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1Latest Papers from Table of Contents or Articles in PressM. B. Gerstein ; A. Kundaje ; M. Hariharan ; S. G. Landt ; K. K. Yan ; C. Cheng ; X. J. Mu ; E. Khurana ; J. Rozowsky ; R. Alexander ; R. Min ; P. Alves ; A. Abyzov ; N. Addleman ; N. Bhardwaj ; A. P. Boyle ; P. Cayting ; A. Charos ; D. Z. Chen ; Y. Cheng ; D. Clarke ; C. Eastman ; G. Euskirchen ; S. Frietze ; Y. Fu ; J. Gertz ; F. Grubert ; A. Harmanci ; P. Jain ; M. Kasowski ; P. Lacroute ; J. Leng ; J. Lian ; H. Monahan ; H. O'Geen ; Z. Ouyang ; E. C. Partridge ; D. Patacsil ; F. Pauli ; D. Raha ; L. Ramirez ; T. E. Reddy ; B. Reed ; M. Shi ; T. Slifer ; J. Wang ; L. Wu ; X. Yang ; K. Y. Yip ; G. Zilberman-Schapira ; S. Batzoglou ; A. Sidow ; P. J. Farnham ; R. M. Myers ; S. M. Weissman ; M. Snyder
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-09-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Cell Line ; DNA/*genetics ; *Encyclopedias as Topic ; GATA1 Transcription Factor/metabolism ; Gene Expression Profiling ; Gene Regulatory Networks/*genetics ; Genome, Human/*genetics ; Genomics ; Humans ; K562 Cells ; *Molecular Sequence Annotation ; Organ Specificity ; Phosphorylation/genetics ; Polymorphism, Single Nucleotide/genetics ; Protein Interaction Maps ; RNA, Untranslated/genetics/metabolism ; Regulatory Sequences, Nucleic Acid/*genetics ; Selection, Genetic/genetics ; Transcription Factors/*metabolism ; Transcription Initiation SitePublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Fractions and subcellular structures were prepared from rat brain homogenate and their purity was assessed using enzyme markers, γ-aminobutyric acid binding, DNA content, and electron microscopy. Insulin binding was highest on the plasma membrane preparations and approximately 50% less so on brain homogenate crude mi-tochondrial (P2), myelinated axon, and synaptosome preparations. Very low levels of binding were found on mitochondria and nuclei. Differences in binding between fractions were due to numbers of binding sites, and not variable binding affinity. There was a close relationship between insulin binding and the activity of Na/K ATPase (E.C. 3.6.1.4) in all fractions (r= 0.98). Insulin binding to the P2 was compared with plasma membrane fractions in seven brain regions, and the results demonstrated the same close relationship between insulin binding and plasma membrane content in all regions except hypothalamus. Plasma membrane insulin binding was well represented by the binding on P2 membranes in all regions except hypothalamus and brainstem. It was concluded that insulin binding is distributed evenly over the surface of brain cells and is not increased on nerve endings.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesTOPPILA, M. ; TYLER, J. P. P. ; FAY, R. ; BAIRD, P. J. ; CRANDON, J. ; EASTMAN, C. J. ; HUDSON, C. N.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. The oestrogen and progestogen receptor status in ovarian cancers from 72 patients was correlated with histological type, primary. or secondary origin and peripheral hormone concentrations. Changes occurred in receptor status during malignant transformations of ovarian tissues, with those for oestrogen being found more often, and those for progestogen less often than in non-diseased ovarian fragments. It is suggested that the similarity in sex steroid receptor content between ovarian and breast cancers warrants prospective study of ovarian sex steroid receptor status as a predictive index of survival and response to hormonal therapy in multi-centre clinical trials. Additional data on androgen receptors are also presented.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesBabadoost, M. ; Chen, W. ; Bratsch, A. D. ; Eastman, C. E.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-3059Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: This study was conducted to determine the causal agent(s) of internal discoloration of horseradish roots. In 1999, 133 roots from 31 fields, and in 2000, 108 roots from nine fields, were assayed to determine the incidence and severity of internal discoloration of horseradish roots as well as the pathogen(s) associated with discoloured tissue. Verticillium dahliae, Verticillium longisporum and Fusarium solani were isolated from 14, 16 and 23% of roots in 1999, and from 24, 20 and 19% of roots in 2000, respectively. Verticillium longisporum on horseradish was identified for the first time. Pathogenicity tests of isolated microorganisms were conducted on horseradish in the glasshouse. In one experiment on the susceptible cultivar 1573, roots (sets) were inoculated by dipping the sets in a suspension of either V. dahliae microsclerotia, V. longisporum microsclerotia, or F. solani conidia and then grown in a soil mix over 5 months. Plants inoculated with any of the three species developed root discoloration similar to that observed in commercial fields. Internal root discoloration symptoms developed over a period of 5 months. For all three pathogens, severity of root discoloration was significantly higher after 5 months compared with 2 months from inoculation. In another experiment on cultivar 1590, tissue culture-generated seedlings and sets were planted in an infested soil mix with V. dahliae or V. longisporum and grown in the glasshouse. Plants developed root discoloration, as observed in the field. The pathogens were reisolated from inoculated plants in both experiments. No pathogen was isolated from the control plants in the experiments. The results of this study suggest that internal discoloration of horseradish roots is a disease complex caused by at least three fungal species.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] REPRODUCTIONS of early figures of the common Mediterranean species of Hippocampus have been pub-lished by Prof. Raymond Osburn in the Zoological Bulletin for March, 1915, and also by the present writer in the annual report of the Smithsonian Institution for the same year. It is remarked ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] As remarked by Dr. Albert Günther, in his article on the history of the Remora (“On the History of the Echeneis,” Ann. Mag. Nat. Hist., 1860, ser. 3, vol v., p. 386), “there is scarcely a fish of the existence of which the ancients have been equally certain, and which has so much occupied their ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] THE discussion in NATURE during the past year concerning the first mention in literature of the opossum and kangaroo has suggested a similar inquiry with regard to certain other well-known animals of the New and Old World. When one examines into the sources whence were derived the ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] IN NATURE of February 18 and July 29, 1915, and in the American Museum Journal for last year, figures were published of ancient Egyptian and also of late fifteenth-century representations of the giraffe. To this series of olden-time drawings may now be added one from Chinese sources, dating ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0264-8377Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0362-3319Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: SociologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0095-0696Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Energy, Environment Protection, Nuclear Power EngineeringEconomicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1573-0891Source: Springer Online Journal Archives 1860-2000Topics: Political ScienceEconomicsNotes: Abstract Systems approaches possess an ability to deal with large numbers of interacting variables and relations. They are here connected tocitizen information systems (distinguished frommanagement information systems) and to mixed, adaptive, conditional models for urban planning. The latter permit flexible and continuing responses to dynamically changing urban conditions, including citizen attitudes and reactions, as well as to changing economics and technologies. These models are “mixed” in that they allow actions and reactions from a multiplicity of decisionmakers. The resulting decisions are made only conditionally, rather than once-and-for-all, on a comprehensive basis as in the customary “master city plan.” Proceeding in this conditional manner, the model then permits adaptation to changing values and objectives as, at each stage, it makes the systems consequences apparent. The systems approach is related to a host of important methodological developments in mathematics, statistics, etc., as well as in electronic computers and their use. These distinguish modern systems approaches from predecessors like the “holism” of Jan Christiaan Smuts and others in pre-war science. The mixed, conditional, adaptive models suggested here are compared with other approaches like “advocacy planning,” the “comprehensive master city plan” and “ad hoc planning.” It is found to be possible at least in principle, to accommodate all of these and even to extend matters further to include day-to-day as well as longer range facilities plans in the indicated systems approach by virtue of the improved methodologies that may now be used or developed for these purposes.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0037-7996Topics: HistoryURL: -
14Articles: DFG German National LicensesCOOPER, W. W. ; EASTMAN, C. ; JOHNSON, N. ; KORTANEK, K.
Amsterdam, etc. : Periodicals Archive Online (PAO)
Published 1971Staff ViewISSN: 0032-2687Topics: Political ScienceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] IN view of the fact that several communications have appeared in NATURE during the past year concerning the first mention of the American opossum in literature, it may not be inopportune to direct attention to some of the early illustrations of this animal in maps and in printed works. First of ...Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesMaberly, G. F. ; Wait, G. A. ; Kilpatrick, J. A. ; Loten, E. G. ; Gain, K. R. ; Stewart, R. D. H. ; Eastman, C. J.
Springer
Published 1982Staff ViewISSN: 1432-0428Keywords: Insulin resistance ; insulin degradation ; diabetes mellitus ; aprotinin ; insulinasesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The period before, during and after resistance to subcutaneous insulin in a 20-year-old, non-obese insulin-dependent patient with ‘brittle’ diabetes is documented and clinical observations are correlated with experimental results of insulin degradation in vitro. Treatment with intravenous but not subcutaneous aprotinin markedly reduced subcutaneous insulin requirements. Insulin resistance recurred following cessation of aprotinin. Serum free insulin levels were low during the subcutaneous resistant phase compared with those during the more sensitive phase. Insulin degradation in vitro by adipose tissue and muscle taken from the patient during a resistant phase was increased compared with degradation by tissue taken during a sensitive phase and by tissue from normal subjects. Chromatography of incubation media revealed that during the resistant phase, tissue from the patient degraded insulin to small fragments. It is concluded that, in this patient, insulin resistance was caused by excessive degradation in both muscle and adipose tissue.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1573-2819Source: Springer Online Journal Archives 1860-2000Topics: PsychologyNotes: Abstract Perceived self-efficacy was introduced by Bandura (1977) as “an integrative theoretical framework to explain and predict psychological changes achieved by different modes of treatment” (p. 191). Subsequent empirical studies appear to support the contention that self-efficacy ratings on specific behavioral tasks are accurate predictors of subsequent behavioral performance on those tasks. In this paper we examine the conceptual basis of self-efficacy theory. In particular, the distinction between outcome and efficacy expectations is analyzed in relation to fear and avoidant behavior. We conclude that self-efficacy theory is conceptually problematic and, in particular, that the central concept of efficacy expectations is not unambiguously differentiated from outcome expectations, despite Bandura's (1978) claim to the contrary. Similarly, we suggest that what is actually being assessed in the empirical studies is unclear. We conclude that the empirical findings are less impressive when the circumscribed nature of the behavioral tasks is recognized. Finally, we suggest that resolutions of both the conceptual and methodological difficulties are necessary before Bandura's (1978) claim, that self-efficacy is a unifying construct, can be properly evaluated.Type of Medium: Electronic ResourceURL: