Search Results - (Author, Cooperation:C. J. Wilson)
-
1Latest Papers from Table of Contents or Articles in PressJ. Barretina ; G. Caponigro ; N. Stransky ; K. Venkatesan ; A. A. Margolin ; S. Kim ; C. J. Wilson ; J. Lehar ; G. V. Kryukov ; D. Sonkin ; A. Reddy ; M. Liu ; L. Murray ; M. F. Berger ; J. E. Monahan ; P. Morais ; J. Meltzer ; A. Korejwa ; J. Jane-Valbuena ; F. A. Mapa ; J. Thibault ; E. Bric-Furlong ; P. Raman ; A. Shipway ; I. H. Engels ; J. Cheng ; G. K. Yu ; J. Yu ; P. Aspesi, Jr. ; M. de Silva ; K. Jagtap ; M. D. Jones ; L. Wang ; C. Hatton ; E. Palescandolo ; S. Gupta ; S. Mahan ; C. Sougnez ; R. C. Onofrio ; T. Liefeld ; L. MacConaill ; W. Winckler ; M. Reich ; N. Li ; J. P. Mesirov ; S. B. Gabriel ; G. Getz ; K. Ardlie ; V. Chan ; V. E. Myer ; B. L. Weber ; J. Porter ; M. Warmuth ; P. Finan ; J. L. Harris ; M. Meyerson ; T. R. Golub ; M. P. Morrissey ; W. R. Sellers ; R. Schlegel ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Lineage ; Chromosomes, Human/genetics ; Clinical Trials as Topic/methods ; *Databases, Factual ; Drug Screening Assays, Antitumor/*methods ; *Encyclopedias as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, ras/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; *Models, Biological ; Neoplasms/*drug therapy/genetics/metabolism/*pathology ; Pharmacogenetics ; Plasma Cells/cytology/drug effects/metabolism ; Precision Medicine/methods ; Receptor, IGF Type 1/antagonists & inhibitors/metabolism ; Receptors, Aryl Hydrocarbon/genetics/metabolism ; Sequence Analysis, DNA ; Topoisomerase Inhibitors/pharmacologyPublished by: -
2Articles: DFG German National LicensesKelsey, D. E. ; White, R. W. ; Powell, R. ; Wilson, C. J. L. ; Quinn, C. D.
Oxford, UK : Blackwell Science Inc
Published 2003Staff ViewISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Abstract Granulite facies metapelites of the Mather and Filla Paragneisses within the Rauer Group, east Antarctica, possess markedly different compositions. The metamorphic evolution of the two metapelite types has been interpreted as temporally distinct, with the Rauer Group preserving at least two distinct granulite facies tectonothermal episodes. Calculated P–T pseudosections and orthopyroxene Al content indicate the revised maximum-preserved P–T conditions within the Mather Paragneiss to lie in the vicinity of 950–975 °C and 10–10.6 kbar, less extreme than previous estimates. The range of possible P–T paths for the Mather Paragneiss consistent with mineral textural relationships and pseudosections contoured for mineral proportion are significantly shallower (dP/dT) than previous estimates. A near-isothermal decompression P–T path, and extreme peak metamorphic conditions, are not necessary to explain the development of preserved mineral reaction textures. The Filla Paragneiss contains pelitic assemblages less amenable to rigorous quantitative analysis. Nevertheless, possibilities for the shared or otherwise metamorphic evolution of the Mather and Filla Paragneisses may be postulated on the basis of calculated pseudosections in the context of existing geochronology for the Rauer Group and preserved microstructures. A shared evolution, most likely during Pan-African granulite facies metamorphism, is plausible and consistent with mineral assemblage development, geochronology and microstructures. A revised interpretation of the Rauer Group's preserved metamorphic evolution may warrant the revision of existing tectonic models, applicable also to the remainder of Prydz Bay. More generally, the employed approach may incite a revision of peak P–T and P–T paths in other granulite facies terranes.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesCARSON, C. J. ; POWELL, * R. ; WILSON, C. J. L. ; DIRKS, P. H. G. M.
Oxford, UK : Blackwell Science Ltd.
Published 1997Staff ViewISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Anatectic migmatites in medium- to low-pressure granulite facies metasediments exposed in the Larsemann Hills, East Antarctica, contain leucosomes with abundant quartz and plagioclase and minor interstitial K-feldspar, and assemblages of garnet–cordierite–spinel–ilmenite–sillimanite. Qualitative modelling in the system K2O–FeO–MgO–Al2O3–SiO2–H2O–TiO2–O2, in conjunction with various P–T calculations indicate that the high-grade retrograde evolution of the terrane was dominated by decompression from peak conditions of c. 7 kbar at c. 800 °C to 4–5 kbar at c. 750 °C. Extensive partial melting during decompression involved the replacement of biotite by the assemblage cordierite–garnet–spinel within the leucosomes. These leucosomes represent the site of partial melt generation, the cordierite–garnet–spinel–ilmenite assemblage representing the solid products and excess reactants from the melting reaction. The extraction and accumulation of this decompression-generated melt led to the formation of syntectonic pegmatites and extensive granitic plutons. Leucosome development and terrane decompression proceeded during crustal transpression, synchronous with upper crustal extension, during a progressive Early Palaeozoic collisional event. Subsequent retrograde evolution was characterized by cooling, as indicated by the growth of biotite replacing spinel and garnet, thin mantles of cordierite replacing spinel and quartz within metapelites, and garnet replacing orthopyroxene and hornblende within metabasites. P–T calculations on late mylonites indicate lower grade conditions of formation of c. 3.5 kbar at c. 650 °C, consistent with the development of late cooling textures.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesHAND, M. ; SCRIMGEOUR, I. ; POWELL, R. ; STÜWE, K. ; WILSON, C. J. L.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Granulite facies metasedimentary gneiss exposed on Jetty Peninsula, east Antarctica, contains assemblages involving garnet-sillimanite-biotite-cordierite-spinel-ilmenite-rutile and garnet-orthopyroxene-cordierite-biotite, as well as quartz and K-feldspar. Peak assemblages involve garnet + sillimanite + ilmenite (±rutile) and garnet + orthopyroxene. P-T calculations suggest formation conditions of approximately 800d̀ C at 7-7.5 kbar. Cooling from peak conditions is suggested by biotite + garnet (±sillimanite) overprinting some peak assemblages. A subsequent increase in temperature is inferred from the formation of cordierite + garnet + biotite + ilmenite, garnet + sillimanite + cordierite + ilmenite and cordierite + orthopyroxene assemblages during D2. In slightly zincian bulk compositions, hercynitic spinel + cordierite + sillimanite constitutes the peak D2 assemblage. Average pressure calculations indicate peak pressures of 5.9 ±0.4 kbar at 700d̀ C for the cordierite-bearing D2 assemblages. Available radiometric data suggest that peak metamorphism occurred at c. 1000 Ma and D2 occurred after 940 ± 20 Ma. The following two possibilities exist for the metamorphic evolution. (1) The formation of the lower pressure cordierite-bearing assemblages is associated with a separate metamorphic event (M2), unrelated to the peak assemblage (M1), and the lower pressure assemblages have no relevance in terms of a single tectonothermal event. (2) The cordierite-bearing assemblages formed during a progression from peak conditions. In this case, the lower pressure assemblages reflect a broadly decompressional metamorphic evolution, during which temperatures fluctuated. Comparison with P-T paths from granulites of similar age in adjacent areas suggests that the second possibility should be preferred. The cooling interval between peak conditions and the development of cordierite-bearing coronas and symplectites suggests affinities with isobarically cooled granulites of similar age immediately to the west, and the low-P/high-T post-peak conditions are similar to the later stages of decompressional paths recognized in much of east Antarctica.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: Cambrian orogenesis (550–490 Ma) in the Lambert Province of the southern Prince Charles Mountains resulted in three successive stages of deformation. The earliest of these deformations resulted in the development of a layer-parallel foliation (S1) that was folded into macro-scale recumbent folds (F2). Subsequent deformation buckled the rocks into long-wavelength (c. 20 km), SW- to NW-trending antiformal closures (F3) mostly separated from each other by west to SW trending, steeply dipping, high-strain zones. Metapelitic rocks from the region are divisible into two compositional types: a high-Al, -Fe and -K type and a high-Mg, -Ca and -Na type. In rocks of both composition, relic staurolite preceded the formation of upper amphibolite facies garnet + biotite + sillimanite ± muscovite mineral assemblages that record peak pressures and temperatures of c. 650–700 °C and 6–7 kbar. Subsequent decompression of c. 3 kbar is implied from texturally late plagioclase and a reduction in the modal abundance of garnet in the high-Al, -Fe and -K metapelites, and from texturally late cordierite in the more magnesium rocks. This clockwise P–T–t path, with prograde heating followed by rapid decompression, is: (i) equivalent to that recorded in the same-aged rocks at Prydz Bay located 600 km to the north, and (ii) similar to the modelled response of the crust to thickening following continent–continent collision. These results indicate that large areas of East Antarctica were thickened and rapidly exhumed, probably in response to collisional orogenesis during the Early Cambrian. This supports the inference that Early Cambrian orogenesis in the Prydz Bay–Prince Charles Mountains region of East Antarctica marks one of the fundamental lithospheric boundaries within Gondwana.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesXU, G. ; POWELL, R. ; WILSON, C. J. L. ; WILL, T. M.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1525-1314Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesNotes: The contact metamorphosed metapelitic and metapsammitic rocks surrounding the Stawell granite, western Victoria, Australia, are divided into three zones: the low-grade zone, the medium-grade zone and the high-grade zone. Detailed petrological study shows consistency of element distributions, implying that equilibrium was widely attained in the rocks, although equilibrium volumes are generally small (millimetre scale) and considerable mineral chemical variations exist between adjacent domains. The metamorphic mineral assemblages are generally of high variance (KFMASH variance ≤ 2). Consequently, the chemical evolution of assemblages is controlled largely by bulk composition and metamorphic temperature, the former factor being more important in most rocks. The chemographic relations of mineral assemblages in low- and medium- to high-grade zones are presented in compatibility diagrams projected from biotite, quartz and H2O, and biotite, K-feldspar and H2O, respectively. These compatibility diagrams have the advantage of showing both quartz-bearing and quartz-absent assemblages. The metamorphic reactions are modelled successfully by a calculated petrogenetic grid that combines both KFASH and KMASH equilibria. Based on petrographic observations and with constraints from the calculated petrogenetic grid, the following KFMASH reactions, in the order of increasing metamorphic grade, are responsible for producing the various mineral assemblages in the Stawell rocks:chl + mu + q = bi + cd + V,chl + q + cd = g + V,mu + bi + q = ksp + cd + V,mu + q = ksp + and + cd + V (or KASH mu + q = ksp + and + V),mu + cd = ksp + and + bi + V,mu + bi + and = ksp + sp + V,and + bi = ksp + sp + cd + V,mu + bi = ksp + cor + sp + V,mu = ksp + cor + and + sp + V (or KASH mu = ksp + cor + V),bi + cd + q = g + ksp + V.The combined KFASH and KMASH grid provides constraints on reaction coefficients in the above sequence of reactions and on temperature and pressure of metamorphism.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesWilson, C. J. ; Ormeggi, A. ; Narbutovskih, M.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Silicon microcantilever beams are fractured and characterized. The specially designed beams, etched into two wafers, are loaded to fracture in bending using a unique measurement system. A finite element model of the beams is created, and ABAQUS is used to calculate the displacements and stresses produced by an applied load force. A special testing scheme is devised to obtain certain model parameters: E〈110〉, the Young's modulus along the length of the beam and Lforce, the position of the applied force. With these parameters defined, the model is well correlated with that of the experimental data. The fracture stress (strength) of the beam is obtained from the stress produced in the model at the fracture location by a load equivalent to the experimental fracture force. This fracture stress can be used as a design parameter for silicon micromechanical structures. Numerous beams are fractured from both the front and back sides of the wafer, and statistical fracture strength results are compiled for each of these cases. The fracture strength of the front side, 3.3 GPa (average), is significantly greater than that of the backside, 1.0 GPa (average). This dissimilarity is attributed to the differences in the surface roughness of these sides. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesWILSON, C. J. N. ; AMBRASEYS, N. N. ; BRADLEY, J. ; WALKER, G. P. L.
[s.l.] : Nature Publishing Group
Published 1981Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] WILSON ET AL. REPLY-We answer Froggatt's five objections to our interpretation1 as follows: (1) We accept that the red Sun, Moon and sky colouration would have been caused by the finest particles (mostly ^0.5 |xm)2 and that particles from sources other than Taupo could have been responsible. We ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. l a, An isotropic block of fine-grained ice with circular strain markers, b, The isotropic sample after 21% shortening and the strain markers are now ellipses, c, The planar fine- and medium-grained layers in the anisotropic block, separated by the films of frozen water, d, The anisotropic ice ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The young age of the Taupo and Rabaul ignimbrites, and their occurrence in humid areas where a luxuriant vegetation anchors and protects pyroclastic deposits very soon after they have formed, has resulted in their remarkably good structural preservation. These ignimbrites shown new features which ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] WALKER ET AL. REPLY-We accept without reservation the relationships described by Fisher and others from the Lesser Antilles. We have long believed in the concept that pyroclastic flows sensu stricto and pyroclastic surges have fundamentally different transport mechanisms. What is in question, ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesWilson, C. J. N. ; Ambraseys, N. N. ; Bradley, J. ; Walker, G. P. L.
[s.l.] : Nature Publishing Group
Published 1980Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The products of the Taupo eruption are rhyolitic and are dispersed over a large part of the North Island2. They consist of an initial plinian pumice-fall deposit (the Hatepe Pumice)2, two phreatoplinian3 ashes (the Putty Ash and Rotongaio Ash)4 which are separated by an erosion break, the ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesWilson, C. J. N. ; Houghton, B. F. ; Kampt, P. J. J. ; McWilliamst, M. O.
[s.l.] : Nature Publishing Group
Published 1995Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The central Taupo Volcanic Zone (TVZ; Fig. 1) is the most productive Quaternary rhyolitic volcanic system on Earth. At least 34 voluminous ignimbrites (30-1,000 km3 bulk volume) have been erupted from eight caldera volcanoes"'12 in central TVZ since 1.6Myr. Several of the New Zealand ignimbrites ...Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Dade and Huppert1 present a model for emplacement of the Taupo ignimbrite (New Zealand) from a turbulent dilute pyroclastic current (0.3% solids by volume). This model contrasts sharply with that of a concentrated current (tens of per cent solids by volume) previously proposed by me2 to explain ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0013-8266Topics: HistoryNotes: NOTES AND DOCUMENTSURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-0819Keywords: explosive volcanism ; dome-building volcanism ; phreatomagmatic acticity ; fall deposits ; surge deposits ; rhyolite ; Maroa volcanoSource: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract The 14 ka Puketarata eruption of Maroa caldera in Taupo Volcanic Zone was a dome-related event in which the bulk of the 0.25 km3 of eruption products were emplaced as phreatomagmatic fall and surge deposits. A rhyolitic dike encountered shallow groundwater during emplacement along a NE-trending normal fault, leading to shallow-seated explosions characterised by low to moderate water/magma ratios. The eruption products consist of two lava domes, a proximal tuff ring, three phreatic collapse craters, and a widespread fall deposit. The pyroclastic deposits contain dominantly dense juvenile clasts and few foreign lithics, and relate to very shallow-level disruption of the growing dome and its feeder dike with relatively little involvement of country rock. The distal fall deposit, representing 88% of the eruption products is, despite its uniform appearance and apparently subplinian dispersal, a composite feature equivalent to numerous discrete proximal phreatomagmatic lapilli fall layers, each deposited from a short-lived eruption column. The Puketarata products are subdivided into four units related to successive phases of:(A) shallow lava intrusion and initial dome growth; (B) rapid growth and destruction of dome lobes; (C) slower, sustained dome growth and restriction of explosive disruption to the dome margins; and (D) post-dome withdrawal of magma and crater-collapse. Phase D was phreatic, phases A and C had moderate water: magma ratios, and phase B a low water: magma ratio. Dome extrusion was most rapid during phase B, but so was destruction, and hence dome growth was largely accomplished during phase C. The Puketarata eruption illustrates how vent geometry and the presence of groundwater may control the style of silicic volcanism. Early activity was dominated by these external influences and sustained dome growth only followed after effective exclusion of external water from newly emplaced magma.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-0819Keywords: dilute gravity current ; rain-flushed ash grain size ; grain morphology ; Hatepe Plinian deposit ; Taupo ; New ZealandSource: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract Two groups of poorly sorted ash-rich beds, previously interpreted as rain-flushed ashes, occur in the ca. AD 180 Hatepe Plinian pumice fall deposit at Taupo volcano, New Zealand. Two ash beds with similar dispersal patterns and an aggregate thickness of up to 13 cm make up the lowermost group (A). Group A beds extend 45 km north-east of the vent and cover 290 km2. In the southern part of the group A distribution area, a coarse ash to lapilli-size Plinian pumice bed (deposit B) separates the two group A beds. The scarcity of lapilli (material seen elsewhere from the still-depositing pumice fall) in group A beds indicates that they were rapidly transported and deposited. However, this rapid transportation and deposition did not produce cross-bedding, nor did it erode the underlying deposits. It is proposed that thick (〉600 m) but dilute gravity currents generated from the collapsing outer margin of the otherwise buoyant Hatepe Plinian eruption column deposited the group A beds. The upper ash beds (group C) consist of one to seven layers, attain an aggregate thickness of ≤35 cm, and vary considerably in thickness and number of beds with respect to distance from vent. Group C beds contain variable amounts of ash mixed with angular Plinian pumices and are genuine rain-flushed ashes. Several recent eruptions at other volcanoes (Ukinrek Maars, Vulcan, Rabaul, La Soufrère de Guadeloupe and Soufrière, St Vincent) have produced gravity currents similar in style, but much smaller than those envisaged for group A deposits. The overloaded margins of otherwise buoyant eruption plumes generated these gravity currents. Laboratory studies have produced experimental gravity current analogues. Hazards from dilute gravity currents are considerable but often overlooked, thus the recognition of gravity current deposits will contribute to more thorough volcanic hazard assessment of prehistoric eruption sequences.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesHoughton, B. F. ; Wilson, C. J. N. ; Rosenberg, M. D. ; Smith, I. E. M. ; Parker, R. J.
Springer
Published 1996Staff ViewISSN: 1432-0819Keywords: Key words Explosive volcanism ; Magmatic ; Phreatomagmatic ; Crater Hill ; BasaltSource: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract A series of alternating phreatomagmatic ("wet") and magmatic ("dry") basaltic pyroclastic deposits forming the Crater Hill tuff ring in New Zealand contains one unit (M1) which can only be interpreted as the products of mixing of ejecta from simultaneous wet and dry explosions at different portions of a multiple vent system. The principal characteristics of M1 are (a) rapid lateral changes in the thicknesses of, and proportions in juvenile components in individual beds, and (b) wide ranges of juvenile clast densities in every sample. M1 appears to have been associated with an elongate source of highly variable and fluctuating magma : water ratios and magma discharge rates. This contrasts with the only other documented mixed (wet and dry) basaltic pyroclastic deposits where mixing from two point sources of quite different but stable character has been inferred.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-1106Keywords: Substantia nigra ; 5-OHDA ; Dendro-dendritic synapses ; Self-inhibition ; Monoamine storage sitesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Intraventricular administration of 1 or 2 mg of the osmiophilic “false transmitter” 5-hydroxydopamine (5-OHDA) was used to label monoamine storage and release sites in the rat substantia nigra. Vesicles containing unusually dense cores indicative of the presence of the marker were seen forming from the Golgi apparatus in the cell bodies of medium-sized neurons of the substantia nigra, pars compacta, and from smooth endoplasmic reticulum in the dendrites of those neurons and in small unmyelinated axons of unknown origin. In serial sections, both axons and dendrites containing synaptic vesicles marked with 5-OHDA were seen to form synapses “en passage” in pars compacta, and some presynaptic dendrites containing vesicles filled by the marker were also observed to form contacts with dendrites in pars reticulata. The only identified postsynaptic elements engaging in monoaminergic synapses in the substantia nigra were dendrites of medium-sized pars compacta neurons.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-1106Keywords: Striatal spiny neurons ; Nigro-striatal fibers ; Striatal PSP's corpus striatum ; Substantia nigra stimulationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Responses of striatal neurons to stimulation in substantia nigra were recorded intracellularly in intact rats and after acute or chronic unilateral lesions of cerebral cortex or after combined cortical lesions and unilateral thalamic transections. Spiny striatal efferent neurons were identified by intracellular injection of horseradish peroxidase. In intact animals substantia nigra stimulation evoked a complex response with both excitatory and inhibitory phases. Acute unilateral decortication abolished the inhibitory phase of the response and reduced the amplitude of the initial EPSP. Thus, part of the excitatory phase and most or all of the inhibitory phase of the response result from polysynaptic routes to striatum involving cerebral cortex. The remaining EPSP observed in acute decorticate animals exhibited two components distinguished on the basis of their time courses. The latter of these was abolished by thalamic transections. The earlier component was shown to be a monosynaptic EPSP evoked by axon collaterals of cortical efferent neurons projecting to brainstem and was not observed in animals subjected to chronic decortication. After removal of all of these non-nigral response components a small long latency EPSP could be evoked by nigral stimulation. This EPSP is probably due to activation of dopaminergic nigro-striatal axons.Type of Medium: Electronic ResourceURL: