulklike behavior is not sharp and depends on the quantity of interest. © 1995 John Wiley & Sons, Inc.Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: