Search Results - (Author, Cooperation:C. H. Lu)

2011-10-29

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Cell Lineage ; Cell Movement ; Clone Cells/cytology/physiology ; Gene Knock-In Techniques ; Interneurons/*cytology/*physiology ; Mice ; Mitosis ; Neocortex/*cytology/embryology ; *Neural Inhibition ; Neural Stem Cells/*cytology/physiology ; *Neurogenesis ; Neuroglia/cytology/physiology ; Preoptic Area/cytology/embryology ; Telencephalon/*cytology/embryology

2013-10-25

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Actin-Related Protein 2-3 Complex/metabolism ; Actins/metabolism ; Adult ; Animals ; Behavior, Animal ; Bipolar Disorder/*drug therapy/genetics/*physiopathology ; Chromosomes, Human, Pair 22/genetics ; Disease Models, Animal ; Excitatory Postsynaptic Potentials ; Female ; Gene Dosage/genetics ; Gene Expression/genetics ; Genes, Duplicate/genetics ; Humans ; Hyperkinesis/genetics/physiopathology ; Inhibitory Postsynaptic Potentials ; Lithium/pharmacology ; Male ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/*genetics/*metabolism ; Seizures/genetics ; Valproic Acid/pharmacology/therapeutic use

2013-05-31

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Ataxin-1 ; Ataxins ; Cell Line, Tumor ; Disease Models, Animal ; Down-Regulation/drug effects ; Drosophila melanogaster/genetics/*metabolism ; Female ; Humans ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mitogen-Activated Protein Kinases/*metabolism ; Molecular Sequence Data ; Molecular Targeted Therapy ; Nerve Tissue Proteins/chemistry/genetics/*metabolism/*toxicity ; Nuclear Proteins/chemistry/genetics/*metabolism/*toxicity ; Phosphorylation ; Protein Stability/drug effects ; Ribosomal Protein S6 Kinases, 90-kDa/deficiency/genetics/*metabolism ; Spinocerebellar Ataxias/*metabolism/*pathology ; Transgenes ; ras Proteins/*metabolism

0001-6918

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Psychology

Electronic Resource

1432-1998

Pericardial anomalies ; Cardiac trauma ; Pericarditis

Springer Online Journal Archives 1860-2000

Medicine

Abstract Three cases of pericardial defect are reported and their unique features are discussed.

Electronic Resource

1439-0973

Key words Adult bacterial meningitis ; Mixed infection ; Nosocomial infection ; Postneurosurgical state

Springer Online Journal Archives 1860-2000

Medicine

Summary 12 adult patients suffering from bacterial meningitis caused by mixed infection were identified at Kaohsiung Chang Gung Memorial Hospital over a period of 13 years (1986–1998), and they accounted for 6.5% (12/184) of our culture-proven adult bacterial meningitis. The 12 cases included seven males and five females, aged 17–74 years. Six of the 12 cases had community-acquired infections and the other six had nosocomially-acquired infections. Ten of the 12 cases had associated underlying diseases, with head trauma and/or neurosurgical procedure being the most frequent. Both gram-negative and gram-positive pathogens were identified in these 12 cases with gram-negative pathogens outnumbering the gram-positive ones. The implicated pathogens, starting with the most frequent, included Enterobacter species (Enterobacter cloacae, Enterobacter aerogenes), Klebsiella species (Klebsiella pneumoniae, Klebsiella oxytoca), Escherichia coli, Staphylococcus species (Staphylococcus aureus, Staphylococcus haemolyticus), Pseudomonas aeruginosa, Acinetobacter baumannii, Enterococcus, Serratia marcescens, Citrobacter diversus, Proteus mirabilis, Streptococcus viridans and Neisseria meningitidis. Six of the 12 cases were found to have multi-antibiotic-resistant strains, which included E. cloacae in one, A. baumannii in one, K. pneumoniae in one and S. aureus in three. The management of these 12 cases included appropriate antibiotics and neurosurgical procedures including shunt revision. Despite the complexity of implicated pathogens and the high incidence of emergence of resistant strains, the overall mortality rate (8.3%, 1/12) was not higher than that in adult bacterial meningitis. However, complete recuperation was difficult in adult patients with mixed bacterial meningitis.

Electronic Resource

1573-269X

nonstationary dynamics

Springer Online Journal Archives 1860-2000

Mathematics

Abstract The study presented in this paper is one of a series of paperspublished by the authors on nonstationary problems. It addresses itselfto the characterization of the types of dynamical responses and theirranges contained in the time flow of the Duffing nonlinear,nonstationary, dissipative, forced oscillator. A new effective method –a Nonstationary Bifurcation Map (EI-Lu map) – has been introduced bythe authors that allows us to do precisely this. This new technique isby far more advantageous than the customary methods in use: the phaseportrait or Poincaré maps. The latter may give inadequate informationbecause of the overlapping dynamical responses contained within rangesof time. The main feature of nonstationary processes is that thenonstationary responses are transient. The phenomena of the transiencyare presented in detail. Significant cases are those when thenonstationary transmission of the signals crosses differentnonstationary bifurcation boundaries. This is significant because mostof dynamical-biological activities occur in the regions between orderand chaos. It characterizes nonstationary dynamical processes. Thepossibility of constructing responses for arbitrary small nonstationaryinputs may be used as nonstationary perturbations, replacing customaryperturbations of integrable Hamiltonians.

Electronic Resource

1573-269X

Springer Online Journal Archives 1860-2000

Mathematics

Abstract The Duffing oscillators are widely used to mathematically model a variety of engineering and physical systems. A computational analysis has been initiated to explore the effects of nonstationary excitations on the response of the softening Duffing oscillator in the region of the parameter space where the period doubling sequences occur. Significant differences between the stationary and nonstationary responses have been uncovered: (i) the stationary transitions from T to 2T, from 2T to 4T ... etc. branches at the stationary period doubling bifurcations are smooth, in nonstationary cases they exhibit jumps to the near stationary branches at the values of the control parameters greater than those for the stationary; this phenomenon is called penetration (delay or memory). The lengths of the penetrations is being compressed to zero with the increasing number of the iterations. (ii) The stationary and nonstationary responses eventually settle on different limit motions, the nonstationary has modulated components. (iii) The jumps appearing in the stationary bifurcation diagram at 2T from the upper to the lower branches of the (x, f) and (x, Ω), i.e., (displacement-forcing amplitude) and (displacement-forcing frequency), diagrams have been replaced by continuous transition in the nonstationary diagram climinating thus the discontinuity. Apart from these differences, some specific characteristic nonstationary responses have been observed not encountered in the stationary cases: (iv) the appearance of the ‘window’ in the nonstationary limit bifurcation diagrams. (v) The nonstationary limit motions located on the upper (lower) branches of the (x, f) or (x, Ω) diagrams expanded rapidly to the lower (upper) branches. (vi) The stationary and nonstationary bifurcation diagrams are extremely sensitive to the initial conditions, manifested by the mirror reflections, called the flipflop phenomenon. (vii) The nonstationary limit motion has been characterized by a complex phase portrait, the appearance of the Cantor-like set of the limit motion bifurcation plot, and continuous spectral density. For the purpose of comparison, a stationary period doubling sequence T, 2T,..., 2 n T,... stationary limit motion, χST which is known to be chaotic has been determined. A far reaching observation has been made in the process of this study: the determination of the nonstationary bifurcations, their branches and limit motions, has been independent of the calculations of the stationary ones, indicating, thus, the existence of an independent class of nonstationary (time varying) dynamics.

Electronic Resource