Search Results - (Author, Cooperation:C. K. Lee)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-08-21Publisher: Institute of Physics (IOP)Print ISSN: 1757-8981Electronic ISSN: 1757-899XTopics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. A. Miller ; S. L. Ding ; S. M. Sunkin ; K. A. Smith ; L. Ng ; A. Szafer ; A. Ebbert ; Z. L. Riley ; J. J. Royall ; K. Aiona ; J. M. Arnold ; C. Bennet ; D. Bertagnolli ; K. Brouner ; S. Butler ; S. Caldejon ; A. Carey ; C. Cuhaciyan ; R. A. Dalley ; N. Dee ; T. A. Dolbeare ; B. A. Facer ; D. Feng ; T. P. Fliss ; G. Gee ; J. Goldy ; L. Gourley ; B. W. Gregor ; G. Gu ; R. E. Howard ; J. M. Jochim ; C. L. Kuan ; C. Lau ; C. K. Lee ; F. Lee ; T. A. Lemon ; P. Lesnar ; B. McMurray ; N. Mastan ; N. Mosqueda ; T. Naluai-Cecchini ; N. K. Ngo ; J. Nyhus ; A. Oldre ; E. Olson ; J. Parente ; P. D. Parker ; S. E. Parry ; A. Stevens ; M. Pletikos ; M. Reding ; K. Roll ; D. Sandman ; M. Sarreal ; S. Shapouri ; N. V. Shapovalova ; E. H. Shen ; N. Sjoquist ; C. R. Slaughterbeck ; M. Smith ; A. J. Sodt ; D. Williams ; L. Zollei ; B. Fischl ; M. B. Gerstein ; D. H. Geschwind ; I. A. Glass ; M. J. Hawrylycz ; R. F. Hevner ; H. Huang ; A. R. Jones ; J. A. Knowles ; P. Levitt ; J. W. Phillips ; N. Sestan ; P. Wohnoutka ; C. Dang ; A. Bernard ; J. G. Hohmann ; E. S. Lein
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-04-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Anatomy, Artistic ; Animals ; Atlases as Topic ; Brain/embryology/*metabolism ; Conserved Sequence/genetics ; Fetus/cytology/embryology/*metabolism ; Gene Expression Regulation, Developmental/*genetics ; Gene Regulatory Networks/genetics ; Humans ; Mice ; Neocortex/embryology/metabolism ; Species Specificity ; *TranscriptomePublished by: -
3Latest Papers from Table of Contents or Articles in PressH. S. Chan ; Z. M. Hsieh ; W. H. Liang ; A. H. Kung ; C. K. Lee ; C. J. Lai ; R. P. Pan ; L. H. Peng
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-01-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressK. C. Lee ; M. R. Sprague ; B. J. Sussman ; J. Nunn ; N. K. Langford ; X. M. Jin ; T. Champion ; P. Michelberger ; K. F. Reim ; D. England ; D. Jaksch ; I. A. Walmsley
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-12-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressNg, C. W. S., Kosmo, B., Lee, P.-L., Lee, C. K., Guo, J., Chen, Z., Chiu, L., Lee, H. K., Ho, S., Zhou, J., Lin, M., Tan, K. M. L., Ban, K. H. K., Tan, T. W., Chng, W. J., Yan, B.
BMJ Publishing Group
Published 2018Staff ViewPublication Date: 2018-05-17Publisher: BMJ Publishing GroupPrint ISSN: 0021-9746Electronic ISSN: 1472-4146Topics: MedicinePublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesLee, C. K. B. ; McDonough, J. M. ; Huang, M. T.
[S.l.] : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: The Grassberger–Procaccia dimension is determined from pressure and temperature measurements in a pool of water agitated by steam injection. For this complex flow system, three distinct values of dimension ranging from ∼4.2 to ∼8.0 (corresponding to three different measurement locations) are obtained.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesLee, C. K. ; Chien, T. J. ; Hsu, J. C. ; Yang, C. Y. ; Hsiao, J. M. ; Huang, Y. R. ; Chang, C. L.
Oxford : Blackwell Science Ltd
Published 1998Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Laryngospasm occurring after tracheal extubation in children is potentially dangerous. This study uses acupuncture with bloodletting at the Shao Shang (L 11) or Shang Yang (Li 1) acupoints to investigate whether this technique can prevent or treat laryngospasm. Seventy-six patients were randomly divided into two groups. Patients in the acupuncture group (n = 38) were treated with bilateral Shao Shang acupunctures at the end of the operation. Patients in the control group (n = 38) were not. The incidence of laryngospasm in the acupuncture group (5.3%) was less than that in the control group (23.7%) (p 〈 0.05). If laryngospasm developed, patients were immediately treated with acupuncture at either the Shao Shang or Shang Yang acupoints. As judged by an increase in peripheral oxygen saturation, the laryngospasm was relieved within 1 min of acupuncture in all patients. It is concluded that acupuncture with bloodletting at the Shao Shang acupoint may prevent and treat laryngospasm occurring after tracheal extubation in children.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Several vaccination studies have been performed in monkeys and humans testing the feasibility of prophylactic and therapeutic immunizations against Helicobacter pylori. The monkey studies showed that immune responses were induced by oral vaccination with the mucosal adjuvant LT (Escherichia coli heat-labile enterotoxin), parenteral administration with a cationic lipid adjuvant, and by mucosal priming followed by parenteral boosts. Both prophylactic and therapeutic activities were demonstrated in monkeys, providing a strong impetus for human vaccine trials. Preliminary studies in humans were undertaken in order to identify a tolerable dose of LT adjuvant or to test the effectiveness of mutant atoxic LT adjuvants. The results from these preliminary studies suggest that native LT causes diarrhoea at doses required for adjuvanticity while a mutant LT does not. In one study in which infected human subjects were vaccinated with orally administered urease antigen with native LT, there was a modest reduction in the level of H. pylori gastric colonization. A second clinical study employing H. pylori whole cell antigen and a mutant LT in infected subjects showed immune responses and although the subjects remained infected, the study was not designed to measure reduction in H. pylori colonization. Recombinant Salmonella expressing urease and other H. pylori antigens have been effective in mice (see accompanying Frontlines Topic Review by John O. Nedrud [1]), but monkey studies are not possible because of host range restriction. Human trials of parenteral immunization, mucosal immunization with mutant LT and live Salmonella vectors are needed to fully assess the ability of vaccines to prevent or treat H. pylori infections.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesLEE, C. K. ; HUI, C. H. ; LIE, A. K. W. ; LIANG, R. ; CHAN, T. K.
Oxford, UK : Blackwell Science Ltd
Published 1997Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. About half of the haemophiliacs in Hong Kong have been infected by human immunodeficiency virus (HIV). This study aimed to determine their clinical course of progression. Forty-seven adult patients with congenital coagulation factor deficiency being followed up regularly from January 1992 onward in the Department of Medicine of Queen Mary Hospital, Hong Kong, were included in this study. Twenty were positive for HIV antibody and the remaining 27 were negative. Three other HIV-positive patients who died before 1992 were excluded. From January 1992 to June 1996, the 47 patients included in the study were followed up in the clinic every 3–6 months with regular CD4, CD8 lymphocyte counts and β2 microglobulin levels. At the initiation of the study in January 1992, the HIV-infected patients had already a lower mean CD4 count (360.4 μL−1 versus 658.8 μL−1, P〈0.01), a reversed CD4/CD8 ratio (0.53) and a higher mean serum β2 microglobulin level (1.853 μg mL−1 versus 1.315 μg mL−1, P〉0.05). On regular follow-up, HIV-positive patients had a more significant progressive fall in their mean CD4 count (301.6 μL−1 versus 360.4 μL−1, P〈0.01) and rise in their mean serum β2 microglobulin level (2.60 μg mL−1, versus 1.853 μg mL−1, P〈0.05). The CD4 and CD8 counts of HIV-positive patients were falling at a rate of 1.44 μL−1 month−1 and 4.03 μL−1 month−1 respectively. During the follow-up period, two of the 20 HIV-positive patients developed clinical acquired immunodeficiency syndrome (AIDS) at 15 and 36 months from the initiation of the study. Both patients had typical features of AIDS with a low CD4 count, reversed CD4/CD8 ratio and elevated β2 microglobulin level. The former patient eventually died of fungal brain abscess. The remaining 18 HIV-positive patients so far remained clinically asymptomatic. Eleven patients were put on antiretroviral drug therapy when their CD4 counts fell below 200 μL−1. Only two of the 20 HIV-infected patients developed AIDS during the observation period of 4 years; this figure of 10% is relatively slow. Two of our patients died of AIDS before the study was initiated in 1992. Even if they were included, still only 17.4% had progressed. The figure is in the lowest rate of progression expected from Western experience. Although our study population is small, it remains unclear why our HIV-infected Chinese haemophiliacs have a slow rate of progression to AIDS.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesLEE, C. K. ; WYETH, J. ; SERCOMBE, J. C. ; PASI, K. J. ; LEE, C. A. ; POUNDER, R. E.
Oxford, UK : Blackwell Science Ltd
Published 1997Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The aim of this study was to identify and eradicate H. pylori infection in patients with haemophilia. Patients were screened for IgG antibodies against H. pylori; active infection was determined using a 13C-urea breath test and infected patients were given combination therapy with antibiotics to eradicate infection. Seventy-eight of 219 (36%) patients with haemophilia were found to have an elevated serum antibody titre against H. pylori; of 36 antibody-positive patients with confirmatory testing, 14 were found to have active H. pylori infection. H. pylori infection was successfully eradicated in every infectedpatient using acombination of ranitidine plus two antibiotics (usually amoxycillin and metronidazole). It is concluded that eradication of H. pylori infection is likely to be a cost-effective screening strategy in patients with haemophilia, to prevent complications of peptic ulcer disease.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesFenyves, E. ; Lande, K. ; Bozoki, G. ; Frati, W. ; Lee, C. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1973Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesFenyves, E. ; Jani, Y. ; Bozoki, G. ; Lande, K. ; Lee, C. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1973Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Chemical modification of simple sugars and glycosides almost always results in products which are bitter, sweet, or bitter/sweet, although they are occasionally tasteless. Bitterness in all these molecules appears to be the result of polar as well as lipophilic molecular features. Ring size and shape also play a part in the bitter response. Unlike sweetness which seems primarily to be associated with the third and fourth hydroxyls of glucopyranosyl structures, bitterness is chiefly associated with hydroxyl groups on carbon atoms 1, 2 and 6, and with the ring oxygen atom. The configuration of substituents on carbon atoms 1 and 2 may determine bitterness in many molecules and indeed β-glycosides and β-linked oligosaccharides are more likely to be bitter than their α-linked counterparts. Unlike sweetness, which requires precise molecular dimensions in glucopyranosyl structures, no distinct interorbital distances can yet be established for bitterness. However, AH,B systems may suffice to explain bitterness in some types of sugar analogue.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesFrati, W. ; Lande, K. ; Supplee, J. ; Bozoki, G. ; Fenyves, E. ; Lee, C. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1975Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesCho, Y. S. ; Park, S. Y. ; Lee, C.-K. ; Lee, E. Y. ; Shin, J.-H. ; Yoo, B. ; Moon, H.-B.
Oxford, UK : Munksgaard International Publishers
Published 2003Staff ViewISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: Although many chronic cough patients have complained of an induced cough by cold air contact, the clinical relevance of cold air to inducing a cough and the diagnostic value of a hyperpnea with cold air (HCA) challenge to detect a hyperreactive cough reflex have not yet been investigated.Methods: Recordings of cough counts after a 2-min HCA challenge were performed in 49 chronic cough patients and 15 healthy controls. Capsaicin cough provocation tests, which determine the threshold concentration of capsaicin that induces five or more consecutive coughs (C5), were also administered.Results: After comparing the results from the capsaicin cough provocation tests of the patients and the controls, the chronic cough patients were divided into two groups: an increased cough sensitivity (ICS) group (n = 28) (C5 〈 32 μmol/l) and a normal cough sensitivity (NCS) group (n = 21) (C5 ≥ 32 μmol/l). The median value of induced cough counts after a HCA challenge was 11 coughs in patients with ICS and was a significantly enhanced cough response compared to that of the patients with NCS and healthy controls (four coughs, respectively).Conclusions: A simple cough provocation test using a HCA challenge may be useful for detecting ICS. It also suggests that hyperreactive cough reflexes may be one of the mechanisms of inducing chronic cough.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesGOH, K.-L. ; QUEK, K.-F. ; YEO, G. T. S. ; HILMI, I. N. ; LEE, C.-K. ; HASNIDA, N. ; AZNAN, M. ; KWAN, K.-L. ; ONG, K.-T.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background : Colorectal cancer is one of the most common forms of gastrointestinal cancer in the world today. In the Asia–Pacific area, it is the fastest emerging gastrointestinal cancer.Aim : To determine the basic demographic features of patients with colorectal cancer and the anatomic distribution and characteristics of the tumour in a local Asian population.Methods : We conducted a review of consecutive patients who had undergone colonoscopy from 1999 to 2003 at the University of Malaya Medical Center, Kuala Lumpur, Malaysia.Results : Analysis was carried out on 3404 patients who underwent colonoscopy. A total of 228 patients (7%) were diagnosed with carcinoma. The mean age of diagnosis (±s.d.) was 64.4 ± 13.1 years. The male to female ratio was 1.15. Polyps were noted in 470 patients (14%). Polyps detected concomitantly with a colorectal cancer were noted in 55 patients (2%). Four patients (0.1%) were diagnosed to have familial adenomatous polyposis coli. Of the 228 patients 209 (92%) had tumours at only one site whereas 19 (8%) had synchronous lesions. Tumours were mainly left sided [198 of 248 patients (80%)] with the majority located in the recto-sigmoid region. Detailed records of treatment were available only in 176 patients. A total of 147 of 176 patients (84%) underwent surgery and 50 (28%) also received adjuvant or palliative chemotherapy (28%). Seven of 154 patients (5%) were diagnosed to have stage A cancers, 64 (42%), stage B, 23 (15%), stage C and 60 (39%), stage D. Multivariate analysis using multiple logistic regression analysis showed that age ≥65 years (OR = 1.78; 95% CI: 1.35– 2.36) and Malay (OR = 2.09; 95% CI: 1.30–3.35) and Chinese (OR = 1.77; 95% CI: 1.77–2.69) race were significant independent predictive factors for colorectal cancer.Conclusions : The demography of colorectal cancer is different from western patients. Tumours were mainly left sided in our patients. However, no differences in anatomic location were found between races, men and women and younger and older age groups. Colorectal cancer presented in an advanced stage in the majority of patients.Type of Medium: Electronic ResourceURL: