Search Results - (Author, Cooperation:C. J. Struchiner)

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  1. 1
    D. E. Neafsey ; R. M. Waterhouse ; M. R. Abai ; S. S. Aganezov ; M. A. Alekseyev ; J. E. Allen ; J. Amon ; B. Arca ; P. Arensburger ; G. Artemov ; L. A. Assour ; H. Basseri ; A. Berlin ; B. W. Birren ; S. A. Blandin ; A. I. Brockman ; T. R. Burkot ; A. Burt ; C. S. Chan ; C. Chauve ; J. C. Chiu ; M. Christensen ; C. Costantini ; V. L. Davidson ; E. Deligianni ; T. Dottorini ; V. Dritsou ; S. B. Gabriel ; W. M. Guelbeogo ; A. B. Hall ; M. V. Han ; T. Hlaing ; D. S. Hughes ; A. M. Jenkins ; X. Jiang ; I. Jungreis ; E. G. Kakani ; M. Kamali ; P. Kemppainen ; R. C. Kennedy ; I. K. Kirmitzoglou ; L. L. Koekemoer ; N. Laban ; N. Langridge ; M. K. Lawniczak ; M. Lirakis ; N. F. Lobo ; E. Lowy ; R. M. MacCallum ; C. Mao ; G. Maslen ; C. Mbogo ; J. McCarthy ; K. Michel ; S. N. Mitchell ; W. Moore ; K. A. Murphy ; A. N. Naumenko ; T. Nolan ; E. M. Novoa ; S. O'Loughlin ; C. Oringanje ; M. A. Oshaghi ; N. Pakpour ; P. A. Papathanos ; A. N. Peery ; M. Povelones ; A. Prakash ; D. P. Price ; A. Rajaraman ; L. J. Reimer ; D. C. Rinker ; A. Rokas ; T. L. Russell ; N. Sagnon ; M. V. Sharakhova ; T. Shea ; F. A. Simao ; F. Simard ; M. A. Slotman ; P. Somboon ; V. Stegniy ; C. J. Struchiner ; G. W. Thomas ; M. Tojo ; P. Topalis ; J. M. Tubio ; M. F. Unger ; J. Vontas ; C. Walton ; C. S. Wilding ; J. H. Willis ; Y. C. Wu ; G. Yan ; E. M. Zdobnov ; X. Zhou ; F. Catteruccia ; G. K. Christophides ; F. H. Collins ; R. S. Cornman ; A. Crisanti ; M. J. Donnelly ; S. J. Emrich ; M. C. Fontaine ; W. Gelbart ; M. W. Hahn ; I. A. Hansen ; P. I. Howell ; F. C. Kafatos ; M. Kellis ; D. Lawson ; C. Louis ; S. Luckhart ; M. A. Muskavitch ; J. M. Ribeiro ; M. A. Riehle ; I. V. Sharakhov ; Z. Tu ; L. J. Zwiebel ; N. J. Besansky
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-01-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Anopheles/classification/*genetics ; Base Sequence ; Chromosomes, Insect/genetics ; Drosophila/genetics ; *Evolution, Molecular ; *Genome, Insect ; Humans ; Insect Vectors/classification/*genetics ; Malaria/*transmission ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Superior colliculus ; Opossum ; Visual representation ; Disparity ; Vertical meridian
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The uniocular visual field representations on the superior colliculus (SC), as estimated from multiunit response field centres about the horizontal meridian, were compared in midpontine pretrigeminal opossums (Didelphis marsupialis aurita Wied 1826). Recordings from the rostral pole (RP) and its caudal neighbour, the direct binocular region (DBR), as defined by Rocha-Miranda et al. (1978), were distinguished by the histological control. The results showed that while the hemifield contralateral to the recording site was well represented on the DBR by both eyes, the ipsilateral hemifield was generously represented at the RP only by the contralateral eye. At the RP the ipsilateral eye usually conveyed information about the vertical meridian, bringing about an expanded representation of the central visual space. Distinct patterns of representation were also recognized on graphs which relate recording sites along the AP axis of the SC with the azimuths of response field centres. The representation of the vertical reference meridian upon this axis on an oculocentric system was estimated from the DBR data and localized in the RP, at about 500 μm from the rostral end, for the ipsilateral eye (Vo') and in the DBR, at about 800 μm for the other eye (Vo). Similarly, plots of the magnification factor against the AP collicular axis indicated different strategies of representation for each eye. At the segment between 500 and 800 μm on this axis the magnification factors of the ipsilateral eye were usually much higher than those of the other eye. Furthermore, horizontal disparities between field centres were shown to have distinct distributions along the AP axis within the RP and DBR regions. At the latter a constant crossed disparity value (median=5.3°) was present along the AP axis while at the former greater variability and higher central disparity values were detected. An argument is developed based on this data to suggest that under our conditions the central binocular axis of the opossum are convergent with respect to the visual axis and their representation centred about the RP/DBR boundary. The different strategy of representation adopted by each eye at these two regions argue against a redundancy in the processing of visual information at the RP and the DBR on the opposite side, both of which bear a representation of the same visual space when considering only the information conveyed by the eye contralateral to the RP. The possible roles of this organization and the relevancy of these findings for studies of plastic rearrangement are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00236944

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-1041
    Keywords:
    Key words Amlodipine ; Limited-sampling models ; Pharmacokinetics
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Abstract Objective: Develop and validate limited-sampling strategy (LSS) models for estimating the area under the plasma concentration versus time curve (AUC) of amlodipine, using data from a bioequivalence study. Methods: Sixteen healthy volunteers received single 5-mg oral doses of amlodipine, as reference or test formulation, at a 14-day interval, in a randomized, crossover protocol. Plasma concentrations of amlodipine (n = 288), measured by mass spectrometry, were used to develop LSS models. Results: Linear regression analysis of the AUC0–72 and a “jack-knife” validation procedure revealed that LSS models based on two sampling times (12 h and 48 h) predict accurately (R2 = 0.99; bias〈0.01%; precision = 0.03%) the AUC0–72 of amlodipine for each formulation. Validation tests indicate that the 2-point LSS model developed for the reference formulation predicts accurately (R2〉0.90): (a) the individual AUC0–72 for the test formulation in the same group of volunteers; (b) the individual AUC0–72 for the same reference formulation in another bioequivalence study in Brazilian volunteers; (c) the average AUC0–72 reported in seven additional international studies performed under protocols similar to the present investigation; (d) the individual AUC0–72 corresponding to concentration data points provided by a first-order compartmental pharmacokinetic model, when the relative values of either the absorption rate (K abs) or the bioavailability (F) model parameters were set at 0.85 or 0.6, of their respective original values. Conclusions: The 2-point LSS models developed in the current study predict accurately the AUC of amlodipine under a variety of experimental conditions and, thus, may be valuable for exploring the relationships between the pharmacokinetics and pharmacodynamics of this calcium antagonist, at reduced costs of sample acquisition and analysis, and avoiding sampling at “unsociable” hours.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002280050688

    Articles: DFG German National Licenses